Ralph Adolphs

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Preferring one taste over another without recognizing either
    Ralph Adolphs
    Department of Neurology and Neuroscience Graduate Program, The University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    Nat Neurosci 8:860-1. 2005
  2. pmc Reward processing in autism: a thematic series
    GABRIEL DICHTER
    Department of Psychiatry and the Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, USA
    J Neurodev Disord 4:20. 2012
  3. pmc The biology of fear
    Ralph Adolphs
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Biol 23:R79-93. 2013
  4. pmc Reduced social preferences in autism: evidence from charitable donations
    Alice Lin
    California Institute of Technology, Pasadena, CA, USA
    J Neurodev Disord 4:8. 2012
  5. pmc Changes in cortical morphology resulting from long-term amygdala damage
    Aaron D Boes
    Department of Pediatric Neurology, Massachusetts General Hospital, Harvard University, USA
    Soc Cogn Affect Neurosci 7:588-95. 2012
  6. pmc What does the amygdala contribute to social cognition?
    Ralph Adolphs
    California Institute of Technology, Pasadena, California 91125, USA
    Ann N Y Acad Sci 1191:42-61. 2010
  7. ncbi request reprint Amygdala damage impairs emotional memory for gist but not details of complex stimuli
    Ralph Adolphs
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
    Nat Neurosci 8:512-8. 2005
  8. pmc Fear, faces, and the human amygdala
    Ralph Adolphs
    Caltech, Pasadena, CA 91125, USA
    Curr Opin Neurobiol 18:166-72. 2008
  9. ncbi request reprint A mechanism for impaired fear recognition after amygdala damage
    Ralph Adolphs
    Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
    Nature 433:68-72. 2005
  10. ncbi request reprint Role of the amygdala in processing visual social stimuli
    Ralph Adolphs
    Division of the Humanities and Social Sciences, HSS 228 77, California Institute of Technology, Pasadena, CA 91125, USA
    Prog Brain Res 156:363-78. 2006

Research Grants

Detail Information

Publications89

  1. ncbi request reprint Preferring one taste over another without recognizing either
    Ralph Adolphs
    Department of Neurology and Neuroscience Graduate Program, The University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    Nat Neurosci 8:860-1. 2005
    ..The pattern of brain damage responsible for the dissociation suggests that reliable behavioral choice among tastes can occur in the absence of the gustatory cortex necessary for taste recognition...
  2. pmc Reward processing in autism: a thematic series
    GABRIEL DICHTER
    Department of Psychiatry and the Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, USA
    J Neurodev Disord 4:20. 2012
    ..Our hope is that this novel framework may further elucidate autism pathophysiology, with the ultimate goal of yielding novel insights with potential therapeutic implications...
  3. pmc The biology of fear
    Ralph Adolphs
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Biol 23:R79-93. 2013
    ..Finally, we should aim even to incorporate the conscious experience of being afraid, reinvigorating the study of feelings across species...
  4. pmc Reduced social preferences in autism: evidence from charitable donations
    Alice Lin
    California Institute of Technology, Pasadena, CA, USA
    J Neurodev Disord 4:8. 2012
    ..abstract:..
  5. pmc Changes in cortical morphology resulting from long-term amygdala damage
    Aaron D Boes
    Department of Pediatric Neurology, Massachusetts General Hospital, Harvard University, USA
    Soc Cogn Affect Neurosci 7:588-95. 2012
    ....
  6. pmc What does the amygdala contribute to social cognition?
    Ralph Adolphs
    California Institute of Technology, Pasadena, California 91125, USA
    Ann N Y Acad Sci 1191:42-61. 2010
    ..These aspects help to clarify the amygdala's contributions to recognizing emotion from faces, to social behavior toward conspecifics, and to reward learning and instrumental behavior...
  7. ncbi request reprint Amygdala damage impairs emotional memory for gist but not details of complex stimuli
    Ralph Adolphs
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
    Nat Neurosci 8:512-8. 2005
    ..The data support a model whereby the amygdala focuses processing resources on gist, possibly accounting for features of traumatic memories and eyewitness testimony in real life...
  8. pmc Fear, faces, and the human amygdala
    Ralph Adolphs
    Caltech, Pasadena, CA 91125, USA
    Curr Opin Neurobiol 18:166-72. 2008
    ..A large current research effort extends the amygdala's putative role to a number of psychiatric illnesses...
  9. ncbi request reprint A mechanism for impaired fear recognition after amygdala damage
    Ralph Adolphs
    Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
    Nature 433:68-72. 2005
    ..This finding provides a mechanism to explain the amygdala's role in fear recognition, and points to new approaches for the possible rehabilitation of patients with defective emotion perception...
  10. ncbi request reprint Role of the amygdala in processing visual social stimuli
    Ralph Adolphs
    Division of the Humanities and Social Sciences, HSS 228 77, California Institute of Technology, Pasadena, CA 91125, USA
    Prog Brain Res 156:363-78. 2006
    ..Finally, we argue that the term emotion be broadened to include increased attention to bodily responses and their representation in cortex...
  11. ncbi request reprint How do we know the minds of others? Domain-specificity, simulation, and enactive social cognition
    Ralph Adolphs
    Division of Humanities and Social Sciences, California Institute of Technology, HSS 228 77, Caltech, Pasadena, CA 91125, USA
    Brain Res 1079:25-35. 2006
    ..Experiments from our own laboratory point to the amygdala as one structure that is critically involved in such processes...
  12. ncbi request reprint Impaired judgments of sadness but not happiness following bilateral amygdala damage
    Ralph Adolphs
    University of Iowa, Iowa, USA
    J Cogn Neurosci 16:453-62. 2004
    ..The findings suggest that the amygdala's role in processing of emotional facial expressions encompasses multiple negatively valenced emotions, including fear and sadness...
  13. pmc Manifestation of ocular-muscle EMG contamination in human intracranial recordings
    Christopher K Kovach
    Department of Neurosurgery, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Neuroimage 54:213-33. 2011
    ..We conclude that eye movement-related contamination should be ruled out when reporting high gamma responses in human intracranial recordings, especially those obtained near anterior and medial temporal lobe...
  14. pmc Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex
    Jan Gläscher
    Division of Humanities and Social Sciences and Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 109:14681-6. 2012
    ..By contrast, regions in the ventral PFC were required for decision-making. These findings provide detailed causal evidence for a remarkable functional-anatomical specificity in the human PFC...
  15. pmc Anterior prefrontal cortex contributes to action selection through tracking of recent reward trends
    Christopher K Kovach
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 32:8434-42. 2012
    ....
  16. pmc Decoding face information in time, frequency and space from direct intracranial recordings of the human brain
    Naotsugu Tsuchiya
    Division of Humanities and Social Sciences, Caltech, Pasadena, California, United States of America
    PLoS ONE 3:e3892. 2008
    ....
  17. ncbi request reprint Neural systems for recognition of emotional prosody: a 3-D lesion study
    Ralph Adolphs
    Department of Neurology, University of Iowa College of Medicine, Iowa City 52242, USA
    Emotion 2:23-51. 2002
    ..Furthermore, there were regions in the left and right temporal lobes that contributed disproportionately to recognition of emotion from faces or prosody, respectively...
  18. pmc Personal space regulation by the human amygdala
    Daniel P Kennedy
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California, USA
    Nat Neurosci 12:1226-7. 2009
    ..The amygdala may be required to trigger the strong emotional reactions normally following personal space violations, thus regulating interpersonal distance in humans...
  19. pmc Lesion mapping of cognitive abilities linked to intelligence
    Jan Gläscher
    Division of Humanities and Social Sciences, Caltech, Pasadena, CA 91125, USA
    Neuron 61:681-91. 2009
    ..Our findings provide comprehensive lesion maps of intelligence factors, and make specific recommendations for interpretation and application of the WAIS to the study of intelligence in health and disease...
  20. pmc Intact rapid detection of fearful faces in the absence of the amygdala
    Naotsugu Tsuchiya
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California, USA
    Nat Neurosci 12:1224-5. 2009
    ..We conclude that the amygdala is not essential for early stages of fear processing but, instead, modulates recognition and social judgment...
  21. pmc Damage to association fiber tracts impairs recognition of the facial expression of emotion
    Carissa L Philippi
    Laboratory of Brain Imaging and Cognitive Neuroscience, Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Neurosci 29:15089-99. 2009
    ..Our findings demonstrate the key role of white matter association tracts in the recognition of the facial expression of emotion and identify specific tracts that may be most critical...
  22. ncbi request reprint Abnormal use of facial information in high-functioning autism
    Michael L Spezio
    Division of Humanities and Social Sciences, 228 77, California Institute of Technology, Caltech, Pasadena, CA 91125, USA
    J Autism Dev Disord 37:929-39. 2007
    ..These findings provide a novel quantitative assessment of how people with autism utilize information in faces when making social judgments...
  23. pmc Damage to the prefrontal cortex increases utilitarian moral judgements
    Michael Koenigs
    Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Nature 446:908-11. 2007
    ..These findings indicate that, for a selective set of moral dilemmas, the VMPC is critical for normal judgements of right and wrong. The findings support a necessary role for emotion in the generation of those judgements...
  24. ncbi request reprint Memories for emotional autobiographical events following unilateral damage to medial temporal lobe
    Tony W Buchanan
    Division of Cognitive Neuroscience, Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
    Brain 129:115-27. 2006
    ..This finding is consistent with the notion that the right, but not the left, anteromedial temporal lobe is involved in the retrieval of negatively valenced, high-intensity memories...
  25. ncbi request reprint Emotional arousal in agenesis of the corpus callosum
    Lynn K Paul
    California Institute of Technology, Division of Humanities and Social Sciences, CA 91125, USA
    Int J Psychophysiol 61:47-56. 2006
    ....
  26. pmc Detestable or marvelous? Neuroanatomical correlates of character judgments
    Katie E Croft
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, IA, USA
    Neuropsychologia 48:1789-801. 2010
    ....
  27. pmc Economic games quantify diminished sense of guilt in patients with damage to the prefrontal cortex
    Ian Krajbich
    Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 29:2188-92. 2009
    ..Instead, the findings argue for a specific insensitivity to guilt, an abnormality that we suggest characterizes a key contribution made by the VMPFC to social behavior...
  28. pmc Social and monetary reward learning engage overlapping neural substrates
    Alice Lin
    California Institute of Technology, Computations and Neural Systems, MC 136 93 Pasadena, CA 91125 7700, USA
    Soc Cogn Affect Neurosci 7:274-81. 2012
    ..Taken together, the findings support the hypothesis that shared anatomical substrates are involved in the computation of both monetary and social rewards...
  29. ncbi request reprint Dominance attributions following damage to the ventromedial prefrontal cortex
    Matthew S Karafin
    University of Iowa, USA
    J Cogn Neurosci 16:1796-804. 2004
    ....
  30. ncbi request reprint Emotional autobiographical memories in amnesic patients with medial temporal lobe damage
    Tony W Buchanan
    Division of Cognitive Neuroscience, Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 25:3151-60. 2005
    ..The amygdala and surrounding cortices of the medial temporal lobe may be a necessary component in the neural circuitry necessary for vivid recollection of unpleasant emotional events...
  31. pmc Insensitivity to social reputation in autism
    Keise Izuma
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 108:17302-7. 2011
    ..The results argue that people with autism lack the ability to take into consideration what others think of them and provide further support for specialized neural systems mediating the effects of social reputation...
  32. pmc A category-specific response to animals in the right human amygdala
    Florian Mormann
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Nat Neurosci 14:1247-9. 2011
    ..This selectivity appeared to be independent of emotional valence or arousal and may reflect the importance that animals held throughout our evolutionary past...
  33. doi request reprint Single-neuron correlates of atypical face processing in autism
    Ueli Rutishauser
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA Computation and Neural Systems Program, California Institute of Technology, Pasadena, CA 91125, USA Electronic address
    Neuron 80:887-99. 2013
    ....
  34. ncbi request reprint Contributions of the amygdala to reward expectancy and choice signals in human prefrontal cortex
    Alan N Hampton
    Computation and Neural Systems Program, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 55:545-55. 2007
    ..These findings support a critical role for the human amygdala in establishing expected reward representations in PFC, which in turn may be used to guide behavioral choice...
  35. pmc A neuroanatomical dissociation for emotion induced by music
    Erica L Johnsen
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Int J Psychophysiol 72:24-33. 2009
    ..The findings provide evidence for a double dissociation between feeling emotions and autonomic responses to emotions, in response to music stimuli...
  36. pmc Distinct face-processing strategies in parents of autistic children
    Ralph Adolphs
    California Institute of Technology, Pasadena, California 91125, USA
    Curr Biol 18:1090-3. 2008
    ....
  37. ncbi request reprint Anteromedial temporal lobe damage blocks startle modulation by fear and disgust
    Tony W Buchanan
    Division of Cognitive Neuroscience, Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
    Behav Neurosci 118:429-37. 2004
    ..The findings suggest that potentiation of the ASR by disgust and fear depends on the integrity of the anteromedial temporal lobe...
  38. ncbi request reprint Cortical regions for judgments of emotions and personality traits from point-light walkers
    Andrea S Heberlein
    University of Iowa, USA
    J Cogn Neurosci 16:1143-58. 2004
    ..These findings suggest that attributions of emotional states and personality traits are accomplished by partially dissociable neural systems...
  39. pmc Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex
    Hiroyuki Oya
    Department of Neurosurgery and Neurology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 102:8351-6. 2005
    ..The finding implicates this brain region in the acquisition of choice bias by means of a continuous updating of expectations about reward and punishment...
  40. pmc Orienting to social stimuli differentiates social cognitive impairment in autism and schizophrenia
    Noah Sasson
    University of North Carolina at Chapel Hill, Neurodevelopmental Disorders Research Center, Chapel Hill, NC 27599 3366, USA
    Neuropsychologia 45:2580-8. 2007
    ..Impairments in social orienting are discussed within the context of evidence suggesting the role of the amygdala in orienting to emotionally meaningful information...
  41. pmc The social brain: neural basis of social knowledge
    Ralph Adolphs
    California Institute of Technology Caltech, Pasadena, California 91125, USA
    Annu Rev Psychol 60:693-716. 2009
    ..Here I provide a broad survey of the key abilities, processes, and ways in which to relate these to data from cognitive neuroscience...
  42. pmc Impaired fixation to eyes following amygdala damage arises from abnormal bottom-up attention
    Daniel P Kennedy
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Neuropsychologia 48:3392-8. 2010
    ....
  43. ncbi request reprint Looking at other people: mechanisms for social perception revealed in subjects with focal amygdala damage
    Ralph Adolphs
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Novartis Found Symp 278:146-59; discussion 160-4, 216-21. 2007
    ..Ongoing studies in our laboratory examine face-to-face social interactions with real people in an attempt to link the above impairments in the laboratory to the dysfunctional social cognition seen in everyday life...
  44. pmc The behavioral and neural mechanisms underlying the tracking of expertise
    Erie D Boorman
    Department of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK Electronic address
    Neuron 80:1558-71. 2013
    ..Moreover, activity in lateral orbitofrontal and medial prefrontal cortex reflected behavioral differences in learning about people and algorithms. These findings provide basic insights into the neural basis of social learning. ..
  45. pmc Social manipulation of preference in the human brain
    Keise Izuma
    Division of Humanities and Social Sciences, California Institute of Technology, 1200 E California Boulevard, Pasadena, CA 91125, USA
    Neuron 78:563-73. 2013
    ..A single social encounter can thus result in long-lasting preference change, a mechanism that recruits dmPFC and that may reflect the aversive nature of cognitive imbalance...
  46. pmc Dynamic construction of stimulus values in the ventromedial prefrontal cortex
    Alison Harris
    Humanities and Social Sciences, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 6:e21074. 2011
    ....
  47. ncbi request reprint Analysis of face gaze in autism using "Bubbles"
    Michael L Spezio
    Division of Humanities and Social Sciences, California Institute of Technology, HSS 228 77, Caltech, Pasadena, CA 91125, USA
    Neuropsychologia 45:144-51. 2007
    ..The findings provide novel detail to the abnormal way in which people with autism look at faces, an impairment that likely influences all subsequent face processing...
  48. ncbi request reprint The influence of autonomic arousal and semantic relatedness on memory for emotional words
    Tony W Buchanan
    Department of Neurology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Int J Psychophysiol 61:26-33. 2006
    ..Relatedness confers an advantage to memory (as in the school-words), but the combination of relatedness and arousal (as in the taboo words) results in the best memory performance...
  49. ncbi request reprint Impaired recognition of social emotions following amygdala damage
    Ralph Adolphs
    Department of Neurology, University of Iowa, Iowa City 52242, USA
    J Cogn Neurosci 14:1264-74. 2002
    ..The results also provide further support for the idea that some of the impairments in social cognition seen in patients with autism may result from dysfunction of the amygdala...
  50. ncbi request reprint Neural systems responding to degrees of uncertainty in human decision-making
    Ming Hsu
    Division of Humanities and Social Sciences, 228 77, California Institute of Technology, Pasadena, CA 91125, USA
    Science 310:1680-3. 2005
    ..Neurological subjects with orbitofrontal lesions were insensitive to the level of ambiguity and risk in behavioral choices. These data suggest a general neural circuit responding to degrees of uncertainty, contrary to decision theory...
  51. ncbi request reprint Evidence for preserved emotional memory in normal older persons
    Natalie L Denburg
    University of Iowa College of Medicine, Department of Neurology, Division of Cognitive Neuroscience, Iowa City, 52242, US
    Emotion 3:239-53. 2003
    ..The results raise the interesting possibility that aging has a differential effect on hippocampal versus amygdala function...
  52. pmc A specific role for the human amygdala in olfactory memory
    Tony W Buchanan
    Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
    Learn Mem 10:319-25. 2003
    ..Taken together, the data provide neuropsychological evidence that the human amygdala is essential for olfactory memory...
  53. pmc Impaired memory retrieval correlates with individual differences in cortisol response but not autonomic response
    Tony W Buchanan
    Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
    Learn Mem 13:382-7. 2006
    ..These results suggest that individual differences in cortisol reactivity affect memory retrieval performance, and help to explain the differential effects of stress on memory...
  54. pmc Spared ability to recognise fear from static and moving whole-body cues following bilateral amygdala damage
    Anthony P Atkinson
    Department of Psychology, Durham University, Science Laboratories, South Road, Durham DH1 3LE, UK
    Neuropsychologia 45:2772-82. 2007
    ..Thus, whatever the role of the amygdala in processing whole-body fear cues, it is apparently not necessary for the normal recognition of fear from either static or dynamic body expressions...
  55. pmc Perception of emotions from facial expressions in high-functioning adults with autism
    Daniel P Kennedy
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, USA
    Neuropsychologia 50:3313-9. 2012
    ..We thus demonstrate a subtle but specific pattern of impairments in facial emotion perception in people with autism...
  56. pmc The social brain in psychiatric and neurological disorders
    Daniel P Kennedy
    California Institute of Technology, 1200 E California Blvd, HSS 228 77, Caltech, Pasadena, CA 91125, USA
    Trends Cogn Sci 16:559-72. 2012
    ..We suggest that the social brain, and its dysfunction and recovery, must be understood not in terms of specific structures, but rather in terms of their interaction in large-scale networks...
  57. pmc Perspective distortion from interpersonal distance is an implicit visual cue for social judgments of faces
    Ronnie Bryan
    Computation and Neural Systems Program, California Institute of Technology, Pasadena, California, United States of America
    PLoS ONE 7:e45301. 2012
    ..These results demonstrate a novel facial cue influencing a range of social judgments as a function of interpersonal distance, an effect that may be processed implicitly...
  58. pmc Becoming a better person: temporal remoteness biases autobiographical memories for moral events
    Jessica R Escobedo
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Emotion 10:511-8. 2010
    ..The effect was independent of chronological age, ethnicity, gender or personality, arguing for a general emotional bias in how we construct our moral autobiography...
  59. pmc The human amygdala and the induction and experience of fear
    Justin S Feinstein
    University of Iowa, Iowa City, IA 52242, USA
    Curr Biol 21:34-8. 2011
    ..The findings support the conclusion that the human amygdala plays a pivotal role in triggering a state of fear and that the absence of such a state precludes the experience of fear itself...
  60. pmc Conceptual challenges and directions for social neuroscience
    Ralph Adolphs
    California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 65:752-67. 2010
    ..It may well be that social neuroscience in the near future will give us an entirely new view of who we are, how we evolved, and what might be in store for the future of our species...
  61. pmc Intact bilateral resting-state networks in the absence of the corpus callosum
    J Michael Tyszka
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 31:15154-62. 2011
    ..The results argue that a normal complement of resting-state networks and intact functional coupling between the hemispheres can emerge in the absence of the corpus callosum, favoring the second over the first possibility listed above...
  62. ncbi request reprint Altered experience of emotion following bilateral amygdala damage
    Daniel Tranel
    University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Cogn Neuropsychiatry 11:219-32. 2006
    ..Bauman, Lavenex, Mason, Capitanio, & Amaral, 2004a), and they provide valuable insights into the emotional life of an individual with complete bilateral amygdala damage...
  63. ncbi request reprint Is the human amygdala specialized for processing social information?
    Ralph Adolphs
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Ann N Y Acad Sci 985:326-40. 2003
    ..While the issue is unresolved, future experiments could provide additional support...
  64. ncbi request reprint Electrophysiological responses in the human amygdala discriminate emotion categories of complex visual stimuli
    Hiroyuki Oya
    Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Neurosci 22:9502-12. 2002
    ....
  65. ncbi request reprint Cognitive neuroscience of human social behaviour
    Ralph Adolphs
    Deparment of Neurology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    Nat Rev Neurosci 4:165-78. 2003
    ..No less important are the links that are also being established across disciplines to understand social behaviour, as neuroscientists, social psychologists, anthropologists, ethologists and philosophers forge new collaborations...
  66. ncbi request reprint Amygdala damage impairs eye contact during conversations with real people
    Michael L Spezio
    Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 27:3994-7. 2007
    ..These novel findings from real social interactions are consistent with an hypothesized role for the amygdala in autism and the approach taken here opens up new directions for quantifying social behavior in humans...
  67. ncbi request reprint Amygdala damage impairs emotion recognition from scenes only when they contain facial expressions
    Ralph Adolphs
    Department of Neurology, Division of Cognitive Neuroscience, University Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Neuropsychologia 41:1281-9. 2003
    ..Bilateral amygdala damage thus disproportionately impairs recognition of certain emotions from complex visual stimuli when subjects utilize information from facial expressions...
  68. ncbi request reprint Selective effects of triazolam on memory for emotional, relative to neutral, stimuli: differential effects on gist versus detail
    Tony W Buchanan
    Department of Neurology, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
    Behav Neurosci 117:517-25. 2003
    ..This pattern of performance is similar to that seen in patients with amygdala damage. Results suggest an effect of GABAergic neurotransmission at the level of the amygdala on memory modulation...
  69. doi request reprint Social cognition: feeling voices to recognize emotions
    Ralph Adolphs
    Division of Humanities and Social Science and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Biol 20:R1071-2. 2010
    ....
  70. ncbi request reprint Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity
    Lynn K Paul
    California Institute of Technology, MC 228 77 Pasadena, California 91125, USA
    Nat Rev Neurosci 8:287-99. 2007
    ..The study of AgCC could provide insight into the integrated cerebral functioning of healthy brains, and may offer a model for understanding certain psychiatric illnesses, such as schizophrenia and autism...
  71. ncbi request reprint Processing of the arousal of subliminal and supraliminal emotional stimuli by the human amygdala
    Jan Gläscher
    NeuroImage Nord, Department of Neurology, University Hospital Hamburg Eppendorf, University of Hamburg, D 20246 Hamburg, Germany
    J Neurosci 23:10274-82. 2003
    ....
  72. ncbi request reprint Trust in the brain
    Ralph Adolphs
    Nat Neurosci 5:192-3. 2002
  73. ncbi request reprint EMPATH: a neural network that categorizes facial expressions
    Matthew N Dailey
    Computer Science and Engineering, University of California, San Diego 92093, USA
    J Cogn Neurosci 14:1158-73. 2002
    ..We thus explain many of the seemingly complex psychological phenomena related to facial expression perception as natural consequences of the tasks' implementations in the brain...
  74. ncbi request reprint Neuroanatomical substrates of social cognition dysfunction in autism
    Kevin Pelphrey
    Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27710, USA
    Ment Retard Dev Disabil Res Rev 10:259-71. 2004
    ..We conclude with a discussion of several potential future directions in the cognitive neuroscience of social deficits in autism...
  75. ncbi request reprint Neural systems for recognizing emotion
    Ralph Adolphs
    Division of Cognitive Neuroscience, Department of Neurology, 200 Hawkins Drive, University of Iowa College of Medicine, 52242, USA
    Curr Opin Neurobiol 12:169-77. 2002
    ..Two important mechanisms for recognition of emotions are the construction of a simulation of the observed emotion in the perceiver, and the modulation of sensory cortices via top-down influences...
  76. pmc Impaired spontaneous anthropomorphizing despite intact perception and social knowledge
    Andrea S Heberlein
    Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 101:7487-91. 2004
    ....
  77. pmc Amygdala damage eliminates monetary loss aversion
    Benedetto De Martino
    California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:3788-92. 2010
    ..The findings suggest that the amygdala plays a key role in generating loss aversion by inhibiting actions with potentially deleterious outcomes...
  78. ncbi request reprint Dissociable neural systems for recognizing emotions
    Ralph Adolphs
    Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Brain Cogn 52:61-9. 2003
    ..Thus the retrieval of knowledge regarding emotions draws upon widely distributed and partly distinct sets of neural structures, depending on the attributes of the stimulus...
  79. ncbi request reprint Recognizing emotion from facial expressions: psychological and neurological mechanisms
    Ralph Adolphs
    University of Iowa College of Medicine, USA
    Behav Cogn Neurosci Rev 1:21-62. 2002
    ..Although recent studies have provided a wealth of detail regarding these mechanisms in the adult human brain, investigations are also being extended to nonhuman primates, to infants, and to patients with psychiatric disorders...
  80. ncbi request reprint Amygdala damage impairs emotion recognition from music
    Nathalie Gosselin
    Department of Psychology, University of Montreal, CP 6128, Succ Centre Ville, Montreal, Que, Canada
    Neuropsychologia 45:236-44. 2007
    ..The use of tempo and mode cues in distinguishing happy from sad music was also spared in S.M. Thus, the amygdala appears to be necessary for emotional processing of music rather than the perceptual processing itself...
  81. ncbi request reprint Investigating the cognitive neuroscience of social behavior
    Ralph Adolphs
    Department of Neurology, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Neuropsychologia 41:119-26. 2003
    ..These issues can be addressed, in part, by giving theory and experiment equal time, and by fostering an interdisciplinary approach that includes neuroscience, psychology, philosophy, anthropology and allied disciplines...
  82. ncbi request reprint Emotion and consciousness
    Naotsugu Tsuchiya
    California Institute of Technology, HSS 228 77, Caltech, Pasadena, CA 91125, USA
    Trends Cogn Sci 11:158-67. 2007
    ..The intersection of consciousness and emotion is ripe for experimental investigation, and we outline possible examples for future studies...
  83. ncbi request reprint Emotional responses to unpleasant music correlates with damage to the parahippocampal cortex
    Nathalie Gosselin
    Department of Psychology, University of Montreal, Montreal, Quebec, Canada
    Brain 129:2585-92. 2006
    ..These findings are consistent with a two-dimensional model of defensive responses to aversive stimuli, in which the PHC and the amygdala subserve different roles...
  84. ncbi request reprint Perception of socially relevant stimuli in schizophrenia
    Nirav O Bigelow
    University of Iowa, Department of Psychiatry, United States
    Schizophr Res 83:257-67. 2006
    ..The findings point towards circumscribed domains of impaired social cognition in schizophrenia and suggest specific further hypotheses about the neural dysfunction that may underlie them...
  85. ncbi request reprint Emotional vision
    Ralph Adolphs
    Nat Neurosci 7:1167-8. 2004
  86. pmc Temporal isolation of neural processes underlying face preference decisions
    Hackjin Kim
    Divisions of Humanities and Social Sciences and Biology, California Institute of Technology, Pasadena, CA 91125, USA corrected
    Proc Natl Acad Sci U S A 104:18253-8. 2007
    ..The findings support a model in which rapid, automatic engagement of the NAC conveys a preference signal to the OFC, which in turn is used to guide choice...
  87. pmc Reprint of: Impaired fixation to eyes following amygdala damage arises from abnormal bottom-up attention
    Daniel P Kennedy
    Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, United States
    Neuropsychologia 49:589-95. 2011
    ....
  88. ncbi request reprint Cardiovascular and respiratory responses during musical mood induction
    Joset A Etzel
    Iowa State University, 2274 Howe Hall, Room 1620, VRAC, Ames, IA 50011 2274, USA
    Int J Psychophysiol 61:57-69. 2006
    ....
  89. ncbi request reprint Analysis of single-unit responses to emotional scenes in human ventromedial prefrontal cortex
    Hiroto Kawasaki
    University of Iowa College of Medicine, USA
    J Cogn Neurosci 17:1509-18. 2005
    ..The findings suggest sparse and widely distributed processing of emotional value in the prefrontal cortex, with a predominance of responses to aversive stimuli...

Research Grants10

  1. NEUROANATOMICAL SUBSTRATES OF EMOTIONAL MEMORY IN HUMANS
    Ralph Adolphs; Fiscal Year: 2002
    ....
  2. EMOTIONAL MODULATION OF MEMORY BY THE HUMAN AMYGDALA
    Ralph Adolphs; Fiscal Year: 2007
    ..abstract_text> ..
  3. Towards an Endophenotype for Amygdala Dysfunction
    Ralph Adolphs; Fiscal Year: 2010
    ..Our stimuli and methods will be made available to researchers and clinicians studying mental illness, and will inform diagnosis as well as provide a basis for designing future interventions. ..