Bruce Hay

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint MicroRNAs and the regulation of cell death
    Peizhang Xu
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Trends Genet 20:617-24. 2004
  2. pmc echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases
    Jeffrey M Copeland
    Division of Biology, MC 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    BMC Dev Biol 7:82. 2007
  3. ncbi request reprint Caspase-dependent cell death in Drosophila
    Bruce A Hay
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Annu Rev Cell Dev Biol 22:623-50. 2006
  4. pmc Engineering the genomes of wild insect populations: challenges, and opportunities provided by synthetic Medea selfish genetic elements
    Bruce A Hay
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, United States
    J Insect Physiol 56:1402-13. 2010
  5. ncbi request reprint The genetics of cell death: approaches, insights and opportunities in Drosophila
    Bruce A Hay
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nat Rev Genet 5:911-22. 2004
  6. ncbi request reprint The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC
    Israel Muro
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    J Biol Chem 277:49644-50. 2002
  7. pmc Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization
    Jun R Huh
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    PLoS Biol 2:E15. 2004
  8. ncbi request reprint Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms
    Soon Ji Yoo
    Division of Biology, MC156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Nat Cell Biol 4:416-24. 2002
  9. ncbi request reprint The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis induce
    Jun R Huh
    Division of Biology, MC 156 29, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 282:2056-68. 2007
  10. ncbi request reprint The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism
    Peizhang Xu
    Division of Biology, MC 156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Curr Biol 13:790-5. 2003

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint MicroRNAs and the regulation of cell death
    Peizhang Xu
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Trends Genet 20:617-24. 2004
    ....
  2. pmc echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases
    Jeffrey M Copeland
    Division of Biology, MC 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    BMC Dev Biol 7:82. 2007
    ..These results have suggested that echinus functions in the pupal retina primarily to promote interommatidial cell death...
  3. ncbi request reprint Caspase-dependent cell death in Drosophila
    Bruce A Hay
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Annu Rev Cell Dev Biol 22:623-50. 2006
    ..We also discuss the significance of recent work showing that a number of key cell death activators also play nonapoptotic roles. We highlight opportunities and outstanding questions along the way...
  4. pmc Engineering the genomes of wild insect populations: challenges, and opportunities provided by synthetic Medea selfish genetic elements
    Bruce A Hay
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, United States
    J Insect Physiol 56:1402-13. 2010
    ..Finally, we highlight several challenges to implementing population replacement in the wild...
  5. ncbi request reprint The genetics of cell death: approaches, insights and opportunities in Drosophila
    Bruce A Hay
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nat Rev Genet 5:911-22. 2004
    ..This review describes these genetic approaches and the key insights into cell-death mechanisms that have been obtained, as well as the outstanding questions that these techniques can help to answer...
  6. ncbi request reprint The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC
    Israel Muro
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    J Biol Chem 277:49644-50. 2002
    ....
  7. pmc Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization
    Jun R Huh
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    PLoS Biol 2:E15. 2004
    ..Our results demonstrate that multiple caspases and caspase regulators, likely acting at distinct points in time and space, are required for spermatid individualization, a nonapoptotic process...
  8. ncbi request reprint Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms
    Soon Ji Yoo
    Division of Biology, MC156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Nat Cell Biol 4:416-24. 2002
    ..Because loss of DIAP1 is sufficient to promote caspase activation, these mechanisms should promote apoptosis...
  9. ncbi request reprint The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis induce
    Jun R Huh
    Division of Biology, MC 156 29, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 282:2056-68. 2007
    ..Therefore, diap2 may identify a point of convergence between apoptosis and immune signaling pathways...
  10. ncbi request reprint The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism
    Peizhang Xu
    Division of Biology, MC 156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Curr Biol 13:790-5. 2003
    ..Deletion of mir-14 results in animals with increased levels of triacylglycerol and diacylglycerol, whereas increases in mir-14 copy number have the converse effect. We discuss possible relationships between these phenotypes...
  11. ncbi request reprint A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila
    Chun Hong Chen
    Division of Biology, Mail Code 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Science 316:597-600. 2007
    ..These selfish elements use microRNA-mediated silencing of a maternally expressed gene essential for embryogenesis, which is coupled with early zygotic expression of a rescuing transgene...
  12. ncbi request reprint Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role
    Jun R Huh
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Curr Biol 14:1262-6. 2004
    ..We speculate that dying cells may communicate cell fate or behavior instructions to their neighbors in other contexts as well...
  13. ncbi request reprint The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process
    Israel Muro
    Division of Biology, MC 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Development 133:3305-15. 2006
    ..Finally, we demonstrate that Ice participates in, but is not absolutely required for, the non-apoptotic process of spermatid differentiation...
  14. ncbi request reprint Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death
    Stephanie Y Vernooy
    Division of Biology, MC 156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena 91125, USA
    Curr Biol 12:1164-8. 2002
    ..dBruce does not block the activity of the apical cell death caspase Dronc or the proapoptotic Bcl-2 family member Debcl/Drob-1/dBorg-1/Dbok. Together, these results argue that dBruce can regulate cell death at a novel point...
  15. ncbi request reprint Coupling cell growth, proliferation, and death. Hippo weighs in
    Bruce A Hay
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Dev Cell 5:361-3. 2003
    ..This, together with the ability of Mst2 to rescue hippo mutant phenotypes, argues that Mst/Hippo proteins are tumor suppressors...
  16. ncbi request reprint Identifying microRNA regulators of cell death in Drosophila
    Chun Hong Chen
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    Methods Mol Biol 342:229-40. 2006
    ..Here we describe a protocol for identifying miRNAs that can act as cell death regulators. We also describe a simple protocol for testing roles for mRNAs identified as candidate miRNA targets using computational or other approaches...
  17. pmc Medea selfish genetic elements as tools for altering traits of wild populations: a theoretical analysis
    Catherine M Ward
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Evolution 65:1149-62. 2011
    ..Our results suggest that Medea elements can drive population replacement under a wide range of conditions...
  18. ncbi request reprint Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    Ira E Clark
    Nature 441:1162-6. 2006
    ..The role of the pink1-parkin pathway in regulating mitochondrial function underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis...
  19. ncbi request reprint A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye
    Sun Yun Yu
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 129:3269-78. 2002
    ..Taken together, these findings indicate that in eye development spatial regulation of cell death and survival is integrated through a single intracellular pathway...
  20. ncbi request reprint Apoptosis: sculpture of a fly's head
    Jun R Huh
    Nature 418:926-8. 2002
  21. ncbi request reprint Reaper is regulated by IAP-mediated ubiquitination
    Michael R Olson
    Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
    J Biol Chem 278:4028-34. 2003
    ..These data demonstrate a novel function for IAPs and suggest that IAPs and Reaper-like proteins mutually control each other's abundance...
  22. ncbi request reprint A reporter for amyloid precursor protein gamma-secretase activity in Drosophila
    Ming Guo
    Department of Neurology, Brain Research Institute, The David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    Hum Mol Genet 12:2669-78. 2003
    ..We have used these flies to carry out a screen for mutations that suppress gamma-secretase activity and have identified a small chromosomal region that contains a gene or genes whose products may promote gamma-secretase activity...
  23. ncbi request reprint Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
    Jijie Chai
    Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, New Jersey 08544, USA
    Nat Struct Biol 10:892-8. 2003
    ..These observations reveal the molecular mechanisms of how DIAP1 recognizes Dronc, and more importantly, how the RHG proteins remove DIAP1-mediated ubiquitination of Dronc...
  24. ncbi request reprint Structure and activation mechanism of the Drosophila initiator caspase Dronc
    Nieng Yan
    Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Princeton, New Jersey 08544, USA
    J Biol Chem 281:8667-74. 2006
    ..This study revealed insights into mechanism of Dronc activation, and in conjunction with other observations, suggests diverse mechanisms for the activation of initiator caspases...
  25. pmc The role of cytochrome c in caspase activation in Drosophila melanogaster cells
    Loretta Dorstyn
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide SA 5000, Australia
    J Cell Biol 156:1089-98. 2002
    ..These results suggest that caspase activation in insects follows a more primitive mechanism that may be the precursor to the caspase activation pathways in mammals...
  26. pmc Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary
    Halyna R Shcherbata
    Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
    Cell Stem Cell 1:698-709. 2007
    ....

Research Grants17

  1. Characterization of microRNA cell death regulators
    Bruce Hay; Fiscal Year: 2007
    ..Therefore, it is likely that successful completion of the proposed experiments will increase our understanding of how cell death is regulated in human health and disease. ..
  2. Nonapoptotic roles for proteases in spermatogenesis
    Bruce Hay; Fiscal Year: 2007
    ..In addition this work is likely to provide insight into the mechanisms by which caspase activity, and the consequences of caspase activation, are regulated. ..
  3. REGULATION OF CELL DEATH IN DROSOPHILA
    Bruce Hay; Fiscal Year: 2006
    ..Finally, we will also characterize the roles and mechanism of action of a second Drosophila lAP, DIAP2. ..
  4. REGULATION OF CELL DEATH IN DROSOPHILA
    Bruce Hay; Fiscal Year: 2002
    ..Because the P element tags the site of insertion we can quickly identify the affected gene. ..