Research Topics
Species | Shanaz H DairkeeSummaryAffiliation: California Pacific Medical Center Country: USA Publications
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Detail Information
Publications
Breast tumor copy number aberration phenotypes and genomic instabilityJane Fridlyand
Department of Epidemiology and Biostatistics, University of California San Francisco, CA 94143, USA
BMC Cancer 6:96. 2006..g. those involved in mitosis, replication, repair, and telomeres) are rarely mutated in chromosomally unstable sporadic tumors, even though such mutations are associated with some heritable cancer prone syndromes...
Partial enzymatic degradation of stroma allows enrichment and expansion of primary breast tumor cellsS H Dairkee
Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco 94115, USA
Cancer Res 57:1590-6. 1997..The simple and rapid method described in this report could enable routine expansion of primary breast tumors and provide adequate numbers of viable cells for studying and manipulating their functional characteristics...- A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissueShanaz H Dairkee
California Pacific Medical Center, San Francisco, CA 94115 1932, USA
BMC Genomics 5:47. 2004..To identify the spectrum of malignant attributes maintained outside the host environment, we have compared global gene expression in primary breast tumors and matched short-term epithelial cultures... - Aberrations of breast cancer susceptibility genes occur early in sporadic breast tumors and in acquisition of breast epithelial immortalizationZhen Hang Meng
California Pacific Medical Center, San Francisco, California 94115, USA
Genes Chromosomes Cancer 41:214-22. 2004..The intimate role of these genes in DNA repair and their early deletion has implications for the possible transforming effects of DNA-damaging agents on unexcised breast tissue harboring LOHint within breast cancer patients... - Genome-wide allelotyping of a new in vitro model system reveals early events in breast cancer progressionZheng Li
Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco 94115, USA
Cancer Res 62:5980-7. 2002.... - Biallelic inactivation of the thyroid hormone receptor beta1 gene in early stage breast cancerZheng Li
Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco, California 94115, USA
Cancer Res 62:1939-43. 2002..The observation of early, frequent, and multiple mechanisms of TRbeta1 inactivation suggests a potential role for this gene in the suppression of breast tumorigenesis... 
Immutable functional attributes of histologic grade revealed by context-independent gene expression in primary breast cancer cellsShanaz H Dairkee
California Pacific Medical Center Research Institute, San Francisco, California, CA 94107, USA
Cancer Res 69:7826-34. 2009....- Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk womenWilliam H Goodson
California Pacific Medical Center, Research Institute, San Francisco, CA 94107, USA
Carcinogenesis 32:1724-33. 2011..Our observations demonstrate the feasibility of studying renewable human samples as surrogates and reinforce the concern that BPA and MP, at low concentrations detected in humans, can have adverse health consequences... - Differentiation of lobular versus ductal breast carcinomas by expression microarray analysisJames E Korkola
Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143-0808, USA
Cancer Res 63:7167-75. 2003..In conclusion, specific changes in gene expression distinguish lobular from ductal breast carcinomas. These genes may be important in understanding the basis of phenotypic differences among breast cancers... 
Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patientsShanaz H Dairkee
California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
Cancer Res 68:2076-80. 2008....- Increased risk of local recurrence is associated with allelic loss in normal lobules of breast cancer patientsZheng Li
Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco, California 94115, USA
Cancer Res 62:1000-3. 2002..These data provide a strong rationale to assess histologically normal breast tissue at the margins of surgically excised cancers for molecular predictors of local recurrence after breast-conserving treatment... - Aging impacts transcriptomes but not genomes of hormone-dependent breast cancersChristina Yau
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Breast Cancer Res 9:R59. 2007..Except for inherited forms of breast cancer, however, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior... - Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancerYamei Zhou
Buck Institute for Age Research, Novato, CA 94945, USA
BMC Cancer 7:59. 2007..Signaling pathways that converge on two different transcription factor complexes, NFkappaB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen...