Kwoon Y Wong

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi Photoreceptor adaptation in intrinsically photosensitive retinal ganglion cells
    Kwoon Y Wong
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Neuron 48:1001-10. 2005
  2. ncbi Retinal bipolar cell input mechanisms in giant danio. I. Electroretinographic analysis
    Kwoon Y Wong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
    J Neurophysiol 93:84-93. 2005
  3. ncbi Retinal bipolar cell input mechanisms in giant danio. II. Patch-clamp analysis of on bipolar cells
    Kwoon Y Wong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
    J Neurophysiol 93:94-107. 2005
  4. ncbi Retinal bipolar cell input mechanisms in giant danio. III. ON-OFF bipolar cells and their color-opponent mechanisms
    Kwoon Y Wong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    J Neurophysiol 94:265-72. 2005
  5. pmc Synaptic influences on rat ganglion-cell photoreceptors
    Kwoon Y Wong
    Department of Neuroscience, Brown University, Box G L471, Providence, RI 02912, USA
    J Physiol 582:279-96. 2007
  6. ncbi The retina-attached SCN slice preparation: an in vitro mammalian circadian visual system
    Kwoon Y Wong
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    J Biol Rhythms 22:400-10. 2007
  7. pmc Dopaminergic modulation of ganglion-cell photoreceptors in rat
    Matthew J Van Hook
    Department of Neuroscience, Brown University, Box G LN, Providence, RI, USA
    Eur J Neurosci 35:507-18. 2012
  8. pmc OFF ganglion cells cannot drive the optokinetic reflex in zebrafish
    Farida Emran
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138 2020, USA
    Proc Natl Acad Sci U S A 104:19126-31. 2007
  9. pmc Ectopic retinal ON bipolar cell synapses in the OFF inner plexiform layer: contacts with dopaminergic amacrine cells and melanopsin ganglion cells
    Olivia N Dumitrescu
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912
    J Comp Neurol 517:226-44. 2009
  10. doi Melanopsin ganglion cells use a membrane-associated rhabdomeric phototransduction cascade
    Dustin M Graham
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    J Neurophysiol 99:2522-32. 2008

Research Grants

Collaborators

Detail Information

Publications14

  1. ncbi Photoreceptor adaptation in intrinsically photosensitive retinal ganglion cells
    Kwoon Y Wong
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Neuron 48:1001-10. 2005
    ..quot; Implications for the mechanisms generating various non-image-forming visual responses are discussed...
  2. ncbi Retinal bipolar cell input mechanisms in giant danio. I. Electroretinographic analysis
    Kwoon Y Wong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
    J Neurophysiol 93:84-93. 2005
    ....
  3. ncbi Retinal bipolar cell input mechanisms in giant danio. II. Patch-clamp analysis of on bipolar cells
    Kwoon Y Wong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
    J Neurophysiol 93:94-107. 2005
    ..Responses to d-aspartate were reduced by l-AP4 and vice versa. Therefore mGluR6 and EAATs suppress each other, and this might underlie mutual suppression between rod and cone signals in Mbs...
  4. ncbi Retinal bipolar cell input mechanisms in giant danio. III. ON-OFF bipolar cells and their color-opponent mechanisms
    Kwoon Y Wong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    J Neurophysiol 94:265-72. 2005
    ..Cabs can generate double color-opponent center responses by receiving inputs from certain cones through EAATs and from other cones through AMPA/kainate receptors...
  5. pmc Synaptic influences on rat ganglion-cell photoreceptors
    Kwoon Y Wong
    Department of Neuroscience, Brown University, Box G L471, Providence, RI 02912, USA
    J Physiol 582:279-96. 2007
    ..These extrinsic ipRGC light responses can explain some of the previously reported properties of circadian photoentrainment and other non-image-forming visual behaviours...
  6. ncbi The retina-attached SCN slice preparation: an in vitro mammalian circadian visual system
    Kwoon Y Wong
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    J Biol Rhythms 22:400-10. 2007
    ..The authors have also been able to generate this preparation from mice, demonstrating the feasibility of applying this method to transgenic mice...
  7. pmc Dopaminergic modulation of ganglion-cell photoreceptors in rat
    Matthew J Van Hook
    Department of Neuroscience, Brown University, Box G LN, Providence, RI, USA
    Eur J Neurosci 35:507-18. 2012
    ..These data suggest that dopamine, acting via D1-family receptors, alters the responses of ipRGCs and thus of non-image-forming vision...
  8. pmc OFF ganglion cells cannot drive the optokinetic reflex in zebrafish
    Farida Emran
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138 2020, USA
    Proc Natl Acad Sci U S A 104:19126-31. 2007
    ..We conclude that the abnormal photoreceptor terminals in nrc mutants predominantly perturb the ON pathway and that the ON pathway is necessary to drive the OKR in larval zebrafish...
  9. pmc Ectopic retinal ON bipolar cell synapses in the OFF inner plexiform layer: contacts with dopaminergic amacrine cells and melanopsin ganglion cells
    Olivia N Dumitrescu
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912
    J Comp Neurol 517:226-44. 2009
    ..Imaging studies in dissociated bipolar cells show that these ectopic ribbon synapses are capable of vesicular release. There is thus an accessory ON sublayer in the outer IPL...
  10. doi Melanopsin ganglion cells use a membrane-associated rhabdomeric phototransduction cascade
    Dustin M Graham
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    J Neurophysiol 99:2522-32. 2008
    ..The striking similarity of phototransduction in ipRGCs and invertebrate rhabdomeric photoreceptors reinforces the emerging view that these cells have a common evolutionary origin...
  11. ncbi Lazy eyes zebrafish mutation affects Müller glial cells, compromising photoreceptor function and causing partial blindness
    Pamela M Kainz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138
    J Comp Neurol 463:265-80. 2003
    ..In summary, the lze gene appears to be required for Müller cell viability and normal visual function. The lze mutant may be a model for the study of the involvement of Müller cells in photoreceptor development and function...
  12. pmc Circadian modulation of melanopsin-driven light response in rat ganglion-cell photoreceptors
    Shijun Weng
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Biol Rhythms 24:391-402. 2009
    ..However, this gain change is probably too modest to contribute much to shape the phase response curve (PRC) for behavioral photoentrainment...
  13. ncbi Induction of photosensitivity by heterologous expression of melanopsin
    Xudong Qiu
    Department of Neuroscience, Box 1953, Brown University, Providence, Rhode Island 02912 1953, USA
    Nature 433:745-9. 2005
    ..We conclude that mammalian melanopsin is a functional sensory photopigment, that it is the photopigment of ganglion-cell photoreceptors, and that these photoreceptors may use an invertebrate-like phototransduction cascade...
  14. pmc Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons
    Dao Qi Zhang
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Proc Natl Acad Sci U S A 105:14181-6. 2008
    ..This unprecedented centrifugal outflow of ganglion-cell signals within the retina provides a novel basis for the restructuring of retinal circuits by light...

Research Grants2

  1. Retinal Inputs to the Mammalian Circadian Pacemaker
    KWOON WONG; Fiscal Year: 2006
    ..These experiments may enable a better understanding of how the mammalian circadian pacemaker is regulated, which in turn may lead to better therapies and workplace policies combating/preventing jet lag problems. ..