ELLEN ROTHENBERG

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint From totipotency to T in a dish
    Ellen V Rothenberg
    Nat Immunol 5:359-60. 2004
  2. pmc The chromatin landscape and transcription factors in T cell programming
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125 USA Electronic address
    Trends Immunol 35:195-204. 2014
  3. pmc Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells
    Satoko Adachi
    Division of Biology 156 29, California Institute of Technology Pasadena, CA 91125, USA
    Nucleic Acids Res 33:3200-10. 2005
  4. pmc Transcriptional control of early T and B cell developmental choices
    Ellen V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena, California 91125 email
    Annu Rev Immunol 32:283-321. 2014
  5. pmc Epigenetic mechanisms and developmental choice hierarchies in T-lymphocyte development
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA Tel 1 626 395 4992 Fax 1 626 449 0756
    Brief Funct Genomics 12:512-24. 2013
  6. pmc Transcriptional drivers of the T-cell lineage program
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Opin Immunol 24:132-8. 2012
  7. pmc T-cell identity and epigenetic memory
    Ellen V Rothenberg
    California Institute of Technology, Pasadena, CA 91125, USA
    Curr Top Microbiol Immunol 356:117-43. 2012
  8. ncbi request reprint Origins of lymphocyte developmental programs: transcription factor evidence
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Semin Immunol 16:227-38. 2004
  9. pmc Multilayered specification of the T-cell lineage fate
    Ellen V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Immunol Rev 238:150-68. 2010
  10. ncbi request reprint Molecular genetics of T cell development
    Ellen V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Annu Rev Immunol 23:601-49. 2005

Research Grants

Collaborators

Detail Information

Publications49

  1. ncbi request reprint From totipotency to T in a dish
    Ellen V Rothenberg
    Nat Immunol 5:359-60. 2004
  2. pmc The chromatin landscape and transcription factors in T cell programming
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125 USA Electronic address
    Trends Immunol 35:195-204. 2014
    ....
  3. pmc Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells
    Satoko Adachi
    Division of Biology 156 29, California Institute of Technology Pasadena, CA 91125, USA
    Nucleic Acids Res 33:3200-10. 2005
    ....
  4. pmc Transcriptional control of early T and B cell developmental choices
    Ellen V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena, California 91125 email
    Annu Rev Immunol 32:283-321. 2014
    ..Complete T cell-like effector differentiation can proceed without T cell receptor rearrangement or selection when E proteins are neutralized, yielding natural killer and other innate lymphoid cells. ..
  5. pmc Epigenetic mechanisms and developmental choice hierarchies in T-lymphocyte development
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA Tel 1 626 395 4992 Fax 1 626 449 0756
    Brief Funct Genomics 12:512-24. 2013
    ..These are evaluated in a framework of reciprocal effects of previous chromatin structure features on transcription factor access and of transcription factor binding on other factors and on future chromatin structure. ..
  6. pmc Transcriptional drivers of the T-cell lineage program
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Opin Immunol 24:132-8. 2012
    ..Several reports now reveal how TCF-1 and GATA-3 are mobilized in early T cells and the pathways for their T-lineage specific effects...
  7. pmc T-cell identity and epigenetic memory
    Ellen V Rothenberg
    California Institute of Technology, Pasadena, CA 91125, USA
    Curr Top Microbiol Immunol 356:117-43. 2012
    ..We argue that epigenetic analysis may achieve its greatest impact for illuminating regulatory biology when it is used to locate cis-regulatory elements by catching them in the act of mediating regulatory change...
  8. ncbi request reprint Origins of lymphocyte developmental programs: transcription factor evidence
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Semin Immunol 16:227-38. 2004
    ..We consider the functions of these factors in animals without lymphocytes in terms of discrete program components, which could have been assembled in a new way to create the lymphocyte developmental program approximately 500 My ago...
  9. pmc Multilayered specification of the T-cell lineage fate
    Ellen V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Immunol Rev 238:150-68. 2010
    ..Here, we review insights into T-cell specification and commitment that emerge from a combination of molecular, cellular, and systems biology approaches. The results reveal the regulatory structure underlying this lineage decision...
  10. ncbi request reprint Molecular genetics of T cell development
    Ellen V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Annu Rev Immunol 23:601-49. 2005
    ....
  11. ncbi request reprint Cell lineage regulators in B and T cell development
    Ellen V Rothenberg
    Division of Biology, 156 29, California Institute of Technology, Pasadena, California 91125, USA
    Nat Immunol 8:441-4. 2007
    ..The comparison among them sheds light on the different ways that an essential regulatory input can affect cellular identity...
  12. ncbi request reprint Regulatory factors for initial T lymphocyte lineage specification
    Ellen V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Curr Opin Hematol 14:322-9. 2007
    ..1, growth factor independence (Gfi)-1, T cell factor (TCF)-1, and Runx factors and their interactions with the Notch pathway to promote T cell development...
  13. ncbi request reprint Negotiation of the T lineage fate decision by transcription-factor interplay and microenvironmental signals
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Immunity 26:690-702. 2007
    ..An additional mechanism, still not fully defined, is required just prior to T cell receptor-mediated selection to end plasticity and make T lineage commitment irreversible...
  14. pmc Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Semin Immunol 20:236-46. 2008
    ..1, and Notch-Delta signals, whose counterbalance appears to be essential for T-cell specification...
  15. pmc T cell lineage commitment: identity and renunciation
    Ellen V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Immunol 186:6649-55. 2011
    ..This regulatory mosaic has notable implications for the hierarchy of relationships linking T lymphocytes to other hematopoietic fates...
  16. ncbi request reprint Immunology. Thymic regulation--hidden in plain sight
    Ellen V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 307:858-9. 2005
  17. ncbi request reprint T-lineage specification and commitment: a gene regulation perspective
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Semin Immunol 14:431-40. 2002
    ..Here we review the current evidence identifying the regulatory components of this commitment pathway, and the first hints of how they work together. Roles for PU.1, GATA-3, and their target genes are highlighted...
  18. ncbi request reprint Elements of transcription factor network design for T-lineage specification
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 246:29-44. 2002
    ..Hypothetical models are proposed to indicate the network nodes that are differentially activated in normal T cell lineage progression and in cells diverted to other potential fates...
  19. ncbi request reprint Stepwise specification of lymphocyte developmental lineages
    E V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Curr Opin Genet Dev 10:370-9. 2000
    ....
  20. ncbi request reprint Transcriptional regulation of lymphocyte lineage commitment
    E V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, California 91125, USA
    Bioessays 21:726-42. 1999
    ....
  21. ncbi request reprint Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage
    M K Anderson
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Development 126:3131-48. 1999
    ....
  22. ncbi request reprint Lineage plasticity and commitment in T-cell development
    Ellen V Rothenberg
    Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Immunol Rev 187:96-115. 2002
    ..However, the response of the population to PU.1 is sharply discontinuous. These studies show a critical role for regulatory context in restricting plasticity, which is probably maintained by interacting transcription factor networks...
  23. ncbi request reprint Expression and function of a stem cell promoter for the murine CBFalpha2 gene: distinct roles and regulation in natural killer and T cell development
    J C Telfer
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 229:363-82. 2001
    ....
  24. ncbi request reprint Different developmental arrest points in RAG-2 -/- and SCID thymocytes on two genetic backgrounds: developmental choices and cell death mechanisms before TCR gene rearrangement
    R A Diamond
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    J Immunol 158:4052-64. 1997
    ..Thus, the SCID thymocytes appear to undergo a normal generation but a premature death as compared with the RAG-2 -/- thymocytes...
  25. pmc Evolution of hematopoiesis: Three members of the PU.1 transcription factor family in a cartilaginous fish, Raja eglanteria
    M K Anderson
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 98:553-8. 2001
    ..The tissue-specific expression patterns of skate PU.1 and Spi-C suggest that these genes share regulatory as well as structural properties with their mammalian orthologs...
  26. ncbi request reprint Differential transcriptional regulation of individual TCR V beta segments before gene rearrangement
    F Chen
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Immunol 166:1771-80. 2001
    ..However, the expression pattern of Vbeta2.1 is highly distinctive and includes cell types apparently outside the T lineage, suggesting potential acquisition of specialized roles...
  27. pmc A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation
    E V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Proc Natl Acad Sci U S A 93:9358-65. 1996
    ..Thus a distinct domain of the IL-2 regulatory sequence may contain sites for competence- or lineage-marking protein contacts...
  28. ncbi request reprint A new regulatory region of the IL-2 locus that confers position-independent transgene expression
    M A Yui
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Immunol 166:1730-9. 2001
    ..Thus, the 6.4 kb of additional upstream IL-2 sequence contains regulatory elements that provide integration site independence and differential regulation of transgene expression in CD8 vs CD4 cells...
  29. ncbi request reprint Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors
    Luigi A Warren
    Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Opin Immunol 15:166-75. 2003
    ..1 versus GATA-1 balance, the intensity of Notch signaling through the CSL pathway, and the ratio of E-box transcription factors to their Id protein antagonists...
  30. ncbi request reprint Functional and phenotypic analysis of thymocytes in SCID mice. Evidence for functional response transitions before and after the SCID arrest point
    E V Rothenberg
    Division of Biology, California Institute of Technology, Pasadena 91125
    J Immunol 151:3530-46. 1993
    ..A model is proposed in which discrete changes in functional competence define novel transitions in early thymocyte development, at least some of which may be linked to TCR-beta gene rearrangement before positive or negative selection...
  31. pmc Regulatory anatomy of the murine interleukin-2 gene
    T J Novak
    Division of Biology, California Institute of Technology, Pasadena 91125
    Nucleic Acids Res 18:4523-33. 1990
    ..Therefore we conclude that IL2 gene expression is controlled primarily through a central TH1-specific signaling pathway, which acts through proximal elements, while distal cis-elements exert a secondary modulating effect...
  32. ncbi request reprint Subversion of T lineage commitment by PU.1 in a clonal cell line system
    Christopher J Dionne
    Division of Biology 156 29, California Institute of Technology, Pasadena, 91125 USA
    Dev Biol 280:448-66. 2005
    ..The adh.2C2 and adh.6D4 clones thus provide an accessible system for defining mechanisms controlling developmental plasticity in early T-cell development...
  33. ncbi request reprint Deranged early T cell development in immunodeficient strains of nonobese diabetic mice
    Mary A Yui
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Immunol 173:5381-91. 2004
    ..Furthermore, this breakthrough may initiate thymic lymphomagenesis that occurs with high frequency in both NOD-scid and -Rag1null mice...
  34. ncbi request reprint Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes
    Janice C Telfer
    Department of Veterinary and Animal Sciences, Paige Laboratory, University of Massachusetts, Amherst, MA 01003, USA
    J Immunol 172:4359-70. 2004
    ..The presence of the nuclear matrix targeting sequence is required for Runx-mediated CD4 repression, suggesting that Runx transcription factors are stabilized on the CD4 silencer via association with the nuclear matrix...
  35. ncbi request reprint Evolutionary origins of lymphocytes: ensembles of T cell and B cell transcriptional regulators in a cartilaginous fish
    Michele K Anderson
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Immunol 172:5851-60. 2004
    ..However, certain factors relevant to the B lineage differ in their tissue-specific expression patterns from their mouse counterparts, suggesting expanded or divergent B lineage characteristics or tissue specificity in these animals...
  36. ncbi request reprint Preferential activation of an IL-2 regulatory sequence transgene in TCR gamma delta and NKT cells: subset-specific differences in IL-2 regulation
    Mary A Yui
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    J Immunol 172:4691-9. 2004
    ....
  37. ncbi request reprint GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation
    Gabriela Hernandez-Hoyos
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Immunity 19:83-94. 2003
    ..We propose that GATA-3 contributes to linking the TCR signal strength to the differentiation program of CD4 and CD8 thymocytes...
  38. pmc Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification
    Yalin Guo
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Blood 112:480-92. 2008
    ..Therefore, the ability of the prethymic cell to respond appropriately to Notch is dependent on CBFbeta, and both signals converge to activate the T-cell developmental program...
  39. pmc Launching the T-cell-lineage developmental programme
    Ellen V Rothenberg
    Division of Biology 156 29, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Immunol 8:9-21. 2008
    ....
  40. pmc Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3
    Tom Taghon
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium
    Nat Immunol 8:845-55. 2007
    ..Our results suggest a close relationship between the pro-T cell and mast cell programs and a previously unknown function for Notch in T lineage fidelity...
  41. ncbi request reprint Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus
    Tom Taghon
    Division of Biology, MC 156 29, California Institute of Technology, 1200 E California Boulevard, Pasadena, California 91125, USA
    Immunity 24:53-64. 2006
    ..Our results also reveal differences in Notch/Delta dependence at the earliest stages of divergence between developing alphabeta and gammadelta T-lineage cells...
  42. ncbi request reprint Progression of regulatory gene expression states in fetal and adult pro-T-cell development
    Elizabeth Sharon David-Fung
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Immunol Rev 209:212-36. 2006
    ..The results also reveal global differences in regulatory alterations triggered by the first T-cell receptor-dependent selection events in fetal and adult thymopoiesis...
  43. ncbi request reprint The basic helix-loop-helix transcription factor HEBAlt is expressed in pro-T cells and enhances the generation of T cell precursors
    Duncheng Wang
    Sunnybrook Research Institute, and Department of Immunology, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada
    J Immunol 177:109-19. 2006
    ..Therefore, HEBAlt and HEBCan are functionally distinct transcription factors, and HEBAlt is specifically required for the efficient generation of early T cell precursors...
  44. pmc Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling
    Tom N Taghon
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Genes Dev 19:965-78. 2005
    ....
  45. ncbi request reprint Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage
    Michele K Anderson
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Immunity 16:285-96. 2002
    ..PU.1 expression can downregulate pre-Talpha, Rag-1, and Rag-2 in a dose-dependent manner, and higher PU.1 levels induce Mac-1 and Id-2. Thus, downregulation of PU.1 is specifically required for progression in the T cell lineage...
  46. ncbi request reprint Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway
    C Chace Tydell
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Immunol 179:421-38. 2007
    ..Bcl11b was uniquely T lineage restricted and induced by Notch/Delta signaling specifically upon entry into the T lineage differentiation pathway...
  47. ncbi request reprint Definition of regulatory network elements for T cell development by perturbation analysis with PU.1 and GATA-3
    Michele K Anderson
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 246:103-21. 2002
    ..The target genes identified here provide insight into the basis of the effects of GATA-3 or PU.1 overexpression and into the regulatory changes that distinguish the developmental time windows for these effects...
  48. pmc Notch/Delta signaling constrains reengineering of pro-T cells by PU.1
    Christopher B Franco
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:11993-8. 2006
    ..The results imply that in T cell precursors, Notch/Delta signaling normally acts to modulate and channel PU.1 transcriptional activities during the stages from T lineage specification until commitment...
  49. doi request reprint Erg in stem cells: a function emerges
    Ellen V Rothenberg
    Nat Immunol 9:714-6. 2008

Research Grants29

  1. LINEAGE ANALYSIS OF FUNCTION IN MURINE LYMPHOCYTES
    ELLEN ROTHENBERG; Fiscal Year: 2004
    ....
  2. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    ELLEN ROTHENBERG; Fiscal Year: 2005
    ..1 itself. ..
  3. GATA-3 in precursor commitment to the T lineage
    ELLEN ROTHENBERG; Fiscal Year: 2006
    ..Definition of mechanistic requirements for GATA-3 perturbation of T-cell development 3. Attempted rescue of GATA-3 overexpression effects by cotransduction with targets of specific repression. ..
  4. CIS-REGULATORY ANALYSIS OF PU.1 BY IN VITRO ES CELL DIFFERENTIATION
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..This should permit faster and cheaper experiments to reveal how powerful regulatory genes are themselves controlled. ..
  5. Reverse engineering genetic network architecture of stem-cell/lymphocyte transiti
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..These computational predictions will guide the experimental program and interpret the data it generates. Ellen Rothenberg will lead the experimental component of the project...
  6. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    ELLEN ROTHENBERG; Fiscal Year: 2009
    ..The mechanisms studied here imply that mixed-lineage thymic lymphomas may also result from primary defects of a natural T/myeloid lineage choice. ..
  7. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    ELLEN ROTHENBERG; Fiscal Year: 2004
    ..1 itself. ..
  8. GATA-3 in precursor commitment to the T lineage
    ELLEN ROTHENBERG; Fiscal Year: 2003
    ..Definition of mechanistic requirements for GATA-3 perturbation of T-cell development 3. Attempted rescue of GATA-3 overexpression effects by cotransduction with targets of specific repression. ..
  9. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    ELLEN ROTHENBERG; Fiscal Year: 2009
    ..The mechanisms studied here imply that mixed-lineage thymic lymphomas may also result from primary defects of a natural T/myeloid lineage choice. ..
  10. LINEAGE ANALYSIS OF FUNC IN THYMOCYTE DIFF.
    ELLEN ROTHENBERG; Fiscal Year: 1999
    ..Specific aim 3: To test the fidelity of T-cell lineage-restricted lL-2 expression by analysis of lL-2/Cre-dependent marking of non-T lineage cells in vivo. ..
  11. LINEAGE ANALYSIS OF FUNCTION IN MURINE LYMPHOCYTES
    ELLEN ROTHENBERG; Fiscal Year: 2000
    ....
  12. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    ELLEN ROTHENBERG; Fiscal Year: 2001
    ..1 itself. ..
  13. LINEAGE ANALYSIS OF FUNCTION IN MURINE LYMPHOCYTES
    ELLEN ROTHENBERG; Fiscal Year: 2001
    ....
  14. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    ELLEN ROTHENBERG; Fiscal Year: 2002
    ..1 itself. ..
  15. LINEAGE ANALYSIS OF FUNCTION IN MURINE LYMPHOCYTES
    ELLEN ROTHENBERG; Fiscal Year: 2002
    ....
  16. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    Ellen V Rothenberg; Fiscal Year: 2010
    ..The mechanisms studied here imply that mixed-lineage thymic lymphomas may also result from primary defects of a natural T/myeloid lineage choice. ..
  17. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..The mechanisms studied here imply that mixed-lineage thymic lymphomas may also result from primary defects of a natural T/myeloid lineage choice. ..
  18. GATA-3 in precursor commitment to the T lineage
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..Definition of mechanistic requirements for GATA-3 perturbation of T-cell development 3. Attempted rescue of GATA-3 overexpression effects by cotransduction with targets of specific repression ..
  19. LINEAGE ANALYSIS OF FUNCTION IN MURINE LYMPHOCYTES
    ELLEN ROTHENBERG; Fiscal Year: 2003
    ....
  20. LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORS
    ELLEN ROTHENBERG; Fiscal Year: 2003
    ..1 itself. ..
  21. Application for a Fluorescence-Activated Cell Sorter
    ELLEN ROTHENBERG; Fiscal Year: 2003
    ..This application is to replace the old sorter with a new sorter that will improve service to existing clients and permit the Facility to carry out new flow cytometric applications that have not been available to the user group before. ..