Akos A Gerencser

Summary

Affiliation: Buck Institute for Age Research
Country: USA

Publications

  1. pmc Measurement of instantaneous velocity vectors of organelle transport: mitochondrial transport and bioenergetics in hippocampal neurons
    Akos A Gerencser
    Buck Institute for Age Research, Novato, California 94945, USA
    Biophys J 95:3079-99. 2008
  2. pmc Quantitative microplate-based respirometry with correction for oxygen diffusion
    Akos A Gerencser
    Buck Institute for Age Research, Novato, CA, USA
    Anal Chem 81:6868-78. 2009
  3. pmc Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria
    Akos A Gerencser
    Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA
    J Physiol 590:2845-71. 2012
  4. pmc Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity
    Akos A Gerencser
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 110:990-1004. 2009
  5. pmc No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease
    Sung W Choi
    Buck Institute Research on Aging, Novato, California 94945, USA
    J Neurosci 32:16775-84. 2012
  6. pmc Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes
    Sung W Choi
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Neurosci 31:4524-34. 2011
  7. pmc Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice
    James M Flynn
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Free Radic Biol Med 50:866-73. 2011
  8. pmc Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure
    Sung W Choi
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 109:1179-91. 2009
  9. pmc A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells
    Matthew J Birket
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    J Cell Sci 124:348-58. 2011
  10. pmc The mechanism of superoxide production by the antimycin-inhibited mitochondrial Q-cycle
    Casey L Quinlan
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Biol Chem 286:31361-72. 2011

Collaborators

Detail Information

Publications15

  1. pmc Measurement of instantaneous velocity vectors of organelle transport: mitochondrial transport and bioenergetics in hippocampal neurons
    Akos A Gerencser
    Buck Institute for Age Research, Novato, California 94945, USA
    Biophys J 95:3079-99. 2008
    ..These mitochondria are more motile than the average; however, mitochondrial motility is only slightly dependent on the observed bioenergetic parameters and is correlated the best to the size of the mitochondria...
  2. pmc Quantitative microplate-based respirometry with correction for oxygen diffusion
    Akos A Gerencser
    Buck Institute for Age Research, Novato, CA, USA
    Anal Chem 81:6868-78. 2009
    ..The algorithm increases the useful range of oxygen consumption rates, the temporal resolution, and durations of measurements. The algorithm is presented in a general format and is therefore applicable to other respirometer systems...
  3. pmc Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria
    Akos A Gerencser
    Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA
    J Physiol 590:2845-71. 2012
    ..Between samples treated in different ways, the typical equivalent error is ∼5 mV...
  4. pmc Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity
    Akos A Gerencser
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 110:990-1004. 2009
    ..However, a role for calpain as a contributing factor or in response to milder glutamate insults is not excluded...
  5. pmc No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease
    Sung W Choi
    Buck Institute Research on Aging, Novato, California 94945, USA
    J Neurosci 32:16775-84. 2012
    ..Our results support the conclusion that the intrinsic bioenergetic capacities of presynaptic nerve terminals are maintained in these symptomatic AD mouse models...
  6. pmc Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes
    Sung W Choi
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Neurosci 31:4524-34. 2011
    ..We conclude that the intrinsic bioenergetic capacities of dopaminergic and nondopaminergic presynaptic synaptosomes from mice do not differ...
  7. pmc Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice
    James M Flynn
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Free Radic Biol Med 50:866-73. 2011
    ....
  8. pmc Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure
    Sung W Choi
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 109:1179-91. 2009
    ....
  9. pmc A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells
    Matthew J Birket
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    J Cell Sci 124:348-58. 2011
    ..Taken together, our developmental model provides an understanding of the metabolic transition from hESCs to more quiescent somatic cell types, and supports important roles for mitochondria and secretion in hESC biology...
  10. pmc The mechanism of superoxide production by the antimycin-inhibited mitochondrial Q-cycle
    Casey L Quinlan
    Buck Institute for Research on Aging, Novato, California 94945, USA
    J Biol Chem 286:31361-72. 2011
    ..These mechanisms limit superoxide production and short circuiting of the Q-cycle when electron transfer slows...
  11. doi request reprint Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase
    Adam L Orr
    Buck Institute for Research on Aging, Novato, California, United States of America
    PLoS ONE 9:e89938. 2014
    ..These novel mGPDH inhibitors are unique tools to investigate the role of glycerol 3-phosphate metabolism in both isolated and intact systems...
  12. pmc Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
    Mark J Barsoum
    Apoptosis and Cell Death Program, Burnham Institute for Medical Research, La Jolla, CA, USA
    EMBO J 25:3900-11. 2006
    ..Importantly, NO-induced neuronal cell death was mitigated by Mfn1 and Drp1(K38A). Thus, persistent mitochondrial fission may play a causal role in NO-mediated neurotoxicity...
  13. pmc Mitochondrial swelling measurement in situ by optimized spatial filtering: astrocyte-neuron differences
    Akos A Gerencser
    Department of Medical Biochemistry, Semmelweis University, Neurobiochemical Group, Hungarian Academy of Sciences, Szentagothai Knowledge Center, Budapest, Hungary
    Biophys J 95:2583-98. 2008
    ..We found that in situ astrocytic mitochondria swell upon short-term uncoupling or inhibition of oxidative phosphorylation, whereas such responses are absent in cultured cortical neurons...
  14. pmc Mitochondrial Ca2+ dynamics reveals limited intramitochondrial Ca2+ diffusion
    Akos A Gerencser
    Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary
    Biophys J 88:698-714. 2005
    ..Our data suggest that mitochondria form syncytia of electrical conductance whereas the passage of Ca2+ is restricted to the individual organelle...
  15. ncbi request reprint Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La3+ in cultured cortical neurones
    Christos Chinopoulos
    Semmelweis University, Department of Medical Biochemistry, Neurobiochemical Group, Hungarian Academy of Sciences, Budapest, Hungary
    J Neurochem 91:471-83. 2004
    ..These results indicate that 2-APB and La3+ influence non-store-operated Ca2+ influx in cortical neurones and that this route of Ca2+ entry is involved in glutamate-induced delayed Ca2+ deregulation...