B D Greenberg
Affiliation: Butler Hospital
- Neurosurgery for intractable obsessive-compulsive disorder and depression: critical issuesBenjamin D Greenberg
Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA
Neurosurg Clin N Am 14:199-212. 2003....
- Update on deep brain stimulationBenjamin D Greenberg
Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island, USA
J ECT 18:193-6. 2002..Investigations in this area should proceed cautiously...
- The evolution of deep brain stimulation for neuropsychiatric disordersBenjamin D Greenberg
Department of Psychiatry and Human Behavior, Warren Alpert Medical School at Brown University, Butler Hospital, Providence, RI 02906, USA
Front Biosci 13:4638-48. 2008..Further development of DBS for these and other illnesses with primarily behavioral symptoms will require thoughtful collaboration among multiple disciplines...
- Mechanisms and the current state of deep brain stimulation in neuropsychiatryBenjamin D Greenberg
Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island, USA
CNS Spectr 8:522-6. 2003..These investigations should proceed cautiously...
- Education and neuromodulation for psychiatric disorders: a perspective for practitionersBenjamin D Greenberg
Department of Psychiatry and Human Behavior, Butler Hospital, Brown Medical School, Providence, Rhode Island 02906, USA
Neurosurgery 59:717-9. 2006
- Neuroanatomically based approaches to obsessive-compulsive disorder. Neurosurgery and transcranial magnetic stimulationB D Greenberg
Adult Obsessive Compulsive Disorder Research Unit, National Institute of Mental Health, Bethesda, Maryland, USA
Psychiatr Clin North Am 23:671-86, xii. 2000..The use of transcranial magnetic stimulation to probe possible neuroanatomic and neurophysiologic substrates of this disorder is considered, and how the knowledge gained from such studies might advance treatment is presented...
- Role of the serotonin transporter gene in temperament and characterD H Hamer
Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Pers Disord 13:312-27. 1999..These results suggest that there is no fundamental mechanistic distinction between character and temperament in regard to the serotonin transporter gene, and that a single neurotransmitter can influence multiple personality traits...
- Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sampleB D Greenberg
Laboratory of Clinical Science, National Institutes of Mental Health, Bethesda, Maryland 20892 1264, USA
Am J Med Genet 96:202-16. 2000..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:202-216, 2000. Published 2000 Wiley-Liss, Inc...
- Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorderD Bengel
Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD, 20892 1264, USA
Mol Psychiatry 4:463-6. 1999..7% vs 32.3%: chi2 = 5.19, P = 0.023). This finding replicates a recent family-based study of this polymorphism in OCD, and thus indicates that the 5-HTTLPR may be associated with susceptibility to OCD...
- Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a preliminary studyB D Greenberg
Laboratory of Clinical Science, NIMH, Bethesda, MD 20892 1264, USA
Am J Psychiatry 154:867-9. 1997..Prefrontal mechanisms are implicated in obsessive-compulsive disorder. The authors investigated whether prefrontal repetitive transcranial magnetic stimulation influenced obsessive-compulsive disorder symptoms...
- Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood plateletsB D Greenberg
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892 1264, USA
Am J Med Genet 88:83-7. 1999..The 5-HT uptake findings support a functional difference in the two 5-HTTLPR variants, reinforcing their attractiveness as candidate genes in neuropsychiatric research...
- Delayed obsessive-compulsive disorder symptom exacerbation after a single dose of a serotonin antagonist in fluoxetine-treated but not untreated patientsB D Greenberg
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892 1264, USA
Psychopharmacology (Berl) 140:434-44. 1998....
- Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trialM S George
Biological Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
Am J Psychiatry 154:1752-6. 1997..Preliminary studies have indicated that daily left prefrontal repetitive transcranial magnetic stimulation might have antidepressant activity. The authors sought to confirm this finding by using a double-blind crossover design...
- Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorderBenjamin D Greenberg
Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital and Rhode Island Hospital, Providence, RI 02906, USA
Neuropsychopharmacology 31:2384-93. 2006..This open study found promising long-term effects of DBS in highly treatment-resistant OCD...
- Obsessive-compulsive disorder: recognition across medical settings, and treatments from behavior therapy to neurosurgeryBenjamin D Greenberg
Outpatient Services, Butler Hospital, Providence RI 02906, USA
Med Health R I 89:162-5. 2006
- Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCDBenjamin D Greenberg
Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University and Butler Hospital, Providence, RI 02906, USA
Neuropsychopharmacology 35:317-36. 2010..Translational research to elucidate how targeting specific nodes in putative OCD circuitry might lead to therapeutic gains is accelerating in tandem with clinical use...
- Self-reported sensitivity to chemical exposures in five clinical populations and healthy controlsS S Nawab
Section on Biological Rhythms, National Institute of Mental Health, Bethesda, MD 20892 1390, USA
Psychiatry Res 95:67-74. 2000..A possible relationship between reported chemical sensitivity and hypothalamic-pituitary-adrenal (HPA)-axis functioning is discussed...
- Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidityGregor Hasler
Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 200, MSC 2670, Bethesda, MD 20892 2670, USA
Psychiatry Res 135:121-32. 2005....
- Vagus nerve stimulation and deep brain stimulation for treatment resistant depressionLinda L Carpenter
Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA
Med Health R I 89:137, 140-1. 2006..Further investigations are currently underway in order to more fully evaluate both of these neurostimulation therapies, with the hope of substantially improving the treatment of refractory depression...
- Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experienceB D Greenberg
Department of Psychiatry and Human Behavior, Division of Neurosurgery, Butler Hospital, Alpert Medical School of Brown University, Providence, RI 02906, USA
Mol Psychiatry 15:64-79. 2010..Taken together, these data show that the procedure can be successfully implemented by dedicated interdisciplinary teams, and support its therapeutic promise...
- Pleiotropy of the serotonin transporter gene for seasonality and neuroticismL Sher
Section on Biological Rhythms, National Institute of Mental Health, Bethesda, Maryland, USA
Psychiatr Genet 10:125-30. 2000..Sibling-pair analysis confirmed that the effects of the 5-HTTLPR are due to genetic pleiotropy rather than population stratification...
- Motor cortex excitability correlates with an anxiety-related personality traitE M Wassermann
Brain Stimulation Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N226, Bethesda, MD 20892, USA
Biol Psychiatry 50:377-82. 2001..Decreased intracortical inhibition may be related more to trait anxiety and depression, which are high in OCD, than to OCD itself. However, the MEP threshold (significantly lowered in OCD) was unrelated to N...
- Obsessive-compulsive disorder and its related disorders: a reappraisal of obsessive-compulsive spectrum conceptsDennis L Murphy
Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, Maryland 20892, USA
Dialogues Clin Neurosci 12:131-48. 2010..Considering the status of current research, the concept of OCD and OCD-related spectrum conditions seems fluid in 2010, and in need of ongoing reappraisal...
- Psychiatric neurosurgery 2009: review and perspectiveCynthia N Read
Brown University Butler Hospital, Providence, Rhode Island 02906, USA
Semin Neurol 29:256-65. 2009....
- The brown longitudinal obsessive compulsive study: treatments received and patient impressions of improvementMaria C Mancebo
Butler Hospital, Providence, RI 02906, USA
J Clin Psychiatry 67:1713-20. 2006..The primary aim of this study was to assess the extent to which individuals with obsessive-compulsive disorder (OCD) received recommended doses of treatment and perceived a response to these treatments...
- Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorderB Porton
Department of Psychiatry and Human Behavior, Brown University, Biomedical Center, Providence, RI 02912, USA
Transl Psychiatry 3:e259. 2013..These initial results reveal the complexity of SLC1A1 regulation and the potential clinical utility of profiling glutamatergic gene expression in OCD and other psychiatric disorders...
- Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorderM A Enoch
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
Biol Psychiatry 49:385-8. 2001..We hypothesized that the 5-HT2A promoter polymorphism, -1438G>A, previously associated with anorexia nervosa, would be more abundant in women with obsessive-compulsive disorder...
- A pilot study of moderate-intensity aerobic exercise for obsessive compulsive disorderRichard A Brown
Butler Hospital Brown Medical School, Providence, RI 02906, USA
J Nerv Ment Dis 195:514-20. 2007..Results of this study suggest that a randomized clinical trial evaluating the efficacy of this 12-week aerobic exercise intervention is warranted...
- Acute changes in obsessions and compulsions following moderate-intensity aerobic exercise among patients with obsessive-compulsive disorderAna M Abrantes
Butler Hospital Alpert Medical School of Brown University, Providence, RI 02906, USA
J Anxiety Disord 23:923-7. 2009..Results of this study point toward the promising effect of exercise for acute symptom reduction in patients with OCD...
- Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics StudyGregor Hasler
Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Biol Psychiatry 61:617-25. 2007..While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions...
- Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onsetStephen Correia
Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Veterans Affairs Medical Center 830 Chalkstone Ave, Providence, RI 02908, USA
Brain Imaging Behav 4:35-45. 2010..This effect was driven by patients whose OCD symptoms began from around adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia...
- Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categoriesAnthony Pinto
Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
Psychiatry Res 160:83-93. 2008..The results support investigation of this multidimensional model in OCD genetic linkage studies...
- Taboo thoughts and doubt/checking: a refinement of the factor structure for obsessive-compulsive disorder symptomsAnthony Pinto
Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02906, USA
Psychiatry Res 151:255-8. 2007....
- Repetitive transcranial magnetic stimulation: a putative add-on treatment for major depression in elderly patientsUrs P Mosimann
Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
Psychiatry Res 126:123-33. 2004..Therapeutic effects of rTMS in this clinically challenging patient group remain to be demonstrated...
- [What is the role of psychiatric neurosurgery in the 21st Century?]Scott L Rauch
Rev Bras Psiquiatr 26:4-5. 2004
- Anatomy and physiology of the basal ganglia: implications for DBS in psychiatryBrian Harris Kopell
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Neurosci Biobehav Rev 32:408-22. 2008..Implementing such therapies optimally will require the creation of treatment centers with specialized expertise in the psychiatric, neurosurgical, and ethical issues that arise with these populations...
- Metabolic imaging of anterior capsular stimulation in refractory obsessive-compulsive disorder: a key role for the subgenual anterior cingulate and ventral striatumKoenraad Van Laere
Division of Nuclear Medicine, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
J Nucl Med 47:740-7. 2006..The mechanism of action is unknown but hypothesized to be secondary to interruption of the corticothalamostriatocortical circuit...
- A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorderScott L Rauch
Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosurg 104:558-65. 2006..The purpose of the current study was to test hypotheses regarding changes in regional cerebral blood flow (rCBF) during acute DBS at the VC/VS target in patients with OCD who were participating in a clinical DBS trial...
- Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorderBernadette Cullen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Depress Anxiety 25:218-24. 2008..Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner...
- Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics StudyJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
Behav Res Ther 45:673-86. 2007..The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families...
- Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorderXian Zhang Hu
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
Am J Hum Genet 78:815-26. 2006..The L(A) allele was twofold overtransmitted to the patients with OCD. The HTTLPR L(A)L(A) genotype exerts a moderate (1.8-fold) effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD...
- Refractory obsessive-compulsive disorder: state-of-the-art treatmentEric Hollander
Department of Psychiatry, Compulsive, Impulsive, and Anxiety Disorders Program, Mount Sinai School of Medicine, New York, NY 10029, USA
J Clin Psychiatry 63:20-9. 2002..The authors synthesize state-of-the-art treatment and give practical advice for clinicians...
- Psychosurgery: avoiding an ethical redux while advancing a therapeutic futureJoseph J Fins
Division of Medical Ethics, New York Presbyterian Weill Cornell Medical Center, New York, New York 10021, USA
Neurosurgery 59:713-6. 2006
- The OCD collaborative genetics study: methods and sample descriptionJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7228, USA
Am J Med Genet B Neuropsychiatr Genet 141:201-7. 2006....
- Transcranial magnetic stimulationMark S George
Department of Psychiatry, 502 North, Institute of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC, USA
Neurosurg Clin N Am 14:283-301. 2003..Whatever road the future takes, TMS is an important new tool that will likely be of interest to neurosurgeons over the next 20 years and perhaps even longer...
- Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics StudyJack Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N Wolfe St, Meyer 4 181, Baltimore, MD 21287 7228, USA
Am J Psychiatry 164:493-9. 2007..The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder...
- What's in a "smile?" Intra-operative observations of contralateral smiles induced by deep brain stimulationMichael S Okun
Movement Disorders Center, University of Florida, Department of Neurology, McKnight Brain Institute, Gaineville, FL 32610, USA
Neurocase 10:271-9. 2004..To describe smiling and euphoria induced by deep brain stimulation (DBS)...