E H Davidson
Affiliation: California Institute of Technology
Davidson E. Emerging properties of animal gene regulatory networks. Nature. 2010;468:911-20 pubmed publisher
..The structural organization of various kinds of GRN reflects their roles in the life process, and causally illuminates both developmental and evolutionary process. ..
Barsi J, Li E, Davidson E. Geometric control of ciliated band regulatory states in the sea urchin embryo. Development. 2015;142:953-61 pubmed publisher
..In total this requires deployment of about ten different repressors, which we identify in this work, thus exemplifying the complexity of information required for spatial regulatory organization during embryogenesis. ..
Gao F, Thompson J, Petsios E, Erkenbrack E, Moats R, Bottjer D, et al
. Juvenile skeletogenesis in anciently diverged sea urchin clades. Dev Biol. 2015;400:148-58 pubmed publisher
..This work opens the way to analysis of the alternative spatial specification processes that were installed at the evolutionary divergence of the two extant subclasses of sea urchins. ..
Erkenbrack E, Davidson E. Evolutionary rewiring of gene regulatory network linkages at divergence of the echinoid subclasses. Proc Natl Acad Sci U S A. 2015;112:E4075-84 pubmed publisher
..This work directly implies a dramatic reorganization of genomic regulatory circuitry concomitant with the divergence of the euechinoids, which began before the end-Permian extinction. ..
Davidson E, Erwin D. Gene regulatory networks and the evolution of animal body plans. Science. 2006;311:796-800 pubmed
..Conservation of phyletic body plans may have been due to the retention since pre-Cambrian time of GRN kernels, which underlie development of major body parts. ..
Davidson E. The sea urchin genome: where will it lead us?. Science. 2006;314:939-40 pubmed
..The sequence will accelerate progress toward complete understanding of the genomic regulatory system that controls developmental specification and morphogenetic function, thus illuminating basic developmental process in all animals...
Davidson E, Levine M. Properties of developmental gene regulatory networks. Proc Natl Acad Sci U S A. 2008;105:20063-6 pubmed publisher
Davidson E. Network design principles from the sea urchin embryo. Curr Opin Genet Dev. 2009;19:535-40 pubmed publisher
..These subcircuits are dedicated to specific developmental functions, unlike simpler 'motifs', and may indicate a repertoire of specific devices of which developmental gene regulatory networks are composed...