BRADFORD WAYNE GIBSON

Summary

Affiliation: Buck Institute for Age Research
Country: USA

Publications

  1. ncbi Novel pathways associated with quinone-induced stress in breast cancer cells
    Christopher C Benz
    Cancer and Developmental Therapeutics Program, Buck Institute for Age Research, Novato, CA 94945, USA
    Drug Metab Rev 38:601-13. 2006
  2. ncbi Identification of a novel sialic acid transporter in Haemophilus ducreyi
    Deborah M B Post
    Buck Institute for Age Research, Novato, CA 94945, USA
    Infect Immun 73:6727-35. 2005
  3. ncbi The human mitochondrial proteome: oxidative stress, protein modifications and oxidative phosphorylation
    Bradford W Gibson
    Chemistry Department, Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Int J Biochem Cell Biol 37:927-34. 2005
  4. ncbi Proteomic analysis of plasma membrane and secretory vesicles from human neutrophils
    Deepa Jethwaney
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proteome Sci 5:12. 2007
  5. ncbi Exploiting proteomics in the discovery of drugs that target mitochondrial oxidative damage
    Bradford W Gibson
    Buck Institute for Age Research, Novato, CA 94945, USA
    Sci Aging Knowledge Environ 2004:pe12. 2004
  6. ncbi DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid
    Jason M Held
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 5:283-91. 2006
  7. ncbi Novel sialic acid transporter of Haemophilus influenzae
    Simon Allen
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, California 94945, USA
    Infect Immun 73:5291-300. 2005
  8. ncbi Lipophilic regulator of a developmental switch in Caenorhabditis elegans
    Matthew S Gill
    Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 3:413-21. 2004
  9. ncbi Biochemical and functional characterization of membrane blebs purified from Neisseria meningitidis serogroup B
    Deborah M B Post
    The Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 280:38383-94. 2005
  10. ncbi Proposed second class of Haemophilus ducreyi strains show altered protein and lipooligosaccharide profiles
    Deborah M B Post
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proteomics 7:3131-42. 2007

Research Grants

  1. STRUCTURE AND ACTIVITY OF HAEMOPHILUS DUCREYI LOS
    Bradford Gibson; Fiscal Year: 2001
  2. QSTAR Elite Quadrupole-o-TOF LC/MS/MS System
    Bradford Gibson; Fiscal Year: 2007
  3. Structure and Function of Haemophilus ducreyi LOS
    Bradford Gibson; Fiscal Year: 2007
  4. 4000 Q TRAP triple quadrupole/linear ion trap LC/MS/MS
    Bradford Gibson; Fiscal Year: 2005
  5. Proteomics of Complex 1 Inhibition in GSH-Depleted Cells
    Bradford Gibson; Fiscal Year: 2004

Collaborators

Detail Information

Publications25

  1. ncbi Novel pathways associated with quinone-induced stress in breast cancer cells
    Christopher C Benz
    Cancer and Developmental Therapeutics Program, Buck Institute for Age Research, Novato, CA 94945, USA
    Drug Metab Rev 38:601-13. 2006
    ....
  2. ncbi Identification of a novel sialic acid transporter in Haemophilus ducreyi
    Deborah M B Post
    Buck Institute for Age Research, Novato, CA 94945, USA
    Infect Immun 73:6727-35. 2005
    ..Uptake assays using radiolabeled sialic acid confirmed that the mutants were unable to transport sialic acid. This study is the first report of bacteria using an ABC transporter for sialic acid uptake...
  3. ncbi The human mitochondrial proteome: oxidative stress, protein modifications and oxidative phosphorylation
    Bradford W Gibson
    Chemistry Department, Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Int J Biochem Cell Biol 37:927-34. 2005
    ....
  4. ncbi Proteomic analysis of plasma membrane and secretory vesicles from human neutrophils
    Deepa Jethwaney
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proteome Sci 5:12. 2007
    ....
  5. ncbi Exploiting proteomics in the discovery of drugs that target mitochondrial oxidative damage
    Bradford W Gibson
    Buck Institute for Age Research, Novato, CA 94945, USA
    Sci Aging Knowledge Environ 2004:pe12. 2004
    ....
  6. ncbi DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid
    Jason M Held
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 5:283-91. 2006
    ..These data suggest that carboxylated sterols may be key determinants of life history...
  7. ncbi Novel sialic acid transporter of Haemophilus influenzae
    Simon Allen
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, California 94945, USA
    Infect Immun 73:5291-300. 2005
    ..In the absence of this transporter, H. influenzae cannot incorporate sialic acid into its lipooligosaccharides, making the organism unable to survive when exposed to human serum and causing reduced viability in biofilm growth...
  8. ncbi Lipophilic regulator of a developmental switch in Caenorhabditis elegans
    Matthew S Gill
    Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 3:413-21. 2004
    ..We propose that the dauer rescuing activity is a hormone synthesized by DAF-9 that acts through DAF-12...
  9. ncbi Biochemical and functional characterization of membrane blebs purified from Neisseria meningitidis serogroup B
    Deborah M B Post
    The Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 280:38383-94. 2005
    ..These findings indicate that the proinflammatory potency of endotoxin may be regulated not only by the intrinsic structural properties of endotoxin but also by its association with neighboring molecules in the outer membrane...
  10. ncbi Proposed second class of Haemophilus ducreyi strains show altered protein and lipooligosaccharide profiles
    Deborah M B Post
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proteomics 7:3131-42. 2007
    ..In this study, the proteomic profiles and the LOS structures from the five potential class II strains were examined and found to be similar to strain 33921...
  11. ncbi Identification of genes involved in the expression of atypical lipooligosaccharide structures from a second class of Haemophilus ducreyi
    Deborah M B Post
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Infect Immun 75:113-21. 2007
    ..These data indicate that the lbgAB genes can serve as one indicator of the classification of H. ducreyi strains...
  12. ncbi Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach
    Jason M Held
    double daggerBuck Institute for Age Research, Novato, California 94945, USA
    Mol Cell Proteomics 9:1400-10. 2010
    ..OxMRM also complements unbiased redox proteomics discovery studies as a verification tool through its high sensitivity, accuracy, precision, and throughput...
  13. ncbi Characterization of lipooligosaccharides from Haemophilus ducreyi containing polylactosamine repeats
    Birgit Schilling
    Buck Institute for Age Research, Novato, California 94945, USA
    J Am Soc Mass Spectrom 13:724-34. 2002
    ..Although LOS containing terminal di-LacNAc have been reported, this is the first time to our knowledge that a linear polyLacNAc structure has been characterized in bacteria...
  14. ncbi Proteome of Haemophilus ducreyi by 2-D SDS-PAGE and mass spectrometry: strain variation, virulence, and carbohydrate expression
    N Karoline Scheffler
    Buck Institute for Age Research, Novato, California 94945, USA
    J Proteome Res 2:523-33. 2003
    ..This African strain may represent a prototype of a second clonal group of H. ducreyi...
  15. ncbi Systematic mapping of posttranslational modifications in human estrogen receptor-alpha with emphasis on novel phosphorylation sites
    Christian Atsriku
    Buck Institute for Age Research, Novato, California 94945, USA
    Mol Cell Proteomics 8:467-80. 2009
    ....
  16. ncbi ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination
    Corina Marx
    Buck Institute for Age Research, Novato, California 94945, USA
    Cancer Res 70:3709-17. 2010
    ....
  17. ncbi Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line
    Birgit Schilling
    Buck Institute for Age Research, Novato, CA 94945, USA
    Mol Cell Proteomics 4:84-96. 2005
    ....
  18. ncbi Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria
    Birgit Schilling
    Buck Institute for Age Research, Novato, CA 94945, USA
    Biochim Biophys Acta 1762:213-22. 2006
    ..The identification of several posttranslational modifications, including the covalent FAD modification of flavoprotein subunit 1 from Complex II, was possible due to high mass spectrometric sequence coverage...
  19. ncbi A novel serine phosphorylation site detected in the N-terminal domain of estrogen receptor isolated from human breast cancer cells
    David J Britton
    Buck Institute for Age Research, Novato, California 94945, USA
    J Am Soc Mass Spectrom 19:729-40. 2008
    ....
  20. ncbi Expanded coverage of the human heart mitochondrial proteome using multidimensional liquid chromatography coupled with tandem mass spectrometry
    Sara P Gaucher
    Buck Institute for Age Research, Novato, California 94945, USA
    J Proteome Res 3:495-505. 2004
    ..Nat. Biotechnol. 2003, 21, 281-286). We now report two subsequent studies where multidimensional liquid chromatography MS/MS was investigated as an alternative means for characterizing the same sample...
  21. ncbi Characterization of lipid A acylation patterns in Francisella tularensis, Francisella novicida, and Francisella philomiragia using multiple-stage mass spectrometry and matrix-assisted laser desorption/ionization on an intermediate vacuum source linear ion
    Birgit Schilling
    The Buck Institute for Age Research, Novato, California 94945, USA
    Anal Chem 79:1034-42. 2007
    ..Overall, we found that MSn analysis on the vMALDI-LIT-MS platform was highly efficient and sensitive, allowing for thorough analysis of very minor lipid A species...
  22. ncbi Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesis
    Kunlin Jin
    Buck Institute for Age Research, Novato, California 94945, USA
    FASEB J 18:287-99. 2004
    ..These results suggest a role for stathmin in the migration of newborn neurons in the adult brain...
  23. ncbi Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease
    Steven R Danielson
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
    Anal Chem 81:7823-8. 2009
    ..This is the first report of increased 3NT levels of a specific tyrosine in a PD model and the first use of MRM mass spectrometry to quantify changes in 3NT modifications at specific sites within a target protein...
  24. ncbi Molecular components of a cell death pathway activated by endoplasmic reticulum stress
    Rammohan V Rao
    The Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 279:177-87. 2004
    ..Our data identify two molecules, valosin-containing protein and apoptosis-linked gene-2 (ALG-2), that appear to play a role in mediating ER stress-induced cell death...
  25. ncbi Stable isotope metabolic labeling of Neisseria meningitidis lipooligosaccharide
    Deborah M B Post
    The Buck Institute for Age Research, Novato, California 94945, USA
    J Endotoxin Res 12:93-8. 2006
    ..The development of this efficient labeling protocol should prove useful in future structural studies analyzing the interactions between LOS and host proteins...

Research Grants12

  1. STRUCTURE AND ACTIVITY OF HAEMOPHILUS DUCREYI LOS
    Bradford Gibson; Fiscal Year: 2001
    ....
  2. QSTAR Elite Quadrupole-o-TOF LC/MS/MS System
    Bradford Gibson; Fiscal Year: 2007
    ....
  3. Structure and Function of Haemophilus ducreyi LOS
    Bradford Gibson; Fiscal Year: 2007
    ..ducreyi. ..
  4. 4000 Q TRAP triple quadrupole/linear ion trap LC/MS/MS
    Bradford Gibson; Fiscal Year: 2005
    ..abstract_text> ..
  5. Proteomics of Complex 1 Inhibition in GSH-Depleted Cells
    Bradford Gibson; Fiscal Year: 2004
    ..Once identified, presence of these alterations will be assessed in future years in both an antiGSH transgenic mouse model of Parkinson disease as well as in Parkinsonian brains. ..