Pierre Yves Desprez

Summary

Affiliation: California Pacific Medical Center
Country: USA

Publications

  1. pmc A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1
    P Y Desprez
    Department of Cell and Molecular Biology, Life Sciences Division, Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Mol Cell Biol 18:4577-88. 1998
  2. ncbi request reprint Helix-loop-helix proteins in mammary gland development and breast cancer
    Pierre Yves Desprez
    California Pacific Medical Center, Cancer Research Institute, San Francisco, California 94115, USA
    J Mammary Gland Biol Neoplasia 8:225-39. 2003
  3. pmc Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis
    Sylvia Fong
    California Pacific Medical Center, Cancer Research Institute, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 100:13543-8. 2003
  4. pmc A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen
    Jean Philippe Coppe
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 5:e9188. 2010
  5. ncbi request reprint Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells
    Yoko Itahana
    Cancer Research Institute, California Pacific Medical Center, Stern Building, 2230 Clay Street, San Francisco, CA 94115, USA
    Cancer Res 63:7098-105. 2003
  6. ncbi request reprint Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex
    Jarnail Singh
    Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco, California, CA 94115, USA
    Oncogene 21:1812-22. 2002
  7. doi request reprint The helix-loop-helix Id-1 inhibits PSA expression in prostate cancer cells
    Anne J Zielinski
    California Pacific Medical Center, Cancer Research Institute, San Francisco, CA 94107, USA
    Int J Cancer 126:2490-6. 2010
  8. pmc Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
    Sean D McAllister
    California Pacific Medical Center, Research Institute, San Francisco, CA 94107, USA
    Breast Cancer Res Treat 129:37-47. 2011
  9. ncbi request reprint Reduction of human metastatic breast cancer cell aggressiveness on introduction of either form a or B of the progesterone receptor and then treatment with progestins
    Tomoki Sumida
    California Pacific Medical Center, Cancer Research Institute, San Francisco, California 94115, USA
    Cancer Res 64:7886-92. 2004
  10. ncbi request reprint Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression
    Jean Philippe Coppe
    California Pacific Medical Center, Cancer Research Institute, San Francisco, California 94115, USA
    Clin Cancer Res 10:2044-51. 2004

Collaborators

Detail Information

Publications28

  1. pmc A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1
    P Y Desprez
    Department of Cell and Molecular Biology, Life Sciences Division, Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Mol Cell Biol 18:4577-88. 1998
    ..This Id-1-regulated invasive phenotype could contribute to involution of the mammary gland and possibly to the development of invasive breast cancer...
  2. ncbi request reprint Helix-loop-helix proteins in mammary gland development and breast cancer
    Pierre Yves Desprez
    California Pacific Medical Center, Cancer Research Institute, San Francisco, California 94115, USA
    J Mammary Gland Biol Neoplasia 8:225-39. 2003
    ..The purpose of this review is to summarize the evidence implicating HLH proteins in the regulation of normal and transformed mammary epithelial cell phenotypes...
  3. pmc Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis
    Sylvia Fong
    California Pacific Medical Center, Cancer Research Institute, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 100:13543-8. 2003
    ....
  4. pmc A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen
    Jean Philippe Coppe
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 5:e9188. 2010
    ..Our findings underscore critical mouse-human differences in oxygen sensitivity, identify conditions to use mouse cells to model human cellular senescence, and reveal novel conserved features of the SASP...
  5. ncbi request reprint Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells
    Yoko Itahana
    Cancer Research Institute, California Pacific Medical Center, Stern Building, 2230 Clay Street, San Francisco, CA 94115, USA
    Cancer Res 63:7098-105. 2003
    ....
  6. ncbi request reprint Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex
    Jarnail Singh
    Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco, California, CA 94115, USA
    Oncogene 21:1812-22. 2002
    ..On the basis of these findings, we propose a mechanism for the loss of regulation of Id-1 promoter in invasive and metastatic human breast cancer cells...
  7. doi request reprint The helix-loop-helix Id-1 inhibits PSA expression in prostate cancer cells
    Anne J Zielinski
    California Pacific Medical Center, Cancer Research Institute, San Francisco, CA 94107, USA
    Int J Cancer 126:2490-6. 2010
    ..Here, we show that the reduction in PSA mRNA and protein expression associated with high-grade prostate cancers, which generally express high levels of Id-1, could be the consequence of Id-1 overexpression...
  8. pmc Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
    Sean D McAllister
    California Pacific Medical Center, Research Institute, San Francisco, CA 94107, USA
    Breast Cancer Res Treat 129:37-47. 2011
    ....
  9. ncbi request reprint Reduction of human metastatic breast cancer cell aggressiveness on introduction of either form a or B of the progesterone receptor and then treatment with progestins
    Tomoki Sumida
    California Pacific Medical Center, Cancer Research Institute, San Francisco, California 94115, USA
    Cancer Res 64:7886-92. 2004
    ....
  10. ncbi request reprint Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression
    Jean Philippe Coppe
    California Pacific Medical Center, Cancer Research Institute, San Francisco, California 94115, USA
    Clin Cancer Res 10:2044-51. 2004
    ..This study aimed to identify the potential role of Id-1 and Id-2 proteins as molecular makers for prostate cancer progression...
  11. pmc Regulation of clusterin expression in mammary epithelial cells
    Yoko Itahana
    California Pacific Medical Center, Cancer Research Institute, 475 Brannan Street, Suite 220, San Francisco, CA 94107, USA
    Exp Cell Res 313:943-51. 2007
    ..Overall, these findings reveal several novel pathways for the regulation of clusterin expression during mammary gland development, and suggest that clusterin is a morphogenic factor that plays a key role during differentiation...
  12. pmc Identification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult mice
    Mohammed Kashani-Sabet
    Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, University of California at San Francisco Cancer Center and Department of Dermatology, University of California, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 99:3878-83. 2002
    ..These studies demonstrate the utility of gene targeting by means of systemic, plasmid-based ribozymes to dissect out the functional genomics of complex biologic phenotypes, including tumor metastasis...
  13. doi request reprint The senescence-associated secretory phenotype: the dark side of tumor suppression
    Jean Philippe Coppe
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Annu Rev Pathol 5:99-118. 2010
    ..The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression...
  14. pmc Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
    Jahan P Marcu
    California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    Mol Cancer Ther 9:180-9. 2010
    ..Our results suggest that the addition of cannabidiol to Delta(9)-THC may improve the overall effectiveness of Delta(9)-THC in the treatment of glioblastoma in cancer patients...
  15. pmc Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
    Jean Philippe Coppe
    Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 286:36396-403. 2011
    ....
  16. ncbi request reprint Id proteins in epithelial cells
    Jean Philippe Coppe
    California Pacific Medical Center, Cancer Research Institute, San Francisco, CA 94115, USA
    Exp Cell Res 285:131-45. 2003
    ..The purpose of this review is to summarize the evidence implicating Id proteins in the regulation of mammalian epithelial cell phenotypes...
  17. ncbi request reprint Id genes and proteins as promising targets in cancer therapy
    Sylvia Fong
    California Pacific Medical Center Research Institute, San Francisco, CA 94115, USA
    Trends Mol Med 10:387-92. 2004
    ....
  18. ncbi request reprint Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
    Sean D McAllister
    California Pacific Medical Center, Research Institute, 475 Brannan Street, San Francisco, CA 94107, USA
    Mol Cancer Ther 6:2921-7. 2007
    ..In conclusion, CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness...
  19. pmc Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family
    Sylvia Fong
    California Pacific Medical Research Institute, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 100:14253-8. 2003
    ..Furthermore, identifying gene regulatory networks that function to control tumor progression may permit more accurate modeling of the complex molecular mechanisms of this disease...
  20. pmc A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion
    Jean Philippe Coppe
    California Pacific Medical Center, Research Institute, San Francisco, CA 94107, USA
    Mol Cancer Res 6:1085-98. 2008
    ..Thus, tobacco may not only initiate mutagenic changes in epithelial cells but also promote the growth and invasion of mutant cells by creating a procarcinogenic stromal environment...
  21. pmc Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    Jean Philippe Coppe
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    PLoS Biol 6:2853-68. 2008
    ..Moreover, they suggest a cell-nonautonomous mechanism by which p53 can restrain, and oncogenic RAS can promote, the development of age-related cancer by altering the tissue microenvironment...
  22. pmc Expression of Id and ITF-2 genes in the mammary gland during pregnancy
    Yoko Itahana
    California Pacific Medical Center, Cancer Research Institute, 475 Brannan Street, Suite 220, San Francisco, CA 94107, USA
    Biochem Biophys Res Commun 372:826-30. 2008
    ..Therefore Id-1 and Id-2, but not the ubiquitous bHLH proteins, appear to represent the key factors whose expression is modulated during different stages of pregnancy in mouse mammary glands...
  23. ncbi request reprint A role for p53 in maintaining and establishing the quiescence growth arrest in human cells
    Koji Itahana
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 277:18206-14. 2002
    ..Our data indicate that p53 is activated during both quiescence and senescence. They further suggest that p53 activity contributes, albeit not exclusively, to the quiescent growth arrest...
  24. ncbi request reprint Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells
    Clifford G Tepper
    Department of Biochemistry and Molecular Medicine, University of California, Davis School of Medicine, Division of Basic Sciences, UC Davis Cancer Center, Sacramento, California 95817, USA
    Prostate 65:375-89. 2005
    ..In this study, we performed gene expression profiling of four LNCaP-p53GOF sublines to test the hypothesis that different p53GOF mutants mediated androgen independence via modulation of a common set of genes...
  25. pmc Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model
    Binwu Tang
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 67:8643-52. 2007
    ..These data suggest new roles for the TGF-beta pathway in regulating tumor cell dynamics that are independent of direct effects on proliferation...
  26. ncbi request reprint E6/E7 of HPV type 16 promotes cell invasion and metastasis of human breast cancer cells
    Amber Yasmeen
    Program in Cancer Genetics, Oncology Department, McGill University, Montreal, Quebec, Canada
    Cell Cycle 6:2038-42. 2007
    ..These data suggest that high-risk HPV infections can induce cell invasion and metastasis in breast cancer through Id-1 regulation...
  27. ncbi request reprint Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for maintenance of the differentiated state
    Yan Zhao
    Department of Biological Sciences and the Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907 2064, USA
    Mol Endocrinol 20:2187-98. 2006
    ....
  28. ncbi request reprint 2-methoxyestradiol induces mammary gland differentiation through amphiregulin-epithelial growth factor receptor-mediated signaling: molecular distinctions from the mammary gland of pregnant mice
    Jung im Huh
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Building 41, 41 Medlars Drive, Bethesda, MD 20892, USA
    Endocrinology 148:1266-77. 2007
    ..These data demonstrate that 2ME(2) can induce a partial differentiation of the mammary gland through mechanisms that differ from those normally used during pregnancy...