June L Round

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi Coordination of tolerogenic immune responses by the commensal microbiota
    June L Round
    Division of Biology, California Institute of Technology, 1200 E California Blvd, Pasadena, CA, USA
    J Autoimmun 34:J220-5. 2010
  2. ncbi The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 332:974-7. 2011
  3. ncbi Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:12204-9. 2010
  4. ncbi The gut microbiota shapes intestinal immune responses during health and disease
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Immunol 9:313-23. 2009
  5. ncbi A microbial symbiosis factor prevents intestinal inflammatory disease
    Sarkis K Mazmanian
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 453:620-5. 2008
  6. ncbi MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, 330 Braun, 1200 E California Boulevard, Pasadena, CA 91125, USA
    Immunity 33:607-19. 2010

Collaborators

Detail Information

Publications6

  1. ncbi Coordination of tolerogenic immune responses by the commensal microbiota
    June L Round
    Division of Biology, California Institute of Technology, 1200 E California Blvd, Pasadena, CA, USA
    J Autoimmun 34:J220-5. 2010
    ....
  2. ncbi The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 332:974-7. 2011
    ..We propose that the immune system can discriminate between pathogens and the microbiota through recognition of symbiotic bacterial molecules in a process that engenders commensal colonization...
  3. ncbi Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:12204-9. 2010
    ..Our results therefore demonstrate that B. fragilis co-opts the Treg lineage differentiation pathway in the gut to actively induce mucosal tolerance...
  4. ncbi The gut microbiota shapes intestinal immune responses during health and disease
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Immunol 9:313-23. 2009
    ..This raises the possibility that the mammalian immune system, which seems to be designed to control microorganisms, is in fact controlled by microorganisms...
  5. ncbi A microbial symbiosis factor prevents intestinal inflammatory disease
    Sarkis K Mazmanian
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 453:620-5. 2008
    ..Harnessing the immunomodulatory capacity of symbiosis factors such as PSA might potentially provide therapeutics for human inflammatory disorders on the basis of entirely novel biological principles...
  6. ncbi MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, 330 Braun, 1200 E California Boulevard, Pasadena, CA 91125, USA
    Immunity 33:607-19. 2010
    ..Our study shows that one aspect of miR-155 function is the promotion of T cell-dependent tissue inflammation, suggesting that miR-155 might be a promising therapeutic target for the treatment of autoimmune disorders...