Steven Cummings

Summary

Affiliation: California Pacific Medical Center
Country: USA

Publications

  1. doi request reprint Goal-directed treatment of osteoporosis
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute and the Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 28:433-8. 2013
  2. pmc Association of blood lead concentrations with mortality in older women: a prospective cohort study
    Naila Khalil
    University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA
    Environ Health 8:15. 2009
  3. pmc Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
  4. ncbi request reprint Aging
    S R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, University of California, San Francisco, CA 94107, USA
    J Musculoskelet Neuronal Interact 7:338-9. 2007
  5. ncbi request reprint The biology of aging
    S R Cummings
    Medicine and Epidemiology, San Francisco Coordinating Center, San Francisco, CA 94107 1762, USA
    J Musculoskelet Neuronal Interact 7:340-1. 2007
  6. doi request reprint Lasofoxifene in postmenopausal women with osteoporosis
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, and University of California, San Francisco, San Francisco, USA
    N Engl J Med 362:686-96. 2010
  7. ncbi request reprint Primary prevention of breast cancer: new approaches
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, University of California, San Francisco, CA, United States
    Maturitas 57:39-41. 2007
  8. ncbi request reprint A 55-year-old woman with osteopenia
    Steven R Cummings
    University of California, San Francisco, USA
    JAMA 296:2601-10. 2006
  9. doi request reprint Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute and the University of California, San Francisco, CA 94107, USA
    J Bone Miner Res 26:397-404. 2011
  10. pmc Prevention of breast cancer in postmenopausal women: approaches to estimating and reducing risk
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, 94107, USA
    J Natl Cancer Inst 101:384-98. 2009

Research Grants

  1. STUDY OF OSTEOPOROTIC FRACTURES
    Steven R Cummings; Fiscal Year: 2010
  2. STUDY OF OSTEOPOROTIC FRACTURES
    Steven Cummings; Fiscal Year: 2005
  3. A CONSORTIUM TO INVESTIGATE HUMAN LONGEVITY AND FRAILTY
    Steven Cummings; Fiscal Year: 2002
  4. WHI Sex Hormone & Genetic Risk Factors for Hip Fracture
    Steven Cummings; Fiscal Year: 2005
  5. Consortium to Study the Genetics of Longevity
    Steven Cummings; Fiscal Year: 2007
  6. STUDY OF OSTEOPOROTIC FRACTURES
    Steven Cummings; Fiscal Year: 2007
  7. STUDY OF OSTEOPOROTIC FRACTURES
    Steven Cummings; Fiscal Year: 2009
  8. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2009
  9. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2007
  10. OSTEOPOROTIC FRACTURES IN MEN
    Steven Cummings; Fiscal Year: 2007

Detail Information

Publications99

  1. doi request reprint Goal-directed treatment of osteoporosis
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute and the Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 28:433-8. 2013
    ..The result could be more rational and effective use of the expanding array of treatments for osteoporosis...
  2. pmc Association of blood lead concentrations with mortality in older women: a prospective cohort study
    Naila Khalil
    University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA
    Environ Health 8:15. 2009
    ..We aimed to determine the association between blood lead, all cause and cause specific mortality in elderly, community residing women...
  3. pmc Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
    ..The aims of this study were to identify predictors of long-term survival in older women and to develop a multivariable model based upon longitudinal data from the Study of Osteoporotic Fractures (SOF)...
  4. ncbi request reprint Aging
    S R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, University of California, San Francisco, CA 94107, USA
    J Musculoskelet Neuronal Interact 7:338-9. 2007
  5. ncbi request reprint The biology of aging
    S R Cummings
    Medicine and Epidemiology, San Francisco Coordinating Center, San Francisco, CA 94107 1762, USA
    J Musculoskelet Neuronal Interact 7:340-1. 2007
  6. doi request reprint Lasofoxifene in postmenopausal women with osteoporosis
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, and University of California, San Francisco, San Francisco, USA
    N Engl J Med 362:686-96. 2010
    ..The effects of lasofoxifene on the risk of fractures, breast cancer, and cardiovascular disease are uncertain...
  7. ncbi request reprint Primary prevention of breast cancer: new approaches
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, University of California, San Francisco, CA, United States
    Maturitas 57:39-41. 2007
    ..I propose that a woman's risk of breast cancer be assessed along with her screening mammogram with consideration of chemoprevention for those at high risk...
  8. ncbi request reprint A 55-year-old woman with osteopenia
    Steven R Cummings
    University of California, San Francisco, USA
    JAMA 296:2601-10. 2006
    ..Decisions about pharmacological treatment to prevent fractures should be based on the patient's risk of fractures, evidence about the efficacy and nonskeletal effects of the specific treatment, and the patient's preferences...
  9. doi request reprint Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute and the University of California, San Francisco, CA 94107, USA
    J Bone Miner Res 26:397-404. 2011
    ..7%, with a 2.3-fold relative increase (95% CI 1.5-3.7). Like other SERMs, arzoxifene decreased vertebral fractures and invasive breast cancer while the risk of venous thromboembolic events increased...
  10. pmc Prevention of breast cancer in postmenopausal women: approaches to estimating and reducing risk
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, 94107, USA
    J Natl Cancer Inst 101:384-98. 2009
    ..It is uncertain whether evidence supports routinely estimating a postmenopausal woman's risk of breast cancer and intervening to reduce risk...
  11. ncbi request reprint Mammographic density and estrogen receptor status of breast cancer
    Elad Ziv
    Department of Medicine, University of California at San Francisco, 1635 Divisadero Street, Suite 600, San Francisco, CA 04115, USA
    Cancer Epidemiol Biomarkers Prev 13:2090-5. 2004
    ..We determined if mammographic density is associated more strongly with ER-positive breast cancer than with ER-negative breast cancer...
  12. ncbi request reprint Safety and adverse effects associated with raloxifene: multiple outcomes of raloxifene evaluation
    Deborah Grady
    University of California San Francisco, 1634 Divisadero Street, Suite 600, San Francisco, CA 94115, USA
    Obstet Gynecol 104:837-44. 2004
    ..To examine the effect of raloxifene on major adverse events that occur with postmenopausal estrogen therapy or tamoxifen...
  13. ncbi request reprint Female sexual dysfunction in postmenopausal women: systematic review of placebo-controlled trials
    Katharina Modelska
    Prevention Sciences Group, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    Am J Obstet Gynecol 188:286-93. 2003
    ..This systematic review includes all randomized and placebo-controlled trials (RCTs) of treatment for female sexual dysfunction (FSD) in postmenopausal women published since 1990...
  14. pmc Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1728, USA
    J Clin Endocrinol Metab 94:3806-15. 2009
    ..As men age, the prevalence of frailty increases whereas levels of androgens decline. Little is known about the relation between these factors...
  15. ncbi request reprint Association between endogenous hormones and sex hormone-binding globulin and bone turnover in older women: study of osteoporotic fractures
    R D Chapurlat
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    Bone 29:381-7. 2001
    ..We conclude that older women with low endogenous hormones have somewhat higher bone turnover, but these associations are weak. Bone turnover is determined mainly by factors other than endogenous concentrations of sex hormones...
  16. ncbi request reprint Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial
    S R Cummings
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    JAMA 280:2077-82. 1998
    ..Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied for women without vertebral fractures...
  17. pmc Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study
    Thomas Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Bone Miner Res 25:513-9. 2010
    ..This characteristic captures a physical characteristic of muscle tissue that may have importance in hip fracture etiology...
  18. ncbi request reprint A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group
    D E Sellmeyer
    Division of Endocrinology, the General Clinical Research Center, and the Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Am J Clin Nutr 73:118-22. 2001
    ..Imbalance between dietary acid and base precursors leads to a chronic net dietary acid load that may have adverse consequences on bone...
  19. ncbi request reprint Monitoring osteoporosis therapy with bone densitometry: misleading changes and regression to the mean. Fracture Intervention Trial Research Group
    S R Cummings
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    JAMA 283:1318-21. 2000
    ..The principle of "regression to the mean" predicts that patients with unusual responses to treatment might represent outliers who are likely to have more typical responses if treatment is continued without change...
  20. ncbi request reprint Effect of alendronate on limited-activity days and bed-disability days caused by back pain in postmenopausal women with existing vertebral fractures. Fracture Intervention Trial Research Group
    M C Nevitt
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    Arch Intern Med 160:77-85. 2000
    ..Women with new vertebral fractures have an increased risk of back pain and functional limitation because of back pain. Alendronate sodium treatment reduces the risk of new vertebral fracture by 50% in postmenopausal women with osteoporosis...
  21. ncbi request reprint The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation
    S R Cummings
    Department of Medicine, University of California, San Francisco, USA
    JAMA 281:2189-97. 1999
    ..Raloxifene hydrochloride is a selective estrogen receptor modulator that has antiestrogenic effects on breast and endometrial tissue and estrogenic effects on bone, lipid metabolism, and blood clotting...
  22. doi request reprint The association of Parkinson's disease with bone mineral density and fracture in older women
    J L Schneider
    California Pacific Medical Center Research Institute, San Francisco, CA, USA
    Osteoporos Int 19:1093-7. 2008
    ..Among community-dwelling older women, compared to those without Parkinson's disease (PD), women with PD have 7.3% lower BMD and an increased risk for hip fracture (HR = 2.6)...
  23. ncbi request reprint Cognitive decline in women in relation to non-protein-bound oestradiol concentrations
    K Yaffe
    Department of Psychiatry, University of California, San Francisco 94121, USA
    Lancet 356:708-12. 2000
    ..We tested the hypothesis that concentrations of non-protein-bound (free) and loosely bound (bioavailable) sex hormones are associated with cognitive function in older women...
  24. ncbi request reprint Prevention of hip fractures in older women: a population-based perspective
    S R Cummings
    University of California, San Francisco, USA
    Osteoporos Int 8:S8-12. 1998
    ....
  25. ncbi request reprint Tibolone for postmenopausal women: systematic review of randomized trials
    Katharina Modelska
    University of California Coordinating Center, Department of Medicine, Prevention Sciences Group, University of California, San Francisco, California 94105, USA
    J Clin Endocrinol Metab 87:16-23. 2002
  26. pmc Oophorectomy, hormone therapy, and subclinical coronary artery disease in women with hysterectomy: the Women's Health Initiative coronary artery calcium study
    Matthew A Allison
    University of California San Diego, La Jolla, CA, USA
    Menopause 15:639-47. 2008
    ..In this study, we aimed to determine the associations between coronary artery calcium (CAC) and hysterectomy, oophorectomy, and hormone therapy use with a focus on the duration of menopause for which there was no hormone therapy use...
  27. ncbi request reprint A randomized controlled trial of a Chinese herbal remedy to increase energy, memory, sexual function, and quality of life in elderly adults in Beijing, China
    Stephen Bent
    Department of Medicine SB, SC, University of California, San Francisco, California, USA
    Am J Med 115:441-7. 2003
    ....
  28. ncbi request reprint Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS study
    D C Bauer
    UCSF, San Francisco, CA 94107, USA
    Osteoporos Int 18:771-7. 2007
    ..We studied 5,607 older men and found that QUS predicts hip and any non-spine fracture risk nearly as well as BMD. Combined measurements of QUS and BMD are not superior to either measurement alone...
  29. pmc PPAR-gamma Pro12Ala genotype and risk of cognitive decline in elders
    K Yaffe
    Department of Psychiatry and Neurology, University of California, San Francisco, CA 94121, United States
    Neurobiol Aging 29:78-83. 2008
    ..We tested whether this polymorphism is associated with cognition...
  30. ncbi request reprint Kidney function and markers of inflammation in elderly persons without chronic kidney disease: the health, aging, and body composition study
    C R Keller
    Department of Medicine, University of California, San Francisco, California, USA
    Kidney Int 71:239-44. 2007
    ..05). Cystatin C has a linear association with inflammatory biomarkers in an ambulatory elderly cohort with estimated glomerular filtration rates >or=60; associations are particularly strong with TNF-alpha and the STNF-R...
  31. ncbi request reprint A normative reference database study for Pronosco X-posure System
    D M Black
    University of California, San Francisco, CA 94106, USA
    J Clin Densitom 4:5-12. 2001
    ..The strong correlation of DXR-BMD from the X-posure System with DXA at the wrist from the Hologic machine suggests that the X-posure System may be an alternative to DXA at the wrist for the assessment of osteoporosis...
  32. ncbi request reprint Older women with diabetes have an increased risk of fracture: a prospective study
    A V Schwartz
    Department of Epidemiology, Division of Endocrinology, University of California San Francisco, San Francisco, California 94105, USA
    J Clin Endocrinol Metab 86:32-8. 2001
    ..This study indicates that diabetes is a risk factor for hip, proximal humerus, and foot fractures among older women, suggesting that fracture prevention efforts should be a consideration in the treatment of diabetes...
  33. ncbi request reprint Influence of smoking on the antiosteoporotic efficacy of raloxifene
    R D Chapurlat
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Clin Endocrinol Metab 86:4178-82. 2001
    ..light smokers. We conclude that smoking does not influence the antiosteoporotic effect of raloxifene. This may represent an advantage over estrogen replacement therapy...
  34. ncbi request reprint Warfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research Group
    S A Jamal
    University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, USA
    Ann Intern Med 128:829-32. 1998
    ..Vitamin K deficiency may be associated with osteoporosis...
  35. ncbi request reprint Continuing screening mammography in women aged 70 to 79 years: impact on life expectancy and cost-effectiveness
    K Kerlikowske
    Department of Epidemiology and Biostatistics, Department of Veterans Affairs, University of California, San Francisco 94121, USA
    JAMA 282:2156-63. 1999
    ..In particular, older women with low bone mineral density (BMD) have a lower risk of breast cancer and may benefit less from continued screening...
  36. pmc Circadian activity rhythms and mortality: the study of osteoporotic fractures
    Gregory J Tranah
    California Pacific Medical Center Research Institute, San Francisco Coordinating Center, UCSF, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, CA 94107, USA
    J Am Geriatr Soc 58:282-91. 2010
    ..To determine whether circadian activity rhythms are associated with mortality in community-dwelling older women...
  37. ncbi request reprint Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women
    W S Browner
    General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 86:631-7. 2001
    ..The association of serum OPG levels with diabetes and with cardiovascular mortality raises the possibility that OPG may be a cause of or a marker for vascular calcification...
  38. ncbi request reprint Changes in biochemical markers of bone turnover in women treated with raloxifene: influence of regression to the mean
    R D Chapurlat
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Osteoporos Int 12:1006-14. 2001
    ....
  39. ncbi request reprint Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group
    D M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    J Clin Endocrinol Metab 85:4118-24. 2000
    ..Furthermore, reduction in risk is evident early in the course of treatment. This pooled analysis provides a more precise estimate of the antifracture efficacy of alendronate in women with osteoporosis than that in prior reports...
  40. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  41. ncbi request reprint Does follow-up of osteoporotic women treated with antiresorptive therapies improve effectiveness?
    Roland D Chapurlat
    Prevention Sciences Group, Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA
    Osteoporos Int 13:738-44. 2002
    ..So, the use of follow-up measures of bone turnover may be based on patient and physician preferences...
  42. ncbi request reprint Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort
    K Yaffe
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Neurobiol Aging 28:171-8. 2007
    ..Older women treated with conjugated estrogens may have an increased risk of dementia, but the effect of naturally occurring sex hormones on cognition is not certain...
  43. ncbi request reprint Renal function and risk of hip and vertebral fractures in older women
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
    Arch Intern Med 167:133-9. 2007
    ..An increased rate of hip fractures has been reported in patients with end-stage renal disease, but the effect of less severe renal dysfunction on fracture risk is uncertain...
  44. ncbi request reprint Alcohol use, physical performance, and functional limitations in older men
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
    J Am Geriatr Soc 55:212-20. 2007
    ..To describe associations between recent alcohol intake, physical performance, and functional limitations in older men...
  45. pmc Serum 25-hydroxyvitamin D concentrations and risk for hip fractures
    Jane A Cauley
    University of Pittsburgh, Department of Epidemiology, 130 DeSoto Street, Crabtree A524, Pittsburgh, PA 15261, USA
    Ann Intern Med 149:242-50. 2008
    ..The relationship between serum 25-hydroxyvitamin D [25(OH) vitamin D] concentration and hip fractures is unclear...
  46. ncbi request reprint Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study
    Jane A Cauley
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 22:1088-95. 2007
    ..We tested this hypothesis in relationship to fractures in 2985 men and women enrolled in the Health ABC study. Results showed that subjects with the greatest number of inflammatory markers have the highest risk of fracture...
  47. ncbi request reprint Effect of ultra-low-dose transdermal estradiol on breast density in postmenopausal women
    Deborah Grady
    University of California Women s Health Clinical Research Center, San Francisco, CA 94115, USA
    Menopause 14:391-6. 2007
    ..The purpose of this study was to determine whether 2 years of treatment with ultra-low-dose transdermal estradiol results in a change in breast density...
  48. ncbi request reprint Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis
    Dennis M Black
    University of California, San Francisco, San Francisco, CA 94107, USA
    N Engl J Med 356:1809-22. 2007
    ..We assessed the effects of annual infusions of zoledronic acid on fracture risk during a 3-year period...
  49. ncbi request reprint Identification of vertebral fracture and non-osteoporotic short vertebral height in men: the MrOS study
    Lynne Ferrar
    Academic Unit of Bone Metabolism, University of Sheffield, United Kingdom
    J Bone Miner Res 22:1434-41. 2007
    ..Non-osteoporotic SVH may mimic VF but is excluded in ABQ. In men, this led to discordance between ABQ and other methods, but SVH was not linked to low bone density. Exclusion of SVH could reduce false positives...
  50. ncbi request reprint Prediction of clinical non-spine fractures in older black and white men and women with volumetric BMD of the spine and areal BMD of the hip: the Health, Aging, and Body Composition Study*
    Dawn C Mackey
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
    J Bone Miner Res 22:1862-8. 2007
    ..4 yr), vertebral TrvBMD from QCT predicted non-spine fracture in black and white women and black men, but it was not a stronger predictor than total hip aBMD from DXA. Hip aBMD predicted non-spine fracture in black men...
  51. ncbi request reprint High-trauma fractures and low bone mineral density in older women and men
    Dawn C Mackey
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    JAMA 298:2381-8. 2007
    ..It is widely believed that fractures resulting from high trauma are not osteoporotic; however, this assumption has not been studied prospectively...
  52. doi request reprint Postmenopausal hormone therapy and age-related maculopathy in older women
    Robin L Seitzman
    Department of Ophthalmology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    Ophthalmic Epidemiol 15:308-16. 2008
    ..To examine the association between postmenopausal hormone therapy and Age-Related Maculopathy (ARM) in older women and to determine if these associations vary by smoking status...
  53. pmc The effects of tibolone in older postmenopausal women
    Steven R Cummings
    San Francisco Coordinating Center and the California Pacific Medical Center Research Institute, San Francisco, USA
    N Engl J Med 359:697-708. 2008
    ..Tibolone has estrogenic, progestogenic, and androgenic effects. Although tibolone prevents bone loss, its effects on fractures, breast cancer, and cardiovascular disease are uncertain...
  54. pmc Cystatin-C, renal function, and incidence of hip fracture in postmenopausal women
    Andrea Z LaCroix
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Am Geriatr Soc 56:1434-41. 2008
    ..To evaluate the association between chronic kidney disease and incident hip fracture using serum cystatin-C as a biomarker of renal function calculated without reference to muscle mass...
  55. pmc Relationship of blood lead levels to incident nonspine fractures and falls in older women: the study of osteoporotic fractures
    Naila Khalil
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 23:1417-25. 2008
    ..07, 2.45; p trend = 0.014) compared with women with lowest lead level. Blood lead levels are associated with an increased risk of falls and fractures, extending the negative health consequences of lead to include osteoporotic fractures...
  56. pmc Using clinical factors and mammographic breast density to estimate breast cancer risk: development and validation of a new predictive model
    Jeffrey A Tice
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California 94143 1732, USA
    Ann Intern Med 148:337-47. 2008
    ..Current models for assessing breast cancer risk are complex and do not include breast density, a strong risk factor for breast cancer that is routinely reported with mammography...
  57. pmc Physical performance and risk of hip fractures in older men
    Peggy Mannen Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
    J Bone Miner Res 23:1037-44. 2008
    ..The repeated chair stands exam should be considered in clinical settings for evaluation of hip fracture risk. Concurrent poor performance on multiple physical function exams is associated with an increased risk of hip fractures...
  58. ncbi request reprint Kidney dysfunction and fatal cardiovascular disease--an association independent of atherosclerotic events: results from the Health, Aging, and Body Composition (Health ABC) study
    Rajat Deo
    Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA
    Am Heart J 155:62-8. 2008
    ..We evaluated whether impaired kidney function predicted risk of fatal cardiovascular disease independent of prevalent and incident cardiovascular events...
  59. doi request reprint Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, General Internal Medicine, Minneapolis, MN 55417, USA
    Arch Intern Med 168:382-9. 2008
    ..Frailty, as defined by the index derived from the Cardiovascular Health Study (CHS index), predicts risk of adverse outcomes in older adults. Use of this index, however, is impractical in clinical practice...
  60. pmc Differences in site-specific fracture risk among older women with discordant results for osteoporosis at hip and spine: study of osteoporotic fractures
    Howard A Fink
    Geriatric Research Education and Clinical Center, VA Medical Center, Minneapolis, MN 55417, USA
    J Clin Densitom 11:250-9. 2008
    ..Women osteoporotic only at spine would not have been identified from hip BMD measurement alone, and may have a sufficiently high fracture risk to warrant preventive treatment...
  61. doi request reprint Actigraphy-measured sleep characteristics and risk of falls in older women
    Katie L Stone
    Research Institute, California Pacific Medical Center, 185 Berry St, Lobby 4, Fifth Floor, Ste 5700, San Francisco, CA 94107 1762, USA
    Arch Intern Med 168:1768-75. 2008
    ..However, no previous study, to our knowledge, has tested the independent associations of objectively estimated characteristics of sleep and risk of falls, accounting for the use of commonly prescribed treatments for insomnia...
  62. ncbi request reprint Binocular visual-field loss increases the risk of future falls in older white women
    Anne L Coleman
    Jules Stein Eye Institute, Los Angeles, CA 90095, USA
    J Am Geriatr Soc 55:357-64. 2007
    ..To examine the relationship between binocular visual field loss and the risk of incident frequent falls in older white women...
  63. ncbi request reprint Bone density screening: a new level of evidence?
    Steven R Cummings
    Ann Intern Med 142:217-9. 2005
  64. ncbi request reprint Effect of raloxifene on prevention of dementia and cognitive impairment in older women: the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, Box 181, 4150 Clement St, San Francisco, CA 94121, USA
    Am J Psychiatry 162:683-90. 2005
    ..This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease...
  65. ncbi request reprint Diabetes and bone loss at the hip in older black and white adults
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 20:596-603. 2005
    ....
  66. ncbi request reprint The genetics of human longevity
    Warren S Browner
    California Pacific Medical Center Research Institute, San Francisco, California 94115, USA
    Am J Med 117:851-60. 2004
    ..Despite the challenges in study design and analysis that face investigators in this area, the identification of genetic pathways that regulate longevity may suggest potential targets for therapy...
  67. ncbi request reprint Continuing outcomes relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifene
    Silvana Martino
    Cancer Institute Medical Group, 2001 Santa Monica Blvd, Ste 560W, Santa Monica, CA 90404, USA
    J Natl Cancer Inst 96:1751-61. 2004
    ..We conducted the Continuing Outcomes Relevant to Evista (CORE) trial to examine the effect of 4 additional years of raloxifene therapy on the incidence of invasive breast cancer in women in MORE who agreed to continue in CORE...
  68. ncbi request reprint Long-term prediction of incident hip fracture risk in elderly white women: study of osteoporotic fractures
    Brent C Taylor
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 52:1479-86. 2004
    ..To identify independent risk factors for first hip fracture over 10 years of follow-up...
  69. ncbi request reprint Osteoporosis in men: epidemiology, diagnosis, prevention, and treatment
    Wojciech P Olszynski
    Department of Medicine, University of Saskatchewan, Saskatoon Osteoporosis Centre, Saskatoon, Saskatchewan, Canada
    Clin Ther 26:15-28. 2004
    ..Osteoporosis and fragility fractures in men account for substantial health care expenditures and decreased quality of life...
  70. ncbi request reprint Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women
    Kristine E Ensrud
    Department of Medicine and Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 51:1740-7. 2003
    ..To test the hypothesis that unintentional weight loss increases the rate of bone loss and risk of hip fracture more than intentional weight loss...
  71. ncbi request reprint BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures
    Katie L Stone
    Department of Medicine, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 18:1947-54. 2003
    ..Although we found almost all fracture types to be related to low BMD, the overall proportion of fractures attributable to low BMD is modest...
  72. ncbi request reprint Lipid-lowering drug use and breast cancer in older women: a prospective study
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Womens Health (Larchmt) 12:749-56. 2003
    ..To test the hypothesis that use of lipid-lowering drugs reduces the risk of breast cancer in older women...
  73. ncbi request reprint Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    JAMA 290:1729-38. 2003
    ..In the Women's Health Initiative trial of estrogen-plus-progestin therapy, women assigned to active treatment had fewer fractures...
  74. ncbi request reprint Relationship of changes in physical activity and mortality among older women
    Edward W Gregg
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    JAMA 289:2379-86. 2003
    ..Physical activity has been related to reduced mortality, but it is not clear whether changes in physical activity affect mortality among older women...
  75. ncbi request reprint Accuracy of mammographic breast density analysis: results of formal operator training
    Sven Prevrhal
    Department of Radiology, University of California, San Francisco, California 94143 1250, USA
    Cancer Epidemiol Biomarkers Prev 11:1389-93. 2002
    ....
  76. ncbi request reprint Clinical use of bone densitometry: scientific review
    Steven R Cummings
    The UCSF Coordinating Center, University of California, San Francisco, USA
    JAMA 288:1889-97. 2002
    ..Measurement of bone mass by densitometry is a primary part of diagnosing osteoporosis and deciding a preventive treatment course. Bone mineral densitometry has become more widely available and commonly used in practice...
  77. ncbi request reprint American Society of Clinical Oncology technology assessment of pharmacologic interventions for breast cancer risk reduction including tamoxifen, raloxifene, and aromatase inhibition
    Rowan T Chlebowski
    Health Services Research Department, American Society of Clinical Oncology, 1900 Duke Street, Suite 200, Alexandria, VA 22314, USA
    J Clin Oncol 20:3328-43. 2002
    ..To update an evidence-based technology assessment of chemoprevention strategies for breast cancer risk reduction. POTENTIAL INTERVENTIONS: Tamoxifen, raloxifene, aromatase inhibition, and fenretinide...
  78. ncbi request reprint Bone mineral density is not diminished by mild to moderate chronic renal insufficiency
    Chi yuan Hsu
    Division of Nephrology, Prevention Science Group, University of California, San Francisco, San Francisco, California 94143 0532, USA
    Kidney Int 61:1814-20. 2002
    ..Persons with mild to moderate chronic renal insufficiency (CRI) may have reduced bone mineral density (BMD) as a result of abnormalities in acid-base and vitamin D-parathyroid hormone homeostasis...
  79. ncbi request reprint Rapid resting heart rate: a simple and powerful predictor of osteoporotic fractures and mortality in older women
    Deborah M Kado
    Division of Geriatrics, Department of Medicine, University of California Los Angeles, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095, USA
    J Am Geriatr Soc 50:455-60. 2002
    ..To determine whether resting heart rate is associated with several types of osteoporotic fractures, mortality, and cause-specific mortality in older women...
  80. ncbi request reprint Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women
    Diana M Antoniucci
    Division of Endocrinology, Department of Medicine, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 20:741-7. 2005
    ..There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures...
  81. ncbi request reprint Association of estrogen receptor alpha polymorphisms with breast cancer risk in older Caucasian women
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Cancer 116:984-91. 2005
    ..60 vs. 1.12 for nulliparous vs. parous women; interaction p = 0.03). ESR1 polymorphisms in combination with lifestyle factors may be associated with breast cancer risk in older Caucasian women...
  82. ncbi request reprint Bone mineral density and the risk of incident nonspinal fractures in black and white women
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    JAMA 293:2102-8. 2005
    ..Black women have a lower rate of fracture than white women, but whether bone mineral density (BMD) predicts fracture risk as well in black women as it does in white women is not established...
  83. ncbi request reprint Alcohol intake and its relationship with bone mineral density, falls, and fracture risk in older men
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
    J Am Geriatr Soc 54:1649-57. 2006
    ..To examine the association between alcohol intake and problem drinking history and bone mineral density (BMD), falls and fracture risk...
  84. ncbi request reprint Risk factors for breast cancer in older women: the relative contribution of bone mineral density and other established risk factors
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Crabtree Hall A524, Pittsburgh, PA 15261, USA
    Breast Cancer Res Treat 102:181-8. 2007
    ..To determine the contribution of bone mineral density (BMD) to breast cancer risk relative to other established breast cancer risk factors in postmenopausal women with osteoporosis...
  85. ncbi request reprint BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    J Bone Miner Res 21:1550-6. 2006
    ..The relationship between hip BMD and hip fracture risk seemed to be stronger than observed in a large prospective study of women. Hip BMD is an excellent test for predicting fracture risk in men...
  86. ncbi request reprint Effect of raloxifene on the incidence of invasive breast cancer in postmenopausal women with osteoporosis categorized by breast cancer risk
    Marc E Lippman
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 12:5242-7. 2006
    ..To assess the effect of raloxifene, indicated for osteoporosis treatment and prevention, on invasive breast cancer in subgroups of postmenopausal women defined by risk factors for breast cancer...
  87. ncbi request reprint Self-reported sleep and nap habits and risk of falls and fractures in older women: the study of osteoporotic fractures
    Katie L Stone
    Research Institute, California Pacific Medical Center, San Francisco, 94107, USA
    J Am Geriatr Soc 54:1177-83. 2006
    ..To test the association between self-reported sleep and nap habits and risk of falls and fractures in a large cohort of older women...
  88. ncbi request reprint Association of endothelial nitric oxide synthase genotypes with bone mineral density, bone loss, hip structure, and risk of fracture in older women: the SOF study
    Brent C Taylor
    Center for Chronic Disease Outcomes Research 152 2E, Minneapolis VA Medical Center, and Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA
    Bone 39:174-80. 2006
    ..Confirmation of these findings is needed in other populations and with additional markers within and flanking the NOS3 gene region...
  89. ncbi request reprint Calcium plus vitamin D supplementation and the risk of fractures
    Rebecca D Jackson
    Division of Endocrinology, Ohio State University, 485 McCampbell, 1581 Dodd Dr, Columbus, OH 43210, USA
    N Engl J Med 354:669-83. 2006
    ..The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal...
  90. ncbi request reprint Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1
    Alka M Kanaya
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, Suite 500, San Francisco, CA 94143 1732, USA
    Arch Intern Med 166:350-6. 2006
    ..Adipose tissue produces "adipocytokines" of uncertain clinical significance...
  91. ncbi request reprint Endogenous sex hormones, breast cancer risk, and tamoxifen response: an ancillary study in the NSABP Breast Cancer Prevention Trial (P-1)
    Mary S Beattie
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA, USA
    J Natl Cancer Inst 98:110-5. 2006
    ..The purpose of this study was to determine whether sex hormone levels were associated with breast cancer risk and with response to tamoxifen in a high-risk population...
  92. ncbi request reprint Cystatin C and mortality risk in the elderly: the health, aging, and body composition study
    Michael G Shlipak
    University of San Francisco, General Internal Medicine Section, VA Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 17:254-61. 2006
    ..39], 0.95 [0.68 to 1.32], 1.11 [0.79 to 1.57], 1.16 [0.86 to 1.58]). Cystatin C is a strong, independent risk factor for mortality in the elderly. Future studies should investigate whether cystatin C has a role in clinical medicine...
  93. ncbi request reprint Mammographic breast density and the Gail model for breast cancer risk prediction in a screening population
    Jeffrey A Tice
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA 94143 1732, USA
    Breast Cancer Res Treat 94:115-22. 2005
    ..Although the current standard, the Gail model, is well calibrated in populations, it performs poorly for individuals. Mammographic breast density (BD) may improve the predictive accuracy of the Gail model...
  94. ncbi request reprint Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville 32608, USA
    Arch Intern Med 165:2148-54. 2005
    ..The aim of this study was to assess the predictive value of a lipoprotein peroxidation marker, oxidized low-density lipoprotein (oxLDL) for incident mobility limitation (ML)...
  95. ncbi request reprint Familial aggregation of bone mineral density and bone mineral content in a Chinese population
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, MA 02115, USA
    Osteoporos Int 16:1917-23. 2005
    ..39)], 8.71 (95% CI 5.74-13.22) and 5.90 (95% CI 3.57-9.76) for total body, total hip and lumbar spine, respectively. This study demonstrates a significant familial aggregation of BMD and BMC in a large sample of rural Chinese adults...
  96. ncbi request reprint Estrogen metabolizing polymorphisms and breast cancer risk among older white women
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, USA
    Breast Cancer Res Treat 93:261-70. 2005
    ..To investigate breast cancer risk according to metabolizing genes polymorphisms in older women...
  97. ncbi request reprint Skeletal effects of raloxifene after 8 years: results from the continuing outcomes relevant to Evista (CORE) study
    Ethel S Siris
    Toni Stabile Osteoporosis Center, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Bone Miner Res 20:1514-24. 2005
    ..CORE had limitations for assessing fracture risk. In a subset of 386 women, 7 years of raloxifene treatment significantly increased lumbar spine and femoral neck BMD compared from the baseline of MORE...
  98. ncbi request reprint Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study
    Manjula Kurella
    Division of Nephrology, University of California San Francisco, Laurel Heights, 3333 California Street, Suite 430, San Francisco, CA 94118 1211, USA
    J Am Soc Nephrol 16:2127-33. 2005
    ..Studies aimed at understanding the mechanism(s) responsible for cognitive impairment in CKD and efforts to interrupt this decline are warranted...
  99. ncbi request reprint Serum estradiol level and risk of breast cancer during treatment with raloxifene
    Steven R Cummings
    Coordinating Center, University of California, Suite 600, 74 New Montgomery St, San Francisco, CA 94105, USA
    JAMA 287:216-20. 2002
    ..Raloxifene competes with endogenous estrogen for binding to estrogen receptors in breast tissue. A woman's estradiol level may alter the effects of raloxifene on breast cancer and other outcomes...

Research Grants47

  1. STUDY OF OSTEOPOROTIC FRACTURES
    Steven R Cummings; Fiscal Year: 2010
    ..If our hypotheses are born out, this may lead to trials and recommendations about lifestyle, vitamin D supplementation, or medication, to promote high levels of function late in life. ..
  2. STUDY OF OSTEOPOROTIC FRACTURES
    Steven Cummings; Fiscal Year: 2005
    ....
  3. A CONSORTIUM TO INVESTIGATE HUMAN LONGEVITY AND FRAILTY
    Steven Cummings; Fiscal Year: 2002
    ..This Consortium will catalyze interactions between outstanding laboratory and clinical scientists that will lead to collaborative studies of the genetic determinants of longevity and frailty. ..
  4. WHI Sex Hormone & Genetic Risk Factors for Hip Fracture
    Steven Cummings; Fiscal Year: 2005
    ..The proposed study is a very efficient approach to understanding the etiologies of hip fracture. ..
  5. Consortium to Study the Genetics of Longevity
    Steven Cummings; Fiscal Year: 2007
    ..The application includes six distinct research projects, and three cores (Administrative, Biostatistics and Bioinformatics, and Genomics). Details are provided below. ..
  6. STUDY OF OSTEOPOROTIC FRACTURES
    Steven Cummings; Fiscal Year: 2007
    ..If our hypotheses are born out, this may lead to trials and recommendations about lifestyle, vitamin D supplementation, or medication, to promote high levels of function late in life. ..
  7. STUDY OF OSTEOPOROTIC FRACTURES
    Steven Cummings; Fiscal Year: 2009
    ..The SOF Coordinating Center was funded for 5 years; SOF clinical centers for 3 years. In order to meet these aims, two years of support is requested for the SOF clinical centers. ..
  8. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2009
    ..The proposed study is a cost-effective approach to determining whether a safe and inexpensive nutritional intervention substantially reduces the risk of fracture and to understanding the mechanism of this effect. ..
  9. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2007
    ..The proposed study is a cost-effective approach to determining whether a safe and inexpensive nutritional intervention substantially reduces the risk of fracture and to understanding the mechanism of this effect. ..
  10. OSTEOPOROTIC FRACTURES IN MEN
    Steven Cummings; Fiscal Year: 2007
    ....
  11. OSTEOPOROTIC FRACTURES
    Steven Cummings; Fiscal Year: 2000
    ..We propose using our archived DNA specimens and existing data about hip and vertebral fractures, breast cancer, bone mass, serum sex hormones and lipoproteins to determine whether these ER variations have biological importance. ..
  12. FRACTURES IN OLDER WOMEN
    Steven Cummings; Fiscal Year: 1993
    ..Continued study of this unique cohort is likely to produce important advances in understanding and preventing fractures in older women...
  13. RISK FACTORS FOR HIP AND COLLES' FRACTURES
    Steven Cummings; Fiscal Year: 1991
    ..The results of our study will guide clinical and public health efforts to prevent these fractures...