Research Topics
Species | Akos A GerencserSummaryAffiliation: Buck Institute for Age Research Country: USA Publications
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Detail Information
Publications
Measurement of instantaneous velocity vectors of organelle transport: mitochondrial transport and bioenergetics in hippocampal neuronsAkos A Gerencser
Buck Institute for Age Research, Novato, California 94945, USA
Biophys J 95:3079-99. 2008..These mitochondria are more motile than the average; however, mitochondrial motility is only slightly dependent on the observed bioenergetic parameters and is correlated the best to the size of the mitochondria...- Quantitative microplate-based respirometry with correction for oxygen diffusionAkos A Gerencser
Buck Institute for Age Research, Novato, CA, USA
Anal Chem 81:6868-78. 2009..The algorithm increases the useful range of oxygen consumption rates, the temporal resolution, and durations of measurements. The algorithm is presented in a general format and is therefore applicable to other respirometer systems... - Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondriaAkos A Gerencser
Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA
J Physiol 590:2845-71. 2012..Between samples treated in different ways, the typical equivalent error is ∼5 mV... - Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicityAkos A Gerencser
Buck Institute for Age Research, Novato, California 94945, USA
J Neurochem 110:990-1004. 2009..However, a role for calpain as a contributing factor or in response to milder glutamate insults is not excluded... 
No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's diseaseSung W Choi
Buck Institute Research on Aging, Novato, California 94945, USA
J Neurosci 32:16775-84. 2012..Our results support the conclusion that the intrinsic bioenergetic capacities of presynaptic nerve terminals are maintained in these symptomatic AD mouse models...- Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomesSung W Choi
Buck Institute for Research on Aging, Novato, California 94945, USA
J Neurosci 31:4524-34. 2011..We conclude that the intrinsic bioenergetic capacities of dopaminergic and nondopaminergic presynaptic synaptosomes from mice do not differ... - Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null miceJames M Flynn
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Free Radic Biol Med 50:866-73. 2011.... - Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failureSung W Choi
Buck Institute for Age Research, Novato, California 94945, USA
J Neurochem 109:1179-91. 2009.... - A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cellsMatthew J Birket
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
J Cell Sci 124:348-58. 2011..Taken together, our developmental model provides an understanding of the metabolic transition from hESCs to more quiescent somatic cell types, and supports important roles for mitochondria and secretion in hESC biology... - The mechanism of superoxide production by the antimycin-inhibited mitochondrial Q-cycleCasey L Quinlan
Buck Institute for Research on Aging, Novato, California 94945, USA
J Biol Chem 286:31361-72. 2011..These mechanisms limit superoxide production and short circuiting of the Q-cycle when electron transfer slows... - Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neuronsMark J Barsoum
Apoptosis and Cell Death Program, Burnham Institute for Medical Research, La Jolla, CA, USA
EMBO J 25:3900-11. 2006..Importantly, NO-induced neuronal cell death was mitigated by Mfn1 and Drp1(K38A). Thus, persistent mitochondrial fission may play a causal role in NO-mediated neurotoxicity... - Mitochondrial swelling measurement in situ by optimized spatial filtering: astrocyte-neuron differencesAkos A Gerencser
Department of Medical Biochemistry, Semmelweis University, Neurobiochemical Group, Hungarian Academy of Sciences, Szentagothai Knowledge Center, Budapest, Hungary
Biophys J 95:2583-98. 2008..We found that in situ astrocytic mitochondria swell upon short-term uncoupling or inhibition of oxidative phosphorylation, whereas such responses are absent in cultured cortical neurons... - Mitochondrial Ca2+ dynamics reveals limited intramitochondrial Ca2+ diffusionAkos A Gerencser
Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary
Biophys J 88:698-714. 2005..Our data suggest that mitochondria form syncytia of electrical conductance whereas the passage of Ca2+ is restricted to the individual organelle... 
Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La3+ in cultured cortical neuronesChristos Chinopoulos
Semmelweis University, Department of Medical Biochemistry, Neurobiochemical Group, Hungarian Academy of Sciences, Budapest, Hungary
J Neurochem 91:471-83. 2004..These results indicate that 2-APB and La3+ influence non-store-operated Ca2+ influx in cortical neurones and that this route of Ca2+ entry is involved in glutamate-induced delayed Ca2+ deregulation...