S Melov

Summary

Affiliation: Buck Institute for Age Research
Country: USA

Publications

  1. ncbi Microarrays as a tool to investigate the biology of aging: a retrospective and a look to the future
    Simon Melov
    Buck Institute for Age Research, Novato, CA 94945, USA
    Sci Aging Knowledge Environ 2004:re7. 2004
  2. ncbi Spotlight on nematode mitochondria in RNAi mega-screen
    Simon Melov
    Buck Institute for Age Research, Novato, CA 94945, USA
    Sci Aging Knowledge Environ 2002:pe18. 2002
  3. ncbi Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment
    Simon Melov
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Free Radic Biol Med 38:258-61. 2005
  4. ncbi Animal models of oxidative stress, aging, and therapeutic antioxidant interventions
    Simon Melov
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Int J Biochem Cell Biol 34:1395-400. 2002
  5. ncbi Resistance exercise reverses aging in human skeletal muscle
    Simon Melov
    Buck Institute for Age Research, Novato, California, United States of America
    PLoS ONE 2:e465. 2007
  6. ncbi '...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease
    Simon Melov
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Trends Neurosci 25:121-3; discussion 123-4. 2002
  7. ncbi Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics
    S Melov
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 21:8348-53. 2001
  8. ncbi Mitochondrial oxidative stress causes hyperphosphorylation of tau
    Simon Melov
    Buck Institute for Age Research, Novato, California, United States of America
    PLoS ONE 2:e536. 2007
  9. ncbi Modeling mitochondrial function in aging neurons
    Simon Melov
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Trends Neurosci 27:601-6. 2004
  10. ncbi Therapeutics against mitochondrial oxidative stress in animal models of aging
    Simon Melov
    Buck Institute for Age Research, Novato, California 94945, USA
    Ann N Y Acad Sci 959:330-40. 2002

Research Grants

  1. MITOCHONDRIAL OXIDATIVE STRESS AND NEURODEGENERATION
    Simon Melov; Fiscal Year: 2004
  2. Comparative Functional Genomics of Longevity Assurance
    Simon Melov; Fiscal Year: 2006

Collaborators

Detail Information

Publications33

  1. ncbi Microarrays as a tool to investigate the biology of aging: a retrospective and a look to the future
    Simon Melov
    Buck Institute for Age Research, Novato, CA 94945, USA
    Sci Aging Knowledge Environ 2004:re7. 2004
    ....
  2. ncbi Spotlight on nematode mitochondria in RNAi mega-screen
    Simon Melov
    Buck Institute for Age Research, Novato, CA 94945, USA
    Sci Aging Knowledge Environ 2002:pe18. 2002
    ..In this Perspective, I discuss the implications of these results and make a plea for a more integrated approach in assessing the role of mitochondrial function, single gene mutations, and longevity...
  3. ncbi Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment
    Simon Melov
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Free Radic Biol Med 38:258-61. 2005
    ..These data support an oxidative etiology for AD-associated lens cataracts and their potential to be treated preventatively with antioxidants...
  4. ncbi Animal models of oxidative stress, aging, and therapeutic antioxidant interventions
    Simon Melov
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Int J Biochem Cell Biol 34:1395-400. 2002
    ....
  5. ncbi Resistance exercise reverses aging in human skeletal muscle
    Simon Melov
    Buck Institute for Age Research, Novato, California, United States of America
    PLoS ONE 2:e465. 2007
    ....
  6. ncbi '...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease
    Simon Melov
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Trends Neurosci 25:121-3; discussion 123-4. 2002
    ..This short review examines the recent studies relating to Clioquinol and AD, and anticipates the imminent results of a Phase II trial of Clioquinol in AD, due in March 2002...
  7. ncbi Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics
    S Melov
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 21:8348-53. 2001
    ....
  8. ncbi Mitochondrial oxidative stress causes hyperphosphorylation of tau
    Simon Melov
    Buck Institute for Age Research, Novato, California, United States of America
    PLoS ONE 2:e536. 2007
    ..These findings mechanistically link mitochondrial oxidative stress with the pathological features of AD...
  9. ncbi Modeling mitochondrial function in aging neurons
    Simon Melov
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Trends Neurosci 27:601-6. 2004
    ..This review will highlight several new animal models of mitochondrial dysfunction in the context of aging...
  10. ncbi Therapeutics against mitochondrial oxidative stress in animal models of aging
    Simon Melov
    Buck Institute for Age Research, Novato, California 94945, USA
    Ann N Y Acad Sci 959:330-40. 2002
    ..Similarly, we have employed the nematode Caenorhabditis elegans to test the hypothesis that effective antioxidant therapy can prolong the life span of an invertebrate...
  11. ncbi Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment
    Karl J Morten
    Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 281:3354-9. 2006
    ..Increased production of O2* resulting from complex II normalization had no effect on steady state levels due to the rapid conversion to H2O2, a process presumably aided by the presence of the EUK189, an SOD mimetic...
  12. ncbi Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy
    Tamara R Golden
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Free Radic Biol Med 39:152-63. 2005
    ..The normalization of expression of some of these pathways by antioxidant treatment suggests approaches to treating disease in which endogenous oxidative stress plays a role...
  13. ncbi Mitochondrial oxidative stress. Physiologic consequences and potential for a role in aging
    S Melov
    Buck Center for Research in Aging, Novato, California 94948 0638, USA
    Ann N Y Acad Sci 908:219-25. 2000
    ..These catalytic antioxidants are discussed in the context of mitochondrial oxidative stress and their potential role in intervening in mitochondrial oxidative stress and aging...
  14. ncbi Microarray analysis of variation in individual aging C. elegans: approaches and challenges
    T R Golden
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Exp Gerontol 41:1040-5. 2006
    ..biological variance as it pertains to uncovering genes of interest in this paradigm of individual aging...
  15. ncbi Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas
    Enrique Samper
    The Buck Institute for Age Research, Novato, CA 94945, USA
    Free Radic Biol Med 46:387-96. 2009
    ..Understanding these adaptations is likely to result in improved therapeutic strategies for this tumor type...
  16. ncbi Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice
    Douglas Hinerfeld
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 88:657-67. 2004
    ..In addition, we observed a striking pattern of neuronal cell death as a result of mitochondrial oxidative stress, and were able to significantly reduce the loss of neurons via antioxidant treatment...
  17. ncbi Mitochondrial DNA mutations, oxidative stress, and aging
    T R Golden
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Mech Ageing Dev 122:1577-89. 2001
    ..We discuss in a historical context the rapid progress in our understanding of the role of mitochondrial DNA mutations in disease, mitochondrial oxidative stress in aging, and the potential interplay between these two phenomena...
  18. ncbi Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans
    Gawain McColl
    Buck Institute for Age Research, Novato, CA 94945, USA
    J Biol Chem 283:350-7. 2008
    ..2), a histone demethylase; knockdown by RNA interference of T08D10.2 is sufficient to extend longevity ( approximately 25% median increase), suggesting Li(+) regulates survival by modulating histone methylation and chromatin structure...
  19. ncbi Oxidative stress and aging: beyond correlation
    Tamara R Golden
    Buck Institute for Age Research, Novato, CA 94945, USA
    Aging Cell 1:117-23. 2002
    ..In mammalian model systems, the effect of oxidative stress on lifespan is less clear, but there is evidence that antioxidant treatment protects against age-related dysfunction, including cognitive decline...
  20. ncbi Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts
    E Samper
    Buck Institute for Age Research, Novato, CA 94945, USA
    Aging Cell 2:277-85. 2003
    ..Our results predict that endogenous mitochondrial oxidative stress can induce genomic instability, and therefore may have a profound effect in cancer and aging...
  21. ncbi Microarray analysis of gene expression with age in individual nematodes
    Tamara R Golden
    The Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Aging Cell 3:111-24. 2004
    ..elegans. In addition, this approach has the potential to uncover the molecular variability between individuals of a population, variation that is missed when studying pools of thousands of individuals...
  22. ncbi Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration
    Jun Peng
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 26:11644-51. 2006
    ..This has novel implications for the use of the weaver mouse as a model for Parkinson's disease, which has been associated with increased neuroinflammation...
  23. ncbi Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegans
    Tamara R Golden
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 6:179-88. 2007
    ..These changes are delayed or attenuated in long-lived daf-2 mutants. We propose that these changes are important pathobiological characteristics of aging nematodes...
  24. ncbi Science fact and the SENS agenda. What can we reasonably expect from ageing research?
    Huber Warner
    Buck Institute for Age Research, Novato, CA, USA
    EMBO Rep 6:1006-8. 2005
  25. ncbi Alzheimer disease beta-amyloid activity mimics cholesterol oxidase
    Luigi Puglielli
    Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Clin Invest 115:2556-63. 2005
    ..Cu2+-mediated oxidation of cholesterol may be a pathogenic mechanism common to atherosclerosis and AD...
  26. ncbi Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice
    Xu Gang Xia
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Genet 2:e10. 2006
    ....
  27. ncbi Hyperplasia, reduced E-cadherin expression, and developmental arrest in mammary glands oxidatively stressed by loss of mitochondrial superoxide dismutase
    Hema Parmar
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Breast 14:256-63. 2005
    ..These findings suggest that excess oxidative stress from loss of SOD2 function can arrest mammary gland maturation and induce hyperplastic epithelium with early premalignant features...
  28. ncbi Microscale fractionation facilitates detection of differentially expressed proteins in Alzheimer's disease brain samples
    Mary F Lopez
    PerkinElmer Life and Analytical Sciences, Boston, MA 02118, USA
    Electrophoresis 25:2557-63. 2004
    ....
  29. ncbi Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation
    Adeel Safdar
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Physiol Genomics 32:219-28. 2008
    ..We are the first to report this large-scale gene expression in the skeletal muscle with short-term CrM supplementation, a response that suggests changes in cellular osmolarity...
  30. ncbi Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
    Simona Parrinello
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Nat Cell Biol 5:741-7. 2003
    ..Our results identify oxygen sensitivity as a critical difference between mouse and human cells, explaining their proliferative differences in culture, and possibly their different rates of cancer and ageing...
  31. ncbi Applied proteomics: mitochondrial proteins and effect on function
    Mary F Lopez
    Proteome Systems, Woburn, MA 01801, USA
    Circ Res 90:380-9. 2002
    ..Future efforts will focus on linking genomic array information to actual protein levels in mitochondria...
  32. ncbi Biomarker discovery and analysis platform: application to Alzheimer's disease
    Scott Kuzdzal
    PerkinElmer Life and Analytical Sciences, Boston, MA, USA
    Biotechniques 39:606-7. 2005
  33. ncbi Microarray workshop on aging
    Prakash N Nair
    Department of Physiology and South Texas Centers for Biology in Medicine, University of Texas Health Science Center in San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA
    Mech Ageing Dev 124:133-8. 2003
    ..Microarray analysis of complex tissues through the use of laser capture microdissection was also discussed...

Research Grants11

  1. MITOCHONDRIAL OXIDATIVE STRESS AND NEURODEGENERATION
    Simon Melov; Fiscal Year: 2004
    ....
  2. Comparative Functional Genomics of Longevity Assurance
    Simon Melov; Fiscal Year: 2006
    ..In years four and five we will apply the functional genomic approach defined above, as well as statistical methods refined during the first three years, to the analysis of mouse RI lines with differential lifespans. ..