Christof Koch

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. doi request reprint Attention and consciousness: related yet different
    Christof Koch
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Trends Cogn Sci 16:103-5. 2012
  2. ncbi request reprint Attention and consciousness: two distinct brain processes
    Christof Koch
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Trends Cogn Sci 11:16-22. 2007
  3. ncbi request reprint Complexity and the nervous system
    C Koch
    Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 284:96-8. 1999
  4. ncbi request reprint Qualia
    Christof Koch
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Curr Biol 14:R496. 2004
  5. ncbi request reprint Towards the neuronal correlate of visual awareness
    C Koch
    Computation and Neural Systems Program, California Institute of Technology, Pasadena 91125, USA
    Curr Opin Neurobiol 6:158-64. 1996
  6. ncbi request reprint The role of single neurons in information processing
    C Koch
    Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Nat Neurosci 3:1171-7. 2000
  7. pmc On-line, voluntary control of human temporal lobe neurons
    Moran Cerf
    Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Nature 467:1104-8. 2010
  8. pmc A category-specific response to animals in the right human amygdala
    Florian Mormann
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Nat Neurosci 14:1247-9. 2011
  9. pmc Latency and selectivity of single neurons indicate hierarchical processing in the human medial temporal lobe
    Florian Mormann
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:8865-72. 2008
  10. ncbi request reprint Top-down biases win against focal attention in the fusiform face area
    Leila Reddy
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA
    Neuroimage 38:730-9. 2007

Research Grants

  1. THE STOCHASTIC NATURE OF SINGLE NEURONS
    Christof Koch; Fiscal Year: 2005
  2. Predoctoral Training in Computational & Neural Systems
    Christof Koch; Fiscal Year: 2007

Collaborators

Detail Information

Publications94

  1. doi request reprint Attention and consciousness: related yet different
    Christof Koch
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Trends Cogn Sci 16:103-5. 2012
    ..Its conclusions support the hypothesis that visual consciousness does not arise from neurons in primary visual cortex and forces a reinterpretation of numerous prior studies...
  2. ncbi request reprint Attention and consciousness: two distinct brain processes
    Christof Koch
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Trends Cogn Sci 11:16-22. 2007
    ..Such dissociations are easier to understand when the different functions of these two processes are considered. Untangling their tight relationship is necessary for the scientific elucidation of consciousness and its material substrate...
  3. ncbi request reprint Complexity and the nervous system
    C Koch
    Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 284:96-8. 1999
    ..This is reflected in their function, their evolutionary history, their structure, and the coding schemes they use to represent information. These four viewpoints need all play a role in any future science of "brain complexity."..
  4. ncbi request reprint Qualia
    Christof Koch
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Curr Biol 14:R496. 2004
  5. ncbi request reprint Towards the neuronal correlate of visual awareness
    C Koch
    Computation and Neural Systems Program, California Institute of Technology, Pasadena 91125, USA
    Curr Opin Neurobiol 6:158-64. 1996
    ..Taken together, these results suggest that the contents of visual awareness reflect neuronal activity in certain extrastriate, but not in striate, visual cortical areas...
  6. ncbi request reprint The role of single neurons in information processing
    C Koch
    Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Nat Neurosci 3:1171-7. 2000
    ....
  7. pmc On-line, voluntary control of human temporal lobe neurons
    Moran Cerf
    Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Nature 467:1104-8. 2010
    ..On the basis of the firing of these MTL neurons, the dynamics of the competition between visual images in the subject's mind was visualized on an external display...
  8. pmc A category-specific response to animals in the right human amygdala
    Florian Mormann
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Nat Neurosci 14:1247-9. 2011
    ..This selectivity appeared to be independent of emotional valence or arousal and may reflect the importance that animals held throughout our evolutionary past...
  9. pmc Latency and selectivity of single neurons indicate hierarchical processing in the human medial temporal lobe
    Florian Mormann
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:8865-72. 2008
    ....
  10. ncbi request reprint Top-down biases win against focal attention in the fusiform face area
    Leila Reddy
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA
    Neuroimage 38:730-9. 2007
    ..These results point to a coherent picture of how spatial attention and top-down task-based attention interact in visual cortex...
  11. ncbi request reprint Local field potentials and spikes in the human medial temporal lobe are selective to image category
    Alexander Kraskov
    California Institute of Technology, California, USA
    J Cogn Neurosci 19:479-92. 2007
    ..Combining spiking and LFP activity enhanced the decoding accuracy in comparison with the accuracy obtained with each signal alone, especially for short time intervals...
  12. doi request reprint Faces and text attract gaze independent of the task: Experimental data and computer model
    Moran Cerf
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA, USA
    J Vis 9:10.1-15. 2009
    ..This suggests that the primate visual system allocates attention using such an enhanced saliency map...
  13. doi request reprint Spatial attention increases performance but not subjective confidence in a discrimination task
    Claudia Wilimzig
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Vis 8:7.1-10. 2008
    ..This dissociation of objective performance and subjective confidence suggests that attention and awareness, as measured by confidence, are distinct, albeit related, phenomena...
  14. ncbi request reprint A bottom-up model of spatial attention predicts human error patterns in rapid scene recognition
    Wolfgang Einhäuser
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    J Vis 7:6.1-13. 2007
    ..Consequently, and contrary to several previously published findings, our results demonstrate that attentional limitations, rather than target recognition alone, affect the detection of targets in rapidly presented visual sequences...
  15. doi request reprint Evidence for two distinct mechanisms directing gaze in natural scenes
    Michael Mackay
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA
    J Vis 12:9. 2012
    ..These results are compatible with a rapid subcortical pathway generating accurate saccades to salient targets after analysis by cortical mechanisms...
  16. ncbi request reprint Probabilistic modeling of eye movement data during conjunction search via feature-based attention
    Ueli Rutishauser
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA
    J Vis 7:5. 2007
    ..Small variations of a few key parameters account well for the intersubject differences. The model is compatible with neurophysiological findings of V4 and frontal eye fields (FEF) neurons and predicts the gain modulation of these cells...
  17. doi request reprint Task-demands can immediately reverse the effects of sensory-driven saliency in complex visual stimuli
    Wolfgang Einhäuser
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    J Vis 8:2.1-19. 2008
    ....
  18. doi request reprint Ephaptic coupling of cortical neurons
    Costas A Anastassiou
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Nat Neurosci 14:217-23. 2011
    ..Our findings indicate that endogenous brain activity can causally affect neural function through field effects under physiological conditions...
  19. ncbi request reprint A learning rule for local synaptic interactions between excitation and shunting inhibition
    Chun Hui Mo
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA
    Neural Comput 16:2507-32. 2004
    ..The learning rule is also applicable to a neuron with multiple-direction-selective subunits and to a pair of cells with opposite-direction selectivities and is stable under different starting conditions, delays, and velocities...
  20. pmc Spatial attention is attracted in a sustained fashion toward singular points in the optic flow
    Shuo Wang
    Computation and Neural Systems, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 7:e41040. 2012
    ..Our results suggest that focal attention is strongly attracted towards singular points that signal the direction of forward ego-motion...
  21. pmc The spiking component of oscillatory extracellular potentials in the rat hippocampus
    Erik W Schomburg
    Department of Physics and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 32:11798-811. 2012
    ..Additionally, substantial power can be generated in the 90-150 Hz epsilon band by the APs of rhythmically firing pyramidal neurons. Thus, high-frequency LFPs may generally contain signatures of local cell assembly activation...
  22. ncbi request reprint Components of bottom-up gaze allocation in natural images
    Robert J Peters
    Computation and Neural Systems, California Institute of Technology, Mail Code 139 74, Caltech, Pasadena, CA 91125, USA
    Vision Res 45:2397-416. 2005
    ..As models of these interactions become more accurate in predicting behaviorally-relevant salient locations, they become useful to a range of applications in computer vision and human-machine interface design...
  23. ncbi request reprint Face adaptation depends on seeing the face
    Farshad Moradi
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 45:169-75. 2005
    ..Thus, cross-modal or cognitive interference that does not affect the visibility of the face does not interfere with the face aftereffect. We conclude that adaptation to face identity depends on seeing the face...
  24. ncbi request reprint Spike propagation in dendrites with stochastic ion channels
    Kamran Diba
    Division of Biology, 1200 E California Blvd, Pasadena, CA, 91125, USA
    J Comput Neurosci 20:77-84. 2006
    ..Additionally, we find that the generation and forward propagation of dendritic Ca(2+) spikes are susceptible to channel variability. This indicates limitations on computations that depend on the precise timing of Ca(2+) spikes...
  25. pmc Visual Motion Area MT+/V5 Responds to Auditory Motion in Human Sight-Recovery Subjects
    Melissa Saenz
    Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:5141-8. 2008
    ..Regarding sight recovery after early blindness, our results further demonstrate that cross-modal responses coexist with regained visual responses within the visual cortex...
  26. doi request reprint Visual saliency computations: mechanisms, constraints, and the effect of feedback
    Alireza Soltani
    Division of Biology and Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 30:12831-43. 2010
    ..In conclusion, using a detailed spiking network model we find biophysical mechanisms and limitations of saliency computations which can be tested experimentally...
  27. doi request reprint Homo economicus in visual search
    Vidhya Navalpakkam
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Vis 9:31.1-16. 2009
    ..Potential applications include designing reward schemes to improve detection of life-critical, rare targets (e.g., cancers in medical images)...
  28. ncbi request reprint A single-neuron correlate of change detection and change blindness in the human medial temporal lobe
    Leila Reddy
    Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Curr Biol 16:2066-72. 2006
    ..In contrast, this prediction was at chance for incorrect, unattended trials. The firing rates of visually selective MTL cells thus constitute a neural correlate of change detection...
  29. ncbi request reprint Observers are consistent when rating image conspicuity
    Moran Cerf
    Computation and Neural Systems Program, California Institute of Technology, Caltech 216 76, Pasadena, CA 91125, USA
    Vision Res 47:3052-60. 2007
    ..Our findings suggest that the rating of image conspicuity is driven by image-immanent, sensory factors common to all observers...
  30. doi request reprint Dynamic moment analysis of the extracellular electric field of a biologically realistic spiking neuron
    Joshua N Milstein
    California Institute of Technology, Pasadena, CA 91125, USA
    Neural Comput 20:2070-84. 2008
    ..This method will serve as a starting point in connecting the microscopic generation of electric fields at the level of neurons to macroscopic observables such as the local field potential...
  31. pmc Opposing effects of attention and consciousness on afterimages
    Jeroen J A van Boxtel
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:8883-8. 2010
    ..These findings provide clear evidence for distinctive influences of selective attention and consciousness on visual perception...
  32. ncbi request reprint The relation of phase noise and luminance contrast to overt attention in complex visual stimuli
    Wolfgang Einhäuser
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    J Vis 6:1148-58. 2006
    ..Our findings provide evidence that deviations from surrounding statistics, rather than contrast per se, underlie the well-established relation of contrast to fixation...
  33. ncbi request reprint Using extracellular action potential recordings to constrain compartmental models
    Carl Gold
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA, USA
    J Comput Neurosci 23:39-58. 2007
    ..Based on these results, we conclude that EAP recordings are an excellent source of data for the purpose of constraining compartmental models...
  34. pmc Neuronal shot noise and Brownian 1/f2 behavior in the local field potential
    Joshua Milstein
    California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 4:e4338. 2009
    ....
  35. doi request reprint The effect of spatially inhomogeneous extracellular electric fields on neurons
    Costas A Anastassiou
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 30:1925-36. 2010
    ..These findings imply that local electric fields, generated by the cooperative action of brain cells, can influence the timing of neural activity...
  36. pmc High-amplitude positive spikes recorded extracellularly in cat visual cortex
    Carl Gold
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA
    J Neurophysiol 102:3340-51. 2009
    ..We conclude that there is a significant gap in our present understanding of either the spike-generation process in pyramidal neurons, the biophysics of extracellular recording, or both...
  37. pmc The duration of the attentional blink in natural scenes depends on stimulus category
    Wolfgang Einhäuser
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    Vision Res 47:597-607. 2007
    ..We found a consistent AB for both target categories but the duration of the AB depended on the target category...
  38. pmc Optimal reward harvesting in complex perceptual environments
    Vidhya Navalpakkam
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:5232-7. 2010
    ..This suggests that individuals are able to harvest rewards optimally and dynamically under time pressure while seeking multiple targets embedded in perceptual clutter...
  39. ncbi request reprint Intrinsic noise in cultured hippocampal neurons: experiment and modeling
    Kamran Diba
    Sloan Swartz Center for Theoretical Neurobiology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 24:9723-33. 2004
    ..Our quantitative model reproduces important voltage- and frequency-dependent features of the data, accounting for the 1/f behavior, as well as the effects of various blockers...
  40. ncbi request reprint Depth of interocular suppression associated with continuous flash suppression, flash suppression, and binocular rivalry
    Naotsugu Tsuchiya
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, USA
    J Vis 6:1068-78. 2006
    ..Our results support the view that CFS is not a stronger version of BR but is due to the accumulated suppressive effects of multiple flashes...
  41. ncbi request reprint Activity in the visual cortex is modulated by top-down attention locked to reaction time
    Farshad Moradi
    Computation and Neural Systems Program, California Institute of Technology, Pasadena, CA 91125, USA
    J Cogn Neurosci 19:331-40. 2007
    ..Control experiments are compatible with the hypothesis that the nonsensory hemodynamic signal is mediated by top-down spatial attention, linked to (but separate from) awareness of the change...
  42. ncbi request reprint Human visual object categorization can be described by models with low memory capacity
    Robert J Peters
    Computation and Neural Systems, Division of Biology, Caltech, 139 74, Pasadena, CA 91125, USA
    Vision Res 43:2265-80. 2003
    ....
  43. ncbi request reprint Face identification in the near-absence of focal attention
    Leila Reddy
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA
    Vision Res 46:2336-43. 2006
    ..These results suggest that the visual system is well able to make complex judgments of natural stimuli, even when attention is not fully available...
  44. ncbi request reprint Modeling reverse-phi motion-selective neurons in cortex: double synaptic-veto mechanism
    Chun Hui Mo
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Neural Comput 15:735-59. 2003
    ..Two-bar interaction maps showed reversed excitation and inhibition regions when two different contrast bars are presented...
  45. ncbi request reprint On the origin of the extracellular action potential waveform: A modeling study
    Carl Gold
    Computation and Neural Systems, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA
    J Neurophysiol 95:3113-28. 2006
    ..Interestingly, each cell's dendritic morphology had very little impact on the EAP waveform. The model also demonstrates that the varied composition of ionic currents in different cells is reflected in the features of the EAP...
  46. ncbi request reprint Competition and selection during visual processing of natural scenes and objects
    Rufin VanRullen
    CNS Program Division of Biology, California Institute of Technology, Pasadena, CA, USA
    J Vis 3:75-85. 2003
    ..These results shed light on neural mechanisms of attentional competition, and representational capacity at different levels of the human visual system...
  47. ncbi request reprint Electrical interactions via the extracellular potential near cell bodies
    G R Holt
    Computation and Neural Systems Program, California Institute of Technology, Pasadena 91125, USA
    J Comput Neurosci 6:169-84. 1999
    ..The magnitude of this induced voltage can be several mV, does not spread electrotonically, and depends only weakly on the passive properties of the cable. We discuss their possible functional relevance...
  48. ncbi request reprint Multiplicative computation in a visual neuron sensitive to looming
    Fabrizio Gabbiani
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 420:320-4. 2002
    ..These results are consistent with an implementation of multiplication based on dendritic subtraction of two converging inputs encoded logarithmically, followed by exponentiation through active membrane conductances...
  49. pmc Rapid natural scene categorization in the near absence of attention
    Fei Fei Li
    Division of Engineering and Applied Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:9596-601. 2002
    ..We conclude that some visual tasks associated with "high-level" cortical areas may proceed in the near absence of attention...
  50. doi request reprint Unsupervised learning of individuals and categories from images
    Stephen Waydo
    Control and Dynamical Systems, California Institute of Technology, Pasadena, CA 91125, USA
    Neural Comput 20:1165-78. 2008
    ....
  51. ncbi request reprint Visual selective behavior can be triggered by a feed-forward process
    Rufin VanRullen
    California Institute of Technology, Pasadena, CA 91125, USA
    J Cogn Neurosci 15:209-17. 2003
    ..Rather, we found that such loops allow the masked stimulus to reverberate in the visual system and affect behavior for nearly 150 msec after the feed-forward sweep...
  52. ncbi request reprint Continuous flash suppression reduces negative afterimages
    Naotsugu Tsuchiya
    Computation and Neural Systems Program, California Institute of Technology, M s 139 74, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nat Neurosci 8:1096-101. 2005
    ..Our results imply that formation of afterimages involves neuronal structures that access input from both eyes but that do not correspond directly to the neuronal correlates of perceptual awareness...
  53. ncbi request reprint Sparse representation in the human medial temporal lobe
    Stephen Waydo
    Control and Dynamical Systems, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 26:10232-4. 2006
    ..Here, we used a probabilistic analysis to show that these data are consistent with a sparse code in which neurons respond in a selective manner to a small fraction of stimuli...
  54. ncbi request reprint Contingency awareness in human aversive conditioning involves the middle frontal gyrus
    Ronald McKell Carter
    MC216 76 Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Neuroimage 29:1007-12. 2006
    ..These results demonstrate that brain regions known to be involved in other aspects of learning and memory also play a specific role, reflecting on each trial the acquisition and representation of contingency awareness...
  55. ncbi request reprint Fusion of competing features is not serial
    Michael H Herzog
    Computation and Neural Systems Program, Caltech, Pasadena, CA, USA
    Vision Res 43:1951-60. 2003
    ..e. the first presented vernier dominates performance. Therefore, feature fusion can neither be explained completely by spatially local mechanisms nor by the temporal order of appearance of elements...
  56. pmc Attention-driven discrete sampling of motion perception
    Rufin VanRullen
    Centre de Recherche Cerveau et Cognition, Centre National de la Recherche Scientifique Université Paul Sabatier, 133 route de Narbonne, 31062 Toulouse, France
    Proc Natl Acad Sci U S A 102:5291-6. 2005
    ..A motion-energy model, coupled with attention-dependent temporal subsampling of the perceptual stream at rates between 10 and 20 Hz, can quantitatively account for the observed data...
  57. ncbi request reprint The continuous wagon wheel illusion is associated with changes in electroencephalogram power at approximately 13 Hz
    Rufin VanRullen
    Centre National de la Recherche Scientifique, Centre de Recherche Cerveau et Cognition, Unité Mixte de Recherche 5549, Faculte de Medecine Rangueil, 31062 Toulouse Cedex 9, France
    J Neurosci 26:502-7. 2006
    ..These data are compatible with the idea that motion perception occurs in snapshots <100 ms in duration...
  58. ncbi request reprint Visual search and dual tasks reveal two distinct attentional resources
    Rufin VanRullen
    CNRS, Centre de Recherche Cerveau et Cognition, 133 route de Narbonne, 31062 Toulouse Cedex, France
    J Cogn Neurosci 16:4-14. 2004
    ..In other words, visual search and dual-task performance reveal attentional resources along two independent dimensions. We suggest an interpretation of these results in terms of neuronal selectivities and receptive field size effects...
  59. doi request reprint Sparse but not 'grandmother-cell' coding in the medial temporal lobe
    R Quian Quiroga
    Department of Engineering, University of Leicester, LE1 7RH, Leicester, UK
    Trends Cogn Sci 12:87-91. 2008
    ..Given the very sparse and abstract representation of visual information by these neurons, they could in principle be considered as 'grandmother cells'. However, we give several arguments that make such an extreme interpretation unlikely...
  60. ncbi request reprint Decoding visual inputs from multiple neurons in the human temporal lobe
    R Quian Quiroga
    Department of Engineering, University of Leicester, Leicester, UK
    J Neurophysiol 98:1997-2007. 2007
    ..The feasibility of decoding sensory information from human extracellular recordings has implications for the development of brain-machine interfaces...
  61. ncbi request reprint From stimulus encoding to feature extraction in weakly electric fish
    F Gabbiani
    Computation and Neural Systems Program, California Institute of Technology, Pasadena 91125, USA
    Nature 384:564-7. 1996
    ..We conclude that the sensory neurons are specialized to acquire information accurately with little processing, whereas the following stage extracts behaviourally relevant features, thus performing a nonlinear pattern-recognition task...
  62. ncbi request reprint Variability and coding efficiency of noisy neural spike encoders
    P N Steinmetz
    Computation and Neural Systems Program, 139 74 California Institute of Technology, Pasadena, CA 91125, USA
    Biosystems 62:87-97. 2001
    ..Moreover, contrary to expectations based on earlier studies, we find that the noisy spike encoding models encode slowly varying stimuli more effectively than rapidly varying ones...
  63. ncbi request reprint Invariant visual representation by single neurons in the human brain
    R Quian Quiroga
    Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Nature 435:1102-7. 2005
    ..These results suggest an invariant, sparse and explicit code, which might be important in the transformation of complex visual percepts into long-term and more abstract memories...
  64. ncbi request reprint Subthreshold voltage noise due to channel fluctuations in active neuronal membranes
    P N Steinmetz
    Computation and Neural Systems Program, California Institute of Technology, Pasadena 91125, USA
    J Comput Neurosci 9:133-48. 2000
    ..For all subthreshold voltage ranges, the quasi-active linearized approximation is accurate within 8% and may thus be used in large-scale simulations of realistic neuronal geometries...
  65. doi request reprint Visual rivalry without spatial conflict
    Jeroen J A van Boxtel
    Division of Biology, California Institute of Technology, USA
    Psychol Sci 23:410-8. 2012
    ..This independence of spatial overlap provides an advantage to the visual system, allowing conflict resolution when an object is nonstationary on the retina (e.g., during frequently occurring eye movements)...
  66. doi request reprint Learning visual saliency by combining feature maps in a nonlinear manner using AdaBoost
    Qi Zhao
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA, USA
    J Vis 12:22. 2012
    ..By combining the output of feature maps via a series of nonlinear classifiers, the new model consistently predicts eye movements better than any of its competitors...
  67. pmc Single-neuron correlates of subjective vision in the human medial temporal lobe
    Gabriel Kreiman
    Computation and Neural Systems Program, California Institute of Technology 139 74, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:8378-83. 2002
    ..Therefore, the activity of most individual neurons in the medial temporal lobe of naive human subjects directly correlates with the phenomenal visual experience...
  68. pmc Pupil dilation reflects perceptual selection and predicts subsequent stability in perceptual rivalry
    Wolfgang Einhäuser
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 105:1704-9. 2008
    ....
  69. ncbi request reprint How does consciousness happen?
    Christof Koch
    California Institute of Technology, USA
    Sci Am 297:76-83. 2007
  70. pmc Trace but not delay fear conditioning requires attention and the anterior cingulate cortex
    C J Han
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 100:13087-92. 2003
    ..These data suggest that trace conditioning may be useful for studying neural substrates of attention in mice, and implicate the ACC as one such substrate...
  71. pmc Consciousness and attention: on sufficiency and necessity
    Jeroen J A van Boxtel
    Division of Biology, California Institute of Technology Pasadena, CA, USA
    Front Psychol 1:217. 2010
    ..Separating the effects of selective visual attention from those of visual consciousness is of paramount importance to untangle the neural substrates of consciousness from those for attention...
  72. ncbi request reprint The impact of spike timing variability on the signal-encoding performance of neural spiking models
    Amit Manwani
    Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA
    Neural Comput 14:347-67. 2002
    ....
  73. ncbi request reprint Quantum mechanics in the brain
    Christof Koch
    Division of Biology and the Division of Engineering and Applied Science, 216 76, California Institute of Technology, Pasadena, California 91125, USA
    Nature 440:611. 2006
  74. ncbi request reprint Face-gender discrimination is possible in the near-absence of attention
    Leila Reddy
    CNS Program, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Vis 4:106-17. 2004
    ..Our results provide further evidence against the notion that only low-level representations can be accessed outside the focus of attention...
  75. ncbi request reprint Detecting and estimating signals over noisy and unreliable synapses: information-theoretic analysis
    A Manwani
    Computation and Neural Systems, California Institute of Technology, Pasadena 91125, USA
    Neural Comput 13:1-33. 2001
    ....
  76. pmc Integrated information increases with fitness in the evolution of animats
    Jeffrey A Edlund
    Computation and Neural Systems, California Institute of Technology, Pasadena, California, United States of America
    PLoS Comput Biol 7:e1002236. 2011
    ....
  77. pmc Working memory and fear conditioning
    Ronald McKell Carter
    Division of Biology and Engineering and Applied Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 100:1399-404. 2003
    ..A postexperimental questionnaire showed a positive correlation between conditioning and awareness for differential trace conditioning extinction...
  78. ncbi request reprint An analog VLSI implementation of a visual interneuron: enhanced sensory processing through biophysical modeling
    R R Harrison
    Computation and Neural Systems Program, California Institute of Technology, Pasedena 91125, USA harrison
    Int J Neural Syst 9:391-5. 1999
    ..This results in enhanced performance in a compact, low-power CMOS motion sensor. Our silicon system also demonstrates that modern, biophysically-detailed models of neural sensory processing systems can be instantiated in VLSI hardware...
  79. ncbi request reprint Flanker effects in peripheral contrast discrimination--psychophysics and modeling
    B Zenger-Landolt
    Caltech 139 74, Computation and Neural Systems, Pasadena, CA 91125, USA
    Vision Res 41:3663-75. 2001
    ....
  80. ncbi request reprint Attention in hierarchical models of object recognition
    Dirk B Walther
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 N Mathews Ave, Urbana, IL 61801, USA
    Prog Brain Res 165:57-78. 2007
    ..Furthermore, we demonstrate a proof-of-concept implementation for sharing complex features between recognition and attention as a mode of top-down attention to particular objects or object categories...
  81. ncbi request reprint Motion-induced blindness does not affect the formation of negative afterimages
    Constanze Hofstoetter
    Institute of Neuroinformatics, Swiss Federal Institute of Technology and University of Zurich, Zurich, Switzerland
    Conscious Cogn 13:691-708. 2004
    ..Our results show that MIB does not affect the persistence and intensity of afterimages. Thus, there is no significant contribution to the formation of afterimages beyond the sites mediating MIB...
  82. ncbi request reprint Betting the house on consciousness
    Christof Koch
    Nat Neurosci 10:140-1. 2007
  83. pmc What is the function of the claustrum?
    Francis C Crick
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 360:1271-9. 2005
    ....
  84. ncbi request reprint Consciousness and neurosurgery
    Francis Crick
    Salk Institute for Biological Studies, La Jolla, California, USA
    Neurosurgery 55:273-281; discussion 281-2. 2004
    ..This article explores the contributions of neurosurgeons to this quest and outlines some of the results that have already been achieved...
  85. ncbi request reprint What do we perceive in a glance of a real-world scene?
    Li Fei-Fei
    Computer Science Department, Princeton University, Princeton, NJ, USA
    J Vis 7:10. 2007
    ..But once subjects recognize more semantic-level components of a scene, there is little evidence suggesting any bias toward either scene-level or object-level recognition...
  86. ncbi request reprint A framework for consciousness
    Francis Crick
    Francis Crick is at the Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 6:119-26. 2003
    ..We also outline some general experimental approaches to the problem and, finally, acknowledge some relevant aspects of the brain that have been left out of the proposed framework...
  87. ncbi request reprint Modeling attention to salient proto-objects
    Dirk Walther
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 N Mathews Ave, Urbana, IL 61801, USA
    Neural Netw 19:1395-407. 2006
    ..We demonstrate that the suggested model can enable a model of object recognition in cortex to expand from recognizing individual objects in isolation to sequentially recognizing all objects in a more complex scene...
  88. ncbi request reprint Stimulus encoding and feature extraction by multiple sensory neurons
    Rüdiger Krahe
    Department of Biology, University of California, Riverside, California 92521, USA
    J Neurosci 22:2374-82. 2002
    ..There, stimulus-induced coincident activity can improve the extraction of behaviorally relevant features from the stimulus...
  89. ncbi request reprint Neural correlates of consciousness in humans
    Geraint Rees
    Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
    Nat Rev Neurosci 3:261-70. 2002
  90. doi request reprint Inverse temporal contributions of the dorsal hippocampus and medial prefrontal cortex to the expression of long-term fear memories
    Jennifer J Quinn
    Department of Psychology and Brain Research Institute, UCLA, Los Angeles, California 90095 1563, USA
    Learn Mem 15:368-72. 2008
    ..These data strongly support the consolidation theory of hippocampus function and implicate the mPFC as a site of long-term memory storage/retrieval...
  91. pmc Subthreshold voltage noise of rat neocortical pyramidal neurones
    Gilad A Jacobson
    Department of Neurobiology, The Hebrew University, Jerusalem 91904, Israel
    J Physiol 564:145-60. 2005
    ....
  92. ncbi request reprint Multiplication and stimulus invariance in a looming-sensitive neuron
    Fabrizio Gabbiani
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Physiol Paris 98:19-34. 2004
    ..Invariance appears to be in part due to non-linear integration of synaptic inputs within the dendritic tree of this neuron...
  93. doi request reprint The neural correlates of consciousness: an update
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA
    Ann N Y Acad Sci 1124:239-61. 2008
    ..Finally, we briefly consider how a theoretical analysis of the fundamental properties of consciousness can usefully complement neurobiological studies...
  94. doi request reprint The sound of change: visually-induced auditory synesthesia
    Melissa Saenz
    Curr Biol 18:R650-R651. 2008

Research Grants7

  1. THE STOCHASTIC NATURE OF SINGLE NEURONS
    Christof Koch; Fiscal Year: 2005
    ..Our research plan will lead to a quantitative picture of the properties of neuronal noise sources and their effect on the information capacity of individual cortical neurons. ..
  2. Predoctoral Training in Computational & Neural Systems
    Christof Koch; Fiscal Year: 2007
    ..Support is requested in each year for ten predoctoral CNS trainees. ..