Peng Zhang

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses
    Peng Zhang
    Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown Univ, 1 Hoppin St, Providence, RI 02903, USA
    Am J Physiol Heart Circ Physiol 301:H147-56. 2011
  2. pmc Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2
    Cindy Park-Windhol
    Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 7:e40048. 2012
  3. pmc Regulators of G-protein signaling in the heart and their potential as therapeutic targets
    Peng Zhang
    Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, 1 Hoppin St, Providence, RI 02903, USA
    Circ Res 109:320-33. 2011
  4. pmc PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension
    Havovi Chichger
    Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Providence, Rhode Island Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island
    Am J Physiol Lung Cell Mol Physiol 308:L827-36. 2015
  5. pmc Heterotrimeric G protein-mediated signaling and its non-canonical regulation in the heart
    Peng Zhang
    Cardiovascular Research Center, Cardiology Division, Rhode Island Hospital, Providence, RI, USA Alpert Medical School of Brown University, Providence, RI, USA
    Life Sci 129:35-41. 2015
  6. pmc Functional role, mechanisms of regulation, and therapeutic potential of regulator of G protein signaling 2 in the heart
    Peng Zhang
    Cardiovascular Research Center, Cardiology Division, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
    Trends Cardiovasc Med 24:85-93. 2014

Collaborators

  • Ulrike Mende
  • Gaurav Choudhary
  • Havovi Chichger
  • Cindy Park-Windhol
  • Kelly A O'Connell
  • Alexander Vang
  • Elizabeth O Harrington
  • Lisa Rickey
  • Michelle E King
  • Ming Zhu
  • Darragh Cullen
  • Angel E Maldonado
  • Leonard Chaves
  • Jialin Su

Detail Information

Publications6

  1. pmc Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses
    Peng Zhang
    Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown Univ, 1 Hoppin St, Providence, RI 02903, USA
    Am J Physiol Heart Circ Physiol 301:H147-56. 2011
    ..Together, these data suggest that RGS2 is a functionally important negative regulator of ANG II-induced cardiac fibroblast responses that may play a role in ANG II-induced fibrosis development...
  2. pmc Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2
    Cindy Park-Windhol
    Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 7:e40048. 2012
    ..Furthermore, our study suggests chamber-specific differences in the regulation of RGS2 functionality and potential future utility of the new transgenic model in mitigating G(q/11) signaling in the atria in vivo...
  3. pmc Regulators of G-protein signaling in the heart and their potential as therapeutic targets
    Peng Zhang
    Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, 1 Hoppin St, Providence, RI 02903, USA
    Circ Res 109:320-33. 2011
    ..In addition, we discuss their potential and promise as therapeutic targets as well as strategies to modulate their expression and function...
  4. pmc PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension
    Havovi Chichger
    Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Providence, Rhode Island Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island
    Am J Physiol Lung Cell Mol Physiol 308:L827-36. 2015
    ....
  5. pmc Heterotrimeric G protein-mediated signaling and its non-canonical regulation in the heart
    Peng Zhang
    Cardiovascular Research Center, Cardiology Division, Rhode Island Hospital, Providence, RI, USA Alpert Medical School of Brown University, Providence, RI, USA
    Life Sci 129:35-41. 2015
    ..Some of these newly characterized mechanisms may be further developed into novel strategies for the treatment of cardiac disease and beyond. ..
  6. pmc Functional role, mechanisms of regulation, and therapeutic potential of regulator of G protein signaling 2 in the heart
    Peng Zhang
    Cardiovascular Research Center, Cardiology Division, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
    Trends Cardiovasc Med 24:85-93. 2014
    ..We highlight key unanswered questions and discuss the potential of RGS2 as a therapeutic target. ..