DAVID ALAN GREENBERG

Summary

Affiliation: Buck Institute for Age Research
Country: USA

Publications

  1. pmc Vascular endothelial growth factors (VEGFs) and stroke
    David A Greenberg
    Buck Institute for Research on Aging, Novato, CA, 94945, USA
    Cell Mol Life Sci 70:1753-61. 2013
  2. ncbi request reprint Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity
    Sun Hee Kim
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Mol Pharmacol 69:691-6. 2006
  3. ncbi request reprint Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury
    Sun Hee Kim
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    J Pharmacol Exp Ther 313:88-94. 2005
  4. ncbi request reprint From angiogenesis to neuropathology
    David A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
    Nature 438:954-9. 2005
  5. ncbi request reprint Neurodegeneration and neurogenesis: focus on Alzheimer's disease
    David A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Curr Alzheimer Res 3:25-8. 2006
  6. pmc Another weapon against amyloid
    David A Greenberg
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 103:7943-4. 2006
  7. pmc Growth factors and stroke
    David A Greenberg
    Buck Institute for Age Research, Novato, CA 94945, USA
    NeuroRx 3:458-65. 2006
  8. pmc Linking acquired neurodevelopmental disorders to defects in cell adhesion
    David A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 100:8043-4. 2003
  9. pmc The jaundice of the cell
    David A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 99:15837-9. 2002
  10. ncbi request reprint Neural gene therapy: sensational finding
    D A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California, USA
    Gene Ther 12:1161-2. 2005

Research Grants

  1. CANNABINOIDS AND NEUROPROTECTION IN CEREBRAL ISCHEMIA
    David Greenberg; Fiscal Year: 2007
  2. Neuroglobin in Neuronal Hypoxi and Cerebral Ischemia
    David Greenberg; Fiscal Year: 2009
  3. Neuroglobin in Neuronal Hypoxi and Cerebral Ischemia
    DAVID ALAN GREENBERG; Fiscal Year: 2010
  4. VEGF in Ischemic Neuroprotection, Neurodegeneration and Repair
    David Greenberg; Fiscal Year: 2009
  5. VEGF in Neurprotection and Neurogenesis
    David Greenberg; Fiscal Year: 2007
  6. ANGIOGENESIS FACTORS AND CEREBRAL ISCHEMIA
    David Greenberg; Fiscal Year: 2001
  7. VEGF in Neurprotection and Neurogenesis
    David Greenberg; Fiscal Year: 2003
  8. CANNABINOIDS AND NEUROPROTECTION IN CEREBRAL ISCHEMIA
    David Greenberg; Fiscal Year: 2004
  9. VEGF in Neurprotection and Neurogenesis
    David Greenberg; Fiscal Year: 2006
  10. VEGF in Ischemic Neuroprotection, Neurodegeneration and Repair
    DAVID ALAN GREENBERG; Fiscal Year: 2010

Collaborators

Detail Information

Publications64

  1. pmc Vascular endothelial growth factors (VEGFs) and stroke
    David A Greenberg
    Buck Institute for Research on Aging, Novato, CA, 94945, USA
    Cell Mol Life Sci 70:1753-61. 2013
    ..VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke...
  2. ncbi request reprint Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity
    Sun Hee Kim
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Mol Pharmacol 69:691-6. 2006
    ..Cannabinoids seem to protect neurons against NMDA toxicity at least in part by activation of CB1R and downstream inhibition of PKA signaling and NO generation...
  3. ncbi request reprint Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury
    Sun Hee Kim
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    J Pharmacol Exp Ther 313:88-94. 2005
    ..Therefore, receptor-stimulated inhibition of protein kinase A seems to be required for the neuroprotective effect of CB1R activation against oxidative neuronal injury...
  4. ncbi request reprint From angiogenesis to neuropathology
    David A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
    Nature 438:954-9. 2005
    ..As our understanding of pathophysiology grows, these developments may point the way towards new molecular and cell-based therapies...
  5. ncbi request reprint Neurodegeneration and neurogenesis: focus on Alzheimer's disease
    David A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Curr Alzheimer Res 3:25-8. 2006
    ..If AD leads to the production of fully functional, mature neurons that can restore brain function, strategies aimed at further increasing endogenous neurogenesis may have therapeutic value...
  6. pmc Another weapon against amyloid
    David A Greenberg
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 103:7943-4. 2006
  7. pmc Growth factors and stroke
    David A Greenberg
    Buck Institute for Age Research, Novato, CA 94945, USA
    NeuroRx 3:458-65. 2006
    ..Finally, growth factors are key mediators of neurogenesis in the adult brain, which could have a role in brain repair and functional recovery following stroke...
  8. pmc Linking acquired neurodevelopmental disorders to defects in cell adhesion
    David A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 100:8043-4. 2003
  9. pmc The jaundice of the cell
    David A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 99:15837-9. 2002
  10. ncbi request reprint Neural gene therapy: sensational finding
    D A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California, USA
    Gene Ther 12:1161-2. 2005
  11. ncbi request reprint Neurogenesis and stroke
    David A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    CNS Neurol Disord Drug Targets 6:321-5. 2007
    ..Alternatively, transplantation of exogenously derived neural cells might also be an approach to the treatment of stroke...
  12. ncbi request reprint DNA microarray analysis of cannabinoid signaling in mouse brain in vivo
    Sophie Parmentier-Batteur
    Buck Institute for Age Research, Novato, California 94945, USA
    Mol Pharmacol 62:828-35. 2002
    ..These findings suggest that MRG1 and GK are cannabinoid-regulated genes and that they may be involved in the vascular and hypothalamic effects of cannabinoids, respectively...
  13. pmc Neuroglobin: an endogenous neuroprotectant
    David A Greenberg
    Buck Institute for Age Research, Novato, CA 94549, USA
    Curr Opin Pharmacol 8:20-4. 2008
    ..However, the mechanisms that underlie hypoxic induction of Ngb and neuroprotection by Ngb are still unclear...
  14. pmc Corpus callosum and experimental stroke: studies in callosotomized rats and acallosal mice
    Kunlin Jin
    Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Stroke 42:2584-8. 2011
    ..Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke...
  15. pmc Regulation of hypoxic neuronal death signaling by neuroglobin
    Adil A Khan
    The Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    FASEB J 22:1737-47. 2008
    ..We link the protective actions of Ngb to inhibition of Pak1 kinase activity and Rac1-GDP-dissociation inhibitor disassociation, and inhibition of actin assembly and death-signaling module polarization...
  16. ncbi request reprint Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administration
    Yunjuan Sun
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Dev Biol 289:329-35. 2006
    ..These results suggest a role for VEGFB in the regulation of adult neurogenesis, which could have therapeutic implications for diseases associated with central neuronal loss...
  17. ncbi request reprint Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling
    Kunlin Jin
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurobiol 66:236-42. 2006
    ..We conclude that VEGF promotes neurite outgrowth from cerebral cortical neurons by interacting with VEGFR2 and activating Rho/ROK signaling pathways...
  18. ncbi request reprint Reelin-deficient mice show impaired neurogenesis and increased stroke size
    Seok Joon Won
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Exp Neurol 198:250-9. 2006
    ..These findings suggest that, in addition to its neurodevelopmental effects, Reln deficiency continues to influence neurogenesis and ischemic neuronal injury in the adult brain...
  19. ncbi request reprint Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor (HB-EGF) reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the rat
    Kunlin Jin
    Buck Institute for Age Research, Novato, California 94945, USA
    J Cereb Blood Flow Metab 24:399-408. 2004
    ..The delayed neuroprotective effect of HB-EGF may have implications for efforts to prolong the therapeutic window for intervention in stroke...
  20. pmc FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease
    Kunlin Jin
    The Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 102:18189-94. 2005
    ..We conclude that FGF-2 improves neurological deficits and longevity in a transgenic mouse model of HD, and that its neuroprotective and neuroproliferative effects may contribute to this improvement...
  21. ncbi request reprint Alzheimer's disease drugs promote neurogenesis
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Brain Res 1085:183-8. 2006
    ..BrdU labeling was associated with neuronal markers, such as Hu and betaIII tubulin. Thus, drugs used to treat AD increase cerebral neurogenesis both in vitro and in vivo, which may contribute to their therapeutic effects...
  22. pmc Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664
    Veronica Galvan
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 103:7130-5. 2006
    ..These results suggest that Asp-664 plays a critical role in the generation of Alzheimer-related pathophysiological and behavioral changes in human APP transgenic mice, possibly as a cleavage site or via protein-protein interactions...
  23. pmc Neuroglobin protects against nitric oxide toxicity
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Neurosci Lett 430:135-7. 2008
    ..The results suggest that the ability of Ngb to neutralize the neurotoxic effects of reactive nitrogen species may be an important contributor to its neuroprotective properties...
  24. pmc Neurogenesis associated with endothelin-induced cortical infarction in the mouse
    Yaoming Wang
    Buck Institute for Age Research, Novato, CA 94945, USA
    Brain Res 1167:118-22. 2007
    ..These findings indicate that small ischemic lesions restricted to adult cerebral cortex can stimulate neuroproliferation at a distance...
  25. pmc A neuroglobin-overexpressing transgenic mouse
    Adil A Khan
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Gene 398:172-6. 2007
    ..We report production of a transgenic mouse in which Ngb is overexpressed under the control of the chicken beta-actin promoter. This mouse should prove helpful for studying Ngb-mediated effects in vitro and in vivo...
  26. ncbi request reprint VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration
    Yaoming Wang
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci Res 85:740-7. 2007
    ....
  27. pmc Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice
    Yaoming Wang
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 27:304-7. 2007
    ..These findings indicate that neuronal VEGF protects against motor neuron degeneration, and may have therapeutic implications for ALS...
  28. pmc Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia
    Adil A Khan
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 103:17944-8. 2006
    ..These findings extend prior evidence for cytoprotection by Ngb and suggest both direct (parenchymatous) and indirect (vasomotor) protective mechanisms...
  29. ncbi request reprint Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat
    Yaoming Wang
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Brain Res 1115:186-93. 2006
    ..We report that VEGF improves functional outcome in ischemic rats, including both sensorimotor and cognitive deficiencies...
  30. pmc Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo
    Adil A Khan
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 104:19114-9. 2007
    ....
  31. ncbi request reprint Turning neurogenesis up a Notch
    David A Greenberg
    Nat Med 12:884-5. 2006
  32. ncbi request reprint Role for neuronal nitric-oxide synthase in cannabinoid-induced neurogenesis
    Sun Hee Kim
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    J Pharmacol Exp Ther 319:150-4. 2006
    ..Thus, cannabinoids appear to stimulate adult neurogenesis by opposing the antineurogenic effect of NO...
  33. pmc Evidence for stroke-induced neurogenesis in the human brain
    Kunlin Jin
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 103:13198-202. 2006
    ..These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy...
  34. ncbi request reprint Heparin-binding epidermal growth factor-like growth factor stimulates cell proliferation in cerebral cortical cultures through phosphatidylinositol 3'-kinase and mitogen-activated protein kinase
    Kunlin Jin
    Buck Institute for Age Research, Novato, California
    J Neurosci Res 81:497-505. 2005
    ..These findings help to clarify the molecular mechanisms through which HB-EGF operates...
  35. ncbi request reprint Increased severity of stroke in CB1 cannabinoid receptor knock-out mice
    Sophie Parmentier-Batteur
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 22:9771-5. 2002
    ....
  36. ncbi request reprint Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility
    Allyn Franklin
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 23:7767-75. 2003
    ....
  37. ncbi request reprint Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 2:175-83. 2003
    ....
  38. pmc VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
    Yunjuan Sun
    Buck Institute for Age Research, Novato, California 94945, USA
    J Clin Invest 111:1843-51. 2003
    ..VEGF may, therefore, improve histological and functional outcome from stroke through multiple mechanisms...
  39. ncbi request reprint Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanism
    Dexi Chen
    R S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Neurochem 85:670-9. 2003
    ..Therefore, Ero-1L/Giig11 may have a role in ischemia-induced neuronal repair or survival mechanisms directed at counteracting abnormalities in protein folding, maturation and distribution...
  40. pmc Neuroglobin protects the brain from experimental stroke in vivo
    Yunjuan Sun
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 100:3497-500. 2003
    ..We conclude that Ngb acts as an endogenous neuroprotective factor in focal cerebral ischemia and may therefore represent a target for the development of new treatments for stroke...
  41. ncbi request reprint Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression
    Yonghua Zhu
    Buck Institute for Age Research, Novato, California 94945, USA
    FASEB J 17:186-93. 2003
    ..These findings help to provide a molecular basis for some of the recently identified neuronal effects of VEGF...
  42. ncbi request reprint Hemin induces neuroglobin expression in neural cells
    Yonghua Zhu
    Buck Institute for Age Research, Novato, CA 94945, USA
    Blood 100:2494-8. 2002
    ..These results provide evidence for regulation of neuroglobin expression by at least 2 signal transduction pathways...
  43. ncbi request reprint Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo
    Kunlin Jin
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 22:5365-73. 2002
    ..Therefore, HB-EGF may help to trigger proliferation of neuronal precursors in brain after hypoxic or ischemic injury...
  44. ncbi request reprint Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia
    Kunlin Jin
    Buck Institute for Age Research, Novato, California, USA
    J Neurochem 81:25-35. 2002
    ..Taken together, the data suggest that caspase-2 induction and activation are important mediators of delayed neuronal death following transient global ischemia...
  45. ncbi request reprint p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons
    Yonghua Zhu
    Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 277:22909-14. 2002
    ..These results demonstrate that p38 and Mdm2 have roles in coupling hypoxic-ischemic neuronal insults to activation of p53 and hypoxic cell death...
  46. ncbi request reprint Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells
    Yonghua Zhu
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, Calif 94945, USA
    Stroke 34:2483-8. 2003
    ..Endoglin (CD105) is a membrane glycoprotein that is mutated in hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease) and shows increased expression in proliferating endothelial cells during angiogenesis...
  47. ncbi request reprint Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Mol Cell Neurosci 24:171-89. 2003
    ..These results indicate that after cerebral ischemia, new neurons are directed toward sites of brain injury, where they might be in a position to participate in brain repair and functional recovery...
  48. ncbi request reprint MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad
    Kunlin Jin
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 80:119-25. 2002
    ..These findings suggest that a cell-survival program involving phospho-activation of MEK1/2 and ERK1/2 and inactivation of Bad is mobilized in hypoxic neurons, and may help to regulate neuronal fate following hypoxic-ischemic injury...
  49. ncbi request reprint Neuronal nitric oxide synthase and ischemia-induced neurogenesis
    Yunjuan Sun
    Buck Institute for Age Research, Novato, California 94945, USA
    J Cereb Blood Flow Metab 25:485-92. 2005
    ..Selective inhibition of neuronal NO synthase may have the potential to both reduce infarct size and enhance neurogenesis in stroke...
  50. ncbi request reprint Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945 0638, USA
    Neurobiol Dis 18:366-74. 2005
    ..Thus, transplantation of neural precursors by a variety of routes can deliver cells with the potential to replace injured neurons to ischemic brain regions...
  51. ncbi request reprint Presence of neuroglobin in cultured astrocytes
    Xiao Qian Chen
    Neuroscience Research Institute, Peking University, Key Laboratory of Neuroscience, Ministry of Education, Department of Neurobiology, Peking University Health Science Center, Beijing, People s Republic of China
    Glia 50:182-6. 2005
    ..Ngb antisense treatment increased apoptosis in ischemic astrocytes. The discovery of Ngb in astrocytes may provide some insight into how oxygen homeostasis is regulated in the brain...
  52. ncbi request reprint Effect of aging on neuroglobin expression in rodent brain
    Yunjuan Sun
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Neurobiol Aging 26:275-8. 2005
    ..Loss of this neuroprotective protein may have a role in increasing susceptibility to age-related neurological disorders...
  53. ncbi request reprint Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice
    Yunjuan Sun
    Buck Institute for Age Research, Novato, California 94945, USA
    J Cereb Blood Flow Metab 24:1146-52. 2004
    ..VegfB also protected cultured cerebral cortical neurons from hypoxic injury, suggesting that its protective action is mediated at least in part through a direct effect on neurons...
  54. pmc Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice
    Kunlin Jin
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 101:13363-7. 2004
    ..Enhanced neurogenesis in AD and animal models of AD suggests that neurogenesis may be a compensatory response and that measures to enhance neurogenesis further could have therapeutic potential...
  55. ncbi request reprint VEGF and ALS: the luckiest growth factor?
    David A Greenberg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Trends Mol Med 10:1-3. 2004
  56. ncbi request reprint Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesis
    Kunlin Jin
    Buck Institute for Age Research, Novato, California 94945, USA
    FASEB J 18:287-99. 2004
    ..These results suggest a role for stathmin in the migration of newborn neurons in the adult brain...
  57. pmc Increased hippocampal neurogenesis in Alzheimer's disease
    Kunlin Jin
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 101:343-7. 2004
    ..These findings suggest that neurogenesis is increased in AD hippocampus, where it may give rise to cells that replace neurons lost in the disease, and that stimulating hippocampal neurogenesis might provide a new treatment strategy...
  58. ncbi request reprint The role of vascular endothelial growth factor in neurogenesis in adult brain
    Veronica Galvan
    Buck Institute for Age Research, Novato, CA 94945, USA
    Mini Rev Med Chem 6:667-9. 2006
    ..Vascular and nervous networks share common molecular mechanisms underlying their morphogenesis. VEGF is likely to regulate both processes during development and in adult organisms...
  59. pmc Electrophysiological neurodifferentiation of subventricular zone-derived precursor cells following stroke
    Bin Lai
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, United States
    Neurosci Lett 442:305-8. 2008
    ..These findings support the hypothesis that enhancing endogenous neurogenesis after stroke might have therapeutic benefit...
  60. ncbi request reprint Cerebral neurogenesis is induced by intranasal administration of growth factors
    Kunlin Jin
    Buck Institute for Age Research, Novato, CA 94945, USA
    Ann Neurol 53:405-9. 2003
    ..These findings indicate that intranasal growth factors may have potential as neurogenesis-promoting therapeutic agents...
  61. pmc Stem cell factor stimulates neurogenesis in vitro and in vivo
    Kunlin Jin
    Buck Institute for Age Research, Novato, California 94945, USA
    J Clin Invest 110:311-9. 2002
    ..Cerebral hypoxia and ischemia may stimulate neurogenesis through trophic factors, including SCF...
  62. pmc Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 99:11946-50. 2002
    ..Cells labeled with BrdUrd after VEGF treatment in vivo include immature and mature neurons, astroglia, and endothelial cells. These findings implicate the angiogenesis factor VEGF in neurogenesis as well...
  63. ncbi request reprint Regenerating the brain
    David A Greenberg
    Buck Institute for Age Research, Novato, California 94945, USA
    Int Rev Neurobiol 77:1-29. 2007
  64. ncbi request reprint Induction of neuronal markers in bone marrow cells: differential effects of growth factors and patterns of intracellular expression
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Exp Neurol 184:78-89. 2003
    ....

Research Grants26

  1. CANNABINOIDS AND NEUROPROTECTION IN CEREBRAL ISCHEMIA
    David Greenberg; Fiscal Year: 2007
    ....
  2. Neuroglobin in Neuronal Hypoxi and Cerebral Ischemia
    David Greenberg; Fiscal Year: 2009
    ..The goal of this research is to find new ways to treat stroke and related neurological disorders. ..
  3. Neuroglobin in Neuronal Hypoxi and Cerebral Ischemia
    DAVID ALAN GREENBERG; Fiscal Year: 2010
    ..The goal of this research is to find new ways to treat stroke and related neurological disorders. ..
  4. VEGF in Ischemic Neuroprotection, Neurodegeneration and Repair
    David Greenberg; Fiscal Year: 2009
    ..The proposed studies will help to delineate the potential and limitations of VEGF family members in the treatment of stroke. ..
  5. VEGF in Neurprotection and Neurogenesis
    David Greenberg; Fiscal Year: 2007
    ..abstract_text> ..
  6. ANGIOGENESIS FACTORS AND CEREBRAL ISCHEMIA
    David Greenberg; Fiscal Year: 2001
    ..4. Evaluate whether angiogenesis induced by prior focal ischemia or by administration of VEGF can decrease the size of cerebral infarcts in the same model. ..
  7. VEGF in Neurprotection and Neurogenesis
    David Greenberg; Fiscal Year: 2003
    ..abstract_text> ..
  8. CANNABINOIDS AND NEUROPROTECTION IN CEREBRAL ISCHEMIA
    David Greenberg; Fiscal Year: 2004
    ..Furthermore these neuroprotective actions of cannabinoids are in keeping with their ability to reduce voltage-gated calcium currents, enhance inwardly rectifying potassium currents, and inhibit glutamate release. ..
  9. VEGF in Neurprotection and Neurogenesis
    David Greenberg; Fiscal Year: 2006
    ..abstract_text> ..
  10. VEGF in Ischemic Neuroprotection, Neurodegeneration and Repair
    DAVID ALAN GREENBERG; Fiscal Year: 2010
    ..The proposed studies will help to delineate the potential and limitations of VEGF family members in the treatment of stroke. ..