David Baltimore

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. doi request reprint MicroRNAs: new regulators of immune cell development and function
    David Baltimore
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nat Immunol 9:839-45. 2008
  2. pmc Dimeric 2G12 as a potent protection against HIV-1
    Xin M Luo
    Division of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS Pathog 6:e1001225. 2010
  3. pmc Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 5:e12009. 2010
  4. pmc Antibody-based protection against HIV infection by vectored immunoprophylaxis
    Alejandro B Balazs
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 481:81-4. 2012
  5. pmc Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder
    Ryan M O'Connell
    Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Med 205:585-94. 2008
  6. pmc The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
    Shengli Hao
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nat Immunol 10:281-8. 2009
  7. pmc Use of mutated self-cleaving 2A peptides as a molecular rheostat to direct simultaneous formation of membrane and secreted anti-HIV immunoglobulins
    Kenneth K Yu
    California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 7:e50438. 2012
  8. pmc A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase
    Jesse D Bloom
    Division of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 6:e22201. 2011
  9. pmc Discovering NF-kappaB
    David Baltimore
    California Institute of Technology, Pasadena, California 91125, USA
    Cold Spring Harb Perspect Biol 1:a000026. 2009
  10. doi request reprint Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes
    Xin M Luo
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Blood 113:1422-31. 2009

Research Grants

  1. NF-kappaB: Orchestration of the Inflammatory Response
    David Baltimore; Fiscal Year: 2010
  2. MOLECULAR BIOLOGY OF LYMPHOCYTE AND NEURONAL GROWTH
    David Baltimore; Fiscal Year: 2007
  3. LEUKEMOGENESIS BY ABL AND OTHER ONCOGENES
    David Baltimore; Fiscal Year: 2004
  4. Molecular Biology Of Lymphocyte & Neuronal Growth
    David Baltimore; Fiscal Year: 2004
  5. Inhibition of HIV by Lentivector-encoded Interfering RNA
    David Baltimore; Fiscal Year: 2005
  6. HIV INDUCED CELLULAR PATHOLOGY
    David Baltimore; Fiscal Year: 2007
  7. MicroRNA Function in the Immune System
    David Baltimore; Fiscal Year: 2010
  8. MOLECULAR BIOLOGY OF LYMPHOCYTE AND NEURONAL GROWTH
    David Baltimore; Fiscal Year: 2000
  9. HIV INDUCED CELLULAR PATHOLOGY
    David Baltimore; Fiscal Year: 2002
  10. LEUKEMOGENESIS BY AB1 AND OTHER ONCOGENES
    David Baltimore; Fiscal Year: 1999

Collaborators

Detail Information

Publications67

  1. doi request reprint MicroRNAs: new regulators of immune cell development and function
    David Baltimore
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nat Immunol 9:839-45. 2008
    ..Here we bring together much of this work, which has so far only scratched the surface of this very fertile field of investigation, and show how the results illuminate many historic questions about hematopoiesis and immune function...
  2. pmc Dimeric 2G12 as a potent protection against HIV-1
    Xin M Luo
    Division of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS Pathog 6:e1001225. 2010
    ..We have therefore identified dimeric 2G12 as a potent prophylactic reagent against HIV-1 in vivo, which could be used as part of an antibody cocktail to prevent HIV-1 infection...
  3. pmc Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 5:e12009. 2010
    ..Taken together, our study unveils a versatile approach to deliver human cytokines to HIS mice, to both improve engraftment and determine the impact of cytokines on human diseases...
  4. pmc Antibody-based protection against HIV infection by vectored immunoprophylaxis
    Alejandro B Balazs
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 481:81-4. 2012
    ..Our results suggest that successful translation of this approach to humans may produce effective prophylaxis against HIV...
  5. pmc Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder
    Ryan M O'Connell
    Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Med 205:585-94. 2008
    ....
  6. pmc The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
    Shengli Hao
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nat Immunol 10:281-8. 2009
    ..Thus, mRNA stability and transcriptional control, two intrinsic characteristics of genes, control the kinetics of gene expression induced by proinflammatory cytokines...
  7. pmc Use of mutated self-cleaving 2A peptides as a molecular rheostat to direct simultaneous formation of membrane and secreted anti-HIV immunoglobulins
    Kenneth K Yu
    California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 7:e50438. 2012
    ..The Molecular Rheostat offers a novel tool for genetically manipulating B cell specificity for B-cell based gene therapy...
  8. pmc A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase
    Jesse D Bloom
    Division of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 6:e22201. 2011
    ....
  9. pmc Discovering NF-kappaB
    David Baltimore
    California Institute of Technology, Pasadena, California 91125, USA
    Cold Spring Harb Perspect Biol 1:a000026. 2009
    b>David Baltimore recalls the experiments that led to the discovery of the NF-kappaB transcription factor more than 20 years ago.
  10. doi request reprint Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes
    Xin M Luo
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Blood 113:1422-31. 2009
    ....
  11. ncbi request reprint One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers
    Thomas H Leung
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 118:453-64. 2004
    ..This suggests that binding sites may impart a specific configuration to bound transcription factors...
  12. ncbi request reprint Achieving stability of lipopolysaccharide-induced NF-kappaB activation
    Markus W Covert
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 309:1854-7. 2005
    ..The MyD88-independent pathway required Inferon regulatory factor 3-dependent expression of TNFalpha to activate NF-kappaB, and the time required for TNFalpha synthesis established the delay...
  13. pmc miR-146a controls the resolution of T cell responses in mice
    Lili Yang
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Med 209:1655-70. 2012
    ..Thus, our results identify miR-146a as an important new member of the negative feedback loop that controls TCR signaling to NF-κB. Our findings also add microRNA to the list of regulators that control the resolution of T cell responses...
  14. pmc Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A
    Aadel A Chaudhuri
    Departments of Biology and Computing and Mathematical Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 109:4233-8. 2012
    ..Thus, the miR-125b target Lin28A is an important regulator of hematopoiesis and a primary target of miR-125b in the hematopoietic system...
  15. pmc Engineered lentivector targeting of dendritic cells for in vivo immunization
    Lili Yang
    Division of Biology, California Institute of Technology, 1200 E California Blvd, Pasadena, California 91125, USA
    Nat Biotechnol 26:326-34. 2008
    ..Thus, lentiviral vectors targeting dendritic cells provide a simple method of producing effective immunity and may provide an alternative route for immunization with protein antigens...
  16. pmc miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
    Mark P Boldin
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Med 208:1189-201. 2011
    ..Collectively, our findings suggest that miR-146a plays a key role as a molecular brake on inflammation, myeloid cell proliferation, and oncogenic transformation...
  17. pmc MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:14235-40. 2010
    ..Our study identifies an evolutionarily conserved subset of miRNAs that is expressed in HSCs and functions to modulate hematopoietic output...
  18. pmc NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies
    Jimmy L Zhao
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 108:9184-9. 2011
    ..Genetic ablation of NF-κB p50 suppresses the myeloproliferation, showing that dysregulation of NF-κB is responsible for the myeloproliferative disease...
  19. pmc Regulation of APC development, immune response, and autoimmunity by Bach1/HO-1 pathway in mice
    Alex Yick Lun So
    Department of Biology, California Institute of Technology, Pasadena, CA 90227, USA
    Blood 120:2428-37. 2012
    ..By contrast, we observed an increase in hematopoietic stem-progenitor cells (HSPCs) in these mice, suggesting a developmental block in the progression of HSPCs to CMP-Flk2(+) and subsequently APCs...
  20. pmc Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells
    Lili Yang
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 102:4518-23. 2005
    ..This methodology of "instructive immunotherapy" could be developed for controlling the growth of human tumors and attacking established pathogens...
  21. pmc Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells
    Lili Yang
    Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:6204-9. 2002
    ....
  22. pmc NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    Konstantin D Taganov
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:12481-6. 2006
    ....
  23. pmc Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice
    Eun Mi Hur
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Blood 120:4571-82. 2012
    ..Our study demonstrates the potential of anti-HIV IgA in immunoprophylaxis in vivo, emphasizing the importance of the mucosal IgA response in defense against HIV/AIDS...
  24. pmc MicroRNA-125b potentiates macrophage activation
    Aadel A Chaudhuri
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Immunol 187:5062-8. 2011
    ....
  25. ncbi request reprint The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation
    Alexander Hoffmann
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 298:1241-5. 2002
    ..Bimodal signal-processing characteristics with respect to stimulus duration are revealed by the model and are shown to generate specificity in gene expression...
  26. pmc MicroRNA-34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1
    Dinesh S Rao
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Immunity 33:48-59. 2010
    ..Knockdown of miR-34a resulted in increased amounts of Foxp1 and mature B cells. These findings identify a role for miR-34a in connecting the p53 network with suppression of Foxp1, a known B cell oncogene...
  27. doi request reprint Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission
    Alejandro B Balazs
    1 Division of Biology, California Institute of Technology, Pasadena, California, USA 2
    Nat Med 20:296-300. 2014
    ....
  28. pmc MicroRNA-155 is induced during the macrophage inflammatory response
    Konstantin D Taganov
    Department of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:1604-9. 2007
    ..Importantly, because miR-155 is known to function as an oncogene, these observations identify a potential link between inflammation and cancer...
  29. ncbi request reprint Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth
    Wange Lu
    California Institute of Technology, Division of Biology, Pasadena, CA 91125, USA
    Cell 119:97-108. 2004
    ..Thus, Ryk appears to play a crucial role in Wnt-mediated signaling...
  30. pmc MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, 330 Braun, 1200 E California Boulevard, Pasadena, CA 91125, USA
    Immunity 33:607-19. 2010
    ..Our study shows that one aspect of miR-155 function is the promotion of T cell-dependent tissue inflammation, suggesting that miR-155 might be a promising therapeutic target for the treatment of autoimmune disorders...
  31. ncbi request reprint Chimeric nucleases stimulate gene targeting in human cells
    Matthew H Porteus
    Department of Biology, California Institute of Technology, Pasadena CA 91125, USA
    Science 300:763. 2003
  32. doi request reprint Broad protection against influenza infection by vectored immunoprophylaxis in mice
    Alejandro B Balazs
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Nat Biotechnol 31:647-52. 2013
    ..If translated to humans, this prophylactic approach may be uniquely capable of protecting immunocompromised or elderly patient populations not reliably protected by existing vaccines. ..
  33. pmc Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks
    Matthew H Porteus
    California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell Biol 23:3558-65. 2003
    ..The frequencies of gene targeting that we achieved with relatively low MOIs suggest that combining rAAV vectors with DSBs is a promising strategy to broaden the application of gene targeting...
  34. pmc Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities
    Alexander Hoffmann
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 22:5530-9. 2003
    ....
  35. doi request reprint Physiological and pathological roles for microRNAs in the immune system
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nat Rev Immunol 10:111-22. 2010
    ..This Review discusses recent advances in our understanding of both the intended functions of miRNAs in managing immune cell biology and their pathological roles when their expression is dysregulated...
  36. pmc Inositol phosphatase SHIP1 is a primary target of miR-155
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 106:7113-8. 2009
    ..Our study unveils a molecular link between miR-155 and SHIP1 and provides evidence that repression of SHIP1 is an important component of miR-155 biology...
  37. pmc Regulation of NF-kappaB activity through lysine monomethylation of p65
    Chee Kwee Ea
    Division of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 106:18972-7. 2009
    ..Moreover, Set9 mediated methylation of p65 is required for the expression of a subset of NF-kappaB target genes in response to TNFalpha stimulation...
  38. ncbi request reprint Physiological functions for brain NF-kappaB
    Mollie K Meffert
    Division of Biology, MC204 31 California Institute of Technology, Pasadena, CA 91125, USA
    Trends Neurosci 28:37-43. 2005
    ....
  39. pmc Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5
    Xiao Feng Qin
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Proc Natl Acad Sci U S A 100:183-8. 2003
    ..Thus, our studies demonstrate the feasibility and potential of lentiviral vector-mediated delivery of siRNAs as a general means of intracellular immunization for the treatment of HIV-1 and other viral diseases...
  40. pmc Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells
    Francesca Giannoni
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, USA
    Mol Ther 21:1044-54. 2013
    ..In summary, we demonstrated the feasibility of engineering human HSPC to express a tumor-specific TCR to serve as a long-term source of tumor-targeted mature T cells for immunotherapy of melanoma...
  41. pmc Targeting lentiviral vectors to specific cell types in vivo
    Lili Yang
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:11479-84. 2006
    ..The only requirement is that the antibody (or other binding protein) must be endocytosed after interaction with its cell surface-binding determinant...
  42. doi request reprint Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylation
    Parameswaran Ramakrishnan
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Sci Signal 6:ra75. 2013
    ..Our findings suggest a stimulus-specific role for hyperglycemia-induced O-GlcNAcylation of c-Rel in promoting T cell-mediated autoimmunity in conditions such as type 1 diabetes by enhancing the production of T helper cell cytokines. ..
  43. ncbi request reprint MicroRNAs and immunity: tiny players in a big field
    Konstantin D Taganov
    Division of Biology, California Institute of Technology, 1200 East California Blvd, Pasadena, CA 91125, USA
    Immunity 26:133-7. 2007
    ..Here, Taganov et al. discuss the role of miRNAs in the innate immune response to microbial infection...
  44. ncbi request reprint NF-kappa B functions in synaptic signaling and behavior
    Mollie K Meffert
    Division of Biology, MC204 31 California Institute of Technology, Pasadena, California 91125, USA
    Nat Neurosci 6:1072-8. 2003
    ..These observations suggest that long-term changes to adult neuronal function caused by synaptic stimulation can be regulated by NF-kappa B nuclear translocation and gene activation...
  45. pmc The Yin and Yang of microRNAs: leukemia and immunity
    Alex Yick Lun So
    Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Immunol Rev 253:129-45. 2013
    ....
  46. pmc RNA splicing regulates the temporal order of TNF-induced gene expression
    Shengli Hao
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 110:11934-9. 2013
    ..We also examined the elongation times, concluding that pre-mRNA synthesis is coordinate but splicing differences directly regulate the timing of mRNA production. ..
  47. pmc MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice
    Jimmy L Zhao
    Department of Biology, California Institute of Technology, Pasadena, United States
    elife 2:e00537. 2013
    ..DOI:http://dx.doi.org/10.7554/eLife.00537.001...
  48. pmc Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
    Eric J Brown
    California Institute of Technology, Pasadena, California 91125, USA
    Genes Dev 17:615-28. 2003
    ..When DNA replication inhibitors are removed, ATR knockout cells proceed to mitosis but do so with chromosome breaks, indicating that ATR provides a key genome maintenance function in S phase...
  49. pmc CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex
    Joel L Pomerantz
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 21:5184-94. 2002
    ..These results implicate CARD11 in factor- specific activation of NF-kappaB by the TCR complex and establish a role for a MAGUK family member in antigen receptor signaling...
  50. doi request reprint Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis
    Jimmy L Zhao
    Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA Electronic address
    Cell Stem Cell 14:445-59. 2014
    ..This study has uncovered an important property of HSPCs that enables them to convert danger signals into versatile cytokine signals for the regulation of stress hematopoiesis. ..
  51. pmc Permissive secondary mutations enable the evolution of influenza oseltamivir resistance
    Jesse D Bloom
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 328:1272-5. 2010
    ..An understanding of this process may provide a basis for predicting the evolution of oseltamivir resistance in other influenza strains...
  52. ncbi request reprint Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors
    Carlos Lois
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 295:868-72. 2002
    ..We have also generated transgenic rats that express GFP at high levels, suggesting that this technique can be used to produce other transgenic animal species...
  53. doi request reprint As good as it gets? The problem of HIV persistence despite antiretroviral drugs
    Alex Sigal
    Division of Biology, California Institute of Technology, Pasadena, 91125, USA
    Cell Host Microbe 12:132-8. 2012
    ..We discuss some of the possible reasons why HIV persists at different points on the infection timeline, focusing on the role ongoing replication may have in maintaining the infection despite drugs at early times postexposure...
  54. pmc Homeostatic cytokines orchestrate the segregation of CD4 and CD8 memory T-cell reservoirs in mice
    Lili Yang
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    Blood 118:3039-50. 2011
    ..IL-15 plays a major role in vivo regulating CD8 T(M)s homing to PLNs. Thus, the reservoir segregation of CD4 and CD8 T(M)s meets their individual needs for homeostatic cytokines and is under feedback control of cytokine stimulation...
  55. ncbi request reprint Two pathways to NF-kappaB
    Joel L Pomerantz
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell 10:693-5. 2002
    ..Four recent papers provide physiological roles for this pathway and expand our understanding of lymphoid development and organogenesis with potential applications in the treatment of autoimmune disease...
  56. doi request reprint Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
    Alex Sigal
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 477:95-8. 2011
    ....
  57. ncbi request reprint Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides
    Nicholas R Wurtz
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 41:7604-9. 2002
    ..Addition of NF-kappa B to the list of protein-DNA complexes that can be disrupted by minor groove binding ligands potentially increases the utility of polyamides as regulators of gene expression...
  58. ncbi request reprint Presidential address. A global perspective on science and technology
    David Baltimore
    California Institute of Technology, USA
    Science 322:544-51. 2008
  59. ncbi request reprint Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation
    Matthew Inlay
    Section of Molecular Biology, Division of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0322, USA
    Nat Immunol 3:463-8. 2002
    ..Our findings also indicate that the two kappa enhancers play overlapping and distinct roles in the demethylation of kappa in B cells...
  60. pmc Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor
    Parameswaran Ramakrishnan
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell 43:167-79. 2011
    ....
  61. pmc Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs
    Elizabeth Alcamo
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Exp Med 195:233-44. 2002
    ....
  62. pmc Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes
    Hajir Dadgostar
    Molecular Biology Institute and Medical Scientist Training Program, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:1497-502. 2002
    ....
  63. pmc The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells
    Thomas Pohl
    The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 99:4514-9. 2002
    ..These findings demonstrate that in the B lineage overlapping roles for NF-kappaB1 and c-Rel appear to be restricted to regulating the activation and function of mature cells...
  64. pmc Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways
    Brian Zarnegar
    Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:8108-13. 2004
    ..Overall, our studies suggest that both type 1 and type 2 NF-kappaB pathways contribute to the gene expression and biological program unique for CD40 in B cell activation...
  65. ncbi request reprint Essential role for STAT5 signaling in CD25+CD4+ regulatory T cell homeostasis and the maintenance of self-tolerance
    Andrey Antov
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Immunol 171:3435-41. 2003
    ..Furthermore, transient activation of STAT5 is sufficient to increase CD25(+)CD4(+) T reg numbers in IL-2-deficient mice. Our study uncovers an essential role for STAT5 in maintaining CD25(+)CD4(+) T reg homeostasis and self-tolerance...
  66. ncbi request reprint Circuitry of nuclear factor kappaB signaling
    Alexander Hoffmann
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Immunol Rev 210:171-86. 2006
    ..Understanding the genetic regulatory circuitry of NF-kappaB functionalities involves system-wide measurements, biophysical studies, and computational modeling...
  67. pmc Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20
    Shannon L Werner
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 22:2093-101. 2008
    ..Our results delineate the nonredundant functions implied by the knockout phenotypes of ikappabalpha and a20, and identify the latter as a signaling cross-talk mediator controlling inflammatory and developmental responses...

Research Grants33

  1. NF-kappaB: Orchestration of the Inflammatory Response
    David Baltimore; Fiscal Year: 2010
    ..abstract_text> ..
  2. MOLECULAR BIOLOGY OF LYMPHOCYTE AND NEURONAL GROWTH
    David Baltimore; Fiscal Year: 2007
    ..Here we have made only minimal progress thus far but we outline a variety of methods of attack using genomic and proteomic tools. ..
  3. LEUKEMOGENESIS BY ABL AND OTHER ONCOGENES
    David Baltimore; Fiscal Year: 2004
    ..These studies are all aimed at a deeper understanding of both the processes of oncogenic transformation and the normal development and function of mammals. ..
  4. Molecular Biology Of Lymphocyte & Neuronal Growth
    David Baltimore; Fiscal Year: 2004
    ..We will focus here on the role of the IL-2 receptor and the molecules by which it sends intracellular signals. ..
  5. Inhibition of HIV by Lentivector-encoded Interfering RNA
    David Baltimore; Fiscal Year: 2005
    ..These too will have to be optimized. Then the vectors must be tested in human T cells in culture. Ultimately, their safety and efficacy in humans will have to be investigated. ..
  6. HIV INDUCED CELLULAR PATHOLOGY
    David Baltimore; Fiscal Year: 2007
    ..For this we will use a novel screening methodology to find and ultimately characterize new proteins that lead to transcription of the HIV genome. ..
  7. MicroRNA Function in the Immune System
    David Baltimore; Fiscal Year: 2010
    ..Our group has found that a small number of miRNAs are potently induced by the innate immune response to infection, and therefore propose to characterize the roles of these miRNAs in host defense against infection and tumorigenesis ..
  8. MOLECULAR BIOLOGY OF LYMPHOCYTE AND NEURONAL GROWTH
    David Baltimore; Fiscal Year: 2000
    ..It will be applied particularly to analyzing the role of the NF-KB transcription factor in nervous system signaling. ..
  9. HIV INDUCED CELLULAR PATHOLOGY
    David Baltimore; Fiscal Year: 2002
    ..The role of Nef in down regulating MHC class I expression will be assessed using techniques that allow characterization by flow cytometric analysis of events in primary and cultured cells with high-titered mutant or wild-type viruses. ..
  10. LEUKEMOGENESIS BY AB1 AND OTHER ONCOGENES
    David Baltimore; Fiscal Year: 1999
    ..These studies can be expected to shed light on the causation of human chronic myelogenous leukemia by Bcr-Abl and on the general issues of the role of protein tyrosine kinases as signaling molecules in normal and tumor cells. ..