Gregory A Cope

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. pmc The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p
    C Zhou
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, MA, USA
    BMC Biochem 2:7. 2001
  2. pmc Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels
    Gregory A Cope
    Department of Biology, California Institute of Technology Pasadena, CA 91125, USA
    BMC Biochem 7:1. 2006
  3. ncbi request reprint COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases
    Gregory A Cope
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Cell 114:663-71. 2003
  4. ncbi request reprint Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1
    Gregory A Cope
    Department of Biology, California Institute of Technology Caltech, Pasadena, CA 91125, USA
    Science 298:608-11. 2002

Collaborators

Detail Information

Publications4

  1. pmc The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p
    C Zhou
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, MA, USA
    BMC Biochem 2:7. 2001
    ..pombe CSN, results in accumulation of Pcu1p exclusively in the modified form. However, it remained unclear whether this reflects global control of all cullins by the entire CSN complex...
  2. pmc Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels
    Gregory A Cope
    Department of Biology, California Institute of Technology Pasadena, CA 91125, USA
    BMC Biochem 7:1. 2006
    ..The removal of Nedd8 is catalyzed by the Jab1/MPN domain metalloenzyme (JAMM) motif within the Csn5 subunit of the Cop9 Signalosome...
  3. ncbi request reprint COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases
    Gregory A Cope
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Cell 114:663-71. 2003
    ..Here, we summarize what is known about CSN, and discuss hypotheses for how CSN promotes the activity of SCF ubiquitin ligases...
  4. ncbi request reprint Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1
    Gregory A Cope
    Department of Biology, California Institute of Technology Caltech, Pasadena, CA 91125, USA
    Science 298:608-11. 2002
    ..We propose that JAMM isopeptidases play important roles in a variety of physiological pathways...