Casey L Quinlan

Summary

Affiliation: Buck Institute for Age Research
Country: USA

Publications

  1. pmc Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters
    Casey L Quinlan
    The Buck Institute for Research on Aging, Novato, CA 94945, USA
    Free Radic Biol Med 53:1807-17. 2012
  2. pmc Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions
    Casey L Quinlan
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Biol Chem 287:27255-64. 2012
  3. pmc The mechanism of superoxide production by the antimycin-inhibited mitochondrial Q-cycle
    Casey L Quinlan
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Biol Chem 286:31361-72. 2011
  4. pmc The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production
    Casey L Quinlan
    The Buck Institute for Research on Aging, Novato, California, USA
    Methods Enzymol 526:189-217. 2013
  5. pmc A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase
    Adam L Orr
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Biol Chem 287:42921-35. 2012
  6. pmc Evidence for two sites of superoxide production by mitochondrial NADH-ubiquinone oxidoreductase (complex I)
    Jason R Treberg
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Biol Chem 286:27103-10. 2011
  7. pmc The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I
    Casey L Quinlan
    From the Buck Institute for Research on Aging, Novato, California 94945
    J Biol Chem 289:8312-25. 2014
  8. pmc Sites of reactive oxygen species generation by mitochondria oxidizing different substrates
    Casey L Quinlan
    The Buck Institute for Research on Aging, Novato, CA 94945, USA
    Redox Biol 1:304-12. 2013
  9. pmc Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria
    Irina V Perevoshchikova
    Buck Institute for Research on Aging, Novato, CA 94945, USA Electronic address
    Free Radic Biol Med 61:298-309. 2013
  10. pmc Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise
    Renata L S Goncalves
    From the Buck Institute for Research on Aging, Novato, California 94945
    J Biol Chem 290:209-27. 2015

Collaborators

Detail Information

Publications13

  1. pmc Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters
    Casey L Quinlan
    The Buck Institute for Research on Aging, Novato, CA 94945, USA
    Free Radic Biol Med 53:1807-17. 2012
    ....
  2. pmc Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions
    Casey L Quinlan
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Biol Chem 287:27255-64. 2012
    ..We suggest that complex II may be an important contributor to physiological and pathological ROS production...
  3. pmc The mechanism of superoxide production by the antimycin-inhibited mitochondrial Q-cycle
    Casey L Quinlan
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Biol Chem 286:31361-72. 2011
    ..These mechanisms limit superoxide production and short circuiting of the Q-cycle when electron transfer slows...
  4. pmc The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production
    Casey L Quinlan
    The Buck Institute for Research on Aging, Novato, California, USA
    Methods Enzymol 526:189-217. 2013
    ..We provide detailed methods for the measurement of H2O2 release and the conditions under which maximal rates from each site can be achieved in intact skeletal muscle mitochondria. ..
  5. pmc A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase
    Adam L Orr
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Biol Chem 287:42921-35. 2012
    ..These results clarify the maximum rate and mechanism of superoxide production by mGPDH...
  6. pmc Evidence for two sites of superoxide production by mitochondrial NADH-ubiquinone oxidoreductase (complex I)
    Jason R Treberg
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Biol Chem 286:27103-10. 2011
    ....
  7. pmc The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I
    Casey L Quinlan
    From the Buck Institute for Research on Aging, Novato, California 94945
    J Biol Chem 289:8312-25. 2014
    ..Depending on the substrates present, the dominant sites of superoxide/H2O2 production at the level of NADH may be the OGDH and PDH complexes, but these activities may often be misattributed to complex I. ..
  8. pmc Sites of reactive oxygen species generation by mitochondria oxidizing different substrates
    Casey L Quinlan
    The Buck Institute for Research on Aging, Novato, CA 94945, USA
    Redox Biol 1:304-12. 2013
    ....
  9. pmc Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria
    Irina V Perevoshchikova
    Buck Institute for Research on Aging, Novato, CA 94945, USA Electronic address
    Free Radic Biol Med 61:298-309. 2013
    ..Thus complex II and the ETF system both contribute to H2O2 productionduring fatty acid oxidation under appropriate conditions. ..
  10. pmc Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise
    Renata L S Goncalves
    From the Buck Institute for Research on Aging, Novato, California 94945
    J Biol Chem 290:209-27. 2015
    ..Under conditions mimicking mild and intense aerobic exercise, total production is much less, and the low capacity site IF dominates. These results give novel insights into which mitochondrial sites may produce superoxide/H2O2 in vivo. ..
  11. pmc Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production--a correction using glutathione depletion
    Jason R Treberg
    Buck Institute for Age Research, Novato, CA 94945, USA
    FEBS J 277:2766-78. 2010
    ..43 x (control rate)]/(0.55 + control rate). These results have significant ramifications for the rates and topology of superoxide production by isolated mitochondria...
  12. pmc Sources of superoxide/H2O2 during mitochondrial proline oxidation
    Renata L S Goncalves
    Buck Institute for Research on Aging, Novato, CA 94945, USA
    Redox Biol 2:901-9. 2014
    ....
  13. doi Measurement of proton leak and electron leak in isolated mitochondria
    Charles Affourtit
    Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945 1400, USA
    Methods Mol Biol 810:165-82. 2012
    ..In this chapter, methods are presented to measure proton and electron leak activities in isolated mitochondria. The relative strength of a modular kinetic approach to probe oxidative phosphorylation is emphasised...