Shanaz H Dairkee

Summary

Affiliation: California Pacific Medical Center
Country: USA

Publications

  1. pmc Breast tumor copy number aberration phenotypes and genomic instability
    Jane Fridlyand
    Department of Epidemiology and Biostatistics, University of California San Francisco, CA 94143, USA
    BMC Cancer 6:96. 2006
  2. ncbi request reprint Partial enzymatic degradation of stroma allows enrichment and expansion of primary breast tumor cells
    S H Dairkee
    Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco 94115, USA
    Cancer Res 57:1590-6. 1997
  3. pmc A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue
    Shanaz H Dairkee
    California Pacific Medical Center, San Francisco, CA 94115 1932, USA
    BMC Genomics 5:47. 2004
  4. ncbi request reprint Aberrations of breast cancer susceptibility genes occur early in sporadic breast tumors and in acquisition of breast epithelial immortalization
    Zhen Hang Meng
    California Pacific Medical Center, San Francisco, California 94115, USA
    Genes Chromosomes Cancer 41:214-22. 2004
  5. ncbi request reprint Genome-wide allelotyping of a new in vitro model system reveals early events in breast cancer progression
    Zheng Li
    Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco 94115, USA
    Cancer Res 62:5980-7. 2002
  6. ncbi request reprint Biallelic inactivation of the thyroid hormone receptor beta1 gene in early stage breast cancer
    Zheng Li
    Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco, California 94115, USA
    Cancer Res 62:1939-43. 2002
  7. pmc Immutable functional attributes of histologic grade revealed by context-independent gene expression in primary breast cancer cells
    Shanaz H Dairkee
    California Pacific Medical Center Research Institute, San Francisco, California, CA 94107, USA
    Cancer Res 69:7826-34. 2009
  8. pmc Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells
    Shanaz H Dairkee
    California Pacific Medical Center Research Institute, 475 Brannan Street, San Francisco, CA 94107, USA
    Carcinogenesis 34:703-12. 2013
  9. pmc Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women
    William H Goodson
    California Pacific Medical Center, Research Institute, San Francisco, CA 94107, USA
    Carcinogenesis 32:1724-33. 2011
  10. ncbi request reprint Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis
    James E Korkola
    Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Cancer Res 63:7167-75. 2003

Collaborators

Detail Information

Publications15

  1. pmc Breast tumor copy number aberration phenotypes and genomic instability
    Jane Fridlyand
    Department of Epidemiology and Biostatistics, University of California San Francisco, CA 94143, USA
    BMC Cancer 6:96. 2006
    ..g. those involved in mitosis, replication, repair, and telomeres) are rarely mutated in chromosomally unstable sporadic tumors, even though such mutations are associated with some heritable cancer prone syndromes...
  2. ncbi request reprint Partial enzymatic degradation of stroma allows enrichment and expansion of primary breast tumor cells
    S H Dairkee
    Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco 94115, USA
    Cancer Res 57:1590-6. 1997
    ..The simple and rapid method described in this report could enable routine expansion of primary breast tumors and provide adequate numbers of viable cells for studying and manipulating their functional characteristics...
  3. pmc A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue
    Shanaz H Dairkee
    California Pacific Medical Center, San Francisco, CA 94115 1932, USA
    BMC Genomics 5:47. 2004
    ..To identify the spectrum of malignant attributes maintained outside the host environment, we have compared global gene expression in primary breast tumors and matched short-term epithelial cultures...
  4. ncbi request reprint Aberrations of breast cancer susceptibility genes occur early in sporadic breast tumors and in acquisition of breast epithelial immortalization
    Zhen Hang Meng
    California Pacific Medical Center, San Francisco, California 94115, USA
    Genes Chromosomes Cancer 41:214-22. 2004
    ..The intimate role of these genes in DNA repair and their early deletion has implications for the possible transforming effects of DNA-damaging agents on unexcised breast tissue harboring LOHint within breast cancer patients...
  5. ncbi request reprint Genome-wide allelotyping of a new in vitro model system reveals early events in breast cancer progression
    Zheng Li
    Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco 94115, USA
    Cancer Res 62:5980-7. 2002
    ....
  6. ncbi request reprint Biallelic inactivation of the thyroid hormone receptor beta1 gene in early stage breast cancer
    Zheng Li
    Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco, California 94115, USA
    Cancer Res 62:1939-43. 2002
    ..The observation of early, frequent, and multiple mechanisms of TRbeta1 inactivation suggests a potential role for this gene in the suppression of breast tumorigenesis...
  7. pmc Immutable functional attributes of histologic grade revealed by context-independent gene expression in primary breast cancer cells
    Shanaz H Dairkee
    California Pacific Medical Center Research Institute, San Francisco, California, CA 94107, USA
    Cancer Res 69:7826-34. 2009
    ....
  8. pmc Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells
    Shanaz H Dairkee
    California Pacific Medical Center Research Institute, 475 Brannan Street, San Francisco, CA 94107, USA
    Carcinogenesis 34:703-12. 2013
    ..We show that BPA exposure induces aberrant expression of multiple checkpoints that regulate cell survival, proliferation and apoptosis and that such changes can be effectively ameliorated...
  9. pmc Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women
    William H Goodson
    California Pacific Medical Center, Research Institute, San Francisco, CA 94107, USA
    Carcinogenesis 32:1724-33. 2011
    ..Our observations demonstrate the feasibility of studying renewable human samples as surrogates and reinforce the concern that BPA and MP, at low concentrations detected in humans, can have adverse health consequences...
  10. ncbi request reprint Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis
    James E Korkola
    Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Cancer Res 63:7167-75. 2003
    ..In conclusion, specific changes in gene expression distinguish lobular from ductal breast carcinomas. These genes may be important in understanding the basis of phenotypic differences among breast cancers...
  11. doi request reprint Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients
    Shanaz H Dairkee
    California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
    Cancer Res 68:2076-80. 2008
    ....
  12. pmc Aberrant regulation of the BST2 (Tetherin) promoter enhances cell proliferation and apoptosis evasion in high grade breast cancer cells
    Aejaz Sayeed
    California Pacific Medical Center Research Institute, San Francisco, California, USA
    PLoS ONE 8:e67191. 2013
    ..We provide evidence for a direct approach that diminishes aberrant BST2 expression in cancer cells as an early targeting strategy to assist in surmounting resistance to pro apoptotic therapies. ..
  13. ncbi request reprint Increased risk of local recurrence is associated with allelic loss in normal lobules of breast cancer patients
    Zheng Li
    Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco, California 94115, USA
    Cancer Res 62:1000-3. 2002
    ..These data provide a strong rationale to assess histologically normal breast tissue at the margins of surgically excised cancers for molecular predictors of local recurrence after breast-conserving treatment...
  14. pmc Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers
    Christina Yau
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Breast Cancer Res 9:R59. 2007
    ..Except for inherited forms of breast cancer, however, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior...
  15. pmc Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer
    Yamei Zhou
    Buck Institute for Age Research, Novato, CA 94945, USA
    BMC Cancer 7:59. 2007
    ..Signaling pathways that converge on two different transcription factor complexes, NFkappaB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen...