Pankaj Kapahi

Summary

Affiliation: Buck Institute for Age Research
Country: USA

Publications

  1. pmc HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans
    Di Chen
    Buck Institute for Age Research, Novato, California, USA
    PLoS Genet 5:e1000486. 2009
  2. pmc Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans
    Wai Jiao Cai
    Institute of Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 6:e28835. 2011
  3. pmc Rapamycin: Killing two birds with one stone
    Amit Khanna
    Buck Institute for Aging Research, Novato CA 94945, USA
    Aging (Albany NY) 3:1043-4. 2011
  4. pmc With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging
    Pankaj Kapahi
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Cell Metab 11:453-65. 2010
  5. ncbi request reprint Protein synthesis and the antagonistic pleiotropy hypothesis of aging
    Pankaj Kapahi
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, California 94945, USA
    Adv Exp Med Biol 694:30-7. 2010
  6. pmc TOR pathway: linking nutrient sensing to life span
    Pankaj Kapahi
    Buck Institute for Age Research, Novato, CA 94945, USA
    Sci Aging Knowledge Environ 2004:PE34. 2004
  7. pmc Longevity determined by developmental arrest genes in Caenorhabditis elegans
    Di Chen
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 6:525-33. 2007
  8. pmc Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster
    Subhash D Katewa
    Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Cell Metab 16:97-103. 2012
  9. pmc Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans
    Aric N Rogers
    Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Cell Metab 14:55-66. 2011
  10. pmc Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
    Kally Z Pan
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Aging Cell 6:111-9. 2007

Collaborators

Detail Information

Publications23

  1. pmc HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans
    Di Chen
    Buck Institute for Age Research, Novato, California, USA
    PLoS Genet 5:e1000486. 2009
    ..Therefore, our results demonstrate a tissue-specific role for HIF-1 in the lifespan extension by DR involving the IRE-1 ER stress pathway...
  2. pmc Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans
    Wai Jiao Cai
    Institute of Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 6:e28835. 2011
    ..In conclusion, we demonstrate a novel natural compound, icariside II as the bioactive form of icariin, extends the healthspan via IIS pathway in C. elegans...
  3. pmc Rapamycin: Killing two birds with one stone
    Amit Khanna
    Buck Institute for Aging Research, Novato CA 94945, USA
    Aging (Albany NY) 3:1043-4. 2011
    ..Rapamycin could be given to people predisposed to cancer based on genetic and family history and may also be useful to treat cancer patients to prevent relapses and metastasis...
  4. pmc With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging
    Pankaj Kapahi
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Cell Metab 11:453-65. 2010
    ....
  5. ncbi request reprint Protein synthesis and the antagonistic pleiotropy hypothesis of aging
    Pankaj Kapahi
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, California 94945, USA
    Adv Exp Med Biol 694:30-7. 2010
    ....
  6. pmc TOR pathway: linking nutrient sensing to life span
    Pankaj Kapahi
    Buck Institute for Age Research, Novato, CA 94945, USA
    Sci Aging Knowledge Environ 2004:PE34. 2004
    ..Additionally, we discuss the interactions between the TOR and insulin-like signaling pathways as well as the key downstream processes that TOR regulates...
  7. pmc Longevity determined by developmental arrest genes in Caenorhabditis elegans
    Di Chen
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 6:525-33. 2007
    ..We have isolated novel lifespan-extension genes, which may help understand the intrinsic link between organism development and adult lifespan...
  8. pmc Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster
    Subhash D Katewa
    Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Cell Metab 16:97-103. 2012
    ..Together, these results suggest that enhanced fat metabolism in the muscle and physical activity play a key role in the protective effects of DR...
  9. pmc Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans
    Aric N Rogers
    Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Cell Metab 14:55-66. 2011
    ..Our results suggest that IFG-1 mediates the antagonistic effects on growth and somatic maintenance by regulating mRNA translation of particular mRNAs based, in part, on transcript length...
  10. pmc Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
    Kally Z Pan
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Aging Cell 6:111-9. 2007
    ..Thus, mRNA translation exerts pleiotropic effects on growth, reproduction, stress resistance and lifespan in C. elegans...
  11. pmc Dietary restriction and aging, 2009
    Subhash D Katewa
    Buck Institute for Age Research, Novato, CA 94945, USA
    Aging Cell 9:105-12. 2010
    ..Here, we summarize a few of the reports published in 2009 that we believe provide novel directions and an improved understanding of dietary restriction...
  12. pmc Role of TOR signaling in aging and related biological processes in Drosophila melanogaster
    Subhash D Katewa
    Buck Institute for Age Research, Novato, CA 94945, USA
    Exp Gerontol 46:382-90. 2011
    ....
  13. pmc A role for S6 kinase and serotonin in postmating dietary switch and balance of nutrients in D. melanogaster
    Misha A Vargas
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Curr Biol 20:1006-11. 2010
    ..Our results suggest that TOR signaling and serotonin may play an important role in maintaining nutrient balance in D. melanogaster. These studies may contribute to our understanding of metabolic disorders such as obesity and diabetes...
  14. pmc Mitobolites: the elixir of life
    Subhash D Katewa
    Buck Institute for Research on Aging, Novato, CA 94945, USA
    Cell Metab 20:8-9. 2014
    ..Chin et al. (2014) reveal how a mitochondrial metabolite (mitobolite) inhibits mitochondrial ATPase and extends lifespan by mimicking dietary restriction in worms...
  15. pmc Glucocorticoids suppress selected components of the senescence-associated secretory phenotype
    Rémi Martin Laberge
    Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 11:569-78. 2012
    ..They further show that glucocorticoids inhibit selected components of the SASP and suggest that corticosterone and cortisol, two FDA-approved drugs, might exert their effects in part by suppressing senescence-associated inflammation...
  16. pmc Cellular senescence: a link between cancer and age-related degenerative disease?
    Judith Campisi
    Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94545, USA
    Semin Cancer Biol 21:354-9. 2011
    ..We propose that both the degenerative and hyperplastic diseases of aging may be fueled by such damage signals...
  17. ncbi request reprint HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans
    Di Chen
    Buck Institute for Age Research, Novato, California, United States of America
    PLoS Genet 5:e1000486. 2009
    ..Therefore, our results demonstrate a tissue-specific role for HIF-1 in the lifespan extension by DR involving the IRE-1 ER stress pathway...
  18. pmc Late-life rapamycin treatment reverses age-related heart dysfunction
    James M Flynn
    Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA
    Aging Cell 12:851-62. 2013
    ....
  19. pmc Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster
    Ursula Edman
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Aging Cell 8:331-8. 2009
    ..However, none of the DR conditions altered the accumulation of spontaneous mutations with age. These results suggest that the beneficial effects of DR are unlikely to be linked to protection against oxidative somatic DNA damage...
  20. pmc Allocrine modulation of feeding behavior by the Sex Peptide of Drosophila
    Gil B Carvalho
    Division of Biology 156 29 and 216 76, California Institute of Technology, Pasadena, 91125, USA
    Curr Biol 16:692-6. 2006
    ..Our observations identify enhanced feeding behavior as a novel component of the Drosophila PMR and suggest that SP represents a molecular link between energy acquisition and reproductive investment...
  21. pmc Compensatory ingestion upon dietary restriction in Drosophila melanogaster
    Gil B Carvalho
    Division of Biology 156 29, California Institute of Technology, Pasadena, California 91125, USA
    Nat Methods 2:813-5. 2005
    ..Our results strongly indicate that feeding behavior and nutritional composition act concertedly to determine fly lifespan. Feeding behavior thus emerges as a central element in D. melanogaster aging...
  22. pmc Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    Pankaj Kapahi
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Biol 14:885-90. 2004
    ..Modulation of expression in the fat is sufficient for the lifespan-extension effects. The lifespan extensions are dependent on nutritional condition, suggesting a possible link between the TOR pathway and dietary restriction...

Research Grants6

  1. Regulation of long term feeding and triglyceride storage using Drosophila
    Pankaj Kapahi; Fiscal Year: 2006
    ..Our findings will significantly affect our understanding of the causes of obesity, which is a growing epidemic in the world. ..
  2. TOR, mRNA Translation and Dietary Restriction in Drosophila
    Pankaj Kapahi; Fiscal Year: 2009
    ..Our findings will have a significant effect on understanding the role of nutrition in aging and age-related diseases in humans. ..
  3. TOR, mRNA Translation and Dietary Restriction in Drosophila
    Pankaj Kapahi; Fiscal Year: 2010
    ..Our findings will have a significant effect on understanding the role of nutrition in aging and age-related diseases in humans. ..
  4. Role of mRNA translation in the effects of dietary restriction on lifespan
    Pankaj Kapahi; Fiscal Year: 2010
    ..Our findings will have a significant effect on understanding the role of nutrition in aging and age related diseases in humans. ..