- MDM2--master regulator of the p53 tumor suppressor proteinJ Momand
California State University at Los Angeles, Department of Chemistry and Biochemistry, 90032, USA
Gene 242:15-29. 2000..This review discusses the major milestones uncovered in MDM2 research during the past 12 years and potential uses of this knowledge in the fight against cancer...
- The evolution of MDM2 family genesJamil Momand
Department of Chemistry and Biochemistry, California State University Los Angeles, 90032, USA
Gene 486:23-30. 2011..We suggest a model where oligomerization is an ancient function of MDM and ubiquitination activity was acquired later near the MDM gene duplication event coinciding with the time of the emergence of p53 as a distinct gene...