Michael Elowitz

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. pmc Programming gene expression with combinatorial promoters
    Robert Sidney Cox
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Syst Biol 3:145. 2007
  2. pmc Pulsed feedback defers cellular differentiation
    Joe H Levine
    Howard Hughes Medical Institute and Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California, United States of America
    PLoS Biol 10:e1001252. 2012
  3. pmc Accurate prediction of gene feedback circuit behavior from component properties
    Nitzan Rosenfeld
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Syst Biol 3:143. 2007
  4. pmc Dynamical consequences of bandpass feedback loops in a bacterial phosphorelay
    Shaunak Sen
    Department of Control and Dynamical Systems, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 6:e25102. 2011
  5. pmc Mutual inactivation of Notch receptors and ligands facilitates developmental patterning
    David Sprinzak
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, USA
    PLoS Comput Biol 7:e1002069. 2011
  6. pmc A synthetic three-color scaffold for monitoring genetic regulation and noise
    Robert Sidney Cox
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    J Biol Eng 4:10. 2010
  7. pmc Frequency-modulated nuclear localization bursts coordinate gene regulation
    Long Cai
    Howard Hughes Medical Institute, Division of Biology and Department of Applied Physics, California Institute of Technology, M C 114 96, Pasadena, California 91125, USA
    Nature 455:485-90. 2008
  8. pmc A general mechanism for network-dosage compensation in gene circuits
    Murat Acar
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 329:1656-60. 2010
  9. ncbi request reprint Functional roles for noise in genetic circuits
    Avigdor Eldar
    Howard Hughes Medical Institute, Caltech M C 114 96, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 467:167-73. 2010
  10. pmc Regulatory activity revealed by dynamic correlations in gene expression noise
    Mary J Dunlop
    Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA
    Nat Genet 40:1493-8. 2008

Collaborators

Detail Information

Publications11

  1. pmc Programming gene expression with combinatorial promoters
    Robert Sidney Cox
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Syst Biol 3:145. 2007
    ..Using these results, we identified heuristic rules for programming gene expression with combinatorial promoters...
  2. pmc Pulsed feedback defers cellular differentiation
    Joe H Levine
    Howard Hughes Medical Institute and Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California, United States of America
    PLoS Biol 10:e1001252. 2012
    ..Together, these results suggest that Bacillus subtilis uses a pulsed positive feedback loop to implement a "timer" that operates over timescales much longer than a cell cycle...
  3. pmc Accurate prediction of gene feedback circuit behavior from component properties
    Nitzan Rosenfeld
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Syst Biol 3:143. 2007
    ..This demonstration that quantitative characterization of regulatory elements can predict the behavior of genetic circuits supports a fundamental requirement of synthetic biology...
  4. pmc Dynamical consequences of bandpass feedback loops in a bacterial phosphorelay
    Shaunak Sen
    Department of Control and Dynamical Systems, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 6:e25102. 2011
    ..These results show that periodically-driven bandpass feedback loops can give rise to complex dynamics in the progression towards sporulation...
  5. pmc Mutual inactivation of Notch receptors and ligands facilitates developmental patterning
    David Sprinzak
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, USA
    PLoS Comput Biol 7:e1002069. 2011
    ..Together, these results provide a framework for analysis of more complex Notch-dependent developmental systems...
  6. pmc A synthetic three-color scaffold for monitoring genetic regulation and noise
    Robert Sidney Cox
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    J Biol Eng 4:10. 2010
    ..Experiments in both natural and synthetic systems would benefit from a well-characterized platform for expressing multiple reporter genes and synthetic network components...
  7. pmc Frequency-modulated nuclear localization bursts coordinate gene regulation
    Long Cai
    Howard Hughes Medical Institute, Division of Biology and Department of Applied Physics, California Institute of Technology, M C 114 96, Pasadena, California 91125, USA
    Nature 455:485-90. 2008
    ....
  8. pmc A general mechanism for network-dosage compensation in gene circuits
    Murat Acar
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 329:1656-60. 2010
    ..This mechanism of network-dosage invariance could represent a general design for gene network structure in cells...
  9. ncbi request reprint Functional roles for noise in genetic circuits
    Avigdor Eldar
    Howard Hughes Medical Institute, Caltech M C 114 96, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 467:167-73. 2010
    ..We further indicate some of the important challenges and opportunities going forward...
  10. pmc Regulatory activity revealed by dynamic correlations in gene expression noise
    Mary J Dunlop
    Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA
    Nat Genet 40:1493-8. 2008
    ..These results show how noise can help analyze the context dependence of regulatory interactions in endogenous gene circuits...
  11. ncbi request reprint An excitable gene regulatory circuit induces transient cellular differentiation
    Gürol M Süel
    Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nature 440:545-50. 2006
    ..Excitable dynamics driven by noise naturally generate stochastic and transient responses, thereby providing an ideal mechanism for competence regulation...

Research Grants5

  1. Amplification and suppression of noise in B. subtilis developmental gene circuits
    Michael Elowitz; Fiscal Year: 2007
    ..In addition, the proposal will investigate the mechanisms leading to the partial penetrance (occurring only in some affected individuals) of mutations. Partial penetrance is also found in human diseases. ..
  2. Genetic Interactions and Synthetic Population Biology
    Michael B Elowitz; Fiscal Year: 2010
    ..These fundamental issues are critical for understanding the link between population genetics and the observed complex disease phenotypes, and are thus central to the development of genomic medicine. ..
  3. Amplification and suppression of noise in B. subtilis developmental gene circuits
    Michael Elowitz; Fiscal Year: 2009
    ..In addition, the proposal will investigate the mechanisms leading to the partial penetrance (occurring only in some affected individuals) of mutations. Partial penetrance is also found in human diseases. ..
  4. Amplification and suppression of noise in B. subtilis developmental gene circuits
    Michael B Elowitz; Fiscal Year: 2010
    ..In addition, the proposal will investigate the mechanisms leading to the partial penetrance (occurring only in some affected individuals) of mutations. Partial penetrance is also found in human diseases. ..