Research Topics
Species | Alicia IzquierdoSummaryAffiliation: California State University Country: USA Publications
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Detail Information
Publications
Genetic and dopaminergic modulation of reversal learning in a touchscreen-based operant procedure for miceAlicia Izquierdo
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute of Alcohol Abuse and Alcoholism, NIH, Rockville, USA
Behav Brain Res 171:181-8. 2006..When combined with emerging molecular techniques uniquely suited to this species such as genetic engineering and RNA modification this paradigm could provide a powerful new tool for behavioral neuroscience...- Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeysAlicia Izquierdo
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurophysiol 91:2023-39. 2004.... 
Basolateral amygdala lesions facilitate reward choices after negative feedback in ratsAlicia Izquierdo
Laboratory of Cognitive Neuroscience, Department of Psychology, California State University, Los Angeles, Los Angeles, California 90032, USA
J Neurosci 33:4105-9. 2013..Our results are discussed in relation to a competitive framework model for OFC and BLA in reward processing...- Impaired reward learning and intact motivation after serotonin depletion in ratsAlicia Izquierdo
Laboratory of Cognitive Neuroscience, Department of Psychology, California State University, Los Angeles, CA 90032, USA
Behav Brain Res 233:494-9. 2012..High performance liquid chromatography (HPLC) with electrochemical detection confirmed 5-HT, and not dopamine, levels in the ventromedial frontal cortex were correlated with this measure of associative reward learning... - Selective bilateral amygdala lesions in rhesus monkeys fail to disrupt object reversal learningAlicia Izquierdo
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:1054-62. 2007..Second, the results implicate a critical contribution to object reversal learning of structures nearby the amygdala, perhaps the subjacent rhinal cortex... - Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in miceAlicia Izquierdo
Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Rockville, Maryland 20852, USA
J Neurosci 26:5733-8. 2006..Present findings suggest that trauma may compromise the functional integrity of the mPFC with implications for the pathophysiology of certain neuropsychiatric disorders... - Reversal learning as a measure of impulsive and compulsive behavior in addictionsAlicia Izquierdo
Department of Psychology, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA
Psychopharmacology (Berl) 219:607-20. 2012..Consequently, reversal learning could index vulnerability for disorders characterized by impulsivity such as proclivity for initial substance abuse as well as the compulsive aspects of dependence... 
Rodent models of adaptive decision makingAlicia Izquierdo
Laboratory of Cognitive Neuroscience, Department of Psychology, California State University, Los Angeles, CA, USA
Methods Mol Biol 829:85-101. 2012..These tasks all recruit regions within the frontal cortex and the striatum, and performance is heavily modulated by the neurotransmitter dopamine, making these assays highly valid measures in the study of psychostimulant addiction...- Reversal-specific learning impairments after a binge regimen of methamphetamine in rats: possible involvement of striatal dopamineAlicia Izquierdo
Department of Psychology, California State University, Los Angeles, CA 90032, USA
Neuropsychopharmacology 35:505-14. 2010..Together, these results lend new information to the growing field documenting impaired cognition after mAMPH exposure, and constitute a rat model of the widely reported decision-making deficits resulting from mAMPH abuse seen in humans... - Orbitofrontal cortex and basolateral amygdala lesions result in suboptimal and dissociable reward choices on cue-guided effort in ratsSerena Ostrander
Laboratory of Cognitive Neuroscience, Department of Psychology, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA
Behav Neurosci 125:350-9. 2011..Control measures rule out an inability to discriminate the cue in either lesion group... - Distinct contributions of the amygdala and hippocampus to fear expressionYogita Chudasama
Neurobiology of Learning and Memory Section, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Eur J Neurosci 30:2327-37. 2009..These data show that the hippocampus and amygdala contribute independently to the overall expression of defensive responses... - Functional interaction of medial mediodorsal thalamic nucleus but not nucleus accumbens with amygdala and orbital prefrontal cortex is essential for adaptive response selection after reinforcer devaluationAlicia Izquierdo
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892 4415, USA
J Neurosci 30:661-9. 2010..In contrast, monkeys that sustained MDm disconnection failed to adjust their object choices. Thus, MDm, but not NA, works together with the amygdala and PFo to support reward-based decision making... - Opposing effects of amygdala and orbital prefrontal cortex lesions on the extinction of instrumental responding in macaque monkeysAlicia Izquierdo
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Eur J Neurosci 22:2341-6. 2005..For comparison, we evaluated the effects of ablation of PFo on the same task. Amygdala lesions facilitated the extinction of instrumental responses, whereas lesions of PFo had the opposite effect... - Work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in ratsAlisa R Kosheleff
Department of Psychology, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA
Psychopharmacology (Berl) 219:411-20. 2012..Effortful decision-making (i.e., how much effort to invest in rewards) is an aspect of cognition that has not yet been explored after mAMPH... - Comparison of the effects of bilateral orbital prefrontal cortex lesions and amygdala lesions on emotional responses in rhesus monkeysAlicia Izquierdo
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 25:8534-42. 2005..In addition, they point to a divergence of the roles of the PFo and amygdala in responding to a social stimulus, the human intruder... - Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in miceJonathan L Brigman
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, MD 20852 9411, USA
Cereb Cortex 20:1955-63. 2010..These findings could have important implications for understanding and treating cognitive inflexibility in neuropsychiatric disease... - Genetic modulation of cognitive flexibility and socioemotional behavior in rhesus monkeysAlicia Izquierdo
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:14128-33. 2007..Because behaviors modulated by the 5-HTTLPR are a subset of those dependent on the VMPFC, analysis of structural and functional correlates of gene variation in this region may inform the nature of the genetic modulation of cognition... - Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingencyAlicia Izquierdo
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4415, USA
J Neurosci 24:7540-8. 2004.... - Comparison of single-dose and extended methamphetamine administration on reversal learning in ratsAlisa R Kosheleff
Department of Psychology, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA
Psychopharmacology (Berl) 224:459-67. 2012..Several studies show that extended exposure to mAMPH may confer protection against cognitive impairments and the insult to monoamine systems typically observed after larger binge doses... - Orbitofrontal cortex and amygdala contributions to affect and action in primatesElisabeth A Murray
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, MD 20892 4415, USA
Ann N Y Acad Sci 1121:273-96. 2007..Both regions contribute to the expression of defensive responses to a potential predator. Contrary to the prevailing view, the amygdala and OFC make distinct contributions to emotional responses and reward processing...