A Zhitkovich

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi Chromium in drinking water: sources, metabolism, and cancer risks
    Anatoly Zhitkovich
    Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI 02912, United States
    Chem Res Toxicol 24:1617-29. 2011
  2. ncbi Killing of chromium-damaged cells by mismatch repair and its relevance to carcinogenesis
    Anatoly Zhitkovich
    Brown University, Center for Genomics and Proteomics, Department of Pathology and Laboratory Medicine, Providence, Rhode Island 02912, USA
    Cell Cycle 4:1050-2. 2005
  3. ncbi Importance of chromium-DNA adducts in mutagenicity and toxicity of chromium(VI)
    Anatoly Zhitkovich
    Department of Pathology and Laboratory Medicine, Brown University, Box G-E507, Providence, Rhode Island 02912, USA
    Chem Res Toxicol 18:3-11. 2005
  4. ncbi Reductive activation with cysteine represents a chromium(III)-dependent pathway in the induction of genotoxicity by carcinogenic chromium(VI)
    Anatoly Zhitkovich
    Department of Pathology and Laboratory Medicine, Brown University, Box G B511, Providence, RI 02912, USA
    Environ Health Perspect 110:729-31. 2002
  5. ncbi Non-oxidative mechanisms are responsible for the induction of mutagenesis by reduction of Cr(VI) with cysteine: role of ternary DNA adducts in Cr(III)-dependent mutagenesis
    A Zhitkovich
    Brown University, Department of Pathology and Laboratory Medicine, Providence, Rhode Island 02912, USA
    Biochemistry 40:549-60. 2001
  6. ncbi Reductive metabolism of Cr(VI) by cysteine leads to the formation of binary and ternary Cr--DNA adducts in the absence of oxidative DNA damage
    A Zhitkovich
    Department of Pathology and Laboratory Medicine, Brown University, Box G B511, Providence, Rhode Island 02912, USA
    Chem Res Toxicol 13:1114-24. 2000
  7. ncbi Mismatch repair proteins are activators of toxic responses to chromium-DNA damage
    Elizabeth Peterson-Roth
    Pathology and Laboratory Medicine, Brown University, 70 Ship St, Box G-E507, Providence, RI 02912, USA
    Mol Cell Biol 25:3596-607. 2005
  8. ncbi Genotoxicity and mutagenicity of chromium(VI)/ascorbate-generated DNA adducts in human and bacterial cells
    George Quievryn
    Brown University, Department of Pathology and Laboratory Medicine, Providence, Rhode Island 02912, USA
    Biochemistry 42:1062-70. 2003
  9. ncbi Reduction of Cr (VI) by cysteine: significance in human lymphocytes and formation of DNA damage in reactions with variable reduction rates
    G Quievryn
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Mol Cell Biochem 222:107-18. 2001
  10. ncbi Human nucleotide excision repair efficiently removes chromium-DNA phosphate adducts and protects cells against chromate toxicity
    Mindy Reynolds
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 279:30419-24. 2004

Research Grants

  1. GENOTOXICITY OF CHROMIUM COMPOUNDS
    Anatoly Zhitkovich; Fiscal Year: 2010
  2. GENOTOXICITY OF CHROMIUM COMPOUNDS
    Anatoly Zhitkovich; Fiscal Year: 2007
  3. Sensitivity Mechanisms in Chromium Toxicity
    Anatoly Zhitkovich; Fiscal Year: 2007
  4. Metal Carcinogenesis: New Concepts
    Anatoly Zhitkovich; Fiscal Year: 2006
  5. GENOTOXICITY OF CHROMIUM COMPOUNDS
    Anatoly Zhitkovich; Fiscal Year: 2001

Collaborators

  • K Salnikow
  • M Costa
  • K S Kasprzak
  • Mindy Reynolds
  • George Quievryn
  • Joseph Messer
  • Alma Zecevic
  • Elizabeth Hagan
  • Tatiana Johnston
  • Andrea Macfie
  • Graham Poage
  • Mindy F Reynolds
  • David Guttmann
  • Lauren Stoddard
  • Elizabeth Peterson-Roth
  • Donna A Dickinson
  • Elizabeth Peterson
  • G Quievryn
  • Haley Menard
  • Haley L Menard
  • Elizabeth C Peterson-Roth
  • Rosamaria DeCaro
  • Ivan A Bespalov
  • Volkan M Gurel
  • Volkan Gurel
  • Ivan Bespalov
  • Jiri Aubrecht
  • Elizabeth Rubitski
  • Gregory R Warnes
  • M Goulart
  • J Messer

Detail Information

Publications24

  1. ncbi Chromium in drinking water: sources, metabolism, and cancer risks
    Anatoly Zhitkovich
    Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI 02912, United States
    Chem Res Toxicol 24:1617-29. 2011
    ..The directly mutagenic mode of action and the incompleteness of gastric detoxification argue against a threshold in low-dose extrapolation of cancer risk for ingested Cr(VI)...
  2. ncbi Killing of chromium-damaged cells by mismatch repair and its relevance to carcinogenesis
    Anatoly Zhitkovich
    Brown University, Center for Genomics and Proteomics, Department of Pathology and Laboratory Medicine, Providence, Rhode Island 02912, USA
    Cell Cycle 4:1050-2. 2005
    ....
  3. ncbi Importance of chromium-DNA adducts in mutagenicity and toxicity of chromium(VI)
    Anatoly Zhitkovich
    Department of Pathology and Laboratory Medicine, Brown University, Box G-E507, Providence, Rhode Island 02912, USA
    Chem Res Toxicol 18:3-11. 2005
  4. ncbi Reductive activation with cysteine represents a chromium(III)-dependent pathway in the induction of genotoxicity by carcinogenic chromium(VI)
    Anatoly Zhitkovich
    Department of Pathology and Laboratory Medicine, Brown University, Box G B511, Providence, RI 02912, USA
    Environ Health Perspect 110:729-31. 2002
    ..The demonstration of the mutagenic potential of Cr-DNA adducts suggests that these lesions can be explored in the development of specific and mechanistically important biomarkers of exposure to toxic forms of Cr...
  5. ncbi Non-oxidative mechanisms are responsible for the induction of mutagenesis by reduction of Cr(VI) with cysteine: role of ternary DNA adducts in Cr(III)-dependent mutagenesis
    A Zhitkovich
    Brown University, Department of Pathology and Laboratory Medicine, Providence, Rhode Island 02912, USA
    Biochemistry 40:549-60. 2001
    ..Overall, our results present the first evidence that Cr(III)-DNA adducts play the dominant role in the mutagenicity caused by the metabolism of Cr(VI) by a biological reducing agent...
  6. ncbi Reductive metabolism of Cr(VI) by cysteine leads to the formation of binary and ternary Cr--DNA adducts in the absence of oxidative DNA damage
    A Zhitkovich
    Department of Pathology and Laboratory Medicine, Brown University, Box G B511, Providence, Rhode Island 02912, USA
    Chem Res Toxicol 13:1114-24. 2000
    ..Overall, a spectrum of DNA damage derived from Cr(VI)-cysteine reactions was similar to that found in exposed cells...
  7. ncbi Mismatch repair proteins are activators of toxic responses to chromium-DNA damage
    Elizabeth Peterson-Roth
    Pathology and Laboratory Medicine, Brown University, 70 Ship St, Box G-E507, Providence, RI 02912, USA
    Mol Cell Biol 25:3596-607. 2005
    ..Selection for Cr(VI) resistant, MMR-deficient cells may explain the very high frequency of lung cancers with microsatellite instability among chromate workers...
  8. ncbi Genotoxicity and mutagenicity of chromium(VI)/ascorbate-generated DNA adducts in human and bacterial cells
    George Quievryn
    Brown University, Department of Pathology and Laboratory Medicine, Providence, Rhode Island 02912, USA
    Biochemistry 42:1062-70. 2003
    ..Our results suggest that phosphotriester-type DNA adducts could play a more important role in human than bacterial mutagenesis...
  9. ncbi Reduction of Cr (VI) by cysteine: significance in human lymphocytes and formation of DNA damage in reactions with variable reduction rates
    G Quievryn
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Mol Cell Biochem 222:107-18. 2001
    ..The role of cysteine in reduction of Cr (VI) becomes more significant under conditions of occupational exposure to Cr (VI)-containing welding fumes...
  10. ncbi Human nucleotide excision repair efficiently removes chromium-DNA phosphate adducts and protects cells against chromate toxicity
    Mindy Reynolds
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 279:30419-24. 2004
    ....
  11. ncbi Lower mutagenicity but higher stability of Cr-DNA adducts formed during gradual chromate activation with ascorbate
    George Quievryn
    Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Room 507, Providence RI 02912, USA
    Carcinogenesis 27:2316-21. 2006
    ..Overall, our findings do not support the possibility that increased Cr(V) formation at depleted ascorbate levels modeling heavy dose exposures causes higher levels of mutagenic DNA damage...
  12. ncbi Utilization of DNA-protein cross-links as a biomarker of chromium exposure
    A Zhitkovich
    Nelson Institute of Environmental Medicine, New York University Medical Center, New York, New York, USA
    Environ Health Perspect 106:969-74. 1998
    ....
  13. ncbi XPA impacts formation but not proteasome-sensitive repair of DNA-protein cross-links induced by chromate
    Alma Zecevic
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Mutagenesis 25:381-8. 2010
    ..Therefore, individual differences in NER activity are expected to alter sensitivity but not persistence of DPC as a biomarker of hexavalent Cr...
  14. ncbi Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair
    Mindy Reynolds
    Department of Pathology and Laboratory Medicine, Brown University Providence, Rhode Island 02912, USA
    Nucleic Acids Res 35:465-76. 2007
    ..Collectively, these studies demonstrated that Asc-dependent metabolism is the main source of genotoxic and mutagenic damage in Cr(VI)-exposed cells...
  15. ncbi Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolism
    David Guttmann
    Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, Rhode Island 02912, USA
    Chem Res Toxicol 21:2188-94. 2008
    ..Overall, our results indicate that chromate reduction by physiological concentrations of GSH is a weakly mutagenic process, which is consistent with low mutagenicity of Cr(VI) in ascorbate-deficient cells...
  16. ncbi WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts
    Alma Zecevic
    Brown University, Department of Pathology and Laboratory Medicine, Providence, RI 02912, USA
    Cell Cycle 8:2769-78. 2009
    ..Our work provides the first demonstration of the major importance of WRN in repair of a specific class of DSB in human cells...
  17. ncbi Mechanism of DNA-protein cross-linking by chromium
    Andrea Macfie
    Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, Rhode Island 02912, USA
    Chem Res Toxicol 23:341-7. 2010
    ....
  18. ncbi Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers
    Mindy F Reynolds
    Department of Pathology, Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Cancer Res 69:1071-9. 2009
    ..Thus, sequential recruitment and unprecedented cooperation of MutSalpha and MutSbeta branches of MMR in processing of Cr-DNA cross-links is the main cause of DSB and chromosomal breakage at low and moderate Cr(VI) doses...
  19. ncbi Carcinogenic chromium(VI) induces cross-linking of vitamin C to DNA in vitro and in human lung A549 cells
    George Quievryn
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biochemistry 41:3156-67. 2002
    ....
  20. ncbi Cellular vitamin C increases chromate toxicity via a death program requiring mismatch repair but not p53
    Mindy Reynolds
    Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Room 507, Providence, RI 02912, USA
    Carcinogenesis 28:1613-20. 2007
    ..Our findings also indicate that Asc plays a dual role in Cr(VI) toxicity: protective outside and potentiating inside the cell...
  21. ncbi Causes of DNA single-strand breaks during reduction of chromate by glutathione in vitro and in cells
    Joseph Messer
    Center for Genomics and Proteomics, Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Room 507, Providence, RI 02912, USA
    Free Radic Biol Med 40:1981-92. 2006
    ..In summary, formation of toxic SSB in cells occurs at relatively high chromate doses, requires H2O2, and is suppressed by high GSH concentrations...
  22. ncbi Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
    Konstantin Salnikow
    National Cancer Institute, Frederick, MD 21702, USA
    Chem Res Toxicol 21:28-44. 2008
    ..Overall, metal carcinogenesis appears to require the formation of specific metal complexes, chromosomal damage, and activation of signal transduction pathways promoting survival and expansion of genetically/epigenetically altered cells...
  23. ncbi Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress
    Konstantin Salnikow
    NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 279:40337-44. 2004
    ....
  24. ncbi Differentiation of DNA reactive and non-reactive genotoxic mechanisms using gene expression profile analysis
    Donna A Dickinson
    Pfizer Global Research and Development Eastern Point Rd, Groton, CT 06340, USA
    Mutat Res 549:29-41. 2004
    ..Our results suggest the potential utility of gene expression profile analysis for elucidating mechanism of action of genotoxic agents...

Research Grants18

  1. GENOTOXICITY OF CHROMIUM COMPOUNDS
    Anatoly Zhitkovich; Fiscal Year: 2010
    ..The completion of the proposed work can lead to the identification of biochemical factors that increase or decrease individual susceptibility to genetic damage by carcinogenic chromium. ..
  2. GENOTOXICITY OF CHROMIUM COMPOUNDS
    Anatoly Zhitkovich; Fiscal Year: 2007
    ..abstract_text> ..
  3. Sensitivity Mechanisms in Chromium Toxicity
    Anatoly Zhitkovich; Fiscal Year: 2007
    ..The results of this work are expected to advance molecular understanding of Cr(VI) injury in the major target cells and to identify damage processing proteins that enhance toxicity of Cr-DNA modifications. ..
  4. Metal Carcinogenesis: New Concepts
    Anatoly Zhitkovich; Fiscal Year: 2006
    ....
  5. GENOTOXICITY OF CHROMIUM COMPOUNDS
    Anatoly Zhitkovich; Fiscal Year: 2001
    ....