Joanna Szmydynger-Chodobska

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Synergistic interactions between cytokines and AVP at the blood-CSF barrier result in increased chemokine production and augmented influx of leukocytes after brain injury
    Joanna Szmydynger-Chodobska
    The Neurotrauma and Brain Barriers Research Laboratory, Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 8:e79328. 2013
  2. pmc Posttraumatic invasion of monocytes across the blood-cerebrospinal fluid barrier
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 32:93-104. 2012
  3. pmc Multiple sites of vasopressin synthesis in the injured brain
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 31:47-51. 2011
  4. pmc Vasopressin amplifies the production of proinflammatory mediators in traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Neurotrauma 27:1449-61. 2010
  5. pmc The role of the choroid plexus in neutrophil invasion after traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 29:1503-16. 2009
  6. ncbi request reprint Chronic hypernatremia increases the expression of vasopressin and voltage-gated Na channels in the rat choroid plexus
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI, USA
    Neuroendocrinology 84:339-45. 2006
  7. pmc The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury
    Chris Pickering
    Uppsala University, Department of Neuroscience, Functional Pharmacology, BMC, Box 593, SE 75124, Uppsala, Sweden
    BMC Neurosci 9:97. 2008
  8. ncbi request reprint Shedding of tumor necrosis factor type 1 receptor after experimental spinal cord injury
    J Frederick Harrington
    Department of Neurosurgery, Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Neurotrauma 22:919-28. 2005
  9. ncbi request reprint Increased expression of vasopressin v1a receptors after traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Neurotrauma 21:1090-102. 2004
  10. doi request reprint Emerging concepts in the pathophysiology of traumatic brain injury
    Brian J Zink
    Department of Emergency Medicine, Alpert Medical School of Brown, University Rhode Island Hospital and The Miriam Hospital, 593 Eddy Street, Claverick 2, Providence, RI 02903, USA
    Psychiatr Clin North Am 33:741-56. 2010

Collaborators

Detail Information

Publications12

  1. pmc Synergistic interactions between cytokines and AVP at the blood-CSF barrier result in increased chemokine production and augmented influx of leukocytes after brain injury
    Joanna Szmydynger-Chodobska
    The Neurotrauma and Brain Barriers Research Laboratory, Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 8:e79328. 2013
    ..These results provide evidence for the synergistic interactions between proinflammatory cytokines and AVP, a ligand for G protein-coupled receptors, and support a pathophysiological role of AVP in post-traumatic neuroinflammation. ..
  2. pmc Posttraumatic invasion of monocytes across the blood-cerebrospinal fluid barrier
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 32:93-104. 2012
    ..These data further support the pathophysiological role of BCSFB in promoting the recruitment of inflammatory cells to the injured brain...
  3. pmc Multiple sites of vasopressin synthesis in the injured brain
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 31:47-51. 2011
    ..In the cortex, vasopressin was predominantly produced by activated microglia/macrophages, and, to a lesser extent, by the cerebrovascular endothelium. These data further support the pathophysiological role of vasopressin in brain injury...
  4. pmc Vasopressin amplifies the production of proinflammatory mediators in traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Neurotrauma 27:1449-61. 2010
    ..These data demonstrate that AVP plays an important role in exacerbating the brain inflammatory response to injury...
  5. pmc The role of the choroid plexus in neutrophil invasion after traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 29:1503-16. 2009
    ..This is the first detailed analysis of the BCSFB function related to neutrophil trafficking. Our observations support the role of this barrier in posttraumatic neutrophil invasion...
  6. ncbi request reprint Chronic hypernatremia increases the expression of vasopressin and voltage-gated Na channels in the rat choroid plexus
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI, USA
    Neuroendocrinology 84:339-45. 2006
    ..It is also suggested that the increased expression of voltage-gated Na(+) channels found in the hypothalamus and CP after salt loading may play a role in the adaptation of AVP-producing cells to chronic hypernatremia...
  7. pmc The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury
    Chris Pickering
    Uppsala University, Department of Neuroscience, Functional Pharmacology, BMC, Box 593, SE 75124, Uppsala, Sweden
    BMC Neurosci 9:97. 2008
    ..We also identified a Drosophila sequence, DmCG15744, which shares a common ancestor with the entire Group III of Adhesion GPCRs, and also contains Ig, LRR and HBD domains which were observed in mammalian GPR125...
  8. ncbi request reprint Shedding of tumor necrosis factor type 1 receptor after experimental spinal cord injury
    J Frederick Harrington
    Department of Neurosurgery, Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Neurotrauma 22:919-28. 2005
    ..It is concluded that the shedding of TNFR1 receptor may represent an important post-traumatic physiological response aimed at reducing the proapoptotic effect of TNF-alpha...
  9. ncbi request reprint Increased expression of vasopressin v1a receptors after traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Neurotrauma 21:1090-102. 2004
    ..It is suggested that the increased expression of V1a receptors plays an important role in the vasopressin-mediated formation of edema in the injured brain...
  10. doi request reprint Emerging concepts in the pathophysiology of traumatic brain injury
    Brian J Zink
    Department of Emergency Medicine, Alpert Medical School of Brown, University Rhode Island Hospital and The Miriam Hospital, 593 Eddy Street, Claverick 2, Providence, RI 02903, USA
    Psychiatr Clin North Am 33:741-56. 2010
    ..Hopefully, improved knowledge of these elements of pathophysiology will provide the mechanistic clues that lead to improved treatment of TBI...
  11. ncbi request reprint Distribution of fibroblast growth factor receptors and their co-localization with vasopressin in the choroid plexus epithelium
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Neuroreport 13:257-9. 2002
    ..These observations are in line with the possible mediatory role of VP in the FGF2-dependent inhibition of CSF secretion and the induction of dark epithelial cells...
  12. pmc Expression of junctional proteins in choroid plexus epithelial cell lines: a comparative study
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Cerebrospinal Fluid Res 4:11. 2007
    ..Accordingly, in the present study, we sought to characterize the expression of these junctional proteins in these three cell lines...