S J Morrison
Affiliation: California Institute of Technology
- Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilizationS J Morrison
Department of Pathology, Stanford University, CA 94305, USA
Proc Natl Acad Sci U S A 94:1908-13. 1997..The data suggest that mobilized HSC isolated from the spleen are less efficient at homing to and engrafting the bone marrow of irradiated recipient mice...
- Hematopoietic stem cells: challenges to expectationsS J Morrison
Division of Biology, California Institute of Technology, Pasadena 91125, USA
Curr Opin Immunol 9:216-21. 1997..Finally, insights have emerged into the complexity of the regulation of HSC proliferation and adhesion properties...
- Identification of a lineage of multipotent hematopoietic progenitorsS J Morrison
Department of Pathology, Stanford University, California 94305, USA
Development 124:1929-39. 1997..Mac-1(lo) CD4(lo) cells did not have detectable self-renewal potential. The identification of a lineage of multipotent progenitors provides an important tool for identifying genes that regulate self-renewal and lineage commitment...
- The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotypeS J Morrison
Department of Pathology, Stanford University School of Medicine, California 94305, USA
Immunity 1:661-73. 1994..The ability to predict the longevity of reconstitution based on lineage marker expression indicates that reconstitution potential is deterministic, not stochastic...
- Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cellsS J Morrison
Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 20:7370-6. 2000..2000) suggests that neural stem cells may exhibit a conserved response to reduced oxygen levels...
- Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytesC A Klug
Department of Pathology, Stanford University School of Medicine, CA 94305 5428, USA
Proc Natl Acad Sci U S A 95:657-62. 1998..Unexpectedly, we found Ikaros localized to heterochromatin in Abelson-transformed pre-B lymphocytes by using immunogold electron microscopy. These observations suggest a complex role for Ikaros in lymphoid development...
- Stem cells, cancer, and cancer stem cellsT Reya
Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94305, USA
Nature 414:105-11. 2001....
- In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cellsS H Cheshier
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 96:3120-5. 1999..Although approximately 75% of LT-HSC are quiescent in G0 at any one time, all HSC are recruited into cycle regularly such that 99% of LT-HSC divide on average every 57 days...