Giuseppe Attardi

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity
    Jordi Asin-Cayuela
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 279:15670-7. 2004
  2. ncbi request reprint Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians
    Nahoko Iwata
    Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Mitochondrion 7:267-72. 2007
  3. ncbi request reprint Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesis
    Jennifer Fish
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 306:2098-101. 2004
  4. ncbi request reprint Polarographic assays of respiratory chain complex activity
    Gaetano Villani
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Methods Cell Biol 80:121-33. 2007
  5. ncbi request reprint Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2
    Petr Hajek
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 282:5670-81. 2007
  6. ncbi request reprint MtDNA mutations in aging and apoptosis
    Anne Chomyn
    Division of Biology, 156 29 California Institute of Technology, Pasadena, CA 91125, USA
    Biochem Biophys Res Commun 304:519-29. 2003
  7. ncbi request reprint Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts
    Marilena Greco
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    FASEB J 17:1706-8. 2003
  8. pmc Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant
    David W Walker
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:16382-7. 2006
  9. ncbi request reprint Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis
    Miguel Martin
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 123:1227-40. 2005
  10. pmc Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity
    Ai Chen
    Division of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 7:e46473. 2012

Research Grants

  1. GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATION
    Giuseppe Attardi; Fiscal Year: 2001
  2. HUMAN MITOCHONDRIAL DNA MUTATIONS AND AGING
    Giuseppe Attardi; Fiscal Year: 2002
  3. GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATION
    Giuseppe Attardi; Fiscal Year: 2003
  4. Human Mitochondrial DNA Mutations in Aging
    Giuseppe Attardi; Fiscal Year: 2005
  5. GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATION
    Giuseppe Attardi; Fiscal Year: 1980
  6. GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATION
    Giuseppe Attardi; Fiscal Year: 1993
  7. GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATION
    Giuseppe Attardi; Fiscal Year: 2006

Collaborators

Detail Information

Publications16

  1. ncbi request reprint A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity
    Jordi Asin-Cayuela
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 279:15670-7. 2004
    ..The estimated molecular weight of this complex and the fact that purified mTERF can be eluted from a gel filtration column as a complex of the same molecular weight strongly suggest that this inactive complex is a homotrimer of mTERF...
  2. ncbi request reprint Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians
    Nahoko Iwata
    Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Mitochondrion 7:267-72. 2007
    ..The T152C transition was not associated with a change in the replication origin at position 151, unlike the C150T transition in the Italian centenarians...
  3. ncbi request reprint Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesis
    Jennifer Fish
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 306:2098-101. 2004
    ....
  4. ncbi request reprint Polarographic assays of respiratory chain complex activity
    Gaetano Villani
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Methods Cell Biol 80:121-33. 2007
  5. ncbi request reprint Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2
    Petr Hajek
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 282:5670-81. 2007
    ..Knockdown of Stoml2 by the short interfering RNA approach showed a reduction of the mitochondrial membrane potential, without, however, any obvious changes in mitochondrial morphology...
  6. ncbi request reprint MtDNA mutations in aging and apoptosis
    Anne Chomyn
    Division of Biology, 156 29 California Institute of Technology, Pasadena, CA 91125, USA
    Biochem Biophys Res Commun 304:519-29. 2003
    ....
  7. ncbi request reprint Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts
    Marilena Greco
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    FASEB J 17:1706-8. 2003
    ..These observations have important implications for understanding the biology of aging, as well as the pathogenesis of aging-related degenerative diseases...
  8. pmc Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant
    David W Walker
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:16382-7. 2006
    ....
  9. ncbi request reprint Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis
    Miguel Martin
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 123:1227-40. 2005
    ..These results strongly suggest that, to satisfy the need for high rate of rDNA transcription, human mitochondrial rRNA synthesis involves mTERF-mediated rDNA looping that promotes recycling of the transcription machinery...
  10. pmc Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity
    Ai Chen
    Division of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 7:e46473. 2012
    ..Of further interest, we found that cybrids with the U3a haplogroup exhibited a higher respiration rate than the other cybrids examined...
  11. pmc Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes
    Jin Zhang
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 100:1116-21. 2003
    ....
  12. ncbi request reprint Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology
    Stéphane Duvezin-Caubet
    Adolf Butenandt Institut für Physiologische Chemie, Ludwig Maximilians Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
    J Biol Chem 281:37972-9. 2006
    ..We present the hypothesis that this pathway regulates mitochondrial morphology and serves as an early response to prevent fusion of dysfunctional mitochondria with the functional mitochondrial network...
  13. ncbi request reprint Genetic and functional analysis of mitochondrial DNA-encoded complex I genes
    Yidong Bai
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Ann N Y Acad Sci 1011:272-83. 2004
    ..In particular, in these transfected cells, the yeast enzyme becomes integrated into the human respiratory chain and fully restores the capacity of the cells to grow in galactose medium...
  14. ncbi request reprint Nuclear control of cloverleaf structure of human mitochondrial tRNA(Lys)
    Mark Helm
    Institut für Pharmazie und Molekulare Biotechnologie Abteilung Chemie, Im Neuenheimer Feld 364 D 69120 Heidelberg, Germany
    J Mol Biol 337:545-60. 2004
    ..Thus, countering the evolutionary loss of structural information in mt-tRNA genes, the mt-tRNA structure is maintained by a modification enzyme encoded in nuclear DNA...
  15. ncbi request reprint Screening for aging-dependent point mutations in mtDNA
    Yuichi Michikawa
    Frontier Research Center, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Methods Mol Biol 197:75-92. 2002
  16. ncbi request reprint Inter-mitochondrial complementation of mtDNA mutations and nuclear context
    Giuseppe Attardi
    Nat Genet 30:360; author reply 361. 2002

Research Grants39

  1. GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATION
    Giuseppe Attardi; Fiscal Year: 2001
    ....
  2. HUMAN MITOCHONDRIAL DNA MUTATIONS AND AGING
    Giuseppe Attardi; Fiscal Year: 2002
    ..abstract_text> ..
  3. GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATION
    Giuseppe Attardi; Fiscal Year: 2003
    ..Furthermore, it is expected that this work will provide important insights into the regulation of mitochondrial gene expression and into fundamental features of mitochondrial genetics in mammalian cells. ..
  4. Human Mitochondrial DNA Mutations in Aging
    Giuseppe Attardi; Fiscal Year: 2005
    ..The achievements of the above aims will have important implications for understanding the role of these novel mtDNA mutations in aging, as well as their possible involvement in aging-related degenerative diseases. ..
  5. GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATION
    Giuseppe Attardi; Fiscal Year: 1980
    ..Furthermore, recently isolated variants of the human cell line VA2-B with altered mitochondrial function will be analyzed as to the site of the mutation and to the nature of the alteration, and additional mutants will be isolated. ..
  6. GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATION
    Giuseppe Attardi; Fiscal Year: 1993
    ..Furthermore, the possibility of introducing new mitochondrial genes into a cell opens exciting prospects for diagnosis and cure of genetic defects of mitochondrial DNA...
  7. GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATION
    Giuseppe Attardi; Fiscal Year: 2006
    ..Furthermore, it is expected that this work will provide important insights into the regulation of mitochondrial gene expression and into fundamental features of mitochondrial genetics in mammalian cells. ..