B D Greenberg

Summary

Affiliation: Butler Hospital
Country: USA

Publications

  1. ncbi request reprint Neurosurgery for intractable obsessive-compulsive disorder and depression: critical issues
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA
    Neurosurg Clin N Am 14:199-212. 2003
  2. ncbi request reprint Update on deep brain stimulation
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island, USA
    J ECT 18:193-6. 2002
  3. ncbi request reprint The evolution of deep brain stimulation for neuropsychiatric disorders
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Warren Alpert Medical School at Brown University, Butler Hospital, Providence, RI 02906, USA
    Front Biosci 13:4638-48. 2008
  4. ncbi request reprint Mechanisms and the current state of deep brain stimulation in neuropsychiatry
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island, USA
    CNS Spectr 8:522-6. 2003
  5. ncbi request reprint Education and neuromodulation for psychiatric disorders: a perspective for practitioners
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Butler Hospital, Brown Medical School, Providence, Rhode Island 02906, USA
    Neurosurgery 59:717-9. 2006
  6. ncbi request reprint Neuroanatomically based approaches to obsessive-compulsive disorder. Neurosurgery and transcranial magnetic stimulation
    B D Greenberg
    Adult Obsessive Compulsive Disorder Research Unit, National Institute of Mental Health, Bethesda, Maryland, USA
    Psychiatr Clin North Am 23:671-86, xii. 2000
  7. ncbi request reprint Role of the serotonin transporter gene in temperament and character
    D H Hamer
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Pers Disord 13:312-27. 1999
  8. ncbi request reprint Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample
    B D Greenberg
    Laboratory of Clinical Science, National Institutes of Mental Health, Bethesda, Maryland 20892 1264, USA
    Am J Med Genet 96:202-16. 2000
  9. ncbi request reprint Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder
    D Bengel
    Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD, 20892 1264, USA
    Mol Psychiatry 4:463-6. 1999
  10. ncbi request reprint Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a preliminary study
    B D Greenberg
    Laboratory of Clinical Science, NIMH, Bethesda, MD 20892 1264, USA
    Am J Psychiatry 154:867-9. 1997

Detail Information

Publications47

  1. ncbi request reprint Neurosurgery for intractable obsessive-compulsive disorder and depression: critical issues
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA
    Neurosurg Clin N Am 14:199-212. 2003
    ....
  2. ncbi request reprint Update on deep brain stimulation
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island, USA
    J ECT 18:193-6. 2002
    ..Investigations in this area should proceed cautiously...
  3. ncbi request reprint The evolution of deep brain stimulation for neuropsychiatric disorders
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Warren Alpert Medical School at Brown University, Butler Hospital, Providence, RI 02906, USA
    Front Biosci 13:4638-48. 2008
    ..Further development of DBS for these and other illnesses with primarily behavioral symptoms will require thoughtful collaboration among multiple disciplines...
  4. ncbi request reprint Mechanisms and the current state of deep brain stimulation in neuropsychiatry
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island, USA
    CNS Spectr 8:522-6. 2003
    ..These investigations should proceed cautiously...
  5. ncbi request reprint Education and neuromodulation for psychiatric disorders: a perspective for practitioners
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Butler Hospital, Brown Medical School, Providence, Rhode Island 02906, USA
    Neurosurgery 59:717-9. 2006
  6. ncbi request reprint Neuroanatomically based approaches to obsessive-compulsive disorder. Neurosurgery and transcranial magnetic stimulation
    B D Greenberg
    Adult Obsessive Compulsive Disorder Research Unit, National Institute of Mental Health, Bethesda, Maryland, USA
    Psychiatr Clin North Am 23:671-86, xii. 2000
    ..The use of transcranial magnetic stimulation to probe possible neuroanatomic and neurophysiologic substrates of this disorder is considered, and how the knowledge gained from such studies might advance treatment is presented...
  7. ncbi request reprint Role of the serotonin transporter gene in temperament and character
    D H Hamer
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Pers Disord 13:312-27. 1999
    ..These results suggest that there is no fundamental mechanistic distinction between character and temperament in regard to the serotonin transporter gene, and that a single neurotransmitter can influence multiple personality traits...
  8. ncbi request reprint Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample
    B D Greenberg
    Laboratory of Clinical Science, National Institutes of Mental Health, Bethesda, Maryland 20892 1264, USA
    Am J Med Genet 96:202-16. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:202-216, 2000. Published 2000 Wiley-Liss, Inc...
  9. ncbi request reprint Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder
    D Bengel
    Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD, 20892 1264, USA
    Mol Psychiatry 4:463-6. 1999
    ..7% vs 32.3%: chi2 = 5.19, P = 0.023). This finding replicates a recent family-based study of this polymorphism in OCD, and thus indicates that the 5-HTTLPR may be associated with susceptibility to OCD...
  10. ncbi request reprint Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a preliminary study
    B D Greenberg
    Laboratory of Clinical Science, NIMH, Bethesda, MD 20892 1264, USA
    Am J Psychiatry 154:867-9. 1997
    ..Prefrontal mechanisms are implicated in obsessive-compulsive disorder. The authors investigated whether prefrontal repetitive transcranial magnetic stimulation influenced obsessive-compulsive disorder symptoms...
  11. ncbi request reprint Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets
    B D Greenberg
    Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892 1264, USA
    Am J Med Genet 88:83-7. 1999
    ..The 5-HT uptake findings support a functional difference in the two 5-HTTLPR variants, reinforcing their attractiveness as candidate genes in neuropsychiatric research...
  12. ncbi request reprint Delayed obsessive-compulsive disorder symptom exacerbation after a single dose of a serotonin antagonist in fluoxetine-treated but not untreated patients
    B D Greenberg
    Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892 1264, USA
    Psychopharmacology (Berl) 140:434-44. 1998
    ....
  13. ncbi request reprint Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial
    M S George
    Biological Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 154:1752-6. 1997
    ..Preliminary studies have indicated that daily left prefrontal repetitive transcranial magnetic stimulation might have antidepressant activity. The authors sought to confirm this finding by using a double-blind crossover design...
  14. ncbi request reprint Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital and Rhode Island Hospital, Providence, RI 02906, USA
    Neuropsychopharmacology 31:2384-93. 2006
    ..This open study found promising long-term effects of DBS in highly treatment-resistant OCD...
  15. ncbi request reprint Obsessive-compulsive disorder: recognition across medical settings, and treatments from behavior therapy to neurosurgery
    Benjamin D Greenberg
    Outpatient Services, Butler Hospital, Providence RI 02906, USA
    Med Health R I 89:162-5. 2006
  16. pmc Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University and Butler Hospital, Providence, RI 02906, USA
    Neuropsychopharmacology 35:317-36. 2010
    ..Translational research to elucidate how targeting specific nodes in putative OCD circuitry might lead to therapeutic gains is accelerating in tandem with clinical use...
  17. ncbi request reprint Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls
    S S Nawab
    Section on Biological Rhythms, National Institute of Mental Health, Bethesda, MD 20892 1390, USA
    Psychiatry Res 95:67-74. 2000
    ..A possible relationship between reported chemical sensitivity and hypothalamic-pituitary-adrenal (HPA)-axis functioning is discussed...
  18. ncbi request reprint Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 200, MSC 2670, Bethesda, MD 20892 2670, USA
    Psychiatry Res 135:121-32. 2005
    ....
  19. ncbi request reprint Vagus nerve stimulation and deep brain stimulation for treatment resistant depression
    Linda L Carpenter
    Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA
    Med Health R I 89:137, 140-1. 2006
    ..Further investigations are currently underway in order to more fully evaluate both of these neurostimulation therapies, with the hope of substantially improving the treatment of refractory depression...
  20. pmc Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experience
    B D Greenberg
    Department of Psychiatry and Human Behavior, Division of Neurosurgery, Butler Hospital, Alpert Medical School of Brown University, Providence, RI 02906, USA
    Mol Psychiatry 15:64-79. 2010
    ..Taken together, these data show that the procedure can be successfully implemented by dedicated interdisciplinary teams, and support its therapeutic promise...
  21. ncbi request reprint Pleiotropy of the serotonin transporter gene for seasonality and neuroticism
    L Sher
    Section on Biological Rhythms, National Institute of Mental Health, Bethesda, Maryland, USA
    Psychiatr Genet 10:125-30. 2000
    ..Sibling-pair analysis confirmed that the effects of the 5-HTTLPR are due to genetic pleiotropy rather than population stratification...
  22. ncbi request reprint Motor cortex excitability correlates with an anxiety-related personality trait
    E M Wassermann
    Brain Stimulation Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N226, Bethesda, MD 20892, USA
    Biol Psychiatry 50:377-82. 2001
    ..Decreased intracortical inhibition may be related more to trait anxiety and depression, which are high in OCD, than to OCD itself. However, the MEP threshold (significantly lowered in OCD) was unrelated to N...
  23. pmc Obsessive-compulsive disorder and its related disorders: a reappraisal of obsessive-compulsive spectrum concepts
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, Maryland 20892, USA
    Dialogues Clin Neurosci 12:131-48. 2010
    ..Considering the status of current research, the concept of OCD and OCD-related spectrum conditions seems fluid in 2010, and in need of ongoing reappraisal...
  24. doi request reprint Psychiatric neurosurgery 2009: review and perspective
    Cynthia N Read
    Brown University Butler Hospital, Providence, Rhode Island 02906, USA
    Semin Neurol 29:256-65. 2009
    ....
  25. ncbi request reprint The brown longitudinal obsessive compulsive study: treatments received and patient impressions of improvement
    Maria C Mancebo
    Butler Hospital, Providence, RI 02906, USA
    J Clin Psychiatry 67:1713-20. 2006
    ..The primary aim of this study was to assess the extent to which individuals with obsessive-compulsive disorder (OCD) received recommended doses of treatment and perceived a response to these treatments...
  26. pmc Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder
    B Porton
    Department of Psychiatry and Human Behavior, Brown University, Biomedical Center, Providence, RI 02912, USA
    Transl Psychiatry 3:e259. 2013
    ..These initial results reveal the complexity of SLC1A1 regulation and the potential clinical utility of profiling glutamatergic gene expression in OCD and other psychiatric disorders...
  27. ncbi request reprint Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
    Biol Psychiatry 49:385-8. 2001
    ..We hypothesized that the 5-HT2A promoter polymorphism, -1438G>A, previously associated with anorexia nervosa, would be more abundant in women with obsessive-compulsive disorder...
  28. ncbi request reprint A pilot study of moderate-intensity aerobic exercise for obsessive compulsive disorder
    Richard A Brown
    Butler Hospital Brown Medical School, Providence, RI 02906, USA
    J Nerv Ment Dis 195:514-20. 2007
    ..Results of this study suggest that a randomized clinical trial evaluating the efficacy of this 12-week aerobic exercise intervention is warranted...
  29. doi request reprint Acute changes in obsessions and compulsions following moderate-intensity aerobic exercise among patients with obsessive-compulsive disorder
    Ana M Abrantes
    Butler Hospital Alpert Medical School of Brown University, Providence, RI 02906, USA
    J Anxiety Disord 23:923-7. 2009
    ..Results of this study point toward the promising effect of exercise for acute symptom reduction in patients with OCD...
  30. ncbi request reprint Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study
    Gregor Hasler
    Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    Biol Psychiatry 61:617-25. 2007
    ..While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions...
  31. pmc Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset
    Stephen Correia
    Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Veterans Affairs Medical Center 830 Chalkstone Ave, Providence, RI 02908, USA
    Brain Imaging Behav 4:35-45. 2010
    ..This effect was driven by patients whose OCD symptoms began from around adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia...
  32. pmc Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories
    Anthony Pinto
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
    Psychiatry Res 160:83-93. 2008
    ..The results support investigation of this multidimensional model in OCD genetic linkage studies...
  33. pmc Taboo thoughts and doubt/checking: a refinement of the factor structure for obsessive-compulsive disorder symptoms
    Anthony Pinto
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02906, USA
    Psychiatry Res 151:255-8. 2007
    ....
  34. ncbi request reprint Repetitive transcranial magnetic stimulation: a putative add-on treatment for major depression in elderly patients
    Urs P Mosimann
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Psychiatry Res 126:123-33. 2004
    ..Therapeutic effects of rTMS in this clinically challenging patient group remain to be demonstrated...
  35. ncbi request reprint [What is the role of psychiatric neurosurgery in the 21st Century?]
    Scott L Rauch
    Rev Bras Psiquiatr 26:4-5. 2004
  36. ncbi request reprint Anatomy and physiology of the basal ganglia: implications for DBS in psychiatry
    Brian Harris Kopell
    Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neurosci Biobehav Rev 32:408-22. 2008
    ..Implementing such therapies optimally will require the creation of treatment centers with specialized expertise in the psychiatric, neurosurgical, and ethical issues that arise with these populations...
  37. ncbi request reprint Metabolic imaging of anterior capsular stimulation in refractory obsessive-compulsive disorder: a key role for the subgenual anterior cingulate and ventral striatum
    Koenraad Van Laere
    Division of Nuclear Medicine, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    J Nucl Med 47:740-7. 2006
    ..The mechanism of action is unknown but hypothesized to be secondary to interruption of the corticothalamostriatocortical circuit...
  38. ncbi request reprint A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder
    Scott L Rauch
    Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosurg 104:558-65. 2006
    ..The purpose of the current study was to test hypotheses regarding changes in regional cerebral blood flow (rCBF) during acute DBS at the VC/VS target in patients with OCD who were participating in a clinical DBS trial...
  39. ncbi request reprint Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder
    Bernadette Cullen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Depress Anxiety 25:218-24. 2008
    ..Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner...
  40. ncbi request reprint Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Behav Res Ther 45:673-86. 2007
    ..The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families...
  41. pmc Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder
    Xian Zhang Hu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Am J Hum Genet 78:815-26. 2006
    ..The L(A) allele was twofold overtransmitted to the patients with OCD. The HTTLPR L(A)L(A) genotype exerts a moderate (1.8-fold) effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD...
  42. ncbi request reprint Refractory obsessive-compulsive disorder: state-of-the-art treatment
    Eric Hollander
    Department of Psychiatry, Compulsive, Impulsive, and Anxiety Disorders Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 63:20-9. 2002
    ..The authors synthesize state-of-the-art treatment and give practical advice for clinicians...
  43. ncbi request reprint Psychosurgery: avoiding an ethical redux while advancing a therapeutic future
    Joseph J Fins
    Division of Medical Ethics, New York Presbyterian Weill Cornell Medical Center, New York, New York 10021, USA
    Neurosurgery 59:713-6. 2006
  44. pmc The OCD collaborative genetics study: methods and sample description
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7228, USA
    Am J Med Genet B Neuropsychiatr Genet 141:201-7. 2006
    ....
  45. ncbi request reprint Transcranial magnetic stimulation
    Mark S George
    Department of Psychiatry, 502 North, Institute of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC, USA
    Neurosurg Clin N Am 14:283-301. 2003
    ..Whatever road the future takes, TMS is an important new tool that will likely be of interest to neurosurgeons over the next 20 years and perhaps even longer...
  46. ncbi request reprint Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study
    Jack Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N Wolfe St, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Am J Psychiatry 164:493-9. 2007
    ..The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder...
  47. ncbi request reprint What's in a "smile?" Intra-operative observations of contralateral smiles induced by deep brain stimulation
    Michael S Okun
    Movement Disorders Center, University of Florida, Department of Neurology, McKnight Brain Institute, Gaineville, FL 32610, USA
    Neurocase 10:271-9. 2004
    ..To describe smiling and euphoria induced by deep brain stimulation (DBS)...