Research Topics
Species | DAVID ALAN GREENBERGSummaryAffiliation: Buck Institute for Age Research Country: USA Publications
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Publications
Vascular endothelial growth factors (VEGFs) and strokeDavid A Greenberg
Buck Institute for Research on Aging, Novato, CA, 94945, USA
Cell Mol Life Sci 70:1753-61. 2013..VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke...
Molecular mechanisms of cannabinoid protection from neuronal excitotoxicitySun Hee Kim
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Mol Pharmacol 69:691-6. 2006..Cannabinoids seem to protect neurons against NMDA toxicity at least in part by activation of CB1R and downstream inhibition of PKA signaling and NO generation...- Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injurySun Hee Kim
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
J Pharmacol Exp Ther 313:88-94. 2005..Therefore, receptor-stimulated inhibition of protein kinase A seems to be required for the neuroprotective effect of CB1R activation against oxidative neuronal injury... - From angiogenesis to neuropathologyDavid A Greenberg
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
Nature 438:954-9. 2005..As our understanding of pathophysiology grows, these developments may point the way towards new molecular and cell-based therapies... - Neurodegeneration and neurogenesis: focus on Alzheimer's diseaseDavid A Greenberg
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Curr Alzheimer Res 3:25-8. 2006..If AD leads to the production of fully functional, mature neurons that can restore brain function, strategies aimed at further increasing endogenous neurogenesis may have therapeutic value... - Another weapon against amyloidDavid A Greenberg
Buck Institute for Age Research, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 103:7943-4. 2006 - Growth factors and strokeDavid A Greenberg
Buck Institute for Age Research, Novato, CA 94945, USA
NeuroRx 3:458-65. 2006..Finally, growth factors are key mediators of neurogenesis in the adult brain, which could have a role in brain repair and functional recovery following stroke... - Linking acquired neurodevelopmental disorders to defects in cell adhesionDavid A Greenberg
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 100:8043-4. 2003 - The jaundice of the cellDavid A Greenberg
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 99:15837-9. 2002 - Neural gene therapy: sensational findingD A Greenberg
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California, USA
Gene Ther 12:1161-2. 2005 - Neurogenesis and strokeDavid A Greenberg
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
CNS Neurol Disord Drug Targets 6:321-5. 2007..Alternatively, transplantation of exogenously derived neural cells might also be an approach to the treatment of stroke... - DNA microarray analysis of cannabinoid signaling in mouse brain in vivoSophie Parmentier-Batteur
Buck Institute for Age Research, Novato, California 94945, USA
Mol Pharmacol 62:828-35. 2002..These findings suggest that MRG1 and GK are cannabinoid-regulated genes and that they may be involved in the vascular and hypothalamic effects of cannabinoids, respectively... - Neuroglobin: an endogenous neuroprotectantDavid A Greenberg
Buck Institute for Age Research, Novato, CA 94549, USA
Curr Opin Pharmacol 8:20-4. 2008..However, the mechanisms that underlie hypoxic induction of Ngb and neuroprotection by Ngb are still unclear... - Corpus callosum and experimental stroke: studies in callosotomized rats and acallosal miceKunlin Jin
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
Stroke 42:2584-8. 2011..Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke... - Regulation of hypoxic neuronal death signaling by neuroglobinAdil A Khan
The Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
FASEB J 22:1737-47. 2008..We link the protective actions of Ngb to inhibition of Pak1 kinase activity and Rac1-GDP-dissociation inhibitor disassociation, and inhibition of actin assembly and death-signaling module polarization... - Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administrationYunjuan Sun
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Dev Biol 289:329-35. 2006..These results suggest a role for VEGFB in the regulation of adult neurogenesis, which could have therapeutic implications for diseases associated with central neuronal loss... - Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signalingKunlin Jin
Buck Institute for Age Research, Novato, California 94945, USA
J Neurobiol 66:236-42. 2006..We conclude that VEGF promotes neurite outgrowth from cerebral cortical neurons by interacting with VEGFR2 and activating Rho/ROK signaling pathways... - Reelin-deficient mice show impaired neurogenesis and increased stroke sizeSeok Joon Won
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
Exp Neurol 198:250-9. 2006..These findings suggest that, in addition to its neurodevelopmental effects, Reln deficiency continues to influence neurogenesis and ischemic neuronal injury in the adult brain... - Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor (HB-EGF) reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the ratKunlin Jin
Buck Institute for Age Research, Novato, California 94945, USA
J Cereb Blood Flow Metab 24:399-408. 2004..The delayed neuroprotective effect of HB-EGF may have implications for efforts to prolong the therapeutic window for intervention in stroke... - FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's diseaseKunlin Jin
The Buck Institute for Age Research, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 102:18189-94. 2005..We conclude that FGF-2 improves neurological deficits and longevity in a transgenic mouse model of HD, and that its neuroprotective and neuroproliferative effects may contribute to this improvement... - Alzheimer's disease drugs promote neurogenesisKunlin Jin
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Brain Res 1085:183-8. 2006..BrdU labeling was associated with neuronal markers, such as Hu and betaIII tubulin. Thus, drugs used to treat AD increase cerebral neurogenesis both in vitro and in vivo, which may contribute to their therapeutic effects... - Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664Veronica Galvan
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 103:7130-5. 2006..These results suggest that Asp-664 plays a critical role in the generation of Alzheimer-related pathophysiological and behavioral changes in human APP transgenic mice, possibly as a cleavage site or via protein-protein interactions... - Neuroglobin protects against nitric oxide toxicityKunlin Jin
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Neurosci Lett 430:135-7. 2008..The results suggest that the ability of Ngb to neutralize the neurotoxic effects of reactive nitrogen species may be an important contributor to its neuroprotective properties... - Neurogenesis associated with endothelin-induced cortical infarction in the mouseYaoming Wang
Buck Institute for Age Research, Novato, CA 94945, USA
Brain Res 1167:118-22. 2007..These findings indicate that small ischemic lesions restricted to adult cerebral cortex can stimulate neuroproliferation at a distance... - A neuroglobin-overexpressing transgenic mouseAdil A Khan
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
Gene 398:172-6. 2007..We report production of a transgenic mouse in which Ngb is overexpressed under the control of the chicken beta-actin promoter. This mouse should prove helpful for studying Ngb-mediated effects in vitro and in vivo... - VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigrationYaoming Wang
Buck Institute for Age Research, Novato, California 94945, USA
J Neurosci Res 85:740-7. 2007.... - Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis miceYaoming Wang
Buck Institute for Age Research, Novato, California 94945, USA
J Neurosci 27:304-7. 2007..These findings indicate that neuronal VEGF protects against motor neuron degeneration, and may have therapeutic implications for ALS... - Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemiaAdil A Khan
Buck Institute for Age Research, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 103:17944-8. 2006..These findings extend prior evidence for cytoprotection by Ngb and suggest both direct (parenchymatous) and indirect (vasomotor) protective mechanisms... - Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the ratYaoming Wang
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Brain Res 1115:186-93. 2006..We report that VEGF improves functional outcome in ischemic rats, including both sensorimotor and cognitive deficiencies... - Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivoAdil A Khan
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 104:19114-9. 2007.... - Turning neurogenesis up a NotchDavid A Greenberg
Nat Med 12:884-5. 2006 - Role for neuronal nitric-oxide synthase in cannabinoid-induced neurogenesisSun Hee Kim
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
J Pharmacol Exp Ther 319:150-4. 2006..Thus, cannabinoids appear to stimulate adult neurogenesis by opposing the antineurogenic effect of NO... - Evidence for stroke-induced neurogenesis in the human brainKunlin Jin
Buck Institute for Age Research, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 103:13198-202. 2006..These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy... - Heparin-binding epidermal growth factor-like growth factor stimulates cell proliferation in cerebral cortical cultures through phosphatidylinositol 3'-kinase and mitogen-activated protein kinaseKunlin Jin
Buck Institute for Age Research, Novato, California
J Neurosci Res 81:497-505. 2005..These findings help to clarify the molecular mechanisms through which HB-EGF operates... - Increased severity of stroke in CB1 cannabinoid receptor knock-out miceSophie Parmentier-Batteur
Buck Institute for Age Research, Novato, California 94945, USA
J Neurosci 22:9771-5. 2002.... - Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motilityAllyn Franklin
Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
J Neurosci 23:7767-75. 2003.... - Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged miceKunlin Jin
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Aging Cell 2:175-83. 2003.... - VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemiaYunjuan Sun
Buck Institute for Age Research, Novato, California 94945, USA
J Clin Invest 111:1843-51. 2003..VEGF may, therefore, improve histological and functional outcome from stroke through multiple mechanisms... - Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanismDexi Chen
R S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
J Neurochem 85:670-9. 2003..Therefore, Ero-1L/Giig11 may have a role in ischemia-induced neuronal repair or survival mechanisms directed at counteracting abnormalities in protein folding, maturation and distribution... - Neuroglobin protects the brain from experimental stroke in vivoYunjuan Sun
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 100:3497-500. 2003..We conclude that Ngb acts as an endogenous neuroprotective factor in focal cerebral ischemia and may therefore represent a target for the development of new treatments for stroke... - Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expressionYonghua Zhu
Buck Institute for Age Research, Novato, California 94945, USA
FASEB J 17:186-93. 2003..These findings help to provide a molecular basis for some of the recently identified neuronal effects of VEGF... - Hemin induces neuroglobin expression in neural cellsYonghua Zhu
Buck Institute for Age Research, Novato, CA 94945, USA
Blood 100:2494-8. 2002..These results provide evidence for regulation of neuroglobin expression by at least 2 signal transduction pathways... - Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivoKunlin Jin
Buck Institute for Age Research, Novato, California 94945, USA
J Neurosci 22:5365-73. 2002..Therefore, HB-EGF may help to trigger proliferation of neuronal precursors in brain after hypoxic or ischemic injury... - Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemiaKunlin Jin
Buck Institute for Age Research, Novato, California, USA
J Neurochem 81:25-35. 2002..Taken together, the data suggest that caspase-2 induction and activation are important mediators of delayed neuronal death following transient global ischemia... - p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neuronsYonghua Zhu
Buck Institute for Age Research, Novato, California 94945, USA
J Biol Chem 277:22909-14. 2002..These results demonstrate that p38 and Mdm2 have roles in coupling hypoxic-ischemic neuronal insults to activation of p53 and hypoxic cell death... - Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cellsYonghua Zhu
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, Calif 94945, USA
Stroke 34:2483-8. 2003..CONCLUSIONS: These results indicate that hypoxia induces the expression of endoglin at both the mRNA and protein levels and that induction is regulated by the p38 and perhaps also JNK pathways... - Directed migration of neuronal precursors into the ischemic cerebral cortex and striatumKunlin Jin
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Mol Cell Neurosci 24:171-89. 2003..These results indicate that after cerebral ischemia, new neurons are directed toward sites of brain injury, where they might be in a position to participate in brain repair and functional recovery... - MEK and ERK protect hypoxic cortical neurons via phosphorylation of BadKunlin Jin
Buck Institute for Age Research, Novato, California 94945, USA
J Neurochem 80:119-25. 2002..These findings suggest that a cell-survival program involving phospho-activation of MEK1/2 and ERK1/2 and inactivation of Bad is mobilized in hypoxic neurons, and may help to regulate neuronal fate following hypoxic-ischemic injury... - Neuronal nitric oxide synthase and ischemia-induced neurogenesisYunjuan Sun
Buck Institute for Age Research, Novato, California 94945, USA
J Cereb Blood Flow Metab 25:485-92. 2005..Selective inhibition of neuronal NO synthase may have the potential to both reduce infarct size and enhance neurogenesis in stroke... - Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the ratKunlin Jin
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945-0638, USA
Neurobiol Dis 18:366-74. 2005..Thus, transplantation of neural precursors by a variety of routes can deliver cells with the potential to replace injured neurons to ischemic brain regions... - Presence of neuroglobin in cultured astrocytesXiao Qian Chen
Neuroscience Research Institute, Peking University, Key Laboratory of Neuroscience, Ministry of Education, Department of Neurobiology, Peking University Health Science Center, Beijing, People s Republic of China
Glia 50:182-6. 2005..Ngb antisense treatment increased apoptosis in ischemic astrocytes. The discovery of Ngb in astrocytes may provide some insight into how oxygen homeostasis is regulated in the brain... - Effect of aging on neuroglobin expression in rodent brainYunjuan Sun
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Neurobiol Aging 26:275-8. 2005..Loss of this neuroprotective protein may have a role in increasing susceptibility to age-related neurological disorders... - Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient miceYunjuan Sun
Buck Institute for Age Research, Novato, California 94945, USA
J Cereb Blood Flow Metab 24:1146-52. 2004..VegfB also protected cultured cerebral cortical neurons from hypoxic injury, suggesting that its protective action is mediated at least in part through a direct effect on neurons... - Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) miceKunlin Jin
Buck Institute for Age Research, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 101:13363-7. 2004..Enhanced neurogenesis in AD and animal models of AD suggests that neurogenesis may be a compensatory response and that measures to enhance neurogenesis further could have therapeutic potential... - VEGF and ALS: the luckiest growth factor?David A Greenberg
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Trends Mol Med 10:1-3. 2004 - Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesisKunlin Jin
Buck Institute for Age Research, Novato, California 94945, USA
FASEB J 18:287-99. 2004..These results suggest a role for stathmin in the migration of newborn neurons in the adult brain... - Increased hippocampal neurogenesis in Alzheimer's diseaseKunlin Jin
Buck Institute for Age Research, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 101:343-7. 2004..These findings suggest that neurogenesis is increased in AD hippocampus, where it may give rise to cells that replace neurons lost in the disease, and that stimulating hippocampal neurogenesis might provide a new treatment strategy... - The role of vascular endothelial growth factor in neurogenesis in adult brainVeronica Galvan
Buck Institute for Age Research, Novato, CA 94945, USA
Mini Rev Med Chem 6:667-9. 2006..Vascular and nervous networks share common molecular mechanisms underlying their morphogenesis. VEGF is likely to regulate both processes during development and in adult organisms... - Electrophysiological neurodifferentiation of subventricular zone-derived precursor cells following strokeBin Lai
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, United States
Neurosci Lett 442:305-8. 2008..These findings support the hypothesis that enhancing endogenous neurogenesis after stroke might have therapeutic benefit... - Cerebral neurogenesis is induced by intranasal administration of growth factorsKunlin Jin
Buck Institute for Age Research, Novato, CA 94945, USA
Ann Neurol 53:405-9. 2003..These findings indicate that intranasal growth factors may have potential as neurogenesis-promoting therapeutic agents... - Stem cell factor stimulates neurogenesis in vitro and in vivoKunlin Jin
Buck Institute for Age Research, Novato, California 94945, USA
J Clin Invest 110:311-9. 2002..Cerebral hypoxia and ischemia may stimulate neurogenesis through trophic factors, including SCF... - Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivoKunlin Jin
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Proc Natl Acad Sci U S A 99:11946-50. 2002..Cells labeled with BrdUrd after VEGF treatment in vivo include immature and mature neurons, astroglia, and endothelial cells. These findings implicate the angiogenesis factor VEGF in neurogenesis as well... - Regenerating the brainDavid A Greenberg
Buck Institute for Age Research, Novato, California 94945, USA
Int Rev Neurobiol 77:1-29. 2007 - Induction of neuronal markers in bone marrow cells: differential effects of growth factors and patterns of intracellular expressionKunlin Jin
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Exp Neurol 184:78-89. 2003....
Research Grants
- CANNABINOIDS AND NEUROPROTECTION IN CEREBRAL ISCHEMIADavid Greenberg; Fiscal Year: 2007....
- Neuroglobin in Neuronal Hypoxi and Cerebral IschemiaDavid Greenberg; Fiscal Year: 2009..The goal of this research is to find new ways to treat stroke and related neurological disorders. ..
- Neuroglobin in Neuronal Hypoxi and Cerebral IschemiaDAVID ALAN GREENBERG; Fiscal Year: 2010..The goal of this research is to find new ways to treat stroke and related neurological disorders. ..
- VEGF in Ischemic Neuroprotection, Neurodegeneration and RepairDavid Greenberg; Fiscal Year: 2009..The proposed studies will help to delineate the potential and limitations of VEGF family members in the treatment of stroke. ..
- VEGF in Neurprotection and NeurogenesisDavid Greenberg; Fiscal Year: 2007..abstract_text> ..
- ANGIOGENESIS FACTORS AND CEREBRAL ISCHEMIADavid Greenberg; Fiscal Year: 2001..4. Evaluate whether angiogenesis induced by prior focal ischemia or by administration of VEGF can decrease the size of cerebral infarcts in the same model. ..
- VEGF in Neurprotection and NeurogenesisDavid Greenberg; Fiscal Year: 2003..abstract_text> ..
- CANNABINOIDS AND NEUROPROTECTION IN CEREBRAL ISCHEMIADavid Greenberg; Fiscal Year: 2004..Furthermore these neuroprotective actions of cannabinoids are in keeping with their ability to reduce voltage-gated calcium currents, enhance inwardly rectifying potassium currents, and inhibit glutamate release. ..
- VEGF in Neurprotection and NeurogenesisDavid Greenberg; Fiscal Year: 2006..abstract_text> ..
- VEGF in Ischemic Neuroprotection, Neurodegeneration and RepairDAVID ALAN GREENBERG; Fiscal Year: 2010..The proposed studies will help to delineate the potential and limitations of VEGF family members in the treatment of stroke. ..