Robert C Karn

Summary

Affiliation: Butler University
Country: USA

Publications

  1. pmc The role of retrotransposons in gene family expansions: insights from the mouse Abp gene family
    Václav Janoušek
    Department of Zoology, Faculty of Science, Charles University in Prague, Prague 128 43, Czech Republic
    BMC Evol Biol 13:107. 2013
  2. pmc The roles of gene duplication, gene conversion and positive selection in rodent Esp and Mup pheromone gene families with comparison to the Abp family
    Robert C Karn
    Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 7:e47697. 2012
  3. pmc Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals
    Christina M Laukaitis
    Department of Medical Genetics, University of Washington, Seattle, USA and Division of Human Biology, Fred Hutchinson CancerResearch Center, Seattle, USA
    BMC Evol Biol 8:46. 2008
  4. pmc Positive selection shaped the convergent evolution of independently expanded kallikrein subfamilies expressed in mouse and rat saliva proteomes
    Robert C Karn
    Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 6:e20979. 2011
  5. ncbi request reprint The complex history of a gene proposed to participate in a sexual isolation mechanism in house mice
    Robert C Karn
    Department of Biological Sciences, Butler University, 4600 Sunset Avenue, Indianapolis, IN 46208, USA
    Mol Biol Evol 19:462-71. 2002
  6. ncbi request reprint Characterization of two forms of mouse salivary androgen-binding protein (ABP): implications for evolutionary relationships and ligand-binding function
    Robert C Karn
    Department of Biological Sciences, Butler University, Indianapolis, Indiana 46208, USA
    Biochemistry 42:7162-70. 2003
  7. pmc Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus
    Christina M Laukaitis
    Department of Biological Sciences, Butler University, 4600 Sunset Ave, Indianapolis, Indiana 46208, USA
    BMC Evol Biol 5:40. 2005
  8. ncbi request reprint The mouse salivary androgen-binding protein (ABP) gene cluster on chromosomes 7: characterization and evolutionary relationships
    Christina M Laukaitis
    Department of Biological Sciences, Butler University, 4600 Sunset Avenue, Indianapolis, Indiana 46208, USA
    Mamm Genome 14:679-91. 2003
  9. pmc Congenic strain analysis reveals genes that are rapidly evolving components of a prezygotic isolation mechanism mediating incipient reinforcement
    Christina M Laukaitis
    Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 7:e35898. 2012
  10. pmc Proteomics and comparative genomic investigations reveal heterogeneity in evolutionary rate of male reproductive proteins in mice (Mus domesticus)
    Matthew D Dean
    Department of Ecology and Evolutionary Biology, University of Arizona, AZ, USA
    Mol Biol Evol 26:1733-43. 2009

Research Grants

Detail Information

Publications12

  1. pmc The role of retrotransposons in gene family expansions: insights from the mouse Abp gene family
    Václav Janoušek
    Department of Zoology, Faculty of Science, Charles University in Prague, Prague 128 43, Czech Republic
    BMC Evol Biol 13:107. 2013
    ..Their precise role, however, is controversial. Here we ask whether retrotransposons contributed to the recent expansions of the Androgen-binding protein (Abp) gene families that occurred independently in the mouse and rat genomes...
  2. pmc The roles of gene duplication, gene conversion and positive selection in rodent Esp and Mup pheromone gene families with comparison to the Abp family
    Robert C Karn
    Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 7:e47697. 2012
    ..We compare and contrast the evolutionary histories of all three mouse pheromone gene families in light of their proposed functions in mouse communication...
  3. pmc Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals
    Christina M Laukaitis
    Department of Medical Genetics, University of Washington, Seattle, USA and Division of Human Biology, Fred Hutchinson CancerResearch Center, Seattle, USA
    BMC Evol Biol 8:46. 2008
    ..Questions arise from imperfections in the initial mouse genome assembly and a dearth of information about the gene family structure in other rodents and mammals...
  4. pmc Positive selection shaped the convergent evolution of independently expanded kallikrein subfamilies expressed in mouse and rat saliva proteomes
    Robert C Karn
    Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 6:e20979. 2011
    ..In addition to or instead of that function, we propose that their sex-limited expression, coupled with their rapid evolution may be clues to an as-yet-undetermined interaction between the sexes...
  5. ncbi request reprint The complex history of a gene proposed to participate in a sexual isolation mechanism in house mice
    Robert C Karn
    Department of Biological Sciences, Butler University, 4600 Sunset Avenue, Indianapolis, IN 46208, USA
    Mol Biol Evol 19:462-71. 2002
    ..Thus the selective mechanism behind the evolution of Abpa remains to be resolved, and we suggest that it may have changed during the recent colonization history of the house mouse...
  6. ncbi request reprint Characterization of two forms of mouse salivary androgen-binding protein (ABP): implications for evolutionary relationships and ligand-binding function
    Robert C Karn
    Department of Biological Sciences, Butler University, Indianapolis, Indiana 46208, USA
    Biochemistry 42:7162-70. 2003
    ..Hofstetter, J., Bonhomme, F., and Karn, R. (1997) J. Hered. 88, 93-97; Karn, R., and Clements, M. (1999) Biochem. Genet. 37, 187-199]...
  7. pmc Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus
    Christina M Laukaitis
    Department of Biological Sciences, Butler University, 4600 Sunset Ave, Indianapolis, Indiana 46208, USA
    BMC Evol Biol 5:40. 2005
    ..This makes ABP an appropriate model system with which to investigate how recent adaptive evolution of paralogous genes results in functional innovation (neofunctionalization)...
  8. ncbi request reprint The mouse salivary androgen-binding protein (ABP) gene cluster on chromosomes 7: characterization and evolutionary relationships
    Christina M Laukaitis
    Department of Biological Sciences, Butler University, 4600 Sunset Avenue, Indianapolis, Indiana 46208, USA
    Mamm Genome 14:679-91. 2003
    ....
  9. pmc Congenic strain analysis reveals genes that are rapidly evolving components of a prezygotic isolation mechanism mediating incipient reinforcement
    Christina M Laukaitis
    Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 7:e35898. 2012
    ..In the sense that they are subunits of the same two functional entities, the ABP dimers, we propose that their evolutionary histories might not be independent of each other...
  10. pmc Proteomics and comparative genomic investigations reveal heterogeneity in evolutionary rate of male reproductive proteins in mice (Mus domesticus)
    Matthew D Dean
    Department of Ecology and Evolutionary Biology, University of Arizona, AZ, USA
    Mol Biol Evol 26:1733-43. 2009
    ..In contrast, proteins from the other five tissues showed significantly lower nonsynonymous substitution, revealing a previously unappreciated level of evolutionary constraint acting on the majority of male reproductive proteins...
  11. pmc The Mechanism of Expansion and the Volatility it created in Three Pheromone Gene Clusters in the Mouse (Mus musculus) Genome
    Robert C Karn
    Department of Medicine, College of Medicine, University of Arizona
    Genome Biol Evol 2009:494-503. 2009
    ..No particularly remarkable volatility was observed in the other two gene families, and we discuss the significance of this in light of the various roles proposed for the three families of mouse proteinaceous pheromones...
  12. pmc Comparative evolutionary genomics of androgen-binding protein genes
    Richard D Emes
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    Genome Res 14:1516-29. 2004
    ..We propose a role for ABPalpha/beta/gamma proteins as pheromones, or in modulating odorant detection. This would account for the extraordinary adaptive evolution of these genes, and surrounding genomic regions, in murid rodents...

Research Grants2

  1. Evolutionary studies of mouse seminal fluid protein genes
    ROBERT KARN; Fiscal Year: 2007
    ..Furthermore, the major source of seminal fluid proteins is the prostate, a common site of male cancer. Disease research may benefit from studies of selection, since positive selection is often associated with human disease genes. ..