Research Topics
| JOHN P O'DOHERTYSummaryAffiliation: California Institute of Technology Country: USA Publications
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Detail Information
Publications
Is avoiding an aversive outcome rewarding? Neural substrates of avoidance learning in the human brainHackjin Kim
PLoS Biol 4:e233. 2006..This neural signal may itself act as an intrinsic reward, thereby serving to reinforce actions during instrumental avoidance...
Model-based fMRI and its application to reward learning and decision makingJOHN P O'DOHERTY
Computational and Neural Systems Program, California Institute of Technology, Pasadena, CA 91125, USA
Ann N Y Acad Sci 1104:35-53. 2007..Finally, some of the limitations of this approach will be discussed...- Predictive neural coding of reward preference involves dissociable responses in human ventral midbrain and ventral striatumJOHN P O'DOHERTY
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
Neuron 49:157-66. 2006..These results provide insight into the neural mechanisms underlying human preference behavior... - Reward representations and reward-related learning in the human brain: insights from neuroimagingJOHN P O'DOHERTY
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
Curr Opin Neurobiol 14:769-76. 2004..Such representations can be used to guide action selection for reward, a process that depends, at least in part, on orbital and medial prefrontal cortex as well as dorsal striatum... - Determining a role for ventromedial prefrontal cortex in encoding action-based value signals during reward-related decision makingJan Gläscher
Division of Humanities and Social Sciences, California Institute of Technology, MC 114 96, 1200 E California Boulevard, Pasadena, CA 91125, USA
Cereb Cortex 19:483-95. 2009..These findings suggest that ventromedial prefrontal cortex may play a role in encoding the value of chosen actions irrespective of whether those actions denote physical motor responses or more abstract decision options... - Anterior prefrontal cortex contributes to action selection through tracking of recent reward trendsChristopher K Kovach
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 32:8434-42. 2012.... - Neural computations underlying action-based decision making in the human brainKlaus Wunderlich
Computation and Neural Systems Program, California Institute of Technology, Pasadena, CA, USA
Proc Natl Acad Sci U S A 106:17199-204. 2009..Furthermore, we also found signals in the dorsomedial frontal cortex that resemble the output of a decision comparator, which implicates this region in the computation of the decision itself... - Calculating consequences: brain systems that encode the causal effects of actionsSaori C Tanaka
Division of the Humanities and Social Sciences and Computation and Neural Systems Program, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 28:6750-5. 2008..These results reveal the involvement of distinct brain regions in the computational processes that establish the causal efficacy of actions, providing insight into the neural mechanisms underlying the adaptive control of behavior... 
Human medial orbitofrontal cortex is recruited during experience of imagined and real rewardsSigne Bray
Computation and Neural Systems, California Institute of Technology, Pasadena, California, USA
J Neurophysiol 103:2506-12. 2010..These findings support a critical role for mOFC in the representation of rewarding goal states, even if hypothetical...- Contributions of the striatum to learning, motivation, and performance: an associative accountMimi Liljeholm
Division of the Humanities and Social Sciences, and Computation and Neural Systems Program, California Institute of Technology, Pasadena, CA 91125, USA
Trends Cogn Sci 16:467-75. 2012.... - Contributions of the ventromedial prefrontal cortex to goal-directed action selectionJOHN P O'DOHERTY
Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA
Ann N Y Acad Sci 1239:118-29. 2011.... - The decision value computations in the vmPFC and striatum use a relative value code that is guided by visual attentionSeung Lark Lim
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 31:13214-23. 2011..These attention-modulated relative value signals might serve as the input of a comparator system that is used to make a choice... - Overlapping prediction errors in dorsal striatum during instrumental learning with juice and money reward in the human brainVivian V Valentin
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California, USA
J Neurophysiol 102:3384-91. 2009.... - The neural mechanisms underlying the influence of pavlovian cues on human decision makingSigne Bray
Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 28:5861-6. 2008..The results of this study are relevant for understanding how marketing actions can affect consumer choice behavior as well as for how environmental cues can influence drug-seeking behavior in addiction... - Anxiety reduction through detachment: subjective, physiological, and neural effectsRaffael Kalisch
University College London, UK
J Cogn Neurosci 17:874-83. 2005..Using functional magnetic resonance imaging, we locate the potential site and source of this modulation of anticipatory anxiety in the medial prefrontal/anterior cingulate and anterolateral prefrontal cortex, respectively... - Neural mechanisms underlying paradoxical performance for monetary incentives are driven by loss aversionVikram S Chib
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Neuron 74:582-94. 2012..These results suggest that incentives associated with successful task performance are initially encoded as a potential gain; however, when actually performing a task, individuals encode the potential loss that would arise from failure... - Temporal difference models describe higher-order learning in humansBen Seymour
Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
Nature 429:664-7. 2004..Taken with existing data on reward learning, our results suggest a critical role for the ventral striatum in integrating complex appetitive and aversive predictions to coordinate behaviour... - Overlapping responses for the expectation of juice and money rewards in human ventromedial prefrontal cortexHackjin Kim
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
Cereb Cortex 21:769-76. 2011..These results indicate that vmPFC and anterior insula contain overlapping representations of anticipatory value, consistent with the existence of a common currency for the value of expected outcomes in these regions... - Opponent appetitive-aversive neural processes underlie predictive learning of pain reliefBen Seymour
Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
Nat Neurosci 8:1234-40. 2005..This dual coding has parallels to 'opponent process' theories in psychology and promotes a formal account of prediction and expectation during pain... - Temporal difference models and reward-related learning in the human brainJOHN P O'DOHERTY
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, WC1N 3BG, London, United Kingdom
Neuron 38:329-37. 2003.... - The human prefrontal cortex mediates integration of potential causes behind observed outcomesKlaus Wunderlich
Computation and Neural Systems Program, California Institute of Technology, Pasadena, California, USA
J Neurophysiol 106:1558-69. 2011..Our results demonstrate that, at the point of choice, the human brain and the prefrontal cortex in particular are capable of a weighted integration of information across multiple evidences... - Neural correlates of instrumental contingency learning: differential effects of action-reward conjunction and disjunctionMimi Liljeholm
Division of the Humanities and Social Sciences, Computation and Neural Systems Program, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 31:2474-80. 2011.... - Empathic neural responses are modulated by the perceived fairness of othersTania Singer
Wellcome Department of Imaging Neuroscience, University College of London, London WC1N 3AR, UK
Nature 439:466-9. 2006.... - Contingency awareness in human aversive conditioning involves the middle frontal gyrusRonald McKell Carter
MC216 76 Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Neuroimage 29:1007-12. 2006..These results demonstrate that brain regions known to be involved in other aspects of learning and memory also play a specific role, reflecting on each trial the acquisition and representation of contingency awareness... - Evidence for a common representation of decision values for dissimilar goods in human ventromedial prefrontal cortexVikram S Chib
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 29:12315-20. 2009..Our results provide evidence that the brain encodes a "common currency" that allows for a shared valuation for different categories of goods... - States versus rewards: dissociable neural prediction error signals underlying model-based and model-free reinforcement learningJan Gläscher
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91101, USA
Neuron 66:585-95. 2010..This finding supports the existence of two unique forms of learning signal in humans, which may form the basis of distinct computational strategies for guiding behavior... - Anything you can do, you can do better: neural substrates of incentive-based performance enhancementMimi Liljeholm
Division of the Humanities and Social Sciences and Computation and Neural Systems Program, California Institute of Technology, Pasadena, California, United States of America
PLoS Biol 10:e1001272. 2012..In particular, it is still an open question how brain areas that encode expectations about reward are able to translate incentives into improved performance across fundamentally different cognitive and physical task requirements... - Neural responses during anticipation of a primary taste rewardJOHN P O'DOHERTY
Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, WC1 3BG, London, United Kingdom
Neuron 33:815-26. 2002..Apart from OFC, these regions were not activated by reward receipt. The findings indicate that when rewards are predictable, brain regions recruited during expectation are, in part, dissociable from areas responding to reward receipt... - Lights, camembert, action! The role of human orbitofrontal cortex in encoding stimuli, rewards, and choicesJOHN P O'DOHERTY
Computation and Neural Systems Program, California Institute of Technology, Pasadena, CA 91125, USA
Ann N Y Acad Sci 1121:254-72. 2007..Finally, some of the outstanding questions for future neuroimaging research of orbitofrontal cortex function will be highlighted... - Choosing for me or choosing for you: value in medial prefrontal cortexSimon Dunne
California Institute of Technology, Pasadena, CA 91125, USA
Neuron 75:942-4. 2012.... - Transformation of stimulus value signals into motor commands during simple choiceTodd A Hare
Computation and Neural Systems Division, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 108:18120-5. 2011..These results describe the network through which stimulus values are transformed into actions during a simple choice task... - Neural correlates of mentalizing-related computations during strategic interactions in humansAlan N Hampton
Computation and Neural Systems Program and Division of Humanities and Social Sciences, California Institute of Technology, 1200 East California Boulevard, M C 228 77, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 105:6741-6. 2008..These results suggest dissociable contributions of different parts of the mentalizing network to the computations underlying higher-order strategizing in humans... - Evidence for model-based computations in the human amygdala during Pavlovian conditioningCharlotte Prévost
Trinity College Institute of Neuroscience and School of Psychology, Dublin, Ireland
PLoS Comput Biol 9:e1002918. 2013..These findings support an important role for model-based algorithms in describing the processes underpinning Pavlovian conditioning, as well as providing evidence of a role for the human amygdala in model-based inference... - Temporal isolation of neural processes underlying face preference decisionsHackjin Kim
Divisions of Humanities and Social Sciences and Biology, California Institute of Technology, Pasadena, CA 91125, USA corrected
Proc Natl Acad Sci U S A 104:18253-8. 2007..The findings support a model in which rapid, automatic engagement of the NAC conveys a preference signal to the OFC, which in turn is used to guide choice... - Neural correlates of specific and general Pavlovian-to-Instrumental Transfer within human amygdalar subregions: a high-resolution fMRI studyCharlotte Prévost
Division of Humanities and Social Sciences, Computation and Neural Systems Program, and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 32:8383-90. 2012..These results add to a burgeoning literature indicating different functional contributions for these different amygdalar subregions in reward-processing and motivation... - Category-dependent and category-independent goal-value codes in human ventromedial prefrontal cortexDaniel McNamee
1 Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland 2 Computation and Neural Systems, California Institute of Technology, Pasadena, California, USA
Nat Neurosci 16:479-85. 2013..These results implicate the medial prefrontal cortex in the implementation of a common currency and suggest a ventral versus dorsal topographical organization of value signals in the vmPFC... - Dorsomedial prefrontal cortex mediates rapid evaluations predicting the outcome of romantic interactionsJeffrey C Cooper
Trinity College Institute of Neuroscience and School of Psychology, Trinity College Dublin, Dublin 2, Ireland
J Neurosci 32:15647-56. 2012..Even a first glance, then, can accurately predict romantic desire, but that glance involves a mix of physical and psychological judgments that depend on specific regions of DMPFC... - Dissociable brain systems mediate vicarious learning of stimulus-response and action-outcome contingenciesMimi Liljeholm
Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
J Neurosci 32:9878-86. 2012.... - Neural prediction errors reveal a risk-sensitive reinforcement-learning process in the human brainYael Niv
Psychology Department and Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08540, USA
J Neurosci 32:551-62. 2012..This suggests that risk sensitivity is integral to human learning, illuminating economic models of choice, neuroscientific models of affective learning, and the workings of the underlying neural mechanisms...