Detail Information
Publications
Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responsesPeng Zhang
Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown Univ, 1 Hoppin St, Providence, RI 02903, USA
Am J Physiol Heart Circ Physiol 301:H147-56. 2011..Together, these data suggest that RGS2 is a functionally important negative regulator of ANG II-induced cardiac fibroblast responses that may play a role in ANG II-induced fibrosis development...
Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2Cindy Park-Windhol
Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
PLoS ONE 7:e40048. 2012..Furthermore, our study suggests chamber-specific differences in the regulation of RGS2 functionality and potential future utility of the new transgenic model in mitigating G(q/11) signaling in the atria in vivo...
Regulators of G-protein signaling in the heart and their potential as therapeutic targetsPeng Zhang
Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, 1 Hoppin St, Providence, RI 02903, USA
Circ Res 109:320-33. 2011..In addition, we discuss their potential and promise as therapeutic targets as well as strategies to modulate their expression and function...
