Genomes and Genes
Gregory A Cope
Affiliation: California Institute of Technology
- The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8pC Zhou
Department of Cancer Cell Biology, Harvard School of Public Health, Boston, MA, USA
BMC Biochem 2:7. 2001..pombe CSN, results in accumulation of Pcu1p exclusively in the modified form. However, it remained unclear whether this reflects global control of all cullins by the entire CSN complex...
- Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levelsGregory A Cope
Department of Biology, California Institute of Technology Pasadena, CA 91125, USA
BMC Biochem 7:1. 2006..The removal of Nedd8 is catalyzed by the Jab1/MPN domain metalloenzyme (JAMM) motif within the Csn5 subunit of the Cop9 Signalosome...
- COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligasesGregory A Cope
Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
Cell 114:663-71. 2003..Here, we summarize what is known about CSN, and discuss hypotheses for how CSN promotes the activity of SCF ubiquitin ligases...
- Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1Gregory A Cope
Department of Biology, California Institute of Technology Caltech, Pasadena, CA 91125, USA
Science 298:608-11. 2002..We propose that JAMM isopeptidases play important roles in a variety of physiological pathways...