AUDREY TYRKA

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Prospective predictors of the onset of anorexic and bulimic syndromes
    Audrey R Tyrka
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island 02906, USA
    Int J Eat Disord 32:282-90. 2002
  2. ncbi request reprint Interplay between childhood maltreatment, parental bonding, and gender effects: impact on quality of life
    Kobita Rikhye
    Mood Disorders Research Program, Butler Hospital, Department of Psychiatry and Human Behavior, Brown Medical School, 345 Blackstone Boulevard, Providence, RI 02906, USA
    Child Abuse Negl 32:19-34. 2008
  3. pmc Neuroendocrine predictors of emotional and behavioral adjustment in boys: longitudinal follow-up of a community sample
    Audrey R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, RI 02906, United States
    Psychoneuroendocrinology 37:2042-6. 2012
  4. pmc Altered response to neuroendocrine challenge linked to indices of the metabolic syndrome in healthy adults
    A R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, Rhode Island, USA
    Horm Metab Res 44:543-9. 2012
  5. pmc Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults
    Audrey R Tyrka
    Laboratory for Clinical Neuroscience, Mood Disorders Research Program, Butler Hospital, Providence, Rhode Island, United States of America
    PLoS ONE 7:e30148. 2012
  6. ncbi request reprint Temperament and response to the Trier Social Stress Test
    A R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Brown Medical School, Providence, RI 02906, USA
    Acta Psychiatr Scand 115:395-402. 2007
  7. pmc Childhood parental loss and adult hypothalamic-pituitary-adrenal function
    Audrey R Tyrka
    Mood Disorders Research Program, Laboratory for Clinical Neuroscience, Butler Hospital, Providence, Rhode Island 02906, USA
    Biol Psychiatry 63:1147-54. 2008
  8. pmc Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity
    Audrey R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, Rhode Island 02906, USA
    Biol Psychiatry 66:681-5. 2009
  9. pmc Cortisol and ACTH responses to the Dex/CRH test: influence of temperament
    Audrey R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA
    Horm Behav 53:518-25. 2008
  10. pmc Childhood parental loss and adult psychopathology: effects of loss characteristics and contextual factors
    Audrey R Tyrka
    Butler Hospital, Providence, RI 02906, USA
    Int J Psychiatry Med 38:329-44. 2008

Research Grants

Detail Information

Publications43

  1. ncbi request reprint Prospective predictors of the onset of anorexic and bulimic syndromes
    Audrey R Tyrka
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island 02906, USA
    Int J Eat Disord 32:282-90. 2002
    ..This study investigated prospective predictors of lifetime history diagnoses of partial- and full-syndrome anorexia nervosa and bulimia nervosa (referred to as anorexic syndrome and bulimic syndrome.)..
  2. ncbi request reprint Interplay between childhood maltreatment, parental bonding, and gender effects: impact on quality of life
    Kobita Rikhye
    Mood Disorders Research Program, Butler Hospital, Department of Psychiatry and Human Behavior, Brown Medical School, 345 Blackstone Boulevard, Providence, RI 02906, USA
    Child Abuse Negl 32:19-34. 2008
    ..The aim of this study was to examine associations between childhood adversity, parental bonding, gender, depressive symptoms, and quality of life in non-treatment-seeking adults from the community...
  3. pmc Neuroendocrine predictors of emotional and behavioral adjustment in boys: longitudinal follow-up of a community sample
    Audrey R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, RI 02906, United States
    Psychoneuroendocrinology 37:2042-6. 2012
    ..Here we examine cortisol-emotional/behavioral associations at a two-year follow-up and test whether initial cortisol is predictive of worsening emotional/behavioral problems two years later...
  4. pmc Altered response to neuroendocrine challenge linked to indices of the metabolic syndrome in healthy adults
    A R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, Rhode Island, USA
    Horm Metab Res 44:543-9. 2012
    ..Identification of premorbid risk processes might allow for detection and intervention prior to the development of disease...
  5. pmc Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults
    Audrey R Tyrka
    Laboratory for Clinical Neuroscience, Mood Disorders Research Program, Butler Hospital, Providence, Rhode Island, United States of America
    PLoS ONE 7:e30148. 2012
    ..Recent studies have begun to examine whether early-life stress leads to epigenetic modifications of the GR gene in humans...
  6. ncbi request reprint Temperament and response to the Trier Social Stress Test
    A R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Brown Medical School, Providence, RI 02906, USA
    Acta Psychiatr Scand 115:395-402. 2007
    ..The present study tested the association between temperament and HPA axis function in the same group of subjects using a standardized psychosocial neuroendocrine stress test...
  7. pmc Childhood parental loss and adult hypothalamic-pituitary-adrenal function
    Audrey R Tyrka
    Mood Disorders Research Program, Laboratory for Clinical Neuroscience, Butler Hospital, Providence, Rhode Island 02906, USA
    Biol Psychiatry 63:1147-54. 2008
    ....
  8. pmc Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity
    Audrey R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, Rhode Island 02906, USA
    Biol Psychiatry 66:681-5. 2009
    ..This study was conducted to determine whether CRHR1 polymorphisms interact with childhood maltreatment to predict hypothalamic-pituitary-adrenal (HPA) axis reactivity, which has been linked to both depression and early life stress...
  9. pmc Cortisol and ACTH responses to the Dex/CRH test: influence of temperament
    Audrey R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA
    Horm Behav 53:518-25. 2008
    ..Increased adrenocortical reactivity, which previously has been linked to major depression and anxiety disorders, may contribute to the association between temperament/personality traits and these disorders...
  10. pmc Childhood parental loss and adult psychopathology: effects of loss characteristics and contextual factors
    Audrey R Tyrka
    Butler Hospital, Providence, RI 02906, USA
    Int J Psychiatry Med 38:329-44. 2008
    ..For parental separation/desertion, our results highlight the overriding influence of risk factors that commonly co-occur with this form of parental loss...
  11. pmc Childhood maltreatment and adult personality disorder symptoms: influence of maltreatment type
    Audrey R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, RI 02906, USA
    Psychiatry Res 165:281-7. 2009
    ..There were no significant differences between the maltreatment groups. These findings indicate that emotional abuse/neglect and physical/sexual abuse are risk factors for a broad array of personality outcomes in a non-clinical sample...
  12. pmc Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging
    Audrey R Tyrka
    Mood Disorders Research Program, Butler Hospital, Providence, Rhode Island, USA
    Biol Psychiatry 67:531-4. 2010
    ..Based on previous evidence linking psychosocial stress to shorter telomere length, this study was designed to evaluate the effect of childhood adversity on telomere length...
  13. pmc Behavioral adjustment in a community sample of boys: links with basal and stress-induced salivary cortisol concentrations
    Audrey R Tyrka
    Butler Hospital, Providence, RI 02906, USA
    Psychoneuroendocrinology 35:1167-77. 2010
    ..The implications of these findings and how they may relate to the pathogenesis of emotional and behavioral problems are discussed...
  14. ncbi request reprint Temperament and hypothalamic-pituitary-adrenal axis function in healthy adults
    Audrey R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, 345 Blackstone Road, Providence, RI 02906, USA
    Psychoneuroendocrinology 31:1036-45. 2006
    ..A recent study found HPA hyperactivity in adults with high levels of neuroticism. The present study investigated associations of temperament and HPA function in 31 healthy adults...
  15. ncbi request reprint Increased cerebrospinal fluid corticotropin-releasing factor concentrations during tryptophan depletion in healthy adults
    Audrey R Tyrka
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA
    Biol Psychiatry 56:531-4. 2004
    ..This study examined the effect of tryptophan depletion, which acutely reduces brain serotonin concentrations, on serial cerebrospinal fluid concentrations of corticotropin-releasing factor in healthy humans...
  16. ncbi request reprint Biomarkers in the human stress system: do they signal risk for depression?
    Audrey R Tyrka
    Department of Psychiatry and Human Behavior, Brown Medical School, USA
    Med Health R I 89:180-2. 2006
  17. ncbi request reprint Psychotic major depression: a benefit-risk assessment of treatment options
    Audrey R Tyrka
    Mood Disorders Research Program, and the Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, Rhode Island 02906, USA
    Drug Saf 29:491-508. 2006
    ..Problems with this literature are highlighted, and strategies for future research are suggested...
  18. ncbi request reprint Sex differences in emotional and physiological responses to the Trier Social Stress Test
    Megan M Kelly
    Mood Disorders Research Program, Department of Psychiatry and Human Behavior, Butler Hospital, Brown Medical School, 345 Blackstone Blvd, Providence, RI 02906, USA
    J Behav Ther Exp Psychiatry 39:87-98. 2008
    ..The broader implications of these results and how they relate to sex differences in the etiology and clinical presentation of anxiety and mood disorders are discussed...
  19. ncbi request reprint Varenicline augmentation in depressed smokers: an 8-week, open-label study
    Noah S Philip
    Mood Disorders Research Program, Butler Hospital, and the Department of Psychiatry and Human Behavior, The Warren Alpert Medical School at Brown University, Providence, R I, USA
    J Clin Psychiatry 70:1026-31. 2009
    ..To assess possible antidepressant effects of varenicline augmentation in outpatients with treatment-resistant depressive disorders and nicotine dependence...
  20. ncbi request reprint Sex differences in the use of coping strategies: predictors of anxiety and depressive symptoms
    Megan M Kelly
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, Rhode Island
    Depress Anxiety 25:839-46. 2008
    ..The observed sex differences in the use of coping strategies and their association with depression and anxiety-related problems underscores differences in the clinical presentation of anxiety and depression between women and men...
  21. pmc Effect of childhood emotional abuse and age on cortisol responsivity in adulthood
    Linda L Carpenter
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Brown Department of Psychiatry and Human Behavior, Providence, Rhode Island 02906, USA
    Biol Psychiatry 66:69-75. 2009
    ..Several studies have shown abnormal cortisol reactivity in phenotypically healthy adults without psychiatric disorders as a function of exposure to adverse early environments...
  22. pmc Dex/CRH test cortisol response in outpatients with major depression and matched healthy controls
    Linda L Carpenter
    Department of Psychiatry and Human Behavior, Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Brown Medical School, Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Psychoneuroendocrinology 34:1208-13. 2009
    ..A diminished hormone response has been observed in chronically depressed outpatients...
  23. ncbi request reprint Cerebrospinal fluid interleukin (IL)-6 in unipolar major depression
    Linda L Carpenter
    Mood Disorders Research Program, Butler Hospital, and Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
    J Affect Disord 79:285-9. 2004
    ..This study was undertaken to determine whether IL-6 concentrations in cerebrospinal fluid (CSF) differ between depressed patients and healthy control subjects...
  24. ncbi request reprint Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects
    Linda L Carpenter
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, RI 02906, USA
    Neuropsychopharmacology 29:777-84. 2004
    ..More work is needed to elucidate the critical nature and timing of early events that may be associated with enduring neuroendocrine changes in humans...
  25. doi request reprint Nicotinic acetylcholine receptors and depression: a review of the preclinical and clinical literature
    Noah S Philip
    Butler Hospital, Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI 02906, USA
    Psychopharmacology (Berl) 212:1-12. 2010
    ..Taken together, the preclinical and clinical evidence suggests that drugs targeting nAChRs may represent an important new approach to the treatment of depression...
  26. ncbi request reprint Decreased cerebrospinal fluid concentrations of substance P in treatment-resistant depression and lack of alteration after acute adjunct vagus nerve stimulation therapy
    Linda L Carpenter
    Mood Disorders Research Program, Butler Hospital, Brown University, Providence, RI, USA
    Psychiatry Res 157:123-9. 2008
    ..Low CSF SP may reflect a biological marker of the subtype of severe and chronic depression that is resistant to standard therapies...
  27. pmc Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults
    Linda L Carpenter
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, RI 02906, USA
    Neuropsychopharmacology 35:2617-23. 2010
    ..Inflammation may be an important developmental mediator linking adverse experiences in early life to poor adult physical and mental health. The results of this preliminary study warrant further investigation in a larger sample...
  28. pmc Gene-environment interactions: early life stress and risk for depressive and anxiety disorders
    Nicole R Nugent
    Bradley Hasbro Children s Research Center, Rhode Island Hospital, Coro West Building, One Hoppin Street, Suite 204, Providence, RI 02903, USA
    Psychopharmacology (Berl) 214:175-96. 2011
    ..e., depressive and anxiety) disorders. Recent findings have suggested a unique role for early life stress (ELS) in the development of internalizing disorders, contributing to the rapid proliferation of research in this area...
  29. ncbi request reprint Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania
    Linda L Carpenter
    Mood Disorders Research Program, Butler Hospital, and Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA
    Psychiatry Res 112:257-62. 2002
    ..3+/-0.8 pg/ml) and their matched controls (n=14) (1.9+/-0.5 pg/ml). These findings fail to support speculation that ongoing immune activation may be causally involved in the pathogenesis of OCD or trichotillomania...
  30. pmc Effect of childhood physical abuse on cortisol stress response
    Linda L Carpenter
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Brown Department of Psychiatry and Human Behavior, Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Psychopharmacology (Berl) 214:367-75. 2011
    ..However, studies of childhood maltreatment and adult HPA function have not yet rigorously investigated the differential effects of maltreatment subtypes, including physical abuse...
  31. ncbi request reprint Service expectations and clinical characteristics of patients receiving psychiatric emergency services
    Linda L Carpenter
    Department of Psychiatry and Human Behavior, Brown Medical School in Providence, Rhode Island 02906, USA
    Psychiatr Serv 56:743-5. 2005
    ..These findings suggest the importance of efforts to educate the public about how to obtain mental health services...
  32. ncbi request reprint Vagus nerve stimulation and deep brain stimulation for treatment resistant depression
    Linda L Carpenter
    Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA
    Med Health R I 89:137, 140-1. 2006
    ..Further investigations are currently underway in order to more fully evaluate both of these neurostimulation therapies, with the hope of substantially improving the treatment of refractory depression...
  33. pmc Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment
    Linda L Carpenter
    Mood Disorders Research Program, Butler Hospital, Brown Medical School, Providence, Rhode Island 02906, USA
    Biol Psychiatry 62:1080-7. 2007
    ..Abnormal HPA response to stress challenge has been reported in adult patients with major depressive disorder and posttraumatic stress disorder...
  34. ncbi request reprint Augmentation with open-label atomoxetine for partial or nonresponse to antidepressants
    Linda L Carpenter
    Mood Disorders Research Program, Butler Hospital, Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02906, USA
    J Clin Psychiatry 66:1234-8. 2005
    ..Other compounds that enhance synaptic norepinephrine have shown efficacy as antidepressant monotherapies and as augmentation agents. This case series study examined the role of atomoxetine in antidepressant augmentation...
  35. ncbi request reprint Open-label tiagabine monotherapy for major depressive disorder with anxiety
    Linda L Carpenter
    Mood Disorders Research Program, Butler Hospital, Brown Medical School, 345 Blackstone Boulevard, Providence, R I 02906, USA
    J Clin Psychiatry 67:66-71. 2006
    ..Tiagabine, a selective GABA reuptake inhibitor (SGRI) that enhances normal GABA tone, was evaluated for its efficacy and safety in the treatment of depression comorbid with significant anxiety...
  36. doi request reprint Augmentation of antidepressants with atypical antipsychotics: a review of the current literature
    Noah S Philip
    Mood Disorders Research Program, Butler Hospital, Providence, RI 02906, USA
    J Psychiatr Pract 14:34-44. 2008
    ....
  37. pmc Pharmacologic approaches to treatment resistant depression: a re-examination for the modern era
    Noah S Philip
    Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Butler Hospital, Providence, RI 02906, USA
    Expert Opin Pharmacother 11:709-22. 2010
    ..The review ends by considering drugs acting on the melatonin, acetylcholine, and glutamate systems that hold promise as future options for TRD...
  38. doi request reprint Patterns of quetiapine use in psychiatric inpatients: an examination of off-label use
    Noah S Philip
    Butler Hospital and Department of Psychiatry and Human Behavior, The Warren Alpert Medical School at Brown University, Providence, RI 02906, USA
    Ann Clin Psychiatry 20:15-20. 2008
    ..To investigate such usage of quetiapine, we evaluated prescribing practices of this drug at our acute-care psychiatric hospital...
  39. ncbi request reprint The relationship between childhood abuse and adult personality disorder symptoms
    Kelly E Grover
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, RI 02906, USA
    J Pers Disord 21:442-7. 2007
    ..These findings link reports of childhood abuse with symptoms of personality disorders in the absence of Axis I psychiatric disorders in a community sample of healthy adults...
  40. ncbi request reprint How similar are correlates of different subclinical eating problems and bulimia nervosa?
    Julia A Graber
    Columbia University, USA
    J Child Psychol Psychiatry 44:262-73. 2003
    ..Participants were from white, upper-middle-class families...
  41. ncbi request reprint [Depression and stress: is there an endophenotype?]
    Andrea Feijo Mello
    Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil, and Programa de Pesquisas em Transtornos do Humor, Hospital Butler, USA
    Rev Bras Psiquiatr 29:S13-8. 2007
    ..To review the new findings about stress, hypothalamic-pituitary-adrenal axis and depression trying to explain a possible endophenotype prone to depression...
  42. ncbi request reprint Adjunctive antidepressant treatment for bipolar depression
    Lawrence H Price
    N Engl J Med 357:614; author reply 615-6. 2007
  43. ncbi request reprint Levetiracetam-induced depression in a healthy adult
    Lauren M Wier
    J Clin Psychiatry 67:1159-60. 2006

Research Grants3

  1. Childhood Maltreatment:Biomarkers of Risk and Resilience
    AUDREY TYRKA; Fiscal Year: 2010
    ..Results of this study may provide insight into the neurobiological markers and mechanisms of psychopathology in these vulnerable children. Such information may contribute to future treatment and prevention efforts. ..
  2. Childhood Maltreatment:Biomarkers of Risk and Resilience
    AUDREY TYRKA; Fiscal Year: 2011
    ..Results of this study may provide insight into the neurobiological markers and mechanisms of psychopathology in these vulnerable children. Such information may contribute to future treatment and prevention efforts. ..