Research Topics
Genomes and Genes | Giuseppe AttardiSummaryAffiliation: California Institute of Technology Country: USA Publications
Research Grants
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Detail Information
Publications
A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activityJordi Asin-Cayuela
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
J Biol Chem 279:15670-7. 2004..The estimated molecular weight of this complex and the fact that purified mTERF can be eluted from a gel filtration column as a complex of the same molecular weight strongly suggest that this inactive complex is a homotrimer of mTERF...- Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenariansNahoko Iwata
Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
Mitochondrion 7:267-72. 2007..The T152C transition was not associated with a change in the replication origin at position 151, unlike the C150T transition in the Italian centenarians... - Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesisJennifer Fish
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Science 306:2098-101. 2004.... - Polarographic assays of respiratory chain complex activityGaetano Villani
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Methods Cell Biol 80:121-33. 2007 - Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2Petr Hajek
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
J Biol Chem 282:5670-81. 2007..Knockdown of Stoml2 by the short interfering RNA approach showed a reduction of the mitochondrial membrane potential, without, however, any obvious changes in mitochondrial morphology... - MtDNA mutations in aging and apoptosisAnne Chomyn
Division of Biology, 156-29 California Institute of Technology, Pasadena, CA 91125, USA
Biochem Biophys Res Commun 304:519-29. 2003.... - Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblastsMarilena Greco
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
FASEB J 17:1706-8. 2003..These observations have important implications for understanding the biology of aging, as well as the pathogenesis of aging-related degenerative diseases... 
Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutantDavid W Walker
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 103:16382-7. 2006....- Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesisMiguel Martin
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Cell 123:1227-40. 2005..These results strongly suggest that, to satisfy the need for high rate of rDNA transcription, human mitochondrial rRNA synthesis involves mTERF-mediated rDNA looping that promotes recycling of the transcription machinery... - Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevityAi Chen
Division of Biology, California Institute of Technology, Pasadena, California, United States of America
PLoS ONE 7:e46473. 2012..Of further interest, we found that cybrids with the U3a haplogroup exhibited a higher respiration rate than the other cybrids examined... - Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytesJin Zhang
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 100:1116-21. 2003.... - Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphologyStéphane Duvezin-Caubet
Adolf Butenandt Institut für Physiologische Chemie, Ludwig Maximilians Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
J Biol Chem 281:37972-9. 2006..We present the hypothesis that this pathway regulates mitochondrial morphology and serves as an early response to prevent fusion of dysfunctional mitochondria with the functional mitochondrial network... - Genetic and functional analysis of mitochondrial DNA-encoded complex I genesYidong Bai
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Ann N Y Acad Sci 1011:272-83. 2004..In particular, in these transfected cells, the yeast enzyme becomes integrated into the human respiratory chain and fully restores the capacity of the cells to grow in galactose medium... - Nuclear control of cloverleaf structure of human mitochondrial tRNA(Lys)Mark Helm
, Im Neuenheimer Feld 364 D-69120 Heidelberg, Germany
J Mol Biol 337:545-60. 2004..Thus, countering the evolutionary loss of structural information in mt-tRNA genes, the mt-tRNA structure is maintained by a modification enzyme encoded in nuclear DNA... - Screening for aging-dependent point mutations in mtDNAYuichi Michikawa
Frontier Research Center, National Institute of Radiological Sciences, Inage, Chiba, Japan
Methods Mol Biol 197:75-92. 2002 - Inter-mitochondrial complementation of mtDNA mutations and nuclear contextGiuseppe Attardi
Nat Genet 30:360; author reply 361. 2002
Research Grants
- GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATIONGiuseppe Attardi; Fiscal Year: 2001....
- HUMAN MITOCHONDRIAL DNA MUTATIONS AND AGINGGiuseppe Attardi; Fiscal Year: 2002..abstract_text> ..
- GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATIONGiuseppe Attardi; Fiscal Year: 2003..Furthermore, it is expected that this work will provide important insights into the regulation of mitochondrial gene expression and into fundamental features of mitochondrial genetics in mammalian cells. ..
- Human Mitochondrial DNA Mutations in AgingGiuseppe Attardi; Fiscal Year: 2005..The achievements of the above aims will have important implications for understanding the role of these novel mtDNA mutations in aging, as well as their possible involvement in aging-related degenerative diseases. ..
- GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATIONGiuseppe Attardi; Fiscal Year: 1980..Furthermore, recently isolated variants of the human cell line VA2-B with altered mitochondrial function will be analyzed as to the site of the mutation and to the nature of the alteration, and additional mutants will be isolated. ..
- GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATIONGiuseppe Attardi; Fiscal Year: 1993..Furthermore, the possibility of introducing new mitochondrial genes into a cell opens exciting prospects for diagnosis and cure of genetic defects of mitochondrial DNA...
- GENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATIONGiuseppe Attardi; Fiscal Year: 2006..Furthermore, it is expected that this work will provide important insights into the regulation of mitochondrial gene expression and into fundamental features of mitochondrial genetics in mammalian cells. ..