Roy J Britten

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. pmc Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels
    Roy J Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 99:13633-5. 2002
  2. pmc Almost all human genes resulted from ancient duplication
    Roy J Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 103:19027-32. 2006
  3. pmc Coding sequences of functioning human genes derived entirely from mobile element sequences
    Roy J Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 101:16825-30. 2004
  4. pmc Majority of divergence between closely related DNA samples is due to indels
    Roy J Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 100:4661-5. 2003
  5. pmc Transposable element insertions have strongly affected human evolution
    Roy J Britten
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:19945-8. 2010
  6. pmc The majority of human genes have regions repeated in other human genes
    Roy J Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 102:5466-70. 2005

Detail Information

Publications6

  1. pmc Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels
    Roy J Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 99:13633-5. 2002
    ..The gaps in alignment are present in about equal amounts in the chimp and human sequences. They occur equally in repeated and nonrepeated sequences, as detected by REPEATMASKER (http://ftp.genome.washington.edu/RM/RepeatMasker.html)...
  2. pmc Almost all human genes resulted from ancient duplication
    Roy J Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 103:19027-32. 2006
    ..The set of matches averaged 0.35% of that observed for the KGMV set of proteins...
  3. pmc Coding sequences of functioning human genes derived entirely from mobile element sequences
    Roy J Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 101:16825-30. 2004
    ..In another example, the gene BNIP3 coding sequence is 97% made up of sequences from an apparent human endogenous retrovirus. The Syncytin gene coding sequence appears to be made from an endogenous retrovirus envelope gene...
  4. pmc Majority of divergence between closely related DNA samples is due to indels
    Roy J Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 100:4661-5. 2003
    ..Human genetic evidence suggests that indels are a major source of gene defects, indicating that indels are a significant source of evolutionary change...
  5. pmc Transposable element insertions have strongly affected human evolution
    Roy J Britten
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:19945-8. 2010
    ..The combination of the results of these events that were selected during human lineage evolution was apparently effective in producing a successful and rapidly evolving species...
  6. pmc The majority of human genes have regions repeated in other human genes
    Roy J Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 102:5466-70. 2005
    ..The magnitude of the set of relationships leads to the conclusion that the principal process by which new gene functions arise has been by making use of preexisting genes...