Paul Patterson

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse
    Bradley J Kerr
    Biology Division, California Institute of Technology, Pasadena 91125, USA
    Exp Neurol 188:391-407. 2004
  2. ncbi Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain
    Sylvian Bauer
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 26:12089-99. 2006
  3. pmc The cell cycle-apoptosis connection revisited in the adult brain
    Sylvian Bauer
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    J Cell Biol 171:641-50. 2005
  4. pmc Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1
    Amber L Southwell
    Division of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 6:e16676. 2011
  5. ncbi Cytokines in Alzheimer's disease and multiple sclerosis
    P H Patterson
    Division of Biology 216 76, California Institute of Technology, Pasadena 91125, USA
    Curr Opin Neurobiol 5:642-6. 1995
  6. pmc Modeling autistic features in animals
    Paul H Patterson
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Pediatr Res 69:34R-40R. 2011
  7. ncbi Immune involvement in schizophrenia and autism: etiology, pathology and animal models
    Paul H Patterson
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Behav Brain Res 204:313-21. 2009
  8. ncbi Neuroscience. Maternal effects on schizophrenia risk
    Paul H Patterson
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 318:576-7. 2007
  9. pmc Maternal infection and immune involvement in autism
    Paul H Patterson
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Trends Mol Med 17:389-94. 2011
  10. ncbi Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness
    Paul H Patterson
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    Curr Opin Neurobiol 12:115-8. 2002

Research Grants

  1. The Role of NFkB in Huntington's Disease
    Paul Patterson; Fiscal Year: 2005
  2. The Role of NFkB in Huntington's Disease
    Paul Patterson; Fiscal Year: 2003
  3. Mobilizing Adult Neural Stem Cells and Disease Models
    Paul H Patterson; Fiscal Year: 2010
  4. LIF and Cell Renewal in Hippocampus and Olfactory Bulb
    Paul Patterson; Fiscal Year: 2004
  5. LIF and Cell Renewal in Hippocampus and Olfactory Bulb
    Paul Patterson; Fiscal Year: 2007
  6. Mobilizing Adult Neural Stem Cells and Disease Models
    Paul Patterson; Fiscal Year: 2009
  7. Maternal Viral Infection and Fetal Brain Development
    Paul Patterson; Fiscal Year: 2006
  8. Intrabodies For Huntington's Disease Therapy
    Paul Patterson; Fiscal Year: 2009
  9. Evaluation of Mouse Hallucinations by fMRI
    Paul Patterson; Fiscal Year: 2009
  10. Intrabodies For Huntington's Disease Therapy
    Paul H Patterson; Fiscal Year: 2010

Collaborators

Detail Information

Publications36

  1. ncbi Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse
    Bradley J Kerr
    Biology Division, California Institute of Technology, Pasadena 91125, USA
    Exp Neurol 188:391-407. 2004
    ..Thus, LIF is a potent pro-inflammatory factor in the adult spinal cord and represents a potential target for the manipulation of inflammatory reactions after spinal cord injury...
  2. ncbi Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain
    Sylvian Bauer
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 26:12089-99. 2006
    ..Our results have implications for the development of therapeutic strategies for brain repair and suggest that LIF may be useful, in combination with other factors, in promoting regeneration in the adult brain...
  3. pmc The cell cycle-apoptosis connection revisited in the adult brain
    Sylvian Bauer
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    J Cell Biol 171:641-50. 2005
    ..These findings have important implications for a controversy surrounding adult neurogenesis: the connection between cell cycle reactivation and apoptosis of terminally differentiated neurons...
  4. pmc Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1
    Amber L Southwell
    Division of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 6:e16676. 2011
    ..Further processing is then required for the degradation of these fragments, which in turn, reduces toxicity. This unknown, secondary degradative process represents a promising therapeutic target for HD...
  5. ncbi Cytokines in Alzheimer's disease and multiple sclerosis
    P H Patterson
    Division of Biology 216 76, California Institute of Technology, Pasadena 91125, USA
    Curr Opin Neurobiol 5:642-6. 1995
    ..The discovery of subclasses of T-helper cells has provided a critical framework to aid in understanding how the cytokine network regulates these diseases...
  6. pmc Modeling autistic features in animals
    Paul H Patterson
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Pediatr Res 69:34R-40R. 2011
    ..Wherever possible, reference is made to reviews rather than to primary articles...
  7. ncbi Immune involvement in schizophrenia and autism: etiology, pathology and animal models
    Paul H Patterson
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Behav Brain Res 204:313-21. 2009
    ..The human and animal results related to immune involvement suggest novel therapeutic avenues based on immune interventions...
  8. ncbi Neuroscience. Maternal effects on schizophrenia risk
    Paul H Patterson
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 318:576-7. 2007
  9. pmc Maternal infection and immune involvement in autism
    Paul H Patterson
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Trends Mol Med 17:389-94. 2011
    ..These rodent models are proving useful for the study of pathogenesis and gene-environment interactions as well as for the exploration of potential therapeutic strategies...
  10. ncbi Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness
    Paul H Patterson
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    Curr Opin Neurobiol 12:115-8. 2002
    ..This effect on fetal brain development might be caused by the maternal antiviral immune response, possibly mediated by cytokines...
  11. ncbi Leukemia inhibitory factor is a key regulator of astrocytic, microglial and neuronal responses in a low-dose pilocarpine injury model
    Kristina H Holmberg
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Brain Res 1075:26-35. 2006
    ..Thus, LIF is required for normal glial responses to brain damage, and, as in the periphery, LIF regulates NPY expression in the CNS...
  12. pmc Maternal immune activation alters fetal brain development through interleukin-6
    Stephen E P Smith
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 27:10695-702. 2007
    ....
  13. pmc Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity
    Amber L Southwell
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:9013-20. 2008
    ..We also note that intrabody binding represents a powerful tool for determining the function of protein epitopes in living cells...
  14. pmc Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington's disease
    Amber L Southwell
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 29:13589-602. 2009
    ..These results indicate that increasing the turnover of mHtt using AAV-Happ1 gene therapy represents a highly specific and effective treatment in diverse mouse models of HD...
  15. ncbi Behavioral stress and tumor progression
    Jennifer P Montgomery
    California Institute of Technology, MC 216 76, Pasadena, CA 91125, USA
    Anticancer Res 26:1189-92. 2006
    ..Previously published findings demonstrated a stress-induced increase in tumor growth of implanted lymphosarcoma in C3H mice. Here, two mouse models were utilized to investigate whether stress alters the growth of solid tumors...
  16. pmc IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin
    Ali Khoshnan
    Biology Division 216 76, California Institute of Technology, Pasadena, California, USA
    PLoS ONE 4:e5768. 2009
    ..One stimulus may be the DNA damage that accumulates in neurons over time, and the subsequent activation of signaling pathways such as those regulated by IkappaB kinase (IKK), which can influence neurodegeneration in HD...
  17. ncbi Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity
    Ali Khoshnan
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 24:7999-8008. 2004
    ..Therefore, aberrant NF-kappaB activation may contribute to the neurodegeneration induced by mutant Htt...
  18. ncbi Leukemia inhibitory factor promotes oligodendrocyte survival after spinal cord injury
    Bradley J Kerr
    Biology Division, California Institute of Technology, Pasadena, California, USA
    Glia 51:73-9. 2005
    ....
  19. pmc Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring
    Hiroshi T Ito
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Brain Behav Immun 24:930-41. 2010
    ..Our results suggest that altered processing of object-related information may be part of the pathogenesis of schizophrenia-like cognitive behaviors...
  20. ncbi Cytokines and CNS development
    Benjamin E Deverman
    Division of Biology, California Institute of Technology, 1200 East California Boulevard M C 216 76, Pasadena, CA 91125, USA
    Neuron 64:61-78. 2009
    ....
  21. pmc Activation of the maternal immune system alters cerebellar development in the offspring
    Limin Shi
    Biology Division, California Institute of Technology, 391 S Holliston Avenue, M C 216 76 Pasadena, CA 91125, USA
    Brain Behav Immun 23:116-23. 2009
    ..Finally, our data suggest that cerebellar abnormalities occur during embryonic development, and may be an early deficit in autism and schizophrenia...
  22. ncbi Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
    Limin Shi
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 23:297-302. 2003
    ..Therefore, maternal viral infection has a profound effect on the behavior of adult offspring, probably via an effect of the maternal immune response on the fetus...
  23. pmc Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity
    Ali Khoshnan
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:1002-7. 2002
    ..Therefore, these anti-htt scFvs can be used to investigate the role of the polyP and polyQ domains in HD pathogenesis, and antibody binding to the polyP domain has potential therapeutic value in HD...
  24. ncbi Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus
    Limin Shi
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Int J Dev Neurosci 23:299-305. 2005
    ..Thus, the effects of maternal infection on fetal brain development are likely to be indirect, probably involving the maternal inflammatory response...
  25. ncbi Antibodies against huntingtin: production and screening of monoclonals and single-chain recombinant forms
    Ali Khoshnan
    Biology Division, California Institute of Technology, Pasadena, USA
    Methods Mol Biol 277:87-102. 2004
    ..This is the protein that, when mutated to contain an expanded polyQ motif, causes Huntington's disease...
  26. pmc Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor
    Jennifer P Montgomery
    California Institute of Technology, 1200 E, California Blvd, MC 216 76, Pasadena, CA 91125, USA
    BMC Cancer 8:354. 2008
    ..Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited...
  27. ncbi Developmental cooperation of leukemia inhibitory factor and insulin-like growth factor I in mice is tissue-specific and essential for lung maturation involving the transcription factors Sp3 and TTF-1
    Jose G Pichel
    Group of Growth Factors in Vertebrate Development, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Mech Dev 120:349-61. 2003
    ..LIF and IGF-I, thus, have cooperative and distinct tissue functions during development. Their essential role in bone ossification apparently involves Sp3, and in lung maturation Sp3 together with TTF-1...
  28. ncbi Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats
    Yuichiro Watanabe
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata 951 8585, Japan
    Neurosci Res 48:345-53. 2004
    ..These results indicate that LIF induction in the periphery of the infant has a significant, but discrete impact on neurobehavioral development...
  29. ncbi Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia
    S Hossein Fatemi
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
    Cell Mol Neurobiol 22:25-33. 2002
    ..Moreover, abnormal corticogenesis is associated with development of abnormal behavior in the exposed adult mice...
  30. ncbi Lymphocyte regulation of neuropeptide gene expression after neuronal injury
    Brian D Armstrong
    Mental Retardation Research Center, Neuropsychiatric Institute, The David Geffen School of Medicine, University of California at Los Angeles, Los Angeles 90024 1759, USA
    J Neurosci Res 74:240-7. 2003
    ..The data suggest that an inflammatory response, most likely involving T lymphocytes, is necessary for the axotomy-induced increase in PACAP but not in VIP. LIF, IL-6, and TNFalpha, however, are not required for this response to injury...
  31. ncbi Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF
    George K Tofaris
    Cambridge Centre for Brain Repair and Department of Neurology, University of Cambridge, Cambridge CB2 2PY, United Kingdom
    J Neurosci 22:6696-703. 2002
    ..They also provide evidence for an autocrine-signaling cascade involving IL-6, LIF, and MCP-1, which amplifies the Schwann cell-derived chemotactic signals gradually, in agreement with the delayed entry of macrophages to injured nerves...
  32. pmc A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals
    Bradley Greger
    University of Utah, Department of Bioengineering, Salt Lake City, UT 84112, United States
    J Neurosci Methods 163:321-5. 2007
    ..Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could quantitatively identify electrical "signatures" of therapeutically useful drugs...
  33. ncbi The neuropoietic cytokine family in development, plasticity, disease and injury
    Sylvian Bauer
    Physiologie Neurovégétative, UMR 6153 CNRS, 1147 INRA, Université Paul Cézanne Aix Marseille 3, Ave Escadrille Normandie Niemen, BP 351 352, 13397 Marseille Cedex 20, France
    Nat Rev Neurosci 8:221-32. 2007
    ..Recent data indicate that these proteins have yet more functions, as key modulators of synaptic plasticity and of various behaviours. In addition, neuropoietic cytokines might be a factor in the aetiology of psychiatric disorders...
  34. ncbi Endothelin receptor B inhibition triggers apoptosis and enhances angiogenesis in melanomas
    Ronit Lahav
    Division of Experimental Pathology, Institut Universitaire de Pathologie Université de Lausanne, Lausanne, Switzerland
    Cancer Res 64:8945-53. 2004
    ....
  35. ncbi Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure
    Mark F Berry
    Department of Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, 6 Silverstein Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 128:866-75. 2004
    ..The cytokine leukemia inhibitory factor regulates the differentiation and growth of embryonic and adult heart tissue. This study examined the effects of gene transfer of leukemia inhibitory factor in infarcted rat hearts...
  36. ncbi Autism: neuropathology, alterations of the GABAergic system, and animal models
    Christoph Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience Maastricht University, The Netherlands
    Int Rev Neurobiol 71:1-26. 2005

Research Grants20

  1. The Role of NFkB in Huntington's Disease
    Paul Patterson; Fiscal Year: 2005
    ..These reagents will be injected into the brains of HD mice in tests of their efficacy in inhibiting mutant Htt toxicity and aggregation. They will also be tested on brain slices from HD mice, in the presence and absence of NMDA. ..
  2. The Role of NFkB in Huntington's Disease
    Paul Patterson; Fiscal Year: 2003
    ..These reagents will be injected into the brains of HD mice in tests of their efficacy in inhibiting mutant Htt toxicity and aggregation. They will also be tested on brain slices from HD mice, in the presence and absence of NMDA. ..
  3. Mobilizing Adult Neural Stem Cells and Disease Models
    Paul H Patterson; Fiscal Year: 2010
    ..abstract_text> ..
  4. LIF and Cell Renewal in Hippocampus and Olfactory Bulb
    Paul Patterson; Fiscal Year: 2004
    ..Cell-specific markers will be used to identify these proliferating cells. Analysis will be done at several stages following viral injection so as to be able to follow the fates of the cells over time. ..
  5. LIF and Cell Renewal in Hippocampus and Olfactory Bulb
    Paul Patterson; Fiscal Year: 2007
    ..Cell-specific markers will be used to identify these proliferating cells. Analysis will be done at several stages following viral injection so as to be able to follow the fates of the cells over time. ..
  6. Mobilizing Adult Neural Stem Cells and Disease Models
    Paul Patterson; Fiscal Year: 2009
    ..Therefore, without further assistance, completion of this experiment would be difficult. Removal of this aim does not undermine our overall objectives. ..
  7. Maternal Viral Infection and Fetal Brain Development
    Paul Patterson; Fiscal Year: 2006
    ..We will also use cytokine injections of non-infected mothers to help identify cytokines that may mediate the effects of maternal viral infection. ..
  8. Intrabodies For Huntington's Disease Therapy
    Paul Patterson; Fiscal Year: 2009
    ..This non-biased approach could uncover new pathways involved in HD pathogenesis. ..
  9. Evaluation of Mouse Hallucinations by fMRI
    Paul Patterson; Fiscal Year: 2009
    ..Since the cause is unknown, an appropriate animal model of hallucination-like brain activity would be extremely useful in exploring novel therapeutic avenues. ..
  10. Intrabodies For Huntington's Disease Therapy
    Paul H Patterson; Fiscal Year: 2010
    ..This non-biased approach could uncover new pathways involved in HD pathogenesis. ..
  11. Intrabodies For Huntington's Disease Therapy
    Paul Patterson; Fiscal Year: 2007
    ..This non-biased approach could uncover new pathways involved in HD pathogenesis. ..
  12. Maternal Viral Infection and Fetal Brain Development
    Paul Patterson; Fiscal Year: 2007
    ..We will also use cytokine injections of non-infected mothers to help identify cytokines that may mediate the effects of maternal viral infection. ..
  13. LIF and Cell Renewal in Hippocampus and Olfactory Bulb
    Paul Patterson; Fiscal Year: 2006
    ..Cell-specific markers will be used to identify these proliferating cells. Analysis will be done at several stages following viral injection so as to be able to follow the fates of the cells over time. ..
  14. Maternal Viral Infection and Fetal Brain Development
    Paul Patterson; Fiscal Year: 2005
    ..We will also use cytokine injections of non-infected mothers to help identify cytokines that may mediate the effects of maternal viral infection. ..
  15. LIF and Cell Renewal in Hippocampus and Olfactory Bulb
    Paul Patterson; Fiscal Year: 2005
    ..Cell-specific markers will be used to identify these proliferating cells. Analysis will be done at several stages following viral injection so as to be able to follow the fates of the cells over time. ..
  16. The Role of NFkB in Huntington's Disease
    Paul Patterson; Fiscal Year: 2004
    ..These reagents will be injected into the brains of HD mice in tests of their efficacy in inhibiting mutant Htt toxicity and aggregation. They will also be tested on brain slices from HD mice, in the presence and absence of NMDA. ..
  17. Maternal Viral Infection and Fetal Brain Development
    Paul Patterson; Fiscal Year: 2004
    ..We will also use cytokine injections of non-infected mothers to help identify cytokines that may mediate the effects of maternal viral infection. ..
  18. Evaluation of Mouse Hallucinations by fMRI
    Paul H Patterson; Fiscal Year: 2010
    ..Since the cause is unknown, an appropriate animal model of hallucination-like brain activity would be extremely useful in exploring novel therapeutic avenues. ..