Research Topics
Species | Tatjana Sauka-SpenglerSummaryAffiliation: California Institute of Technology Country: USA Publications
| Collaborators
|
Detail Information
Publications
Insights from a sea lamprey into the evolution of neural crest gene regulatory networkTatjana Sauka-Spengler
Division of Biology 139 74, California Institute of Technology, Pasadena, California 91125, USA
Biol Bull 214:303-14. 2008..In contrast, certain differences were observed in deployment of some neural crest specifier and downstream effector genes expected to confer species-specific migratory and differentiation properties...
A gene regulatory network orchestrates neural crest formationTatjana Sauka-Spengler
Division of Biology 13974, California Institute of Technology, Pasadena, California 91125, USA
Nat Rev Mol Cell Biol 9:557-68. 2008..Here, we review our current understanding of these processes and discuss the molecular players that are involved in the neural crest gene regulatory network...
Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancersHugo J Parker
Division of Systems Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
BMC Genomics 12:637. 2011..Whilst comparative genomics approaches have identified thousands of putative regulatory elements, our knowledge of their mechanism of action is poor and very little progress has been made in systematically de-coding them...- Whole-mount in situ hybridization on lamprey embryosNatalya Nikitina
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Cold Spring Harb Protoc 2009:pdb.prot5125. 2009..In addition, studies of features that are unique to lampreys can provide insights into mechanisms of parallel evolution. This protocol describes an optimized procedure for RNA in situ hybridization in lamprey embryos... - The sea lamprey Petromyzon marinus: a model for evolutionary and developmental biologyNatalya Nikitina
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Cold Spring Harb Protoc 2009:pdb.emo113. 2009..marinus is poised to become an evolutionary developmental model of choice... - Expression of sympathetic nervous system genes in Lamprey suggests their recruitment for specification of a new vertebrate featureDaniela Häming
Division of Biology, California Institute of Technology, Pasadena, California, United States of America
PLoS ONE 6:e26543. 2011..This raises the intriguing possibility that they may have been recruited during gnathostome evolution to a new function in a neural crest derivative... - Histone demethylase JmjD2A regulates neural crest specificationPablo Hernan Strobl-Mazzulla
Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
Dev Cell 19:460-8. 2010..Our findings show that chromatin modifications directly control neural crest genes in vertebrate embryos via modulating histone methylation... - Dynamic and differential regulation of stem cell factor FoxD3 in the neural crest is Encrypted in the genomeMarcos S Simões-Costa
Division of Biology, California Institute of Technology, Pasadena, California, USA
PLoS Genet 8:e1003142. 2012.... - Expression of Sox family genes in early lamprey developmentBenjamin R Uy
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Int J Dev Biol 56:377-83. 2012..Coupled with phylogenetic analysis of these Sox genes, the results provide insight into gene duplication and di-vergence in paralog deployment occurring during early vertebrate evolution... - Immunostaining of whole-mount and sectioned lamprey embryosNatalya Nikitina
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Cold Spring Harb Protoc 2009:pdb.prot5126. 2009..This protocol describes how to immunostain whole-mount or sectioned lamprey embryos using an antibody raised against the protein of interest and detected with a horseradish peroxidase (HRP)-conjugated secondary antibody... - Assembling neural crest regulatory circuits into a gene regulatory networkPaola Betancur
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
Annu Rev Cell Dev Biol 26:581-603. 2010.... - Chapter 1. Gene regulatory networks in neural crest development and evolutionNatalya Nikitina
Divison of Biology, California Institute of Technology, Pasadena, CA, USA
Curr Top Dev Biol 86:1-14. 2009..We summarize recent evidence for the ongoing diversification of the neural crest in several vertebrate species, with particular reference to studies in nontraditional vertebrate model organisms... - DiI cell labeling in lamprey embryosNatalya Nikitina
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Cold Spring Harb Protoc 2009:pdb.prot5124. 2009..This protocol describes how to label lamprey embryo cells by microinjecting the fluorescent dye DiI (1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate) to study cell fate during development... - DNA methyltransferase3A as a molecular switch mediating the neural tube-to-neural crest fate transitionNa Hu
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Genes Dev 26:2380-5. 2012..Thus, DNMT3A functions as a molecular switch, repressing neural to favor neural crest cell fate... - A Sox10 enhancer element common to the otic placode and neural crest is activated by tissue-specific paralogsPaola Betancur
Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
Development 138:3689-98. 2011.... - Microinjection of RNA and morpholino oligos into lamprey embryosNatalya Nikitina
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Cold Spring Harb Protoc 2009:pdb.prot5123. 2009..Finally, the second division lasts for several hours, providing a very large injection window. This protocol describes how to microinject RNA and morpholinos into lamprey embryos for genetic modification studies... - Culturing lamprey embryosNatalya Nikitina
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Cold Spring Harb Protoc 2009:pdb.prot5122. 2009..This protocol describes how to produce lamprey embryos by collecting sperm and eggs from mature lampreys, performing fertilization, and culturing the embryos through to the desired developmental stage... - Genomic code for Sox10 activation reveals a key regulatory enhancer for cranial neural crestPaola Betancur
Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 107:3570-5. 2010..Using cis-regulatory analysis as a tool, our study makes critical connections within the neural crest gene regulatory network, thus being unique in establishing a direct link of upstream effectors to a key neural crest specifier... - Ancient evolutionary origin of the neural crest gene regulatory networkTatjana Sauka Spengler
Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
Dev Cell 13:405-20. 2007..By testing the collective expression and function of neural crest genes in a single, basal vertebrate, we reveal the ground state of the NC-GRN and resolve ambiguities between model organisms... - Dissecting early regulatory relationships in the lamprey neural crest gene networkNatalya Nikitina
Division of Biology, California Institute of Technology, Pasadena, CA 81125, USA
Proc Natl Acad Sci U S A 105:20083-8. 2008..These findings provide an ancestral framework for performing comparative tests in higher vertebrates in which network linkages may be more difficult to resolve because of their rapid development... - Evolution of the neural crest viewed from a gene regulatory perspectiveTatjana Sauka-Spengler
Division of Biology 139 74, California Institute of Technology, Pasadena, California 91125, USA
Genesis 46:673-82. 2008..Analyzing neural crest formation from a gene regulatory viewpoint provides insights into both the developmental mechanisms and evolutionary origins of this vertebrate-specific cell type... - Development and evolution of the migratory neural crest: a gene regulatory perspectiveTatjana Sauka-Spengler
Division of Biology 139-74, California Institute of Technology, Pasadena, CA 91125, USA
Curr Opin Genet Dev 16:360-6. 2006..These in turn regulate other transcription factors termed neural crest-specifiers, which control genes involved in neural crest delamination, the generation of migratory cells and ultimately the acquisition of appropriate fates... - Gain- and loss-of-function approaches in the chick embryoTatjana Sauka-Spengler
California Institute of Technology, Pasadena, California 91125, USA
Methods Cell Biol 87:237-56. 2008..We routinely overexpress constructs containing 3-4 kb inserts and coharboring a GFP or RFP reporter whose translation is initiated from an internal ribosomal entry site (IRES), thus allowing easy detection of the electroporated cells... - Expression of the polycomb group gene bmi-1 in the early chick embryoPaige E Fraser
Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
Gene Expr Patterns 5:23-7. 2004..Bmi-1 expression was also present in the developing heart primordia and the sensory placodes. The data show that bmi-1 is present in, but not restricted to, tissue containing multipotent precursor cells...