Philip A Romero

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. pmc Exploring protein fitness landscapes by directed evolution
    Philip A Romero
    Division of Chemistry and Chemical Engineering, 21041, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Mol Cell Biol 10:866-76. 2009
  2. pmc SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis
    Philip A Romero
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    ACS Synth Biol 1:221-8. 2012
  3. pmc Directed evolution of protein-based neurotransmitter sensors for MRI
    Philip A Romero
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA
    Methods Mol Biol 995:193-205. 2013
  4. pmc Navigating the protein fitness landscape with Gaussian processes
    Philip A Romero
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 110:E193-201. 2013
  5. doi request reprint Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods
    Russell S Komor
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Protein Eng Des Sel 25:827-33. 2012
  6. pmc Random field model reveals structure of the protein recombinational landscape
    Philip A Romero
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America
    PLoS Comput Biol 8:e1002713. 2012
  7. pmc Chimeragenesis of distantly-related proteins by noncontiguous recombination
    Matthew A Smith
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Protein Sci 22:231-8. 2013

Collaborators

Detail Information

Publications7

  1. pmc Exploring protein fitness landscapes by directed evolution
    Philip A Romero
    Division of Chemistry and Chemical Engineering, 21041, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Mol Cell Biol 10:866-76. 2009
    ..Directed evolution has also shown how mutations that are functionally neutral can set the stage for further adaptation...
  2. pmc SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis
    Philip A Romero
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    ACS Synth Biol 1:221-8. 2012
    ..This approach revealed a striking correlation between the isoelectric point and the long-term stability of the enzyme to deactivation under physiological conditions...
  3. pmc Directed evolution of protein-based neurotransmitter sensors for MRI
    Philip A Romero
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA
    Methods Mol Biol 995:193-205. 2013
    ..The directed evolution method involves successive cycles of mutagenesis and screening that could be generalized to produce contrast agents sensitive to a variety of molecular targets in the nervous system...
  4. pmc Navigating the protein fitness landscape with Gaussian processes
    Philip A Romero
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 110:E193-201. 2013
    ..These algorithms allowed us to engineer active P450 enzymes that are more thermostable than any previously made by chimeragenesis, rational design, or directed evolution...
  5. doi request reprint Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods
    Russell S Komor
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Protein Eng Des Sel 25:827-33. 2012
    ..emersonii CBH I...
  6. pmc Random field model reveals structure of the protein recombinational landscape
    Philip A Romero
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America
    PLoS Comput Biol 8:e1002713. 2012
    ..Intragenic recombination explores a unique subset of sequence space that promotes rapid molecular diversification and functional adaptation...
  7. pmc Chimeragenesis of distantly-related proteins by noncontiguous recombination
    Matthew A Smith
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Protein Sci 22:231-8. 2013
    ..This simple method, which does not rely on detailed atomic models, can be used to design chimeras that take structural, and functional, elements from distantly-related proteins...