Research Topics
Species | Eric J BrownSummaryAffiliation: California Institute of Technology Country: USA Publications
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Detail Information
Publications
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesisXiaolan Guo
Department of Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
EMBO J 26:4709-19. 2007..In addition, our results suggest that loss of ATM can cooperate with dysfunctional telomeres to promote cellular transformation and tumor formation in vivo...- Essential and dispensable roles of ATR in cell cycle arrest and genome maintenanceEric J Brown
California Institute of Technology, Pasadena, California 91125, USA
Genes Dev 17:615-28. 2003..When DNA replication inhibitors are removed, ATR knockout cells proceed to mitosis but do so with chromosome breaks, indicating that ATR provides a key genome maintenance function in S phase... 
The ATR-independent DNA replication checkpointEric J Brown
California Institute of Technology, Mail Code 147-75, Pasadena, CA 91125, USA
Cell Cycle 2:188-9. 2003- Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectorsCarlos Lois
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Science 295:868-72. 2002..We have also generated transgenic rats that express GFP at high levels, suggesting that this technique can be used to produce other transgenic animal species... - Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell lossYaroslava Ruzankina
Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
Cell Stem Cell 1:113-26. 2007..In aggregate, these studies suggest that reduced regenerative capacity in adults via deletion of a developmentally essential DDR gene is sufficient to cause the premature appearance of age-related phenotypes... - The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expressionYa Xiong Chen
Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
Proc Natl Acad Sci U S A 103:1018-23. 2006..These studies uncover an important role for menin in both normal hematopoiesis and myeloid transformation and provide a mechanistic understanding of menin's function in these processes that may be used for therapy... - Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrestAdemi E Santiago-Walker
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, 19104 6061, USA
J Biol Chem 280:32107-14. 2005..Importantly, they reveal the existence of a novel, cell cycle-dependent mechanism through which PKCdelta stimulates cell death... - The DNA damage pathway regulates innate immune system ligands of the NKG2D receptorStephan Gasser
Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
Nature 436:1186-90. 2005..Thus, the DNA damage response, previously shown to arrest the cell cycle and enhance DNA repair functions, or to trigger apoptosis, may also participate in alerting the immune system to the presence of potentially dangerous cells... - Replicative stress, stem cells and agingYaroslava Ruzankina
Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
Mech Ageing Dev 129:460-6. 2008.... - Analysis of cell cycle progression and genomic integrity in early lethal knockoutsEric J Brown
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
Methods Mol Biol 280:201-12. 2004..It is interesting to note that recently developed methods to introduce single-copy transgenes into one-cell zygotes via lentiviruses may provide a means to generate Cre/lox-conditional cell lines from these conventional knockouts... - Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47Isabelle Mouro-Chanteloup
Institut National de la Santé et de la Recherche Médicale INSERM U76, Institut National de la Transfusion Sanguine, Paris, France
Blood 101:338-44. 2003..2(-) and Rh(null) red cells... - The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosisElsa Noah N'Diaye
Macrophage Biology Laboratory, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Mol Biol Cell 19:1252-60. 2008..Identification of a negative regulator of GPCR clustering reveals a new function of ubiquitin-like proteins and highlights a cellular requirement for exquisite regulation of receptor dynamics... - Role for lysosomal enzyme beta-hexosaminidase in the control of mycobacteria infectionIngrid Chou Koo
Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 105:710-5. 2008..Thus, secretion of lysosomal enzymes is a mycobactericidal mechanism that may have a more general role in host defense... - Generation of mice with a conditional allele of the p120 Ras GTPase-activating proteinPhilip E Lapinski
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Genesis 45:762-7. 2007..The conditional rasa1 mouse will be useful for the analysis of the role of RasGAP in mature cell types... - Involvement of a CD47-dependent pathway in platelet adhesion on inflamed vascular endothelium under flowPatricia Lagadec
Unité Institut National de la Santé et de la Recherche Médicale INSERM U343 et Laboratoire d Immunologie, Nice, France
Blood 101:4836-43. 2003..Overall, CD47 antagonists may be potentially useful to inhibit platelet adhesion on inflamed endothelium... - Acute postnatal ablation of Hif-2alpha results in anemiaMichaela Gruber
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 104:2301-6. 2007.... - The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with GbetagammaElsa Noah N'Diaye
Program in Host Pathogen Interactions, University of California, San Francisco, Campus Box 2140, 600 16th St, San Francisco, CA 94143 2140, USA
J Cell Biol 163:1157-65. 2003..Thus, PLIC-1 inhibits Gi signaling by direct association with Gbetagamma; because it also interacts with CD47, a modulator of integrin function, it likely has a role integrating adhesion and signaling components of cell migration... - Role of the WASP family proteins for Mycobacterium marinum actin tail formationLuisa M Stamm
Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 102:14837-42. 2005..Together, these data demonstrate that M. marinum subversion of host actin polymerization is most similar to distantly related Gram-negative organisms but that its mechanism for activating WASP family proteins is unique... - Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell developmentYann Gaël Gangloff
Genome Research Institute, University of Cincinnati, 2180 E Galbraith Rd, Cincinnati, OH 45237, USA
Mol Cell Biol 24:9508-16. 2004..Moreover, mTOR(-/-) embryos display a lesion in inner cell mass proliferation, consistent with the inability to establish embryonic stem cells from mTOR(-/-) embryos...