Smadar Ben-Tabou de-Leon

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Deciphering the underlying mechanism of specification and differentiation: the sea urchin gene regulatory network
    Smadar Ben-Tabou de-Leon
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Sci STKE 2006:pe47. 2006
  2. ncbi request reprint Gene regulation: gene control network in development
    Smadar Ben-Tabou de-Leon
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Annu Rev Biophys Biomol Struct 36:191. 2007
  3. doi request reprint Modeling the dynamics of transcriptional gene regulatory networks for animal development
    Smadar Ben-Tabou de-Leon
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Biol 325:317-28. 2009
  4. pmc Information processing at the foxa node of the sea urchin endomesoderm specification network
    Smadar Ben Tabou de-Leon
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:10103-8. 2010
  5. pmc Perturbation analysis analyzed--athematical modeling of intact and perturbed gene regulatory circuits for animal development
    Smadar Ben-Tabou de-Leon
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Biol 344:1110-8. 2010
  6. pmc The conserved role and divergent regulation of foxa, a pan-eumetazoan developmental regulatory gene
    Smadar Ben Tabou de-Leon
    Division of Biology, California Institute of Technology, Pasadena, 91125, USA
    Dev Biol 357:21-6. 2011
  7. pmc Experimentally based sea urchin gene regulatory network and the causal explanation of developmental phenomenology
    Smadar Ben-Tabou de-Leon
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Wiley Interdiscip Rev Syst Biol Med 1:237-46. 2009

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Deciphering the underlying mechanism of specification and differentiation: the sea urchin gene regulatory network
    Smadar Ben-Tabou de-Leon
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Sci STKE 2006:pe47. 2006
    ..It demonstrates how the static physical genomic components define functional connections between the various regulatory genes that act together to conduct the dynamical developmental program...
  2. ncbi request reprint Gene regulation: gene control network in development
    Smadar Ben-Tabou de-Leon
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Annu Rev Biophys Biomol Struct 36:191. 2007
    ....
  3. doi request reprint Modeling the dynamics of transcriptional gene regulatory networks for animal development
    Smadar Ben-Tabou de-Leon
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Biol 325:317-28. 2009
    ..Model simulations display the effects of mutation of binding sites, or perturbation of upstream gene expression. The model is a generally useful tool for understanding gene regulation and the dynamics of cell fate specification...
  4. pmc Information processing at the foxa node of the sea urchin endomesoderm specification network
    Smadar Ben Tabou de-Leon
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:10103-8. 2010
    ..This study shed light on the mesoderm-endoderm fate decision and provides a functional explanation, in terms of the genomic regulatory code, for the spatial and temporal expression of a key developmental control gene...
  5. pmc Perturbation analysis analyzed--athematical modeling of intact and perturbed gene regulatory circuits for animal development
    Smadar Ben-Tabou de-Leon
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Biol 344:1110-8. 2010
    ..The model improves our ability to analyze experimental data and construct from it the network topology. The model also illuminates information processing properties of gene regulatory circuits for animal development...
  6. pmc The conserved role and divergent regulation of foxa, a pan-eumetazoan developmental regulatory gene
    Smadar Ben Tabou de-Leon
    Division of Biology, California Institute of Technology, Pasadena, 91125, USA
    Dev Biol 357:21-6. 2011
    ..foxa transcriptional regulation had evolved to support the developmental program in each species so foxa would play its role controlling morphogenesis at the necessary embryonic address...
  7. pmc Experimentally based sea urchin gene regulatory network and the causal explanation of developmental phenomenology
    Smadar Ben-Tabou de-Leon
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Wiley Interdiscip Rev Syst Biol Med 1:237-46. 2009
    ..The experimentally based gene regulatory network for endomesoderm specification in the sea urchin embryo provides unique insights into the system level properties of cell fate specification and its evolution...