M B Kennedy

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. pmc A dynamic model of interactions of Ca2+, calmodulin, and catalytic subunits of Ca2+/calmodulin-dependent protein kinase II
    Shirley Pepke
    Center for Advanced Computing Research, California Institute of Technology, Pasadena, California, USA
    PLoS Comput Biol 6:e1000675. 2010
  2. ncbi request reprint Integration of biochemical signalling in spines
    Mary B Kennedy
    Division of Biology 216 76, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Neurosci 6:423-34. 2005
  3. ncbi request reprint Signal-processing machines at the postsynaptic density
    M B Kennedy
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 290:750-4. 2000
  4. ncbi request reprint Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin
    R S Walikonis
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 21:423-33. 2001
  5. ncbi request reprint Signal transduction molecules at the glutamatergic postsynaptic membrane
    M B Kennedy
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Brain Res Brain Res Rev 26:243-57. 1998
  6. ncbi request reprint A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II
    H J Chen
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Neuron 20:895-904. 1998
  7. ncbi request reprint Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus
    W Zhang
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 19:96-108. 1999
  8. ncbi request reprint Identification of proteins in the postsynaptic density fraction by mass spectrometry
    R S Walikonis
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 20:4069-80. 2000
  9. ncbi request reprint Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family
    M L Apperson
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 16:6839-52. 1996
  10. pmc Autophosphorylation of type II CaM kinase in hippocampal neurons: localization of phospho- and dephosphokinase with complementary phosphorylation site-specific antibodies
    B L Patton
    Division of Biology, California Institute of Technology, Pasadena 91125
    Mol Biol Cell 4:159-72. 1993

Collaborators

  • Y Ouyang
  • Stefan Mihalas
  • W Zhang
  • M Ito
  • R F Bulleit
  • M K Bennett
  • O N Jensen
  • H J Chen
  • K M Harris
  • Alcino Silva
  • Terrence J Sejnowski
  • R S Walikonis
  • Shirley Pepke
  • Yu Zhou
  • Julia M Shifman
  • Holly J Carlisle
  • Luis E Vazquez
  • Tamara Kinzer-Ursem
  • Johannes W Hell
  • Weidong Li
  • Brian Wiltgen
  • Guo dong Li
  • Dan Ehninger
  • Amy Halt
  • Eiki Takahashi
  • Mee H Choi
  • Stephen L Mayo
  • Irina Sokolova
  • Irene Knuesel
  • S Kindler
  • M L Apperson
  • R V Omkumar
  • C J Jeng
  • A Oguni
  • E M Khorosheva
  • F J Asuncion
  • J A Mercer
  • M Mann
  • D W Provance
  • M J Kiely
  • I S Moon
  • A J Rosenstein
  • K O Cho
  • B L Patton
  • K T Min
  • S S Molloy
  • C A Hunt
  • P C Pugh
  • J B Wall
  • S A Mueller

Detail Information

Publications21

  1. pmc A dynamic model of interactions of Ca2+, calmodulin, and catalytic subunits of Ca2+/calmodulin-dependent protein kinase II
    Shirley Pepke
    Center for Advanced Computing Research, California Institute of Technology, Pasadena, California, USA
    PLoS Comput Biol 6:e1000675. 2010
    ..This model provides a quantitative base from which to build more complex dynamic models of postsynaptic signal transduction during learning...
  2. ncbi request reprint Integration of biochemical signalling in spines
    Mary B Kennedy
    Division of Biology 216 76, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Neurosci 6:423-34. 2005
    ..Here, we present an initial working representation of the interactions of five signalling cascades that are usually studied individually. We discuss their integrated function in the regulation of postsynaptic plasticity...
  3. ncbi request reprint Signal-processing machines at the postsynaptic density
    M B Kennedy
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 290:750-4. 2000
    ..By changing synaptic strength in response to neural activity, the postsynaptic density contributes to information processing and the formation of memories...
  4. ncbi request reprint Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin
    R S Walikonis
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 21:423-33. 2001
    ....
  5. ncbi request reprint Signal transduction molecules at the glutamatergic postsynaptic membrane
    M B Kennedy
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Brain Res Brain Res Rev 26:243-57. 1998
    ..Over the next several years we will apply similar methods to study regulatory changes that occur at the molecular level in glutamatergic synapses in the CNS as the brain processes and stores new information...
  6. ncbi request reprint A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II
    H J Chen
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Neuron 20:895-904. 1998
    ..Inhibition of p135 SynGAP by CaMKII will stop inactivation of GTP-bound Ras and thus could result in activation of the mitogen-activated protein (MAP) kinase pathway in hippocampal neurons upon activation of NMDA receptors...
  7. ncbi request reprint Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus
    W Zhang
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 19:96-108. 1999
    ..Thus, in the hippocampus, signal transduction complexes associated with postsynaptic NMDA receptors are different in glutamatergic and GABAergic neurons and are specialized in a way that is specific to the hippocampus...
  8. ncbi request reprint Identification of proteins in the postsynaptic density fraction by mass spectrometry
    R S Walikonis
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 20:4069-80. 2000
    ..The results support a role for myosin-Va in transport of materials into spines and for septins in the formation or maintenance of spines...
  9. ncbi request reprint Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family
    M L Apperson
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 16:6839-52. 1996
    ..We propose that densin-180 participates in specific adhesion between presynaptic and postsynaptic membranes at glutamatergic synapses...
  10. pmc Autophosphorylation of type II CaM kinase in hippocampal neurons: localization of phospho- and dephosphokinase with complementary phosphorylation site-specific antibodies
    B L Patton
    Division of Biology, California Institute of Technology, Pasadena 91125
    Mol Biol Cell 4:159-72. 1993
    ....
  11. ncbi request reprint Visualization of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in hippocampal slices
    S Kindler
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    J Neurosci Methods 68:61-70. 1996
    ....
  12. ncbi request reprint Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus
    Y Ouyang
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 17:5416-27. 1997
    ....
  13. ncbi request reprint Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons
    Y Ouyang
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 19:7823-33. 1999
    ..1997), will produce a prolonged increase in steady-state kinase activity in the dendrites, potentially influencing mechanisms of synaptic plasticity that are controlled through phosphorylation by CaMKII...
  14. ncbi request reprint The alpha subunit of type II Ca2+/calmodulin-dependent protein kinase is highly conserved in Drosophila
    K O Cho
    Division of Biology, California Institute of Technology, Pasadena 91125
    Neuron 7:439-50. 1991
    ..The protein product of this gene is expressed at much higher levels in the fly head than in the body. Thus, both the amino acid sequence and the tissue specificity of the mammalian kinase are highly conserved in Drosophila...
  15. ncbi request reprint Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor
    R V Omkumar
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 271:31670-8. 1996
    ..We show that serine 1303 in the full-length NR2B and/or the cognate site in NR2A is a major site of phosphorylation of the receptor both in the postsynaptic density fraction and in living hippocampal neurons...
  16. ncbi request reprint Conserved and variable regions in the subunits of brain type II Ca2+/calmodulin-dependent protein kinase
    R F Bulleit
    Division of Biology, California Institute of Technology, Pasadena 91125
    Neuron 1:63-72. 1988
    ..The alpha and beta subunits are encoded by distinct genes expressed primarily, if not exclusively, in brain. Rather than being encoded by a third gene, beta' may arise by alternative splicing of the beta gene transcript...
  17. ncbi request reprint The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein
    K O Cho
    Division of Biology, California Institute of Technology, Pasadena 91125
    Neuron 9:929-42. 1992
    ..The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain...
  18. ncbi request reprint Spine architecture and synaptic plasticity
    Holly J Carlisle
    California Institute of Technology, Division of Biology 216 76, Pasadena, CA 91125, USA
    Trends Neurosci 28:182-7. 2005
    ..This review, part of the TINS Synaptic Connectivity series, discusses recent studies that implicate EphB and NMDA receptors in the regulation of actin-binding proteins through modulation of Rho family small GTPases...
  19. ncbi request reprint SynGAP regulates spine formation
    Luis E Vazquez
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 24:8862-72. 2004
    ..Thus, the GAP activity of synGAP and its association with PSD-95 are important for normal regulation of spine and synapse formation in hippocampal neurons...
  20. pmc Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums
    Julia M Shifman
    Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:13968-73. 2006
    ..Our results support the idea that competition for binding of CaM with two bound Ca2+ ions may influence significantly the outcome of local Ca2+ signaling in spines and, perhaps, in other signaling pathways...
  21. ncbi request reprint Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning
    Yu Zhou
    Department of Neurobiology, Semel Institute, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    J Neurosci 27:13843-53. 2007
    ..Together our results demonstrate the importance of interactions between CaMKII and NR2B for CaMKII activity, synaptic plasticity, and learning...

Research Grants40

  1. CALCIUM AND CALMODULIN DEPENDENT PROTEIN KINASE
    Mary Kennedy; Fiscal Year: 2000
    ..In the fifth aim, the investigator proposes to create mutant mice lacking SynGAP. The investigator will test the effect of the SynGAP knockout on regulation of the MAP kinase pathway by NMDA receptors. ..
  2. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 1992
  3. BRAIN CALCIUM AND CALMODULIN-DEPENDENT PROTEIN KINASE
    Mary Kennedy; Fiscal Year: 1993
    ..Such data will permit testing of predictions made by explicit models of the organization of regulatory pathways in different types of synapses...
  4. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 1991
  5. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 2001
    ..We will also determine whether densin contributes to the translocation of CAMKII to the PSD that occurs upon stimulation of hippocampal neurons with glutamate. ..
  6. CALCIUM AND CALMODULIN DEPENDENT PROTEIN KINASE
    Mary Kennedy; Fiscal Year: 2002
    ..In the fifth aim, the investigator proposes to create mutant mice lacking SynGAP. The investigator will test the effect of the SynGAP knockout on regulation of the MAP kinase pathway by NMDA receptors. ..
  7. BRAIN CALCIUM AND CALMODULIN-DEPENDENT PROTEIN KINASE
    Mary Kennedy; Fiscal Year: 1990
    ..Our long-term goal is to correlate information about this pathway with similar information about other calcium regulated pathways in order to understand the concerted responses to changing calcium levels in CNS neurons...
  8. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 2009
    ..Our work may illuminate how synaptic dysregulation can lead eventually to neuronal apoptosis. ..
  9. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 2004
    ..We will also determine whether densin contributes to the translocation of CAMKII to the PSD that occurs upon stimulation of hippocampal neurons with glutamate. ..
  10. CALCIUM AND CALMODULIN DEPENDENT PROTEIN KINASE
    Mary Kennedy; Fiscal Year: 2006
    ..abstract_text> ..
  11. CRCNS: Modeling Activation of CaMKII in Spines
    Terrence J Sejnowski; Fiscal Year: 2010
    ....
  12. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 2002
    ..We will also determine whether densin contributes to the translocation of CAMKII to the PSD that occurs upon stimulation of hippocampal neurons with glutamate. ..
  13. CALCIUM AND CALMODULIN DEPENDENT PROTEIN KINASE
    Mary Kennedy; Fiscal Year: 2007
    ..abstract_text> ..
  14. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 2003
    ..We will also determine whether densin contributes to the translocation of CAMKII to the PSD that occurs upon stimulation of hippocampal neurons with glutamate. ..
  15. CALCIUM AND CALMODULIN DEPENDENT PROTEIN KINASE
    Mary Kennedy; Fiscal Year: 2001
    ..In the fifth aim, the investigator proposes to create mutant mice lacking SynGAP. The investigator will test the effect of the SynGAP knockout on regulation of the MAP kinase pathway by NMDA receptors. ..
  16. BRAIN CALCIUM AND CALMODULIN-DEPENDENT PROTEIN KINASE
    Mary Kennedy; Fiscal Year: 1991
    ..Our long-term goal is to correlate information about this pathway with similar information about other calcium regulated pathways in order to understand the concerted responses to changing calcium levels in CNS neurons...
  17. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 1999
    ....
  18. Analysis and Modeling of Ca2+ Signaling Spines
    Mary Kennedy; Fiscal Year: 2007
    ..Thus, we view the models and the simulations we propose to generate as powerful quantitative tools with which to study the dynamics of synaptic signaling, and not as an end in themselves. ..
  19. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 2007
    ..Our work may illuminate how synaptic dysregulation can lead eventually to neuronal apoptosis. ..
  20. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 2006
    ..Our work may illuminate how synaptic dysregulation can lead eventually to neuronal apoptosis. ..
  21. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 1993
    ..The detailed structural information obtained in this study will provide an improved conceptual framework for future studies of synaptic transmission in the central nervous system...
  22. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 2000
    ....