M B Kennedy

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Signal-processing machines at the postsynaptic density
    M B Kennedy
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 290:750-4. 2000
  2. ncbi request reprint Signal transduction molecules at the glutamatergic postsynaptic membrane
    M B Kennedy
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Brain Res Brain Res Rev 26:243-57. 1998
  3. ncbi request reprint Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin
    R S Walikonis
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 21:423-33. 2001
  4. ncbi request reprint Identification of proteins in the postsynaptic density fraction by mass spectrometry
    R S Walikonis
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 20:4069-80. 2000
  5. ncbi request reprint A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II
    H J Chen
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Neuron 20:895-904. 1998
  6. ncbi request reprint Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus
    W Zhang
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 19:96-108. 1999
  7. ncbi request reprint Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus
    Y Ouyang
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 17:5416-27. 1997
  8. ncbi request reprint Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons
    Y Ouyang
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 19:7823-33. 1999
  9. ncbi request reprint Integration of biochemical signalling in spines
    Mary B Kennedy
    Division of Biology 216 76, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Neurosci 6:423-34. 2005
  10. ncbi request reprint Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family
    M L Apperson
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 16:6839-52. 1996

Collaborators

  • Y Ouyang
  • W Zhang
  • H J Chen
  • O N Jensen
  • Alcino Silva
  • Holly J Carlisle
  • R S Walikonis
  • Yu Zhou
  • Julia M Shifman
  • Luis E Vazquez
  • Edoardo Marcora
  • Pasquale Manzerra
  • Johannes W Hell
  • Weidong Li
  • Brian Wiltgen
  • Guo dong Li
  • Dan Ehninger
  • Amy Halt
  • Eiki Takahashi
  • Mee H Choi
  • Stefan Mihalas
  • Stephen L Mayo
  • Irina Sokolova
  • Irene Knuesel
  • S Kindler
  • M L Apperson
  • R V Omkumar
  • C J Jeng
  • A Oguni
  • E M Khorosheva
  • F J Asuncion
  • J A Mercer
  • M Mann
  • D W Provance
  • M J Kiely
  • I S Moon
  • A J Rosenstein
  • K T Min

Detail Information

Publications17

  1. ncbi request reprint Signal-processing machines at the postsynaptic density
    M B Kennedy
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 290:750-4. 2000
    ..By changing synaptic strength in response to neural activity, the postsynaptic density contributes to information processing and the formation of memories...
  2. ncbi request reprint Signal transduction molecules at the glutamatergic postsynaptic membrane
    M B Kennedy
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Brain Res Brain Res Rev 26:243-57. 1998
    ..Over the next several years we will apply similar methods to study regulatory changes that occur at the molecular level in glutamatergic synapses in the CNS as the brain processes and stores new information...
  3. ncbi request reprint Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin
    R S Walikonis
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 21:423-33. 2001
    ....
  4. ncbi request reprint Identification of proteins in the postsynaptic density fraction by mass spectrometry
    R S Walikonis
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 20:4069-80. 2000
    ..The results support a role for myosin-Va in transport of materials into spines and for septins in the formation or maintenance of spines...
  5. ncbi request reprint A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II
    H J Chen
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Neuron 20:895-904. 1998
    ..Inhibition of p135 SynGAP by CaMKII will stop inactivation of GTP-bound Ras and thus could result in activation of the mitogen-activated protein (MAP) kinase pathway in hippocampal neurons upon activation of NMDA receptors...
  6. ncbi request reprint Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus
    W Zhang
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 19:96-108. 1999
    ..Thus, in the hippocampus, signal transduction complexes associated with postsynaptic NMDA receptors are different in glutamatergic and GABAergic neurons and are specialized in a way that is specific to the hippocampus...
  7. ncbi request reprint Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus
    Y Ouyang
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 17:5416-27. 1997
    ....
  8. ncbi request reprint Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons
    Y Ouyang
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 19:7823-33. 1999
    ..1997), will produce a prolonged increase in steady-state kinase activity in the dendrites, potentially influencing mechanisms of synaptic plasticity that are controlled through phosphorylation by CaMKII...
  9. ncbi request reprint Integration of biochemical signalling in spines
    Mary B Kennedy
    Division of Biology 216 76, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Neurosci 6:423-34. 2005
    ..Here, we present an initial working representation of the interactions of five signalling cascades that are usually studied individually. We discuss their integrated function in the regulation of postsynaptic plasticity...
  10. ncbi request reprint Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family
    M L Apperson
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 16:6839-52. 1996
    ..We propose that densin-180 participates in specific adhesion between presynaptic and postsynaptic membranes at glutamatergic synapses...
  11. ncbi request reprint Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor
    R V Omkumar
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 271:31670-8. 1996
    ..We show that serine 1303 in the full-length NR2B and/or the cognate site in NR2A is a major site of phosphorylation of the receptor both in the postsynaptic density fraction and in living hippocampal neurons...
  12. ncbi request reprint Visualization of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in hippocampal slices
    S Kindler
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    J Neurosci Methods 68:61-70. 1996
    ....
  13. ncbi request reprint Spine architecture and synaptic plasticity
    Holly J Carlisle
    California Institute of Technology, Division of Biology 216 76, Pasadena, CA 91125, USA
    Trends Neurosci 28:182-7. 2005
    ..This review, part of the TINS Synaptic Connectivity series, discusses recent studies that implicate EphB and NMDA receptors in the regulation of actin-binding proteins through modulation of Rho family small GTPases...
  14. pmc Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums
    Julia M Shifman
    Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:13968-73. 2006
    ..Our results support the idea that competition for binding of CaM with two bound Ca2+ ions may influence significantly the outcome of local Ca2+ signaling in spines and, perhaps, in other signaling pathways...
  15. ncbi request reprint SynGAP regulates spine formation
    Luis E Vazquez
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 24:8862-72. 2004
    ..Thus, the GAP activity of synGAP and its association with PSD-95 are important for normal regulation of spine and synapse formation in hippocampal neurons...
  16. pmc SynGAP regulates steady-state and activity-dependent phosphorylation of cofilin
    Holly J Carlisle
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:13673-83. 2008
    ..Our data show that synGAP mediates a rate-limiting step in steady-state regulation of spine morphology and in transient NMDA-receptor-dependent regulation of the spine cytoskeleton...
  17. ncbi request reprint Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning
    Yu Zhou
    Department of Neurobiology, Semel Institute, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    J Neurosci 27:13843-53. 2007
    ..Together our results demonstrate the importance of interactions between CaMKII and NR2B for CaMKII activity, synaptic plasticity, and learning...