Research Topics
Genomes and Genes | Robert C KarnSummaryAffiliation: Butler University Country: USA Publications
Research Grants
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Detail Information
Publications
The roles of gene duplication, gene conversion and positive selection in rodent Esp and Mup pheromone gene families with comparison to the Abp familyRobert C Karn
Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America
PLoS ONE 7:e47697. 2012..We compare and contrast the evolutionary histories of all three mouse pheromone gene families in light of their proposed functions in mouse communication...- Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammalsChristina M Laukaitis
Department of Medical Genetics, University of Washington, Seattle, USA and Division of Human Biology, Fred Hutchinson CancerResearch Center, Seattle, USA
BMC Evol Biol 8:46. 2008..Questions arise from imperfections in the initial mouse genome assembly and a dearth of information about the gene family structure in other rodents and mammals... 
Characterization of two forms of mouse salivary androgen-binding protein (ABP): implications for evolutionary relationships and ligand-binding functionRobert C Karn
Department of Biological Sciences, Butler University, Indianapolis, Indiana 46208, USA
Biochemistry 42:7162-70. 2003..Hofstetter, J., Bonhomme, F., and Karn, R. (1997) J. Hered. 88, 93-97; Karn, R., and Clements, M. (1999) Biochem. Genet. 37, 187-199]...- Positive selection shaped the convergent evolution of independently expanded kallikrein subfamilies expressed in mouse and rat saliva proteomesRobert C Karn
Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America
PLoS ONE 6:e20979. 2011..In addition to or instead of that function, we propose that their sex-limited expression, coupled with their rapid evolution may be clues to an as-yet-undetermined interaction between the sexes... - The complex history of a gene proposed to participate in a sexual isolation mechanism in house miceRobert C Karn
Department of Biological Sciences, Butler University, 4600 Sunset Avenue, Indianapolis, IN 46208, USA
Mol Biol Evol 19:462-71. 2002..Thus the selective mechanism behind the evolution of Abpa remains to be resolved, and we suggest that it may have changed during the recent colonization history of the house mouse... - Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculusChristina M Laukaitis
Department of Biological Sciences, Butler University, 4600 Sunset Ave, Indianapolis, Indiana 46208, USA
BMC Evol Biol 5:40. 2005..This makes ABP an appropriate model system with which to investigate how recent adaptive evolution of paralogous genes results in functional innovation (neofunctionalization)... - The mouse salivary androgen-binding protein (ABP) gene cluster on Chromosomes 7: characterization and evolutionary relationshipsChristina M Laukaitis
Department of Biological Sciences, Butler University, 4600 Sunset Avenue, Indianapolis, Indiana 46208, USA
Mamm Genome 14:679-91. 2003.... - Congenic strain analysis reveals genes that are rapidly evolving components of a prezygotic isolation mechanism mediating incipient reinforcementChristina M Laukaitis
Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America
PLoS ONE 7:e35898. 2012..In the sense that they are subunits of the same two functional entities, the ABP dimers, we propose that their evolutionary histories might not be independent of each other... - Proteomics and comparative genomic investigations reveal heterogeneity in evolutionary rate of male reproductive proteins in mice (Mus domesticus)Matthew D Dean
Department of Ecology and Evolutionary Biology, University of Arizona, AZ, USA
Mol Biol Evol 26:1733-43. 2009..In contrast, proteins from the other five tissues showed significantly lower nonsynonymous substitution, revealing a previously unappreciated level of evolutionary constraint acting on the majority of male reproductive proteins... - The Mechanism of Expansion and the Volatility it created in Three Pheromone Gene Clusters in the Mouse (Mus musculus) GenomeRobert C Karn
Department of Medicine, College of Medicine, University of Arizona
Genome Biol Evol 2009:494-503. 2009..No particularly remarkable volatility was observed in the other two gene families, and we discuss the significance of this in light of the various roles proposed for the three families of mouse proteinaceous pheromones... - Comparative evolutionary genomics of androgen-binding protein genesRichard D Emes
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Genome Res 14:1516-29. 2004..We propose a role for ABPalpha/beta/gamma proteins as pheromones, or in modulating odorant detection. This would account for the extraordinary adaptive evolution of these genes, and surrounding genomic regions, in murid rodents...
Research Grants
- Evolutionary studies of mouse seminal fluid protein genesROBERT KARN; Fiscal Year: 2007..Furthermore, the major source of seminal fluid proteins is the prostate, a common site of male cancer. Disease research may benefit from studies of selection, since positive selection is often associated with human disease genes. ..