Lei Wei

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation
    Lei Wei
    Department of Orthopaedics, The Warren Alpert Medical School of Brown University Rhode Island Hospital, Suite 402A, 1 Hoppin Street, Providence RI 02903, USA
    Dev Biol 341:236-45. 2010
  2. ncbi Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV
    Yingjie Guan
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Am J Physiol Cell Physiol 303:C33-40. 2012
  3. ncbi MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4
    Ying jie Guan
    Cell and Molecular Biology Laboratory, Department of Orthopaedics, Alpert Medical School of Brown University Rhode Island Hospital, 1 Hoppin St, Ste 402, Providence, RI 02903, USA
    FASEB J 25:4457-66. 2011
  4. ncbi CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression
    Xiaojuan Sun
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, USA
    Mol Cancer 9:17. 2010
  5. ncbi Chondrocyte death induced by pathological concentration of chemokine stromal cell-derived factor-1
    Lei Wei
    Department of Orthopaedics, Brown Medical School-Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Rheumatol 33:1818-26. 2006
  6. ncbi Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, Morgantown, WV 26506, USA
    Differentiation 78:260-8. 2009
  7. ncbi HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity
    Xiaojuan Sun
    Department of Orthopaedics, Warren Alpert Medical School, Brown University and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Biol Chem 284:21881-90. 2009
  8. ncbi Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    J Pineal Res 46:181-7. 2009
  9. ncbi Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model
    Lei Wei
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Orthop Res 28:900-6. 2010
  10. ncbi CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase
    Lei Wei
    Department of Orthopaedics, Brown Medical School Rhode Island Hospital, Providence, Rhode Island, USA
    Arthritis Res Ther 8:R37. 2006

Collaborators

Detail Information

Publications11

  1. ncbi Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation
    Lei Wei
    Department of Orthopaedics, The Warren Alpert Medical School of Brown University Rhode Island Hospital, Suite 402A, 1 Hoppin Street, Providence RI 02903, USA
    Dev Biol 341:236-45. 2010
    ..This suggests a positive feedback loop of stimulation of chondrocyte hypertrophy by SDF-1/CXCR4, which is mediated by Runx2...
  2. ncbi Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV
    Yingjie Guan
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Am J Physiol Cell Physiol 303:C33-40. 2012
    ..Thus, CaMKIV plays an important regulatory role during chondrocyte differentiation...
  3. ncbi MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4
    Ying jie Guan
    Cell and Molecular Biology Laboratory, Department of Orthopaedics, Alpert Medical School of Brown University Rhode Island Hospital, 1 Hoppin St, Ste 402, Providence, RI 02903, USA
    FASEB J 25:4457-66. 2011
    ..Taken together, miR-365 is the first identified mechanically responsive microRNA that regulates chondrocyte differentiation via directly targeting HDAC4...
  4. ncbi CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression
    Xiaojuan Sun
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, USA
    Mol Cancer 9:17. 2010
    ..The present study determined the effect of hypoxia and specifically HIF-1a on expression of CXCR4 and MMP1 and their role in chondrosarcoma cell invasion...
  5. ncbi Chondrocyte death induced by pathological concentration of chemokine stromal cell-derived factor-1
    Lei Wei
    Department of Orthopaedics, Brown Medical School-Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Rheumatol 33:1818-26. 2006
    ..CONCLUSION: Our findings suggest a novel pathological mechanism by which high concentrations of SDF-1 in SF induce chondrocyte death during OA and RA...
  6. ncbi Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, Morgantown, WV 26506, USA
    Differentiation 78:260-8. 2009
    ..The mechanism underlying this process needs further investigation...
  7. ncbi HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity
    Xiaojuan Sun
    Department of Orthopaedics, Warren Alpert Medical School, Brown University and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Biol Chem 284:21881-90. 2009
    ..Thus, both hypoxia and dysregulated expression of a developmental pathway are causes of increased VEGF expression in chondrosarcoma...
  8. ncbi Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    J Pineal Res 46:181-7. 2009
    ..Melatonin may prove to be a highly valuable addition to current therapeutic models for degenerative cartilage repair...
  9. ncbi Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model
    Lei Wei
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Orthop Res 28:900-6. 2010
    ..This study indicates that the biomarkers and progression of OA may differ in the Hartley guinea pig models with and without posttraumatic OA...
  10. ncbi CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase
    Lei Wei
    Department of Orthopaedics, Brown Medical School Rhode Island Hospital, Providence, Rhode Island, USA
    Arthritis Res Ther 8:R37. 2006
    ..Thus, p38 MAPK is a potential therapeutic target, inhibition of which may maintain the cellularity of articular chondrocytes by inhibiting cell death and its amplification signal and by increasing cell proliferation...
  11. ncbi Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway
    Fangyuan Wei
    Department of Orthopaedics, The Warren Alpert Medical School of Brown University Rhode Island Hospital, 1 Hoppin Street, Providence, RI 02903, USA
    Arthritis Res Ther 14:R177. 2012
    ..Together, these findings raise the possibility that disruption of the SDF-1/CXCR4 signaling can be used as a therapeutic approach to attenuate cartilage degeneration...