S R Quake

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint From micro- to nanofabrication with soft materials
    S R Quake
    Department of Applied Physics, MS 128 95, California Institute of Technology, Pasadena, CA 91125, USA
    Science 290:1536-40. 2000
  2. ncbi request reprint Developing optofluidic technology through the fusion of microfluidics and optics
    Demetri Psaltis
    Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nature 442:381-6. 2006
  3. ncbi request reprint Microfluidic digital PCR enables multigene analysis of individual environmental bacteria
    Elizabeth A Ottesen
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 314:1464-7. 2006
  4. ncbi request reprint Microfluidic large-scale integration: the evolution of design rules for biological automation
    Jessica Melin
    Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California 94305, USA
    Annu Rev Biophys Biomol Struct 36:213-31. 2007
  5. ncbi request reprint Crystal structure of a hyperactive Escherichia coli glycerol kinase mutant Gly230 --> Asp obtained using microfluidic crystallization devices
    Megan J Anderson
    Department of Biochemistry and Molecular Biophysics, California Institute of Technology, MS 128 95, Pasadena, California 91125, USA
    Biochemistry 46:5722-31. 2007
  6. pmc Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth
    Yann Marcy
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:11889-94. 2007
  7. ncbi request reprint Detection of aneuploidy with digital polymerase chain reaction
    H Christina Fan
    Anal Chem 79:7576-9. 2007
  8. pmc Nanoliter reactors improve multiple displacement amplification of genomes from single cells
    Yann Marcy
    Department of Bioengineering, Stanford University, Stanford, California, USA
    PLoS Genet 3:1702-8. 2007
  9. ncbi request reprint Versatile, fully automated, microfluidic cell culture system
    Rafael Gomez-Sjoberg
    Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California 94305, USA
    Anal Chem 79:8557-63. 2007
  10. ncbi request reprint Microfluidic single-cell mRNA isolation and analysis
    Joshua S Marcus
    Biochemistry and Molecular Biophysics, California Institute of Technology, MS 128 95, Pasadena, California 91125, USA
    Anal Chem 78:3084-9. 2006

Collaborators

  • Changhuei Yang
  • Demetri Psaltis
  • James R Heath
  • Yann Marcy
  • Frederick K Balagadde
  • Joshua S Marcus
  • Carl L Hansen
  • Jong Wook Hong
  • Megan J Anderson
  • Jessica Melin
  • H Christina Fan
  • Rafael Gomez-Sjoberg
  • Frances H Arnold
  • Lingchong You
  • W French Anderson
  • Elizabeth A Ottesen
  • Chung Cheng Lee
  • Emil P Kartalov
  • Jordan M Gerton
  • Elena M Filippova
  • Carl Hansen
  • Matthew Barnet
  • Cynthia H Collins
  • Hao Song
  • Jun Ozaki
  • Karen Y Beeson
  • Anu Raghunathan
  • Darren Platt
  • Timothy B Stockwell
  • Bernhard O Palsson
  • Dana M Pirone
  • Natalia Ivanova
  • Axel T Brunger
  • Ernest Szeto
  • Hector Garcia Martin
  • Aaron L Halpern
  • Philip Hugenholtz
  • Tina Lösekann
  • Byron DeLaBarre
  • Christopher S Chen
  • Thomas Ishoey
  • David A Relman
  • Brian P Walenz
  • Cleber Ouverney
  • Anne A Leyrat
  • Roger S Lasken
  • Elisabeth M Bik
  • Susanne M D Goldberg
  • Jared R Leadbetter
  • Alek N Dooley
  • David Stout
  • Antoine Daridon
  • Michael E Phelps
  • Arkadij Elizarov
  • Hsian Rong Tseng
  • Nagichettiar Satyamurthy
  • Paul Wyatt
  • Chengyi Jenny Shu
  • Hartmuth C Kolb
  • Young Shik Shin
  • Jiang Huang
  • Owen N Witte
  • Guodong Sui
  • Lawrence A Wade
  • Morten O A Sommer
  • Guillaume A Lessard
  • Z Ma
  • John C Sutherland
  • John G Trunk
  • Betsy M Sutherland
  • Denise C Monteleone

Detail Information

Publications20

  1. ncbi request reprint From micro- to nanofabrication with soft materials
    S R Quake
    Department of Applied Physics, MS 128 95, California Institute of Technology, Pasadena, CA 91125, USA
    Science 290:1536-40. 2000
    ....
  2. ncbi request reprint Developing optofluidic technology through the fusion of microfluidics and optics
    Demetri Psaltis
    Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nature 442:381-6. 2006
    ..We categorize optofluidics according to three broad categories of interactions: fluid-solid interfaces, purely fluidic interfaces and colloidal suspensions. We describe examples of optofluidic devices in each category...
  3. ncbi request reprint Microfluidic digital PCR enables multigene analysis of individual environmental bacteria
    Elizabeth A Ottesen
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 314:1464-7. 2006
    ..The ability to systematically identify bacteria carrying a particular gene and to link any two or more genes of interest to single species residing in complex ecosystems opens up new opportunities for research on the environment...
  4. ncbi request reprint Microfluidic large-scale integration: the evolution of design rules for biological automation
    Jessica Melin
    Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California 94305, USA
    Annu Rev Biophys Biomol Struct 36:213-31. 2007
    ..Several microfluidic components used as building blocks to create effective, complex, and highly integrated microfluidic networks are also highlighted...
  5. ncbi request reprint Crystal structure of a hyperactive Escherichia coli glycerol kinase mutant Gly230 --> Asp obtained using microfluidic crystallization devices
    Megan J Anderson
    Department of Biochemistry and Molecular Biophysics, California Institute of Technology, MS 128 95, Pasadena, California 91125, USA
    Biochemistry 46:5722-31. 2007
    ....
  6. pmc Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth
    Yann Marcy
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:11889-94. 2007
    ..This approach enables single-cell genetic analysis of any uncultivated minority member of a microbial community...
  7. ncbi request reprint Detection of aneuploidy with digital polymerase chain reaction
    H Christina Fan
    Anal Chem 79:7576-9. 2007
    ..dPCR is generally applicable to any aneuploidy, does not depend on allelic distribution or gender, and is able to detect signals in the presence of mosaics or contaminating maternal DNA...
  8. pmc Nanoliter reactors improve multiple displacement amplification of genomes from single cells
    Yann Marcy
    Department of Bioengineering, Stanford University, Stanford, California, USA
    PLoS Genet 3:1702-8. 2007
    ..Single-cell amplicons from both microliter and nanoliter volumes provided high-quality sequence data by high-throughput pyrosequencing, thereby demonstrating a straightforward route to sequencing genomes from single cells...
  9. ncbi request reprint Versatile, fully automated, microfluidic cell culture system
    Rafael Gomez-Sjoberg
    Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California 94305, USA
    Anal Chem 79:8557-63. 2007
    ..Using this device, we perform the first quantitative measurements of the influence of transient stimulation schedules on the proliferation, osteogenic differentiation, and motility of human primary mesenchymal stem cells...
  10. ncbi request reprint Microfluidic single-cell mRNA isolation and analysis
    Joshua S Marcus
    Biochemistry and Molecular Biophysics, California Institute of Technology, MS 128 95, Pasadena, California 91125, USA
    Anal Chem 78:3084-9. 2006
    ..The techniques presented here form the foundation for highly parallel single-cell gene expression studies...
  11. ncbi request reprint Parallel picoliter rt-PCR assays using microfluidics
    Joshua S Marcus
    Option in Biochemistry and Molecular Biophysics, Department of Applied Physics, California Institute of Technology, Pasadena, 91125, USA
    Anal Chem 78:956-8. 2006
    ..We took advantage of Taqman hydrolysis probe chemistry to detect RNA templates as low as 34 copies. The device and method presented here may enable highly parallel single cell gene expression analysis...
  12. pmc Quantifying double-strand breaks and clustered damages in DNA by single-molecule laser fluorescence sizing
    Elena M Filippova
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Biophys J 84:1281-90. 2003
    ..For a given size range of DNA molecules, single-molecule sizing is as or more sensitive than gel electrophoresis, and requires several orders-of-magnitude less DNA to determine damage levels...
  13. ncbi request reprint Integrated nanoliter systems
    Jong Wook Hong
    Department of Applied Physics, California Institute of Technology, MC 128 95, Pasadena, California 91125, USA
    Nat Biotechnol 21:1179-83. 2003
    ..These strategies allow levels of integration density and platform complexity that promise to make them into serious alternatives to current robotic systems...
  14. ncbi request reprint Microfluidics in structural biology: smaller, faster em leader better
    Carl Hansen
    Department of Applied Physics, California Institute of Technology, MS 128 95, Pasadena, CA 91125, USA
    Curr Opin Struct Biol 13:538-44. 2003
    ..Diverse applications ranging from time-resolved studies of protein folding to highly efficient protein crystal growth suggest that microfluidics may become an indispensable tool in biology...
  15. pmc Microfluidic device reads up to four consecutive base pairs in DNA sequencing-by-synthesis
    Emil P Kartalov
    Applied Physics Department, California Institute of Technology, Pasadena, CA 91125, USA
    Nucleic Acids Res 32:2873-9. 2004
    ..The surface chemistry that was designed to anchor the DNA to elastomeric microchannels is useful in a broad range of studies and applications...
  16. pmc Systematic investigation of protein phase behavior with a microfluidic formulator
    Carl L Hansen
    Department of Applied Physics, California Institute of Technology, MS 128 95, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 101:14431-6. 2004
    ..This formulations tool allows a physics-based approach to protein crystallization that may prove useful in structural genomics efforts...
  17. ncbi request reprint Tip-enhanced fluorescence microscopy at 10 nanometer resolution
    Jordan M Gerton
    Department of Applied Physics, California Institute of Technology, MC 128 95, Pasadena, CA 91125, USA
    Phys Rev Lett 93:180801. 2004
    ..Laterally encoded demodulation yields images with <10 nm spatial resolution, consistent with independent measurements of tip sharpness...
  18. ncbi request reprint Long-term monitoring of bacteria undergoing programmed population control in a microchemostat
    Frederick K Balagadde
    Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Science 309:137-40. 2005
    ..The microfluidic bioreactor enabled long-term monitoring of unnatural behavior programmed by the synthetic circuit, which included sustained oscillations in cell density and associated morphological changes, over hundreds of hours...
  19. ncbi request reprint Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics
    Chung Cheng Lee
    Department of Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA
    Science 310:1793-6. 2005
    ..These results, which constitute a proof of principle for automated multistep syntheses at the nanogram to microgram scale, could be generalized to a range of radiolabeled substrates...
  20. pmc A synthetic Escherichia coli predator-prey ecosystem
    Frederick K Balagadde
    Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, CA, USA
    Mol Syst Biol 4:187. 2008
    ..A simple mathematical model is developed to capture these system dynamics. Coherent interplay between experiments and mathematical analysis enables exploration of the dynamics of interacting populations in a predictable manner...