Karen E Mark

Summary

Affiliation: California Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Three Phase III Randomized Controlled Trials of Topical Resiquimod 0.01-Percent Gel To Reduce Anogenital Herpes Recurrences
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington, USA Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Antimicrob Agents Chemother 58:5016-23. 2014
  2. pmc Rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in HIV-infected adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 54:482-8. 2010
  3. ncbi request reprint Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: a randomized, controlled trial
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 195:1324-31. 2007
  4. pmc Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 198:1141-9. 2008
  5. pmc Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes
    Joshua T Schiffer
    Department of Medicine, Laboratory Medicine, Global Health Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:18973-8. 2010
  6. pmc Peripheral blood CD4 T-cell and plasmacytoid dendritic cell (pDC) reactivity to herpes simplex virus 2 and pDC number do not correlate with the clinical or virologic severity of recurrent genital herpes
    Nicholas J Moss
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
    J Virol 86:9952-63. 2012
  7. pmc Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model
    Joshua T Schiffer
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Sci Transl Med 1:7ra16. 2009
  8. pmc Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract
    Joshua T Schiffer
    Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, United States Department of Medicine, University of Washington, Seattle, United States
    elife 2:e00288. 2013
  9. ncbi request reprint Prevalence of and associated risk factors for fluoroquinolone-resistant Neisseria gonorrhoeae in California, 2000-2003
    Heidi M Bauer
    California Department of Health Services Sexually Transmitted Disease Control Branch, Oakland, CA, USA
    Clin Infect Dis 41:795-803. 2005
  10. ncbi request reprint Contraception among HIV concordant and discordant couples in Zambia: a randomized controlled trial
    Karen E Mark
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA
    J Womens Health (Larchmt) 16:1200-10. 2007

Detail Information

Publications13

  1. ncbi request reprint Three Phase III Randomized Controlled Trials of Topical Resiquimod 0.01-Percent Gel To Reduce Anogenital Herpes Recurrences
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington, USA Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Antimicrob Agents Chemother 58:5016-23. 2014
    ..In conclusion, no posttreatment efficacy of resiquimod 0.01% gel was observed. Increased application site reactions and initial recurrence healing time are consistent with resiquimod-induced cytokine effects. ..
  2. pmc Rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in HIV-infected adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 54:482-8. 2010
    ..To determine whether rapidly cleared episodes of herpes simplex virus (HSV) reactivation occur in HIV-infected adults...
  3. ncbi request reprint Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: a randomized, controlled trial
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 195:1324-31. 2007
    ..In animal models, induction of Th1-specific responses modifies experimental herpes simplex virus (HSV) infection...
  4. pmc Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 198:1141-9. 2008
    ..Recent in situ data show the localization of HSV-specific CD8(+) T cells at the dermal epidermal junction next to peripheral sensory nerve endings, suggesting that viral reactivation may occur more frequently than previously appreciated...
  5. pmc Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes
    Joshua T Schiffer
    Department of Medicine, Laboratory Medicine, Global Health Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:18973-8. 2010
    ..The model suggests that the rate of containment of infected cells by the peripheral mucosal immune system is the major driver of duration and severity of HSV-2 reactivation in the immunocompetent host...
  6. pmc Peripheral blood CD4 T-cell and plasmacytoid dendritic cell (pDC) reactivity to herpes simplex virus 2 and pDC number do not correlate with the clinical or virologic severity of recurrent genital herpes
    Nicholas J Moss
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
    J Virol 86:9952-63. 2012
    ..These data suggest that other immune cell subsets with alternate phenotypes or anatomical locations may be responsible for genital herpes control in chronically infected individuals...
  7. pmc Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model
    Joshua T Schiffer
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Sci Transl Med 1:7ra16. 2009
    ..Frequent HSV-2 shedding episodes in humans are explained by nearly constant release of small numbers of viruses from neurons that terminate in the genital tract...
  8. pmc Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract
    Joshua T Schiffer
    Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, United States Department of Medicine, University of Washington, Seattle, United States
    elife 2:e00288. 2013
    ..We conclude that HSV-2 infection is characterized by extremely rapid virological growth and containment at multiple contemporaneous sites within genital epithelium. DOI:http://dx.doi.org/10.7554/eLife.00288.001...
  9. ncbi request reprint Prevalence of and associated risk factors for fluoroquinolone-resistant Neisseria gonorrhoeae in California, 2000-2003
    Heidi M Bauer
    California Department of Health Services Sexually Transmitted Disease Control Branch, Oakland, CA, USA
    Clin Infect Dis 41:795-803. 2005
    ..Rates of fluoroquinolone-resistant Neisseria gonorrhoeae (QRNG) are increasing worldwide and in California...
  10. ncbi request reprint Contraception among HIV concordant and discordant couples in Zambia: a randomized controlled trial
    Karen E Mark
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA
    J Womens Health (Larchmt) 16:1200-10. 2007
    ..This study examines the impact of an intervention to promote dual-method contraceptive use among HIV concordant and discordant couples already using condoms for HIV prevention...
  11. pmc Impact of herpes simplex virus type 2 on HIV-1 acquisition and progression in an HIV vaccine trial (the Step study)
    Ruanne V Barnabas
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Acquir Immune Defic Syndr 57:238-44. 2011
    ..To explore these relationships, we examined the impact of preexisting HSV-2 infection in an international HIV vaccine trial...
  12. pmc Internet and email use among STD clinic patients
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    Sex Transm Dis 35:960-5. 2008
    ..Little data exist on Internet and email use among STD clinic patients for research and clinical care communication...
  13. ncbi request reprint Targeted prenatal herpes simplex virus testing: can we identify women at risk of transmission to the neonate?
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 194:408-14. 2006
    ..The cost-effectiveness of these interventions would be improved if high-risk pregnancies could be easily identified for targeted testing...