Ali Khoshnan

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Antibodies against huntingtin: production and screening of monoclonals and single-chain recombinant forms
    Ali Khoshnan
    Biology Division, California Institute of Technology, Pasadena, USA
    Methods Mol Biol 277:87-102. 2004
  2. pmc Elevated IKKα accelerates the differentiation of human neuronal progenitor cells and induces MeCP2-dependent BDNF expression
    Ali Khoshnan
    Biology Division 216 76, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 7:e41794. 2012
  3. ncbi request reprint Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity
    Ali Khoshnan
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 24:7999-8008. 2004
  4. pmc IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin
    Ali Khoshnan
    Biology Division 216 76, California Institute of Technology, Pasadena, California, USA
    PLoS ONE 4:e5768. 2009
  5. pmc The role of IκB kinase complex in the neurobiology of Huntington's disease
    Ali Khoshnan
    Biology Division, 216 76, California Institute of Technology, Pasadena CA 91125, USA
    Neurobiol Dis 43:305-11. 2011
  6. pmc Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity
    Amber L Southwell
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:9013-20. 2008
  7. doi request reprint Antibodies and intrabodies against huntingtin: production and screening of monoclonals and single-chain recombinant forms
    Ali Khoshnan
    Biology Division, California Institute of Technology, Pasadena, CA, USA
    Methods Mol Biol 1010:231-51. 2013
  8. pmc Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity
    Ali Khoshnan
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:1002-7. 2002

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Antibodies against huntingtin: production and screening of monoclonals and single-chain recombinant forms
    Ali Khoshnan
    Biology Division, California Institute of Technology, Pasadena, USA
    Methods Mol Biol 277:87-102. 2004
    ..This is the protein that, when mutated to contain an expanded polyQ motif, causes Huntington's disease...
  2. pmc Elevated IKKα accelerates the differentiation of human neuronal progenitor cells and induces MeCP2-dependent BDNF expression
    Ali Khoshnan
    Biology Division 216 76, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 7:e41794. 2012
    ..These studies highlight a role for IKKα in accelerating the differentiation of human NPCs and identify IKKα as a potential regulator of MeCP2 function and BDNF expression...
  3. ncbi request reprint Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity
    Ali Khoshnan
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 24:7999-8008. 2004
    ..Therefore, aberrant NF-kappaB activation may contribute to the neurodegeneration induced by mutant Htt...
  4. pmc IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin
    Ali Khoshnan
    Biology Division 216 76, California Institute of Technology, Pasadena, California, USA
    PLoS ONE 4:e5768. 2009
    ..One stimulus may be the DNA damage that accumulates in neurons over time, and the subsequent activation of signaling pathways such as those regulated by IkappaB kinase (IKK), which can influence neurodegeneration in HD...
  5. pmc The role of IκB kinase complex in the neurobiology of Huntington's disease
    Ali Khoshnan
    Biology Division, 216 76, California Institute of Technology, Pasadena CA 91125, USA
    Neurobiol Dis 43:305-11. 2011
    ..We will summarize these findings and describe the therapeutic potentials of IKKβ for HD...
  6. pmc Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity
    Amber L Southwell
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:9013-20. 2008
    ..We also note that intrabody binding represents a powerful tool for determining the function of protein epitopes in living cells...
  7. doi request reprint Antibodies and intrabodies against huntingtin: production and screening of monoclonals and single-chain recombinant forms
    Ali Khoshnan
    Biology Division, California Institute of Technology, Pasadena, CA, USA
    Methods Mol Biol 1010:231-51. 2013
    ..Thus, the production of antibodies and intrabodies has made a significant contribution to the understanding of HD pathogenesis and has introduced a novel strategy to treat this debilitating neurodegenerative disorder...
  8. pmc Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity
    Ali Khoshnan
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:1002-7. 2002
    ..Therefore, these anti-htt scFvs can be used to investigate the role of the polyP and polyQ domains in HD pathogenesis, and antibody binding to the polyP domain has potential therapeutic value in HD...