Robert Swift

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review
    Robert Swift
    Brown University Alpert Medical School, Center for Alcohol and Addiction Studies, 121 South Main Street, Room 404, Providence, Rhode Island 02903, USA
    J Stud Alcohol Drugs 72:1012-8. 2011
  2. ncbi request reprint Emerging approaches to managing alcohol dependence
    Robert Swift
    Brown University Medical School, Center for Alcohol and Addiction Studies, Providence VA Medical Center, Providence, RI 02912, USA
    Am J Health Syst Pharm 64:S12-22. 2007
  3. doi request reprint Effects of naltrexone during the descending limb of the blood alcohol curve
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA Lara
    Am J Addict 17:257-64. 2008
  4. doi request reprint Effects of topiramate on urge to drink and the subjective effects of alcohol: a preliminary laboratory study
    Robert Miranda
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
    Alcohol Clin Exp Res 32:489-97. 2008
  5. pmc Contingency management for alcohol use reduction: a pilot study using a transdermal alcohol sensor
    Nancy P Barnett
    Center for Alcohol and Addiction Studies, Brown University, Box G S121 5, Providence, RI 02912, USA
    Drug Alcohol Depend 118:391-9. 2011
  6. ncbi request reprint Direct measurement of alcohol and its metabolites
    Robert Swift
    Brown University, Providence VA Medical Center, Providence, RI 02908, USA
    Addiction 98:73-80. 2003
  7. ncbi request reprint High-dose transdermal nicotine and naltrexone: effects on nicotine withdrawal, urges, smoking, and effects of smoking
    Damaris J Rohsenow
    Research Service, Providence Veterans Affairs Medical Center, RI, USA
    Exp Clin Psychopharmacol 15:81-92. 2007
  8. ncbi request reprint Pharmacotherapy of dual substance abuse and dependence
    George A Kenna
    Department of Community Health, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA
    CNS Drugs 21:213-37. 2007
  9. doi request reprint A safety and tolerability laboratory study of the combination of aripiprazole and topiramate in volunteers who drink alcohol
    George A Kenna
    Department of Psychiatry and the Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA
    Hum Psychopharmacol 24:465-72. 2009
  10. pmc Moderators of naltrexone's effects on drinking, urge, and alcohol effects in non-treatment-seeking heavy drinkers in the natural environment
    Jennifer W Tidey
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
    Alcohol Clin Exp Res 32:58-66. 2008

Detail Information

Publications46

  1. ncbi request reprint Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review
    Robert Swift
    Brown University Alpert Medical School, Center for Alcohol and Addiction Studies, 121 South Main Street, Room 404, Providence, Rhode Island 02903, USA
    J Stud Alcohol Drugs 72:1012-8. 2011
    ..The aim of the current study was to evaluate the extent to which variability in patient adherence to treatment contributed to the range of clinical responses observed during naltrexone treatment...
  2. ncbi request reprint Emerging approaches to managing alcohol dependence
    Robert Swift
    Brown University Medical School, Center for Alcohol and Addiction Studies, Providence VA Medical Center, Providence, RI 02912, USA
    Am J Health Syst Pharm 64:S12-22. 2007
    ..To review pharmacotherapies and psychosocial interventions for the treatment of alcohol dependence, including recent developments that may minimize nonadherence...
  3. doi request reprint Effects of naltrexone during the descending limb of the blood alcohol curve
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA Lara
    Am J Addict 17:257-64. 2008
    ..Additionally, these results highlight the potential utility of considering limb of blood alcohol curve when examining the mechanisms of action of pharmacotherapies thought to alter subjective responses to alcohol...
  4. doi request reprint Effects of topiramate on urge to drink and the subjective effects of alcohol: a preliminary laboratory study
    Robert Miranda
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
    Alcohol Clin Exp Res 32:489-97. 2008
    ..This laboratory study systematically examined the dose-dependent effects of topiramate on cue-elicited craving and other putative mechanisms of its pharmacotherapeutic effects on drinking...
  5. pmc Contingency management for alcohol use reduction: a pilot study using a transdermal alcohol sensor
    Nancy P Barnett
    Center for Alcohol and Addiction Studies, Brown University, Box G S121 5, Providence, RI 02912, USA
    Drug Alcohol Depend 118:391-9. 2011
    ..Transdermal alcohol sensors detect alcohol regularly throughout the day, providing remote monitoring and allowing for rapid reinforcement of reductions in use...
  6. ncbi request reprint Direct measurement of alcohol and its metabolites
    Robert Swift
    Brown University, Providence VA Medical Center, Providence, RI 02908, USA
    Addiction 98:73-80. 2003
    ..However, the persistence of ethanol in the body is short lived and ethanol's metabolism and distribution within the body are extremely complex...
  7. ncbi request reprint High-dose transdermal nicotine and naltrexone: effects on nicotine withdrawal, urges, smoking, and effects of smoking
    Damaris J Rohsenow
    Research Service, Providence Veterans Affairs Medical Center, RI, USA
    Exp Clin Psychopharmacol 15:81-92. 2007
    ..Results suggest that starting smokers with 42 mg TNR may increase comfort during initial abstinence, but limited support is seen for naltrexone during smoking abstinence...
  8. ncbi request reprint Pharmacotherapy of dual substance abuse and dependence
    George A Kenna
    Department of Community Health, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA
    CNS Drugs 21:213-37. 2007
    ..While ondansetron and olanzapine show some efficacy in treating alcohol and cocaine dependence, more research is needed to better delineate the subpopulation in which these drugs may provide their maximum effect...
  9. doi request reprint A safety and tolerability laboratory study of the combination of aripiprazole and topiramate in volunteers who drink alcohol
    George A Kenna
    Department of Psychiatry and the Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA
    Hum Psychopharmacol 24:465-72. 2009
    ..The ultimate aim for this research is to determine whether this combination is safe and is superior to either drug taken alone in reducing alcohol use in alcohol dependent patients...
  10. pmc Moderators of naltrexone's effects on drinking, urge, and alcohol effects in non-treatment-seeking heavy drinkers in the natural environment
    Jennifer W Tidey
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
    Alcohol Clin Exp Res 32:58-66. 2008
    ..Polymorphisms in the D4 dopamine receptor (DRD4) gene and the mu-opiate receptor (OPRM1) gene, family history of alcohol problems, age of onset of alcoholism and gender were explored as potential moderators of NTX's effects...
  11. ncbi request reprint New developments for the pharmacological treatment of alcohol withdrawal syndrome. A focus on non-benzodiazepine GABAergic medications
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, RI 02912, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:1106-17. 2008
    ..The promising results in terms of both safety and efficacy are reported. However, we also note the need of more methodologically controlled studies on a greater number of patients, involving more complicated forms of AWS...
  12. doi request reprint A within-group design of nontreatment seeking 5-HTTLPR genotyped alcohol-dependent subjects receiving ondansetron and sertraline
    George A Kenna
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02908, USA
    Alcohol Clin Exp Res 33:315-23. 2009
    ..The aim of this study was to match and mismatch L/L, S/S, or S/L genotypes with administration of ondansetron and sertraline...
  13. doi request reprint Renin and aldosterone but not the natriuretic peptide correlate with obsessive craving in medium-term abstinent alcohol-dependent patients: a longitudinal study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol 42:375-81. 2008
    ..In conclusion, the renin-aldosterone axis could play a role in craving in medium-term abstinent patients and thereby leading to the hypothesis that alcohol craving could be influenced by the fluid volume intake...
  14. pmc Blood glucose level, alcohol heavy drinking, and alcohol craving during treatment for alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Alcohol Clin Exp Res 33:1539-44. 2009
    ..Heavy drinking may increase blood glucose levels. Moreover, in alcohol-dependent subjects, glucose may play a putative role in alcohol preference...
  15. pmc Effects of smoking abstinence, smoking cues and nicotine replacement in smokers with schizophrenia and controls
    Jennifer W Tidey
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Nicotine Tob Res 10:1047-56. 2008
    ....
  16. doi request reprint Relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients: a longitudinal study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Clin Exp Res 32:2047-53. 2008
    ..Investigating this association in alcohol-dependent (AD) patients was the aim of this preliminary and exploratory study...
  17. doi request reprint Olanzapine reduces urge to smoke and nicotine withdrawal symptoms in community smokers
    Damaris J Rohsenow
    Providence Veterans Affairs Medical Center and Center for Alcohol and Addiction Studies, Brown University, RI, USA
    Exp Clin Psychopharmacol 16:215-22. 2008
    ..The results indicate a potentially beneficial effect of 2.5 mg OLAN on tobacco withdrawal and urge to smoke. Combined 5HT/DA antagonists should be considered for future development of pharmacotherapies for smoking cessation...
  18. ncbi request reprint Review of topiramate: an antiepileptic for the treatment of alcohol dependence
    George A Kenna
    Department of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02908, USA
    Curr Drug Abuse Rev 2:135-42. 2009
    ..While the manufacturer will not pursue approval of an indication for the treatment of alcohol dependence, the drug will soon be available generically, making it more affordable for a greater proportion of the public...
  19. ncbi request reprint Subjective and physiological responses to smoking cues in smokers with schizophrenia
    Jennifer W Tidey
    Brown Medical School and Providence Veterans Affairs Medical Center, Brown University, RI 02912, USA
    Nicotine Tob Res 7:421-9. 2005
    ..These results indicate that smoking cue reactivity laboratory models may be useful for investigating potential smoking treatments for, or neurobiological contributions to, smoking behavior in smokers with schizophrenia...
  20. doi request reprint Typologies of alcohol dependence. From Jellinek to genetics and beyond
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Box G S 121 4, Providence, RI 02912, USA
    Neuropsychol Rev 19:115-29. 2009
    ..Greater emphasis, however, must be made to more clearly delineate this field of research, while moving toward more standardized typologies...
  21. ncbi request reprint Turning the clock ahead: potential preclinical and clinical neuropharmacological targets for alcohol dependence
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University Medical School, Providence, RI 02912, USA
    Curr Pharm Des 16:2159-18. 2010
    ....
  22. ncbi request reprint Naltrexone treatment for alcoholics: effect on cigarette smoking rates
    Damaris J Rohsenow
    Providence Veterans Affairs Medical Center, Providence, RI and Brown University Medical School Providence RI 02912, USA
    Nicotine Tob Res 5:231-6. 2003
    ..Further research is needed on possible effects with smokers motivated to quit smoking and on other methods of promoting smoking cessation among alcoholics...
  23. ncbi request reprint Pharmacotherapy, pharmacogenomics, and the future of alcohol dependence treatment, part 1
    George A Kenna
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
    Am J Health Syst Pharm 61:2272-9. 2004
    ..The neurobiological basis of alcohol dependence, established pharmacotherapies for alcohol dependence, pharmacotherapies under investigation, and obstacles to treatment are discussed...
  24. ncbi request reprint Pharmacotherapy, pharmacogenomics, and the future of alcohol dependence treatment, Part 2
    George A Kenna
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
    Am J Health Syst Pharm 61:2380-8. 2004
    ..The neurobiological basis of alcohol dependence, established pharmacotherapies for alcohol dependence, pharmacotherapies under investigation, and obstacles to treatment are discussed...
  25. doi request reprint HIV testing in hazardous drinking: a survey analysis
    Miriam Fenton
    Department of Community Health, Brown University Medical School, Providence, Rhode Island 02912, USA
    Subst Use Misuse 45:204-12. 2010
    ..89) the odds of ever having had an HIV test compared to nonhazardous drinkers. Therefore public health interventions targeted at hazardous drinkers to increase the rate of HIV testing are suggested. The study's limitations are noted...
  26. ncbi request reprint Cigarette smoking topography in smokers with schizophrenia and matched non-psychiatric controls
    Jennifer W Tidey
    Brown University Center for Alcohol and Addiction Studies, Box G BH, Providence, RI 02912, USA
    Drug Alcohol Depend 80:259-65. 2005
    ..These findings suggest that smokers with schizophrenia smoke more intensely than matched non-psychiatric smokers and that their smoking behavior is reliable when assessed under laboratory conditions...
  27. doi request reprint Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University Medical School, Providence, Rhode Island, USA
    Alcohol Clin Exp Res 35:194-202. 2011
    ..Although more research is needed, data available suggest that studying feeding-related pathways in alcohol dependence may have theoretic, biologic, diagnostic, and therapeutic implications...
  28. pmc Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial
    Peter D Friedmann
    Program to Integrate Psychosocial and Health Services, Research Service, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA
    Alcohol Clin Exp Res 32:1652-60. 2008
    ..Trazodone is a commonly prescribed off-label for sleep disturbance in alcohol-dependent patients, but its safety and efficacy for this indication is unknown...
  29. ncbi request reprint Medications acting on the dopaminergic system in the treatment of alcoholic patients
    Robert Swift
    Brown University Center for Alcohol and Addiction Studies, 121 South Main Street, Room 404, Providence, RI 02903, USA
    Curr Pharm Des 16:2136-40. 2010
    ..Dopaminergic medications can have significant side effects. A better understanding of how dopamine affects the various aspects of addictive behavior may lead to more effective medications...
  30. ncbi request reprint Topiramate for the treatment of alcohol dependence: initiating abstinence
    Robert M Swift
    Providence VA Medical Center, Providence, RI 02908, USA
    Lancet 361:1666-7. 2003
  31. pmc Polymorphisms of the mu-opioid receptor and dopamine D4 receptor genes and subjective responses to alcohol in the natural environment
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University and Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    J Abnorm Psychol 119:115-25. 2010
    ..This study extends findings on subjective intoxication, urge to drink, and their genetic bases from controlled laboratory to naturalistic settings...
  32. ncbi request reprint Genetic moderators of naltrexone's effects on alcohol cue reactivity
    John E McGeary
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02906, USA
    Alcohol Clin Exp Res 30:1288-96. 2006
    ..This study examined these candidate genes as moderators of the effects of NTX on cue-elicited urge to drink in non-treatment-seeking heavy drinkers...
  33. ncbi request reprint Depressive symptoms and readiness to quit smoking among cigarette smokers in outpatient alcohol treatment
    Brian Hitsman
    Centers for Behavioral and Preventive Medicine, Brown Medical School, The Miriam Hospital, Providence, Rhode Island 02903, USA
    Psychol Addict Behav 16:264-8. 2002
    ..S. Radloff, 1977). The findings suggest that alcoholic smokers with low depressive symptoms are more receptive to quitting smoking after sustained alcohol abstinence...
  34. ncbi request reprint Alcohol relapses associated with September 11, 2001: a case report
    William H Zywiak
    Decision Sciences Institute, Pacific Institute for Research and Evaluation, Providence, Rhode Island 02906, USA
    Subst Abus 24:123-8. 2003
    ..Results suggest that terrorist events may lead to a greater likelihood of relapse for those in alcohol recovery. These effects may be ameliorated by public education and outreach...
  35. ncbi request reprint Olanzapine attenuates cue-elicited craving for tobacco
    Kent E Hutchison
    Department of Psychology, University of Colorado, Campus Box 345, Boulder, CO, 80309 0345, USA
    Psychopharmacology (Berl) 175:407-13. 2004
    ..Imaging, and pharmacological studies have supported a role for dopaminergic structures in cue-elicited craving for tobacco...
  36. doi request reprint Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Arch Intern Med 168:1188-99. 2008
    ..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...
  37. ncbi request reprint Olanzapine reduces craving for alcohol: a DRD4 VNTR polymorphism by pharmacotherapy interaction
    Kent E Hutchison
    Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Neuropsychopharmacology 28:1882-8. 2003
    ..The findings indicated that olanzapine reduces craving for alcohol at baseline for both DRD4 S and DRD4 L individuals, but only reduces craving after exposure to alcohol cues and after a priming dose of alcohol for DRD4 L individuals...
  38. ncbi request reprint Current pharmacotherapies of alcoholism: a U.S. perspective
    Raymond F Anton
    Department of Psychiatry and the Alcohol Research Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Addict 12:S53-68. 2003
    ..The serotonin type-3 antagonist, ondansetron, has shown promise in early-onset alcoholics but needs more extensive study...
  39. ncbi request reprint The DRD4 VNTR polymorphism moderates craving after alcohol consumption
    Kent E Hutchison
    Department of Psychology, University of Colorado at Boulder, 80309 0345, USA
    Health Psychol 21:139-46. 2002
    ..Results suggested that DRD4 L participants demonstrated significantly higher craving after consumption of alcohol as compared with the control beverage...
  40. ncbi request reprint Challenges and opportunities for medications development in alcoholism: an international perspective on collaborations between academia and industry
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
    Alcohol Clin Exp Res 29:1528-40. 2005
    ..Swift, MD, PhD; (4) A European Perspective on Medications Development, by Otto M. Lesch, MD, PhD, and (5) A Scandinavian Perspective on Evidence-Based Addiction Treatment, by Mats Berglund, MD...
  41. ncbi request reprint Topiramate for treating alcohol dependence: a randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908, USA
    JAMA 298:1641-51. 2007
    ....
  42. ncbi request reprint Advances in the pharmacotherapy of alcoholism: challenging misconceptions
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut, USA
    Alcohol Clin Exp Res 30:272-81. 2006
    ..Gastfriend; (5) System Challenges in the Adoption of Pharmacotherapy, by Robert M. Swift; and (6) Pharmacotherapy for Alcohol Dependence: Strengths, Challenges, and Future Directions, by Mark L. Willenbring...
  43. ncbi request reprint Safety and efficacy of GABAergic medications for treating alcoholism
    Bankole A Johnson
    Department of Psychiatric Medicine, The University of Virginia, Charlottesville, Virginia 22908 0623, USA
    Alcohol Clin Exp Res 29:248-54. 2005
    ..Johnson; (5) Evaluating the Risk of Benzodiazepine Prescription to Alcohol-Dependent Individuals, by Domenic A. Ciraulo; and (6) Safety and Efficacy of GABAergic Agents in Treating Alcoholics: Discussion, by Robert M. Swift...
  44. ncbi request reprint Hospital Use of Ethanol Survey (HUES): preliminary results
    Steven H Smoger
    Department of Veteran Affairs, Louisville, KY, USA
    J Addict Dis 21:65-73. 2002
    ..Alcohol is widely dispensed with few guidelines in this sample of acute-care hospitals. Additional research on therapeutic efficacy, consequences, and institutional oversight of alcohol in hospitals is needed...
  45. ncbi request reprint Ethanol in formularies of US teaching hospitals
    Richard D Blondell
    JAMA 289:552. 2003
  46. ncbi request reprint Development of novel pharmacotherapies for the treatment of alcohol dependence: focus on antiepileptics
    Bankole A Johnson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Alcohol Clin Exp Res 28:295-301. 2004
    ..DiClemente; (5) Synopsis of promising medications to treat alcoholism, by Robert M. Swift; and (6) New knowledge on the development of antiepileptic medications for the treatment of alcoholism, by Robert J. Malcolm, Jr...

Research Grants9

  1. Aripiprazole and Topiramate on Free-Choice Alcohol Use
    Robert M Swift; Fiscal Year: 2010
    ..The long term objectives of this research are to improve medications available for alcoholism treatment and inform research and theory on the mechanisms of action of such medications. ..
  2. MEDICATION/PSYCHOTHERAPY TAILORED TO PATIENT RESOURCES
    Robert Swift; Fiscal Year: 2004
    ..However, each study site has provided site-specific information on the budget, budget justifications, listing of key personnel, consultant/consortium agreements, and human subjects sections of their respective proposals. ..
  3. Device for Acamprosate Transcutaneous Delivery to Reduce Alcohol Consumption.
    Robert Swift; Fiscal Year: 2006
    ..Thus, the transcutaneous, flow-modulated, microneedle array-enhanced delivery of acamprosate is expected to increase up to 5-7 times its poor (11%) oral bioavailability, so that 55-80% of a dose is absorbed in a rat-model study. ..
  4. Alcohol Phenotype Development in American Samoa
    Robert Swift; Fiscal Year: 2007
    ..We will also utilize behavioral testing to assess the potential endophenotypes of sweet preference, risk taking, and cue-induced alcohol craving in the participants. ..
  5. Aripiprazole and Topiramate on Free-Choice Alcohol Use
    Robert Swift; Fiscal Year: 2007
    ..The long term objectives of this research are to improve medications available for alcoholism treatment and inform research and theory on the mechanisms of action of such medications. ..
  6. Aripiprazole and Topiramate on Free-Choice Alcohol Use
    Robert Swift; Fiscal Year: 2009
    ..The long term objectives of this research are to improve medications available for alcoholism treatment and inform research and theory on the mechanisms of action of such medications. ..