Lei Wei

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Type II collagen fragment HELIX-II is a marker for early cartilage lesions but does not predict the progression of cartilage destruction in human knee joint synovial fluid
    Xiaochun Wei
    Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, People s Republic of China
    Rheumatol Int 33:1895-9. 2013
  2. pmc Nutrition and degeneration of articular cartilage
    Yuze Wang
    Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, People s Republic of China
    Knee Surg Sports Traumatol Arthrosc 21:1751-62. 2013
  3. pmc Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation
    Lei Wei
    Department of Orthopaedics, The Warren Alpert Medical School of Brown University Rhode Island Hospital, Suite 402A, 1 Hoppin Street, Providence RI 02903, USA
    Dev Biol 341:236-45. 2010
  4. pmc Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV
    Yingjie Guan
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Am J Physiol Cell Physiol 303:C33-40. 2012
  5. pmc MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4
    Ying jie Guan
    Cell and Molecular Biology Laboratory, Department of Orthopaedics, Alpert Medical School of Brown University Rhode Island Hospital, 1 Hoppin St, Ste 402, Providence, RI 02903, USA
    FASEB J 25:4457-66. 2011
  6. ncbi request reprint Chondrocyte death induced by pathological concentration of chemokine stromal cell-derived factor-1
    Lei Wei
    Department of Orthopaedics, Brown Medical School Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Rheumatol 33:1818-26. 2006
  7. pmc CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression
    Xiaojuan Sun
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, USA
    Mol Cancer 9:17. 2010
  8. doi request reprint Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, Morgantown, WV 26506, USA
    Differentiation 78:260-8. 2009
  9. pmc CXCR4-targeted therapy inhibits VEGF expression and chondrosarcoma angiogenesis and metastasis
    Xiaojuan Sun
    Department of Orthopaedics, Warren Alpert Medical School of Brown University and Rhode Island Hospital, Coro West Building, 1 Hoppin St, Providence, RI 02903, USA
    Mol Cancer Ther 12:1163-70. 2013
  10. pmc HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity
    Xiaojuan Sun
    Department of Orthopaedics, Warren Alpert Medical School, Brown University and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Biol Chem 284:21881-90. 2009

Collaborators

Detail Information

Publications14

  1. pmc Type II collagen fragment HELIX-II is a marker for early cartilage lesions but does not predict the progression of cartilage destruction in human knee joint synovial fluid
    Xiaochun Wei
    Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, People s Republic of China
    Rheumatol Int 33:1895-9. 2013
    ..807) and maximum scores (r = 0.794). Thus, elevated HELIX-II level is correlated with early cartilage lesions, but does not have the sensitivity to predict the progression of severity of cartilage damage in the knee joint. ..
  2. pmc Nutrition and degeneration of articular cartilage
    Yuze Wang
    Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, People s Republic of China
    Knee Surg Sports Traumatol Arthrosc 21:1751-62. 2013
    ..To determine the importance of synovial fluid (SF) or subchondral bone marrow (BM) as nutrition sources in cartilage degeneration...
  3. pmc Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation
    Lei Wei
    Department of Orthopaedics, The Warren Alpert Medical School of Brown University Rhode Island Hospital, Suite 402A, 1 Hoppin Street, Providence RI 02903, USA
    Dev Biol 341:236-45. 2010
    ..This suggests a positive feedback loop of stimulation of chondrocyte hypertrophy by SDF-1/CXCR4, which is mediated by Runx2...
  4. pmc Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV
    Yingjie Guan
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Am J Physiol Cell Physiol 303:C33-40. 2012
    ..Thus, CaMKIV plays an important regulatory role during chondrocyte differentiation...
  5. pmc MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4
    Ying jie Guan
    Cell and Molecular Biology Laboratory, Department of Orthopaedics, Alpert Medical School of Brown University Rhode Island Hospital, 1 Hoppin St, Ste 402, Providence, RI 02903, USA
    FASEB J 25:4457-66. 2011
    ..Taken together, miR-365 is the first identified mechanically responsive microRNA that regulates chondrocyte differentiation via directly targeting HDAC4...
  6. ncbi request reprint Chondrocyte death induced by pathological concentration of chemokine stromal cell-derived factor-1
    Lei Wei
    Department of Orthopaedics, Brown Medical School Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Rheumatol 33:1818-26. 2006
    ..Our aim was to determine whether the pathological concentration of SDF-1 induces chondrocyte death and to investigate mechanisms underlying such death...
  7. pmc CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression
    Xiaojuan Sun
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, USA
    Mol Cancer 9:17. 2010
    ..The present study determined the effect of hypoxia and specifically HIF-1a on expression of CXCR4 and MMP1 and their role in chondrosarcoma cell invasion...
  8. doi request reprint Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, Morgantown, WV 26506, USA
    Differentiation 78:260-8. 2009
    ..The mechanism underlying this process needs further investigation...
  9. pmc CXCR4-targeted therapy inhibits VEGF expression and chondrosarcoma angiogenesis and metastasis
    Xiaojuan Sun
    Department of Orthopaedics, Warren Alpert Medical School of Brown University and Rhode Island Hospital, Coro West Building, 1 Hoppin St, Providence, RI 02903, USA
    Mol Cancer Ther 12:1163-70. 2013
    ..61 cm(3) in the treatment group. The number of lung metastatic nodules was 23 ± 9 in control compared with 10 ± 6 in the treatment group (N = 8/group). Therefore, CXCR4-targeted therapy may be a treatment strategy for chondrosarcoma...
  10. pmc HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity
    Xiaojuan Sun
    Department of Orthopaedics, Warren Alpert Medical School, Brown University and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Biol Chem 284:21881-90. 2009
    ..Thus, both hypoxia and dysregulated expression of a developmental pathway are causes of increased VEGF expression in chondrosarcoma...
  11. pmc Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model
    Lei Wei
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Orthop Res 28:900-6. 2010
    ..This study indicates that the biomarkers and progression of OA may differ in the Hartley guinea pig models with and without posttraumatic OA...
  12. doi request reprint Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    J Pineal Res 46:181-7. 2009
    ..Melatonin may prove to be a highly valuable addition to current therapeutic models for degenerative cartilage repair...
  13. pmc Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway
    Fangyuan Wei
    Department of Orthopaedics, The Warren Alpert Medical School of Brown University Rhode Island Hospital, 1 Hoppin Street, Providence, RI 02903, USA
    Arthritis Res Ther 14:R177. 2012
    ..Together, these findings raise the possibility that disruption of the SDF-1/CXCR4 signaling can be used as a therapeutic approach to attenuate cartilage degeneration...
  14. pmc CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase
    Lei Wei
    Department of Orthopaedics, Brown Medical School Rhode Island Hospital, Providence, Rhode Island, USA
    Arthritis Res Ther 8:R37. 2006
    ..Thus, p38 MAPK is a potential therapeutic target, inhibition of which may maintain the cellularity of articular chondrocytes by inhibiting cell death and its amplification signal and by increasing cell proliferation...