Joanna L Jankowsky

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease
    Joanna L Jankowsky
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neuropathol Exp Neurol 62:1220-7. 2003
  2. ncbi request reprint Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease
    Joanna L Jankowsky
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:5217-24. 2005
  3. pmc Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease
    Joanna L Jankowsky
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Med 2:e355. 2005
  4. ncbi request reprint Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase
    Joanna L Jankowsky
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 13:159-70. 2004
  5. ncbi request reprint APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1
    Joanna L Jankowsky
    Department of Pathology, The Johns Hopkins University School of Medicine, 558 Ross Research Building, 720 Rutland Ave, Baltimore, MD 21205, USA
    Neurobiol Aging 25:885-92. 2004
  6. ncbi request reprint Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development
    Joanna L Jankowsky
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Building Room 558, Baltimore, MD 21205, USA
    Curr Neurol Neurosci Rep 2:457-64. 2002
  7. ncbi request reprint Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice
    Joanna L Jankowsky
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 282:22707-20. 2007
  8. ncbi request reprint Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis
    Laure Verret
    Centre National de la Recherche Scientifique, Universite Paul Sabatier, 31062 Toulouse, France
    J Neurosci 27:6771-80. 2007

Research Grants

Detail Information

Publications8

  1. ncbi request reprint Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease
    Joanna L Jankowsky
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neuropathol Exp Neurol 62:1220-7. 2003
    ....
  2. ncbi request reprint Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease
    Joanna L Jankowsky
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:5217-24. 2005
    ..These results demonstrate that the generation of Abeta in vivo and its impact on the function of the nervous system can be strongly modulated by environmental factors...
  3. pmc Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease
    Joanna L Jankowsky
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Med 2:e355. 2005
    ..However, no long-term studies using animal models of amyloid pathology have yet been performed to test this hypothesis...
  4. ncbi request reprint Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase
    Joanna L Jankowsky
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 13:159-70. 2004
    ..These data suggest that PS1 variants do not simply alter the preferred cleavage site for gamma-secretase, but rather that they have more complex effects on the regulation of gamma-secretase and its access to substrates...
  5. ncbi request reprint APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1
    Joanna L Jankowsky
    Department of Pathology, The Johns Hopkins University School of Medicine, 558 Ross Research Building, 720 Rutland Ave, Baltimore, MD 21205, USA
    Neurobiol Aging 25:885-92. 2004
    ..Instead, our data are consistent with a gain of property mechanism...
  6. ncbi request reprint Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development
    Joanna L Jankowsky
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Building Room 558, Baltimore, MD 21205, USA
    Curr Neurol Neurosci Rep 2:457-64. 2002
    ....
  7. ncbi request reprint Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice
    Joanna L Jankowsky
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 282:22707-20. 2007
    ..These findings suggest that, although mouse A beta does not influence the rate of amyloid formation, the incorporation of A beta peptides with differing sequences alters the solubility and localization of the resulting aggregates...
  8. ncbi request reprint Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis
    Laure Verret
    Centre National de la Recherche Scientifique, Universite Paul Sabatier, 31062 Toulouse, France
    J Neurosci 27:6771-80. 2007
    ..Diminished capacity for hippocampal neuron replacement may contribute to the cognitive decline observed in these mice...

Research Grants2

  1. Interaction of ABeta & the alpha7 AChR in mouse AD model
    JOANNA JANKOWSKY; Fiscal Year: 2007
    ..abstract_text> ..