Michael Elowitz

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. pmc A synthetic three-color scaffold for monitoring genetic regulation and noise
    Robert Sidney Cox
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    J Biol Eng 4:10. 2010
  2. pmc Frequency-modulated nuclear localization bursts coordinate gene regulation
    Long Cai
    Howard Hughes Medical Institute, Division of Biology and Department of Applied Physics, California Institute of Technology, M C 114 96, Pasadena, California 91125, USA
    Nature 455:485-90. 2008
  3. pmc A general mechanism for network-dosage compensation in gene circuits
    Murat Acar
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 329:1656-60. 2010
  4. ncbi request reprint An excitable gene regulatory circuit induces transient cellular differentiation
    Gürol M Süel
    Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nature 440:545-50. 2006
  5. pmc Programming gene expression with combinatorial promoters
    Robert Sidney Cox
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Syst Biol 3:145. 2007
  6. pmc Regulatory activity revealed by dynamic correlations in gene expression noise
    Mary J Dunlop
    Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA
    Nat Genet 40:1493-8. 2008
  7. doi request reprint Functional roles for noise in genetic circuits
    Avigdor Eldar
    Howard Hughes Medical Institute, Caltech M C 114 96, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 467:167-73. 2010

Collaborators

  • Frances Arnold
  • Murat Acar
  • Robert Sidney Cox
  • Mary J Dunlop
  • Avigdor Eldar
  • Long Cai
  • Gürol M Süel
  • Richard M Murray
  • Chiraj K Dalal
  • Joseph H Levine
  • Michael G Surette
  • Jordi Garcia-Ojalvo
  • Louisa M Liberman

Detail Information

Publications7

  1. pmc A synthetic three-color scaffold for monitoring genetic regulation and noise
    Robert Sidney Cox
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    J Biol Eng 4:10. 2010
    ..Experiments in both natural and synthetic systems would benefit from a well-characterized platform for expressing multiple reporter genes and synthetic network components...
  2. pmc Frequency-modulated nuclear localization bursts coordinate gene regulation
    Long Cai
    Howard Hughes Medical Institute, Division of Biology and Department of Applied Physics, California Institute of Technology, M C 114 96, Pasadena, California 91125, USA
    Nature 455:485-90. 2008
    ....
  3. pmc A general mechanism for network-dosage compensation in gene circuits
    Murat Acar
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 329:1656-60. 2010
    ..This mechanism of network-dosage invariance could represent a general design for gene network structure in cells...
  4. ncbi request reprint An excitable gene regulatory circuit induces transient cellular differentiation
    Gürol M Süel
    Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nature 440:545-50. 2006
    ..Excitable dynamics driven by noise naturally generate stochastic and transient responses, thereby providing an ideal mechanism for competence regulation...
  5. pmc Programming gene expression with combinatorial promoters
    Robert Sidney Cox
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Syst Biol 3:145. 2007
    ..Using these results, we identified heuristic rules for programming gene expression with combinatorial promoters...
  6. pmc Regulatory activity revealed by dynamic correlations in gene expression noise
    Mary J Dunlop
    Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA
    Nat Genet 40:1493-8. 2008
    ..These results show how noise can help analyze the context dependence of regulatory interactions in endogenous gene circuits...
  7. doi request reprint Functional roles for noise in genetic circuits
    Avigdor Eldar
    Howard Hughes Medical Institute, Caltech M C 114 96, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 467:167-73. 2010
    ..We further indicate some of the important challenges and opportunities going forward...

Research Grants5

  1. Amplification and suppression of noise in B. subtilis developmental gene circuits
    Michael Elowitz; Fiscal Year: 2007
    ..In addition, the proposal will investigate the mechanisms leading to the partial penetrance (occurring only in some affected individuals) of mutations. Partial penetrance is also found in human diseases. ..
  2. Genetic Interactions and Synthetic Population Biology
    Michael B Elowitz; Fiscal Year: 2010
    ..These fundamental issues are critical for understanding the link between population genetics and the observed complex disease phenotypes, and are thus central to the development of genomic medicine. ..
  3. Amplification and suppression of noise in B. subtilis developmental gene circuits
    Michael Elowitz; Fiscal Year: 2009
    ..In addition, the proposal will investigate the mechanisms leading to the partial penetrance (occurring only in some affected individuals) of mutations. Partial penetrance is also found in human diseases. ..
  4. Amplification and suppression of noise in B. subtilis developmental gene circuits
    Michael B Elowitz; Fiscal Year: 2010
    ..In addition, the proposal will investigate the mechanisms leading to the partial penetrance (occurring only in some affected individuals) of mutations. Partial penetrance is also found in human diseases. ..