Affiliation: Brown University
Min K, Tatar M. Unraveling the Molecular Mechanism of Immunosenescence in Drosophila. Int J Mol Sci. 2018;19: pubmed publisher
..Lastly, the emerging role of microbiota on the regulation of immunity and aging in Drosophila is discussed. ..
Tatar M, Chien S, Priest N. Negligible Senescence during Reproductive Dormancy in Drosophila melanogaster. Am Nat. 2001;158:248-58 pubmed publisher
..quot; We suggest that low temperature reduces neuroendocrine function, which in turn slows senescence as a function of altered stress response, nutrient reallocation, and metabolism. ..
Tatar M. The plate half-full: status of research on the mechanisms of dietary restriction in Drosophila melanogaster. Exp Gerontol. 2011;46:363-8 pubmed publisher
..Strong analyses of genes required for DR should be a priority in future research with Drosophila and this may be made most robust by considering the effect of mutants in the context of the geometric framework. ..
Zheng W, Rus F, Hernandez A, Kang P, Goldman W, Silverman N, et al
. Dehydration triggers ecdysone-mediated recognition-protein priming and elevated anti-bacterial immune responses in Drosophila Malpighian tubule renal cells. BMC Biol. 2018;16:60 pubmed publisher
..This activity of the renal system may contribute to the immunosenescence observed in Drosophila. ..
Tatar M. Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models?. J Gerontol A Biol Sci Med Sci. 2009;64:161-3 pubmed publisher
..It was the consensus of the working session that making healthspan an operational metric would be an innovation needed for the genetic power of model systems to address this aspect of human aging. ..
Tatar M, Post S, Yu K. Nutrient control of Drosophila longevity. Trends Endocrinol Metab. 2014;25:509-17 pubmed publisher
..Nutrient sensing of protein and carbohydrate may occur in the fat body through signals to hypothalamic-like neurons in the fly brain and, thus, control secretion of insulin-like peptides that regulate longevity. ..
Yamamoto R, Bai H, Dolezal A, Amdam G, Tatar M. Juvenile hormone regulation of Drosophila aging. BMC Biol. 2013;11:85 pubmed publisher
..We identify transcripts that change in response to juvenile hormone independent of reproductive state and suggest these represent somatically expressed genes that could modulate how juvenile hormone controls persistence and longevity. ..
Neretti N, Remondini D, Tatar M, Sedivy J, Pierini M, Mazzatti D, et al
. Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation. BMC Bioinformatics. 2007;8 Suppl 1:S16 pubmed
Tatar M, Kopelman A, Epstein D, Tu M, Yin C, Garofalo R. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science. 2001;292:107-10 pubmed