M Tatar

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila
    Hua Bai
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America
    PLoS Genet 9:e1003941. 2013
  2. pmc Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain
    Hua Bai
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Aging Cell 11:978-85. 2012
  3. pmc Juvenile hormone regulation of Drosophila aging
    Rochele Yamamoto
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USA
    BMC Biol 11:85. 2013
  4. pmc Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation
    Nicola Neretti
    Institute for Brain and Neural Systems, Brown University, Providence RI, USA
    BMC Bioinformatics 8:S16. 2007
  5. ncbi request reprint Metabolism by remote control
    Marc Tatar
    Brown University, Providence, RI 02912, USA
    Cell Metab 10:164-6. 2009
  6. pmc Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models?
    Marc Tatar
    Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Gerontol A Biol Sci Med Sci 64:161-3. 2009
  7. ncbi request reprint The neuroendocrine regulation of Drosophila aging
    Marc Tatar
    Division of Biology and Medicine, Brown University, Box G W, Providence, Rhode Island 02192, USA
    Exp Gerontol 39:1745-50. 2004
  8. ncbi request reprint Diet restriction in Drosophila melanogaster. Design and analysis
    Marc Tatar
    Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Interdiscip Top Gerontol 35:115-36. 2007
  9. ncbi request reprint Comment on "Long-lived Drosophila with overexpressed dFOXO in adult fat body"
    Marc Tatar
    Brown University, Division of Biology and Medicine, Box G W, Providence, RI 02912, USA
    Science 307:675; author reply 675. 2005
  10. ncbi request reprint A smell to die for
    Marc Tatar
    Department Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Dev Cell 12:322-4. 2007

Research Grants

Collaborators

Detail Information

Publications45

  1. pmc Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila
    Hua Bai
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America
    PLoS Genet 9:e1003941. 2013
    ..Reduced insulin secretion from the brain may subsequently reinforce longevity assurance through decreased systemic insulin/IGF signaling. ..
  2. pmc Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain
    Hua Bai
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Aging Cell 11:978-85. 2012
    ..dilp6 thus appears to bridge dFOXO, adipose tissue and brain endocrine function to regulate Drosophila longevity...
  3. pmc Juvenile hormone regulation of Drosophila aging
    Rochele Yamamoto
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USA
    BMC Biol 11:85. 2013
    ..With this system we test potential explanations for how juvenile hormone modulates aging...
  4. pmc Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation
    Nicola Neretti
    Institute for Brain and Neural Systems, Brown University, Providence RI, USA
    BMC Bioinformatics 8:S16. 2007
    ....
  5. ncbi request reprint Metabolism by remote control
    Marc Tatar
    Brown University, Providence, RI 02912, USA
    Cell Metab 10:164-6. 2009
    ..In this issue of Cell Metabolism, GĂ©minard et al. (2009) describe how secretion of insulin-like peptides is remotely controlled by the fat body (an adipose, liver-like tissue) in response to dietary amino acids...
  6. pmc Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models?
    Marc Tatar
    Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Gerontol A Biol Sci Med Sci 64:161-3. 2009
    ..It was the consensus of the working session that making healthspan an operational metric would be an innovation needed for the genetic power of model systems to address this aspect of human aging...
  7. ncbi request reprint The neuroendocrine regulation of Drosophila aging
    Marc Tatar
    Division of Biology and Medicine, Brown University, Box G W, Providence, Rhode Island 02192, USA
    Exp Gerontol 39:1745-50. 2004
    ....
  8. ncbi request reprint Diet restriction in Drosophila melanogaster. Design and analysis
    Marc Tatar
    Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Interdiscip Top Gerontol 35:115-36. 2007
    ..Finally, it remains unknown whether or not DR functions through insulin-related signaling...
  9. ncbi request reprint Comment on "Long-lived Drosophila with overexpressed dFOXO in adult fat body"
    Marc Tatar
    Brown University, Division of Biology and Medicine, Box G W, Providence, RI 02912, USA
    Science 307:675; author reply 675. 2005
  10. ncbi request reprint A smell to die for
    Marc Tatar
    Department Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Dev Cell 12:322-4. 2007
    ..How dietary restriction extends life span may involve anticipatory neurons. The odor of dietary yeast is sufficient to speed Drosophila aging while mutants of an odorant-binding protein extend life span...
  11. ncbi request reprint Regulation of aging by germline stem cells
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Sci Aging Knowledge Environ 2002:pe2. 2002
    ..The author compares the new results to previous findings in the fruit fly and discusses possible mechanisms behind the inverse relationship between reproduction and life-span extension...
  12. pmc Reproductive aging in invertebrate genetic models
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Ann N Y Acad Sci 1204:149-55. 2010
    ..elegans and D. melanogaster appears to be regulated by signaling that depends on the presence of germline stem cells in the adult gonad. These invertebrate models provide powerful tools to dissect conserved causes of reproductive aging...
  13. ncbi request reprint A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    M Tatar
    Brown University, Providence, RI 02912, USA, University of Massachusetts, Amherst, MA 01003, USA
    Science 292:107-10. 2001
    ....
  14. pmc The plate half-full: status of research on the mechanisms of dietary restriction in Drosophila melanogaster
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Exp Gerontol 46:363-8. 2011
    ..Strong analyses of genes required for DR should be a priority in future research with Drosophila and this may be made most robust by considering the effect of mutants in the context of the geometric framework...
  15. ncbi request reprint Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms
    M Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Exp Gerontol 36:723-38. 2001
    ..elegans daf-2. We propose neuroendocrine control of reproductive diapause in D. melanogaster that includes phenotypic plasticity for rates of senescence...
  16. ncbi request reprint Unearthing Loci that influence life span
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Sci Aging Knowledge Environ 2003:PE5. 2003
    ..In this Perspective, I discuss the implications of this result in the context of gene regulation and mechanisms of aging...
  17. ncbi request reprint Aging. Dietary advice on Q
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 295:54-5. 2002
  18. ncbi request reprint Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    Dae Sung Hwangbo
    Division of Biology and Medicine, Box G W, Brown University, Providence, Rhode Island 02912, USA
    Nature 429:562-6. 2004
    ..These findings suggest that autonomous and non-autonomous roles of insulin signalling combine to control ageing...
  19. ncbi request reprint The endocrine regulation of aging by insulin-like signals
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 299:1346-51. 2003
    ....
  20. ncbi request reprint The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico
    Meng Ping Tu
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, USA
    Aging Cell 1:75-80. 2002
    ..Remarkably, in similarly sized cohorts of male and female ch1/ch1 and of male ch1/+ mortality deceleration is absent. Mortality deceleration is a phenotype of chico...
  21. ncbi request reprint Reproductive costs of heat shock protein in transgenic Drosophila melanogaster
    R Silbermann
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Evolution 54:2038-45. 2000
    ..The contervailing effects of hsp70 upon fecundity and subsequent age-specific mortality exemplify antagonistic pleiotropy, and this trade-off could contribute to the evolution of Drosophila senescence...
  22. pmc Drosophila lifespan control by dietary restriction independent of insulin-like signaling
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Aging Cell 7:199-206. 2008
    ....
  23. pmc Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    J Exp Biol 211:2712-24. 2008
    ..Our results suggest that 20E and JH play major roles in the regulation of gene expression in response to immune challenge...
  24. ncbi request reprint High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO
    Boris Gershman
    Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    Physiol Genomics 29:24-34. 2007
    ....
  25. ncbi request reprint Impaired ovarian ecdysone synthesis of Drosophila melanogaster insulin receptor mutants
    Meng Ping Tu
    Brown University, Providence, Rhode Island 02912, USA
    Aging Cell 1:158-60. 2002
  26. pmc Drosophila germ-line modulation of insulin signaling and lifespan
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 105:6368-73. 2008
    ..These results suggest that signals from the gonad regulate lifespan and modulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved...
  27. ncbi request reprint Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster
    Meng Ping Tu
    Department of Ecology and Evolutionary Biology, Box G W, Brown University, Providence, RI 02912, USA
    Aging Cell 2:327-33. 2003
    ..Although nutritional conditions of the larvae can affect the subsequent body size and fecundity of adults, these are not sufficient to slow aging...
  28. ncbi request reprint Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster
    Meng Ping Tu
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Gen Comp Endocrinol 142:347-56. 2005
    ....
  29. ncbi request reprint Reduced polymorphism in the chimpanzee semen coagulating protein, semenogelin I
    Sarah B Kingan
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    J Mol Evol 57:159-69. 2003
    ..Our results suggest that there is a positive relationship between the intensity of sperm competition in a species and the strength of positive Darwinian selection on the seminal protein semenogelin I...
  30. pmc Quantitative trait loci affecting phenotypic plasticity and the allometric relationship of ovariole number and thorax length in Drosophila melanogaster
    Alan O Bergland
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Genetics 180:567-82. 2008
    ..The results are discussed in the context of multivariate trait evolution...
  31. pmc A role for Drosophila dFoxO and dFoxO 5'UTR internal ribosomal entry sites during fasting
    Eugenia Villa-Cuesta
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 5:e11521. 2010
    ..IRES mediated translation of dFoxO and dInR may be essential to ensure function and sensitivity of the insulin signaling pathway during fasting...
  32. ncbi request reprint Restriction of amino acids extends lifespan in Drosophila melanogaster
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Mech Ageing Dev 127:643-6. 2006
    ..Dietary restriction through dilution of yeast may extend longevity because this limits the intake of amino acids...
  33. ncbi request reprint Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Bioessays 27:999-1010. 2005
    ..In particular, we illustrate the role of JH as a key mediator of life history trade-offs...
  34. pmc Counting calories in Drosophila diet restriction
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Exp Gerontol 42:247-51. 2007
    ..Since caloric intake correlates with yeast concentration and thus with the intake of every metabolite in this dietary component, it is premature to conclude for Drosophila that calories do not explain extension of life span...
  35. ncbi request reprint Aging of the innate immune response in Drosophila melanogaster
    Melissa Zerofsky
    Brown University, Division of Biology and Medicine, Providence, RI 02912, USA
    Aging Cell 4:103-8. 2005
    ..Consequently, maximum reproduction will occur when the immune response is tightly controlled in young females, even if this increases infection risk at later ages...
  36. ncbi request reprint SIR2 calls upon the ER
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Cell Metab 2:281-2. 2005
    ..Paradoxically, these stress genes are repressed by SIR2, suggesting that resveratrol increases life span by inhibiting this SIR2 action...
  37. ncbi request reprint Drosophila diet restriction in practice: do flies consume fewer nutrients?
    Kyung Jin Min
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Mech Ageing Dev 127:93-6. 2006
    ..To understand the importance of specific nutrients relative to calories as mediators of Drosophila aging, we must directly measure food intake and control for the feeding stimulation of nutrients...
  38. ncbi request reprint Resource allocation to reproduction and soma in Drosophila: a stable isotope analysis of carbon from dietary sugar
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    J Insect Physiol 52:763-70. 2006
    ..Because carbon from larval sucrose appears to be fairly "replaceable", larval sucrose cannot be a limiting substrate in resource allocation between reproduction and lifespan...
  39. ncbi request reprint Insulin regulation of heart function in aging fruit flies
    Robert J Wessells
    The Burnham Institute, Center for Neuroscience and Aging, 10901 Torrey Pines Road, La Jolla, California 92037, USA
    Nat Genet 36:1275-81. 2004
    ..The aging fly heart is a model for studying the genetics of age-sensitive organ-specific pathology...
  40. ncbi request reprint Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    Jason G Wood
    Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 430:686-9. 2004
    ..Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction...
  41. doi request reprint Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling
    Kyu Sun Lee
    Centre for Regenerative Medicine, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon 305 333, Korea
    Nat Cell Biol 10:468-75. 2008
    ..Drosophila sNPF and the evolutionarily conserved mammalian NPY seem to regulate ERK-mediated insulin expression and thus to systemically modulate growth, metabolism and lifespan...
  42. doi request reprint Use of stable isotopes to examine how dietary restriction extends Drosophila lifespan
    Diane M O'Brien
    Curr Biol 18:R155-6. 2008
  43. pmc The aging baboon: comparative demography in a non-human primate
    Anne M Bronikowski
    Department of Zoology and Genetics, Iowa State University, Ames, IA 50011, USA
    Proc Natl Acad Sci U S A 99:9591-5. 2002
    ..In contrast, primate taxa are differentiated by rates of demographic aging, even if they cannot be characterized by species-specific lifespan...
  44. ncbi request reprint What are the effects of maternal and pre-adult environments on ageing in humans, and are there lessons from animal models?
    Paul M Brakefield
    Institute of Biology, Leiden University, PO Box 9516, 2300 RA Leiden, The Netherlands
    Mech Ageing Dev 126:431-8. 2005
    ....
  45. ncbi request reprint Science on the fly
    Ingfei Chen
    Sci Aging Knowledge Environ 2003:NF13. 2003

Research Grants25

  1. MECHANISMS OF AGING REGULATION BY DROSOPHILA GERMLINE
    Marc Tatar; Fiscal Year: 2010
    ..This proposal works with the fly Drosophila melanogaster to explore the effects of reproduction upon candidate aging regulatory hormone systems that are common to insects and mammals. ..
  2. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 1999
    ..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..
  3. Functions and Interactions dFOXO in Drosopila Aging
    Marc Tatar; Fiscal Year: 2007
    ....
  4. Genetics of Reproductive Senescence
    Marc Tatar; Fiscal Year: 2006
    ..Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent. ..
  5. Genetics of Reproductive Senescence
    Marc Tatar; Fiscal Year: 2007
    ..Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent. ..
  6. Genetics of Reproductive Senescence
    Marc Tatar; Fiscal Year: 2009
    ..Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent. ..
  7. MECHANISMS OF AGING REGULATION BY DROSOPHILA GERMLINE
    Marc Tatar; Fiscal Year: 2009
    ..This proposal works with the fly Drosophila melanogaster to explore the effects of reproduction upon candidate aging regulatory hormone systems that are common to insects and mammals. ..
  8. Genetics of Reproductive Senescence
    Marc Tatar; Fiscal Year: 2010
    ..Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent. ..
  9. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2007
    ..In a comprehensive experimental design, we shall assess qualifies of stress resistance, central metabolism and mitochondria function to determine which feature best predicts variance in life span ..
  10. Functions and Interactions dFOXO in Drosopila Aging
    Marc Tatar; Fiscal Year: 2006
    ....
  11. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2006
    ..In a comprehensive experimental design, we shall assess qualifies of stress resistance, central metabolism and mitochondria function to determine which feature best predicts variance in life span ..
  12. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 2000
    ..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..
  13. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 2001
    ..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..
  14. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 2001
    ..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..
  15. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 2002
    ..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..
  16. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2003
    ..In a comprehensive experimental design, we shall assess qualifies of stress resistance, central metabolism and mitochondria function to determine which feature best predicts variance in life span ..
  17. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 2003
    ..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..
  18. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2004
    ..In a comprehensive experimental design, we shall assess qualifies of stress resistance, central metabolism and mitochondria function to determine which feature best predicts variance in life span ..
  19. Functions and Interactions dFOXO in Drosopila Aging
    Marc Tatar; Fiscal Year: 2004
    ....
  20. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2005
    ..In a comprehensive experimental design, we shall assess qualifies of stress resistance, central metabolism and mitochondria function to determine which feature best predicts variance in life span ..
  21. Functions and Interactions dFOXO in Drosopila Aging
    Marc Tatar; Fiscal Year: 2005
    ....
  22. Functions and Interactions dFOXO in Drosopila Aging
    Marc Tatar; Fiscal Year: 2010
    ....