Vivian Y Hook

Summary

Affiliation: Buck Institute for Age Research
Country: USA

Publications

  1. ncbi request reprint Proteolysis of ProPTHrP(1-141) by "prohormone thiol protease" at multibasic residues generates PTHrP-related peptides: implications for PTHrP peptide production in lung cancer cells
    V Y Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    Biochem Biophys Res Commun 285:932-8. 2001
  2. ncbi request reprint Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 81:237-56. 2002
  3. ncbi request reprint Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, CA 94945, USA
    J Neurosci Res 74:393-405. 2003
  4. ncbi request reprint Protein trafficking to chromaffin granules and proteolytic processing within regulated secretory vesicles of neuroendocrine chromaffin cells
    Vivian Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    Ann N Y Acad Sci 971:397-405. 2002
  5. ncbi request reprint Novel chromaffin granule serpins, endopin 1 and endopin 2: endogenous protease inhibitors with distinct target protease specificities
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    Ann N Y Acad Sci 971:426-44. 2002
  6. ncbi request reprint The novel serpin endopin 2 demonstrates cross-class inhibition of papain and elastase: localization of endopin 2 to regulated secretory vesicles of neuroendocrine chromaffin cells
    Shin Rong Hwang
    Buck Institute for Age Research, Novato, California 94945, USA
    Biochemistry 41:10397-405. 2002
  7. ncbi request reprint Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells
    Jean C Lee
    The Buck Institute for Age Research, Novato, California 94945, USA
    Biochemistry 42:6938-46. 2003
  8. ncbi request reprint Novel secretory vesicle serpins, endopin 1 and endopin 2: endogenous protease inhibitors with distinct target protease specificities
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, CA 94945, USA
    Biol Chem 383:1067-74. 2002
  9. ncbi request reprint Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice
    Ruthellen Miller
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 86:556-63. 2003
  10. ncbi request reprint Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice
    Ruthellen Miller
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA, USA
    Neuropeptides 37:140-8. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Proteolysis of ProPTHrP(1-141) by "prohormone thiol protease" at multibasic residues generates PTHrP-related peptides: implications for PTHrP peptide production in lung cancer cells
    V Y Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    Biochem Biophys Res Commun 285:932-8. 2001
    ..The presence of PTP immunoreactivity in PTHrP-containing lung cancer cells suggests PTP as a candidate processing enzyme for the PTHrP precursor...
  2. ncbi request reprint Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 81:237-56. 2002
    ..These findings suggest that drug inhibition of several proteases may be required for reducing Abeta levels as a potential therapeutic approach for AD...
  3. ncbi request reprint Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, CA 94945, USA
    J Neurosci Res 74:393-405. 2003
    ..These results indicate that inhibition of multiple proteases may be needed to decrease Abeta production as a therapeutic strategy for Alzheimer's disease...
  4. ncbi request reprint Protein trafficking to chromaffin granules and proteolytic processing within regulated secretory vesicles of neuroendocrine chromaffin cells
    Vivian Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    Ann N Y Acad Sci 971:397-405. 2002
    ..These studies demonstrate multiple components as regulatory factors in the control of secretory vesicle function for the biosynthesis and secretion of neuropeptides and catecholamines...
  5. ncbi request reprint Novel chromaffin granule serpins, endopin 1 and endopin 2: endogenous protease inhibitors with distinct target protease specificities
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    Ann N Y Acad Sci 971:426-44. 2002
    ..These findings indicate the presence of endogenous endopin 1 and endopin 2 in secretory vesicle function...
  6. ncbi request reprint The novel serpin endopin 2 demonstrates cross-class inhibition of papain and elastase: localization of endopin 2 to regulated secretory vesicles of neuroendocrine chromaffin cells
    Shin Rong Hwang
    Buck Institute for Age Research, Novato, California 94945, USA
    Biochemistry 41:10397-405. 2002
    ..These findings demonstrate that endopin 2 inhibitory functions may occur in the regulated secretory pathway...
  7. ncbi request reprint Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells
    Jean C Lee
    The Buck Institute for Age Research, Novato, California 94945, USA
    Biochemistry 42:6938-46. 2003
    ..These findings demonstrate that production of catestatin involves cleavage of CgA at paired basic and monobasic residues, necessary steps for catestatin peptide regulation of nicotinic cholinergic-induced catecholamine release...
  8. ncbi request reprint Novel secretory vesicle serpins, endopin 1 and endopin 2: endogenous protease inhibitors with distinct target protease specificities
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, CA 94945, USA
    Biol Chem 383:1067-74. 2002
    ..It will be of interest in future studies to define the endogenous protease targets of these two novel secretory vesicle serpins...
  9. ncbi request reprint Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice
    Ruthellen Miller
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 86:556-63. 2003
    ..Overall, these studies demonstrated that the PC2 processing enzyme is critical for the in vivo production of alpha-MSH in pituitary and brain...
  10. ncbi request reprint Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice
    Ruthellen Miller
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA, USA
    Neuropeptides 37:140-8. 2003
    ..These results demonstrate the selective role of PC2 in neuropeptide production that provides active peptide neurotransmitter or hormones for biological functions in brain and neuroendocrine systems...
  11. ncbi request reprint The novel bovine serpin endopin 2C demonstrates selective inhibition of the cysteine protease cathepsin L compared to the serine protease elastase, in cross-class inhibition
    Shin Rong Hwang
    Department of Pharmacology, Medicine, and Neurosciences, University of California, San Diego, La Jolla, CA 92093 0324, USA
    Biochemistry 44:7757-67. 2005
    ..These findings demonstrate endopin 2C as a novel serpin that possesses cross-class inhibition with selectivity for inhibition of cathepsin L...
  12. pmc Multiple domains of endopin 2A for serpin cross-class inhibition of papain
    Shin Rong Hwang
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0744, USA
    Arch Biochem Biophys 461:219-24. 2007
    ..These findings indicate that the NH(2)-domain and the RSL region both participate in endopin 2A inhibition of papain...
  13. ncbi request reprint Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics
    Gregory Hook
    American Life Science Pharmaceuticals Inc, San Diego, CA 92121, USA
    Biol Chem 388:979-83. 2007
    ..The results suggest that cysteine protease inhibitors generally, and reversible cysteine protease inhibitors specifically, have potential for development as AD therapeutics...
  14. doi request reprint Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein
    Vivian Y H Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 283:7745-53. 2008
    ....
  15. ncbi request reprint Regulation of ACTH levels in anterior pituitary cells during stimulated secretion: evidence for aspartyl and cysteine proteases in the cellular metabolism of ACTH
    Catherine Sei
    Department of Neurosciences and Medicine, University of California, San Diego, La Jolla, CA, USA
    Peptides 24:717-25. 2003
    ..Thus, aspartyl and cysteine proteases may be involved in the cellular metabolism of ACTH...
  16. ncbi request reprint Regulation of cellular alpha-MSH and beta-endorphin during stimulated secretion from intermediate pituitary cells: involvement of aspartyl and cysteine proteases in the control of cellular levels of alpha-MSH and beta-endorphin
    Catherine Sei
    Department of Medicine, University of California, San Diego, La Jolla, CA, USA
    Peptides 23:1409-18. 2002
    ..These findings demonstrate the parallel regulation of cellular levels of alpha-MSH and beta-endorphin during their cosecretion, which may involve aspartyl and cysteine proteases in the metabolism of these peptide hormones...
  17. ncbi request reprint Demonstration of GTG as an alternative initiation codon for the serpin endopin 2B-2
    Shin Rong Hwang
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA
    Biochem Biophys Res Commun 327:837-44. 2005
    ..Significantly, further analyses of mammalian genomes based on GTG as an alternative initiation codon may predict new candidate gene products expressed by mammalian and human genomes...
  18. ncbi request reprint Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease
    Vivian Y H Hook
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, School of Medicine, University of California at San Diego, La Jolla, 92093 0744, USA
    Biol Chem 387:1429-39. 2006
    ..These results demonstrate newly identified roles for cathepsins L and B in neurosecretory vesicles in the production of biologically active peptides...