Kaspar P Locher

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism
    Kaspar P Locher
    Howard Hughes Medical Institute and Division of Chemistry and Chemical Engineering, Mail Code 147 75CH, California Institute of Technology, Pasadena, CA 91125, USA
    Science 296:1091-8. 2002
  2. ncbi request reprint In vitro functional characterization of BtuCD-F, the Escherichia coli ABC transporter for vitamin B12 uptake
    Elizabeth L Borths
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 44:16301-9. 2005
  3. pmc The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter
    Elizabeth L Borths
    Howard Hughes Medical Institute and Division of Chemistry and Chemical Engineering, Mail Code 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:16642-7. 2002
  4. pmc A distinct mechanism for the ABC transporter BtuCD-BtuF revealed by the dynamics of complex formation
    Oded Lewinson
    Division of Chemistry and Chemical Engineering, Pasadena, California, USA
    Nat Struct Mol Biol 17:332-8. 2010
  5. ncbi request reprint The structures of BtuCD and MscS and their implications for transporter and channel function
    Randal B Bass
    Division of Chemistry and Chemical Engineering, 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    FEBS Lett 555:111-5. 2003
  6. ncbi request reprint ABC transporter architecture and mechanism: implications from the crystal structures of BtuCD and BtuF
    Kaspar P Locher
    Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    FEBS Lett 564:264-8. 2004
  7. doi request reprint Structural basis of trans-inhibition in a molybdate/tungstate ABC transporter
    Sabina Gerber
    Institute of Molecular Biology and Biophysics, ETH Zurich, HPK D14 3, 8093 Zurich, Switzerland
    Science 321:246-50. 2008
  8. ncbi request reprint Structure and mechanism of ABC transporter proteins
    Kaspar Hollenstein
    Institute of Molecular Biology and Biophysics, ETH Zurich HPK D14 3, 8093 Zurich, Switzerland
    Curr Opin Struct Biol 17:412-8. 2007
  9. ncbi request reprint Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF
    Rikki N Hvorup
    Institute of Molecular Biology and Biophysics, ETH Zurich, HPK D14 3, 8093 Zurich, Switzerland
    Science 317:1387-90. 2007
  10. ncbi request reprint Uptake or extrusion: crystal structures of full ABC transporters suggest a common mechanism
    Roger J P Dawson
    Institute of Molecular Biology and Biophysics, ETH Zurich HPK D14 3, 8093 Zurich, Switzerland
    Mol Microbiol 65:250-7. 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism
    Kaspar P Locher
    Howard Hughes Medical Institute and Division of Chemistry and Chemical Engineering, Mail Code 147 75CH, California Institute of Technology, Pasadena, CA 91125, USA
    Science 296:1091-8. 2002
    ..A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and appears to represent a conserved motif among the ABC transporters...
  2. ncbi request reprint In vitro functional characterization of BtuCD-F, the Escherichia coli ABC transporter for vitamin B12 uptake
    Elizabeth L Borths
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 44:16301-9. 2005
    ....
  3. pmc The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter
    Elizabeth L Borths
    Howard Hughes Medical Institute and Division of Chemistry and Chemical Engineering, Mail Code 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:16642-7. 2002
    ..These glutamate and arginine residues are conserved among binding proteins and ABC transporters mediating iron and B12 uptake, suggesting that they may have a role in docking and the transmission of conformational changes...
  4. pmc A distinct mechanism for the ABC transporter BtuCD-BtuF revealed by the dynamics of complex formation
    Oded Lewinson
    Division of Chemistry and Chemical Engineering, Pasadena, California, USA
    Nat Struct Mol Biol 17:332-8. 2010
    ....
  5. ncbi request reprint The structures of BtuCD and MscS and their implications for transporter and channel function
    Randal B Bass
    Division of Chemistry and Chemical Engineering, 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    FEBS Lett 555:111-5. 2003
    ....
  6. ncbi request reprint ABC transporter architecture and mechanism: implications from the crystal structures of BtuCD and BtuF
    Kaspar P Locher
    Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    FEBS Lett 564:264-8. 2004
    ..In the following, we will briefly review the results of these structural investigations and outline their mechanistic implications...
  7. doi request reprint Structural basis of trans-inhibition in a molybdate/tungstate ABC transporter
    Sabina Gerber
    Institute of Molecular Biology and Biophysics, ETH Zurich, HPK D14 3, 8093 Zurich, Switzerland
    Science 321:246-50. 2008
    ..This allosteric effect prevents the transporter from switching between the inward-facing and the outward-facing states, thus interfering with the alternating access and release mechanism...
  8. ncbi request reprint Structure and mechanism of ABC transporter proteins
    Kaspar Hollenstein
    Institute of Molecular Biology and Biophysics, ETH Zurich HPK D14 3, 8093 Zurich, Switzerland
    Curr Opin Struct Biol 17:412-8. 2007
    ..This basic scheme can, in principle, explain nutrient import by ABC importers and drug extrusion by ABC exporters...
  9. ncbi request reprint Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF
    Rikki N Hvorup
    Institute of Molecular Biology and Biophysics, ETH Zurich, HPK D14 3, 8093 Zurich, Switzerland
    Science 317:1387-90. 2007
    ..A comparison with BtuCD and the homologous HI1470/71 protein suggests that the structure of BtuCD-F may reflect a posttranslocation intermediate...
  10. ncbi request reprint Uptake or extrusion: crystal structures of full ABC transporters suggest a common mechanism
    Roger J P Dawson
    Institute of Molecular Biology and Biophysics, ETH Zurich HPK D14 3, 8093 Zurich, Switzerland
    Mol Microbiol 65:250-7. 2007
    ..This basic scheme can in principle explain ATP-driven drug export and binding protein-dependent nutrient uptake...
  11. ncbi request reprint Structure of an ABC transporter in complex with its binding protein
    Kaspar Hollenstein
    Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
    Nature 446:213-6. 2007
    ....
  12. ncbi request reprint Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP
    Roger J P Dawson
    Institute of Molecular Biology and Biophysics, ETH Zurich HPK D14 3, 8093 Zurich, Switzerland
    FEBS Lett 581:935-8. 2007
    ..The results confirm that the ATP-bound state of multidrug ABC transporters is coupled to an outward-facing conformation of the transmembrane domains...
  13. ncbi request reprint Structural biology. Breaching the barrier
    Kaspar P Locher
    Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule Zurich, Zurich CH 8093, Switzerland
    Science 301:603-4. 2003
  14. ncbi request reprint Structure and mechanism of ABC transporters
    Kaspar P Locher
    Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule Zurich, 8093 Zurich, Switzerland
    Curr Opin Struct Biol 14:426-31. 2004
    ..Two distinct mechanistic schemes for how ABC engines couple ATP hydrolysis to substrate transport have been proposed recently and are being explored...
  15. ncbi request reprint Structure of a bacterial multidrug ABC transporter
    Roger J P Dawson
    Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
    Nature 443:180-5. 2006
    ....
  16. ncbi request reprint Conversion of a mechanosensitive channel protein from a membrane-embedded to a water-soluble form by covalent modification with amphiphiles
    Christian F W Becker
    Gryphon Therapeutics, 600 Gateway Blvd, South San Francisco, CA 94080, USA
    J Mol Biol 343:747-58. 2004
    ..Solubilization of membrane proteins by covalent attachment of amphiphiles results in homogeneous particles that may prove useful for crystallization, solution NMR spectroscopy, and electron microscopy...