Research Topics
| W ByneSummaryCountry: USA Publications
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Publications
Postmortem assessment of thalamic nuclear volumes in subjects with schizophreniaWilliam Byne
Department of Psychiatry and Pathology, Mount Sinai School of Medicine, New York, USA
Am J Psychiatry 159:59-65. 2002..The authors assessed schizophrenia-associated changes in volume and neuronal number in the mediodorsal nucleus and the pulvinar regions of the thalamus...
The medial preoptic and anterior hypothalamic regions of the rhesus monkey: cytoarchitectonic comparison with the human and evidence for sexual dimorphismW Byne
Laboratory of Neuroanatomy and Morphometrics, Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, New York, NY 10029, USA
Brain Res 793:346-50. 1998..It is hoped that the present report will stimulate interest in further examinations of the rhesus hypothalamus that will test both the suggested homologies and the evidence for sexual dimorphism...
A lack of dimorphism of sex or sexual orientation in the human anterior commissureMitchell S Lasco
Department of Applied Psychology, New York University, 239 Greene Street, New York, NY 10003, USA
Brain Res 936:95-8. 2002..We examined the cross-sectional area of the AC in postmortem material from 120 individuals, and found no variation in the size of the AC with age, HIV status, sex, or sexual orientation...
The interstitial nuclei of the human anterior hypothalamus: an investigation of variation with sex, sexual orientation, and HIV statusW Byne
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
Horm Behav 40:86-92. 2001..Although there was a trend for INAH3 to occupy a smaller volume in homosexual men than in heterosexual men, there was no difference in the number of neurons within the nucleus based on sexual orientation...
Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorderW Byne
Mount Sinai School of Medicine, New York, NY, USA
Arch Gen Psychiatry 58:133-40. 2001..Because frontal and temporal lobe volumes are diminished in schizophrenia, volume loss could characterize their primary thalamic relay nuclei (mediodorsal nucleus [MDN] and pulvinar)...
The interstitial nuclei of the human anterior hypothalamus: an investigation of sexual variation in volume and cell size, number and densityW Byne
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
Brain Res 856:254-8. 2000..The present data corroborate two previous reports of sexual dimorphism of INAH3 but provide no support for previous reports of sexual variation in other INAH...
Three-dimensional analysis with MRI and PET of the size, shape, and function of the thalamus in the schizophrenia spectrumE A Hazlett
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Am J Psychiatry 156:1190-9. 1999....
Thalamic activation during an attention-to-prepulse startle modification paradigm: a functional MRI studyE A Hazlett
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
Biol Psychiatry 50:281-91. 2001..Further fMRI investigations may elucidate other key structures in the circuitry underlying normal and disordered modulation of PPI...
Correlations between volumes of the pulvinar, centromedian, and mediodorsal nuclei and cortical Brodmann's areas in schizophreniaSerge A Mitelman
Department of Psychiatry, Neuroscience PET Laboratory, Mount Sinai School of Medicine, Mount Sinai Medical Center, Box 1505, One Gustave L Levy Place, NY 10029, USA
Neurosci Lett 392:16-21. 2006....
Schizophrenia-associated reduction of neuronal and oligodendrocyte numbers in the anterior principal thalamic nucleusWilliam Byne
Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, NY 10467, USA
Schizophr Res 85:245-53. 2006..These findings are consistent with a previous report of reduced neuronal number in the anterior principal nucleus of male SZs and add to a growing body of evidence implicating oligodendrocyte abnormalities in SZ...
Metabolic thalamocortical correlations during a verbal learning task and their comparison with correlations among regional volumesSerge A Mitelman
Department of Psychiatry, Neuroscience PET Laboratory, Box 1505, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Brain Res 1114:125-37. 2006....
Reduction of right medial pulvinar volume and neuron number in schizophreniaWilliam Byne
Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, USA
Schizophr Res 90:71-5. 2007..The medial pulvinar interconnects various heteromodal cortical regions suggesting that these deficits may contribute to the abnormalities of higher order integrative functions characteristic of schizophrenia...
Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nucleiWilliam Byne
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, United States
Schizophr Res 98:118-28. 2008..All markers were differentially expressed across nuclei...
Metabolic disconnection between the mediodorsal nucleus of the thalamus and cortical Brodmann's areas of the left hemisphere in schizophreniaSerge A Mitelman
Department of Psychiatry, Neuroscience PET Laboratory, Box 1505, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
Am J Psychiatry 162:1733-5. 2005..The authors' goal was to examine interregional correlations of thalamocortical metabolic activity during a verbal learning task in schizophrenia...
Thalamic and prefrontal FDG uptake in never medicated patients with schizophreniaDouglas S Lehrer
Wright State University Department of Psychiatry, c o The Wallace Kettering Neuroscience Institute, 3533 Southern Blvd, Suite 5200, Kettering, OH 45429, USA
Am J Psychiatry 162:931-8. 2005....
Abnormal glucose metabolism in the mediodorsal nucleus of the thalamus in schizophreniaErin A Hazlett
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Am J Psychiatry 161:305-14. 2004....
Magnetic resonance imaging of mediodorsal, pulvinar, and centromedian nuclei of the thalamus in patients with schizophreniaEileen M Kemether
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Arch Gen Psychiatry 60:983-91. 2003..CONCLUSIONS: Three association regions of the thalamus that have reciprocal connectivity to schizophrenia-associated regions of the cortex have significantly smaller volumes on MRI in patients with schizophrenia...
Thalamus size and outcome in schizophreniaAdam M Brickman
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
Schizophr Res 71:473-84. 2004..These findings are consistent with post-mortem and MRI measurement suggesting reduction in volume of the pulvinar, which occupies a large proportion of the ventral thalamus and which has prominent connections to the temporal lobe...
Alterations in MAP2 immunocytochemistry in areas 9 and 32 of schizophrenic prefrontal cortexLiesl B Jones
Lehman College, Department Biological Sciences, 250 Bedford Park Blvd, NY 10468, Bronx, USA
Psychiatry Res 114:137-48. 2002..Neither region exhibited a significant change in the density of pyramidal cells. These data are consistent with the hypothesis of a schizophrenia-associated decrease in dendritic material in the PFC...
Diffusion tensor anisotropy in adolescents and adultsJason S Schneiderman
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Neuropsychobiology 55:96-111. 2007..Sex differences were found in the majority of areas but were most marked in the cingulum bundle and internal capsule. These results suggest continuing white matter development between adolescence and adulthood...
Developmental endocrine influences on gender identity: implications for management of disorders of sex developmentWilliam Byne
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
Mt Sinai J Med 73:950-9. 2006..In keeping with the neuropsychiatry theme of this issue, the focus of this article is on prenatal sexual differentiation of the brain as it pertains to the question of psychosexual neutrality at birth...
Evidence for a decrease in basilar dendrites of pyramidal cells in schizophrenic medial prefrontal cortexKevin Broadbelt
Department of Biological Sciences, Lehman College, 250 Bedford Park Boulevard, Bronx, New York, NY 10468, USA
Schizophr Res 58:75-81. 2002..Similarly, in layer III there was also a decrease in both primary (17%) and secondary (15%) basilar dendrites. These findings suggest a decrease in synaptic surface area which could lead to aberrant information processing...
Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophreniaPatrick R Hof
Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
Biol Psychiatry 53:1075-85. 2003..The data support recent evidence that several genes encoding myelin-related proteins consistently exhibit reduced expression in schizophrenia...
Thalamocortical circuits: fMRI assessment of the pulvinar and medial dorsal nucleus in normal volunteersMonte S Buchsbaum
Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, New York, NY 10029 6574, USA
Neurosci Lett 404:282-7. 2006..For the pulvinar, maximal functional connectivity was with parietal BA39; for anterior thalamus, with anterior cingulate...
Ionotropic glutamate receptor mRNA expression in the human thalamus: absence of change in schizophreniaStella Dracheva
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
Brain Res 1214:23-34. 2008..These results provide detailed and quantitative information on iGluR subunit expression in multiple nuclei of the human thalamus but suggest that alterations in their expression are not a prominent feature of schizophrenia...
