Research Topics
| Pankaj KapahiSummaryAffiliation: Buck Institute for Age Research Country: USA Publications
Research Grants
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Detail Information
Publications
TOR pathway: linking nutrient sensing to life spanPankaj Kapahi
Buck Institute for Age Research, Novato, CA 94945, USA
Sci Aging Knowledge Environ 2004:PE34. 2004..Additionally, we discuss the interactions between the TOR and insulin-like signaling pathways as well as the key downstream processes that TOR regulates...
Protein synthesis and the antagonistic pleiotropy hypothesis of agingPankaj Kapahi
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, California 94945, USA
Adv Exp Med Biol 694:30-7. 2010....- With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in agingPankaj Kapahi
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Cell Metab 11:453-65. 2010.... - Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogasterSubhash D Katewa
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
Cell Metab 16:97-103. 2012..Together, these results suggest that enhanced fat metabolism in the muscle and physical activity play a key role in the protective effects of DR... - Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegansAric N Rogers
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
Cell Metab 14:55-66. 2011..Our results suggest that IFG-1 mediates the antagonistic effects on growth and somatic maintenance by regulating mRNA translation of particular mRNAs based, in part, on transcript length... - HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegansDi Chen
Buck Institute for Age Research, Novato, California, USA
PLoS Genet 5:e1000486. 2009..Therefore, our results demonstrate a tissue-specific role for HIF-1 in the lifespan extension by DR involving the IRE-1 ER stress pathway... - Longevity determined by developmental arrest genes in Caenorhabditis elegansDi Chen
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Aging Cell 6:525-33. 2007..We have isolated novel lifespan-extension genes, which may help understand the intrinsic link between organism development and adult lifespan... - Role of TOR signaling in aging and related biological processes in Drosophila melanogasterSubhash D Katewa
Buck Institute for Age Research, Novato, CA 94945, USA
Exp Gerontol 46:382-90. 2011.... - Dietary restriction and aging, 2009Subhash D Katewa
Buck Institute for Age Research, Novato, CA 94945, USA
Aging Cell 9:105-12. 2010..Here, we summarize a few of the reports published in 2009 that we believe provide novel directions and an improved understanding of dietary restriction... - Inhibition of mRNA translation extends lifespan in Caenorhabditis elegansKally Z Pan
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
Aging Cell 6:111-9. 2007..Thus, mRNA translation exerts pleiotropic effects on growth, reproduction, stress resistance and lifespan in C. elegans... - A role for S6 kinase and serotonin in postmating dietary switch and balance of nutrients in D. melanogasterMisha A Vargas
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Curr Biol 20:1006-11. 2010..Our results suggest that TOR signaling and serotonin may play an important role in maintaining nutrient balance in D. melanogaster. These studies may contribute to our understanding of metabolic disorders such as obesity and diabetes... - Glucocorticoids suppress selected components of the senescence-associated secretory phenotypeRémi Martin Laberge
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
Aging Cell 11:569-78. 2012..They further show that glucocorticoids inhibit selected components of the SASP and suggest that corticosterone and cortisol, two FDA-approved drugs, might exert their effects in part by suppressing senescence-associated inflammation... - Cellular senescence: a link between cancer and age-related degenerative disease?Judith Campisi
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94545, USA
Semin Cancer Biol 21:354-9. 2011..We propose that both the degenerative and hyperplastic diseases of aging may be fueled by such damage signals... - HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegansDi Chen
Buck Institute for Age Research, Novato, California, United States of America
PLoS Genet 5:e1000486. 2009..Therefore, our results demonstrate a tissue-specific role for HIF-1 in the lifespan extension by DR involving the IRE-1 ER stress pathway... - Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogasterUrsula Edman
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
Aging Cell 8:331-8. 2009..However, none of the DR conditions altered the accumulation of spontaneous mutations with age. These results suggest that the beneficial effects of DR are unlikely to be linked to protection against oxidative somatic DNA damage... - Allocrine modulation of feeding behavior by the Sex Peptide of DrosophilaGil B Carvalho
Division of Biology 156 29 and 216 76, California Institute of Technology, Pasadena, 91125, USA
Curr Biol 16:692-6. 2006..Our observations identify enhanced feeding behavior as a novel component of the Drosophila PMR and suggest that SP represents a molecular link between energy acquisition and reproductive investment... - Compensatory ingestion upon dietary restriction in Drosophila melanogasterGil B Carvalho
Division of Biology 156-29, California Institute of Technology, Pasadena, California 91125, USA
Nat Methods 2:813-5. 2005..Our results strongly indicate that feeding behavior and nutritional composition act concertedly to determine fly lifespan. Feeding behavior thus emerges as a central element in D. melanogaster aging... - Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathwayPankaj Kapahi
Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
Curr Biol 14:885-90. 2004..Modulation of expression in the fat is sufficient for the lifespan-extension effects. The lifespan extensions are dependent on nutritional condition, suggesting a possible link between the TOR pathway and dietary restriction...
Research Grants
- Regulation of long term feeding and triglyceride storage using DrosophilaPankaj Kapahi; Fiscal Year: 2006..Our findings will significantly affect our understanding of the causes of obesity, which is a growing epidemic in the world. ..
- TOR, mRNA Translation and Dietary Restriction in DrosophilaPankaj Kapahi; Fiscal Year: 2009..Our findings will have a significant effect on understanding the role of nutrition in aging and age-related diseases in humans. ..
- TOR, mRNA Translation and Dietary Restriction in DrosophilaPankaj Kapahi; Fiscal Year: 2010..Our findings will have a significant effect on understanding the role of nutrition in aging and age-related diseases in humans. ..
- Role of mRNA translation in the effects of dietary restriction on lifespanPankaj Kapahi; Fiscal Year: 2010..Our findings will have a significant effect on understanding the role of nutrition in aging and age related diseases in humans. ..