David Chan

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Eliminating mitochondrial DNA from sperm
    David C Chan
    Division of Biology, California Institute of Technology, and the Howard Hughes Medical Institute, Pasadena, CA 91125, USA
    Dev Cell 22:469-70. 2012
  2. pmc Regulation of mitochondrial permeability transition pore by PINK1
    Clement A Gautier
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Neurodegener 7:22. 2012
  3. doi request reprint Fusion and fission: interlinked processes critical for mitochondrial health
    David C Chan
    Division of Biology and the Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    Annu Rev Genet 46:265-87. 2012
  4. ncbi request reprint Mitochondria: dynamic organelles in disease, aging, and development
    David C Chan
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 125:1241-52. 2006
  5. ncbi request reprint Mitochondrial fusion and fission in mammals
    David C Chan
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Annu Rev Cell Dev Biol 22:79-99. 2006
  6. ncbi request reprint Mitochondrial dynamics in cell life and death
    D Chan
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell Death Differ 13:680-4. 2006
  7. pmc New insights into mitochondrial fusion
    Yan Zhang
    Division of Biology, California Institute of Technology, MC114 96, Pasadena, CA 91125, USA
    FEBS Lett 581:2168-73. 2007
  8. ncbi request reprint Dissecting mitochondrial fusion
    David C Chan
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Dev Cell 11:592-4. 2006
  9. ncbi request reprint Mitochondrial dynamics in mammals
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Curr Top Dev Biol 59:119-44. 2004
  10. ncbi request reprint Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion
    Erik E Griffin
    Division of Biology, California Institute of Technology, 1200 E California Boulevard, Pasadena, CA 91125, USA
    J Biol Chem 281:16599-606. 2006

Collaborators

  • Damien Arnoult
  • Erin Schuman
  • Terrence G Frey
  • Marc Vermulst
  • Richard J Youle
  • Hsiuchen Chen
  • Scott A Detmer
  • Erik E Griffin
  • Zhiyin Song
  • J Michael McCaffery
  • Yan Zhang
  • Takumi Koshiba
  • Clement A Gautier
  • Anne Chomyn
  • Francesc X Soriano
  • Seok Yong Choi
  • Tara R Suntoke
  • Mariusz Karbowski
  • Carlos Villalobos
  • Erica Caballero
  • Lucía Núñez
  • Emilie Giaime
  • Jie Shen
  • Tomas A Prolla
  • Yun E Wang
  • Mariam Ghochani
  • Don W Cleveland
  • Christine Vande Velde
  • Maja Fiket
  • Christiane Alexander
  • Daniel Bach
  • Antonio Zorzano
  • Ping Huang
  • Gary M Jenkins
  • Michael A Frohman
  • Juergen Schiller
  • Manuel Palacin
  • Marc Liesa
  • Johannes Graumann
  • Carolyn L Smith
  • Jens T Kaiser
  • Scott E Fraser
  • Andrew J Ewald

Detail Information

Publications34

  1. ncbi request reprint Eliminating mitochondrial DNA from sperm
    David C Chan
    Division of Biology, California Institute of Technology, and the Howard Hughes Medical Institute, Pasadena, CA 91125, USA
    Dev Cell 22:469-70. 2012
    ..In this issue of Developmental Cell, DeLuca and O'Farrell (2012) show that active elimination of mtDNA during sperm development in Drosophila ensures that mature spermatozoa are devoid of DNA...
  2. pmc Regulation of mitochondrial permeability transition pore by PINK1
    Clement A Gautier
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Neurodegener 7:22. 2012
    ..We previously reported that loss of PINK1 impairs mitochondrial respiratory activity in mouse brains...
  3. doi request reprint Fusion and fission: interlinked processes critical for mitochondrial health
    David C Chan
    Division of Biology and the Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    Annu Rev Genet 46:265-87. 2012
    ..A better understanding of these processes likely will ultimately lead to improvements in human health...
  4. ncbi request reprint Mitochondria: dynamic organelles in disease, aging, and development
    David C Chan
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 125:1241-52. 2006
    ..Clearly, much about the basic biology of mitochondria remains to be understood. Here we discuss recent work that suggests that the dynamics (fusion and fission) of these organelles is important in development and disease...
  5. ncbi request reprint Mitochondrial fusion and fission in mammals
    David C Chan
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Annu Rev Cell Dev Biol 22:79-99. 2006
    ..These components play important roles in mitochondrial function and development as well as programmed cell death. Disruption of the fusion machinery leads to neurodegenerative disease...
  6. ncbi request reprint Mitochondrial dynamics in cell life and death
    D Chan
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell Death Differ 13:680-4. 2006
  7. pmc New insights into mitochondrial fusion
    Yan Zhang
    Division of Biology, California Institute of Technology, MC114 96, Pasadena, CA 91125, USA
    FEBS Lett 581:2168-73. 2007
    ..We highlight recent findings that have advanced our understanding of the mechanism, function, and regulation of mitochondrial fusion...
  8. ncbi request reprint Dissecting mitochondrial fusion
    David C Chan
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Dev Cell 11:592-4. 2006
    ..Fusion of the outer membranes requires mitofusins. A new study published in Cell (Meeusen et al., 2006) shows that inner membrane fusion requires the dynamin-related protein Mgm1/OPA1...
  9. ncbi request reprint Mitochondrial dynamics in mammals
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Curr Top Dev Biol 59:119-44. 2004
  10. ncbi request reprint Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion
    Erik E Griffin
    Division of Biology, California Institute of Technology, 1200 E California Boulevard, Pasadena, CA 91125, USA
    J Biol Chem 281:16599-606. 2006
    ..Each of the null alleles disrupts the interaction of these two fragments, suggesting that we have identified a key interaction involving the GTPase domain and heptad repeats essential for fusion...
  11. ncbi request reprint Fueling synapses
    Erin Schuman
    Division of Biology 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 119:738-40. 2004
    ..2004 [this issue of Cell])...
  12. ncbi request reprint Mitochondrial dynamics in disease
    David C Chan
    California Institute of Technology, Pasadena, USA
    N Engl J Med 356:1707-9. 2007
  13. ncbi request reprint Mitochondrial fusion protects against neurodegeneration in the cerebellum
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 130:548-62. 2007
    ....
  14. pmc OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L
    Zhiyin Song
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Cell Biol 178:749-55. 2007
    ..Cleavage at S2 is regulated by the i-AAA protease Yme1L. Our results suggest that mammalian cells have multiple pathways to control mitochondrial fusion through regulation of the spectrum of OPA1 isoforms...
  15. pmc Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations
    Scott A Detmer
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Cell Biol 176:405-14. 2007
    ..Furthermore, they suggest that tissues with low Mfn1 expression are vulnerable in CMT2A and that methods to increase Mfn1 expression in the peripheral nervous system would benefit CMT2A patients...
  16. ncbi request reprint Functions and dysfunctions of mitochondrial dynamics
    Scott A Detmer
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Mol Cell Biol 8:870-9. 2007
    ..But what are the molecular mechanisms that control mitochondrial dynamics, and why are they important for mitochondrial function? We review these issues and explore how defects in mitochondrial dynamics might cause neuronal disease...
  17. pmc Structural basis for recruitment of mitochondrial fission complexes by Fis1
    Yan Zhang
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, MC 114 96, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:18526-30. 2007
    ..Our results reveal how Fis1 recruits the mitochondrial fission complex and will facilitate efforts to manipulate mitochondrial fission...
  18. pmc Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
    Hsiuchen Chen
    Division of Biology, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA
    J Cell Biol 160:189-200. 2003
    ..Therefore, mitochondrial fusion is essential for embryonic development, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population...
  19. pmc Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion
    Zhiyin Song
    Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Biol Cell 20:3525-32. 2009
    ..These results indicate that mammalian mitofusins and OPA1 mediate distinct sequential fusion steps that are readily uncoupled, in contrast to the situation in yeast...
  20. pmc Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases
    Hsiuchen Chen
    Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    Hum Mol Genet 18:R169-76. 2009
    ..We review how mitochondrial dynamics is altered in these neurodegenerative diseases and discuss the reciprocal interactions between mitochondrial fusion, fission, transport and mitophagy...
  21. pmc Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 141:280-9. 2010
    ..With its dual function in safeguarding mtDNA integrity and preserving mtDNA function in the face of mutations, mitochondrial fusion is likely to be a protective factor in human disorders associated with mtDNA mutations...
  22. ncbi request reprint Structural basis of mitochondrial tethering by mitofusin complexes
    Takumi Koshiba
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, MC114 96, Pasadena, CA 91125, USA
    Science 305:858-62. 2004
    ..Consistent with this proposal, truncated mitofusin, in an HR2-dependent manner, causes mitochondria to become apposed with a uniform gap. Our results suggest that HR2 functions as a mitochondrial tether before fusion...
  23. ncbi request reprint Emerging functions of mammalian mitochondrial fusion and fission
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, 1200 E California Boulevard, MC114 96, Pasadena, CA 91125, USA
    Hum Mol Genet 14:R283-9. 2005
    ..These studies provide insight into how mitochondria communicate with one another to coordinate mitochondrial function and morphology...
  24. pmc The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria
    Erik E Griffin
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Cell Biol 170:237-48. 2005
    ..Our studies support a revised model for assembly of the mitochondrial fission apparatus...
  25. doi request reprint Physiological functions of mitochondrial fusion
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Ann N Y Acad Sci 1201:21-5. 2010
    ..Such mtDNA defects lead to respiration-deficient mitochondria, and their accumulation in neurons leads to impaired outgrowth of cellular processes and ultimately neurodegeneration...
  26. ncbi request reprint Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A
    Scott A Detmer
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, MC114 96, Pasadena, CA 91125, USA
    Hum Mol Genet 17:367-75. 2008
    ..This transgenic line recapitulates key motor features of CMT2A and provides a system to dissect the function of mitochondria in the axons of mammalian motor neurons...
  27. ncbi request reprint The prefusogenic intermediate of HIV-1 gp41 contains exposed C-peptide regions
    Takumi Koshiba
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 278:7573-9. 2003
    ..These results provide important structural information about this intermediate that should facilitate the development of HIV-1 entry inhibitors and may lead to new vaccine strategies...
  28. ncbi request reprint Critical dependence of neurons on mitochondrial dynamics
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, 1200 East California Blvd, MC114 96, Pasadena, CA 91125, United States
    Curr Opin Cell Biol 18:453-9. 2006
    ..Perhaps it is the strict spatial and functional requirements for mitochondria in neurons that cause defects in mitochondrial fusion to manifest primarily as neurodegenerative diseases...
  29. ncbi request reprint Molecular mechanism of mitochondrial membrane fusion
    Erik E Griffin
    Division of Biology, California Institute of Technology, 1200 East California Blvd, MC114 96, Pasadena, CA 91125, USA
    Biochim Biophys Acta 1763:482-9. 2006
    ..An understanding of the molecular mechanism of fusion may have implications for Charcot-Marie-Tooth subtype 2A and autosomal dominant optic atrophy, neurodegenerative diseases caused by mutations in Mfn2 and OPA1...
  30. ncbi request reprint Disruption of fusion results in mitochondrial heterogeneity and dysfunction
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 280:26185-92. 2005
    ..In contrast, fragmentation of mitochondria, without severe loss of fusion, did not result in such cellular defects. Our results showed that key cellular functions decline as mitochondrial fusion is progressively abrogated...
  31. ncbi request reprint The fusion activity of HIV-1 gp41 depends on interhelical interactions
    Tara R Suntoke
    Division of Biology, California Institute of Technology, Pasadena, 91125, USA
    J Biol Chem 280:19852-7. 2005
    ..These results provide evidence that gp41 hairpin stability is critical for mediating fusion and suggest a novel role for the glutamine layer in gp41 function...
  32. pmc Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis
    Mariusz Karbowski
    Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 164:493-9. 2004
    ..The block in mitochondrial fusion occurs within the same time range as Bax coalescence on the mitochondria and outer mitochondrial membrane permeabilization, and it may be a consequence of Bax/Bak activation during apoptosis...
  33. ncbi request reprint A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis
    Seok Yong Choi
    Graduate Program in Molecular and Cellular Biology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794 5140, USA
    Nat Cell Biol 8:1255-62. 2006
    ..Moreover, our findings suggest a novel basis for the mitochondrial fragmentation observed during apoptosis...
  34. ncbi request reprint Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2
    Francesc X Soriano
    Institute for Research in Biomedicine IRB, Scientific Park of Barcelona, Departament of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barelona, Spain
    Diabetes 55:1783-91. 2006
    ..Our results indicate the existence of a regulatory pathway involving PGC-1 alpha, ERR alpha, and Mfn2. Alterations in this regulatory pathway may participate in the pathophysiology of insulin-resistant conditions and type 2 diabetes...

Research Grants15

  1. Mitochondrial fusion: analysis of Fzo function
    David Chan; Fiscal Year: 2009
    ..These studies will lead to an understanding of the pathogenesis CMT2A at the cellular and whole-animal level. In addition, they will likely impact the understanding of the pathogenesis of mitochondrial encephalomyopathies. ..
  2. Structural and mechanistic studies of mitochondrial fission
    David Chan; Fiscal Year: 2007
    ..These studies will lead to structural insights that will enable investigators to manipulate mitochondrial fission, and thereby potentially modulate processes such as apoptosis, cancer, and nerve function. ..
  3. Mitochondrial fusion: analysis of Fzo function
    David Chan; Fiscal Year: 2007
    ..These studies will lead to an understanding of the pathogenesis CMT2A at the cellular and whole-animal level. In addition, they will likely impact the understanding of the pathogenesis of mitochondrial encephalomyopathies. ..
  4. Mitochondrial fusion: analysis of Fzo function
    David Chan; Fiscal Year: 2005
    ..In addition to clarifying a basic cellular process, these studies may further understanding of human mitochondrial diseases and aging. ..
  5. Structural and mechanistic studies of mitochondrial fission
    David C Chan; Fiscal Year: 2010
    ..These studies will lead to structural insights that will enable investigators to manipulate mitochondrial fission, and thereby potentially modulate processes such as apoptosis, cancer, and nerve function. ..