Jennifer A Sanders

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat
    Jennifer A Sanders
    Department of Pediatrics, Division of Endocrinology and Metabolism, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903 USA
    Exp Mol Pathol 93:40-9. 2012
  2. pmc Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    BMC Physiol 12:1. 2012
  3. pmc The effect of rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats
    Jennifer A Sanders
    Dept of Pediatrics, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Cell Physiol 295:C406-13. 2008
  4. pmc Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR)
    ROSA H JIMENEZ
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 5:e9084. 2010
  5. pmc Hepatic translation control in the late-gestation fetal rat
    Philip A Gruppuso
    Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Regul Integr Comp Physiol 295:R558-67. 2008
  6. pmc Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines
    ROSA H JIMENEZ
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island, USA
    PLoS ONE 4:e7373. 2009
  7. ncbi request reprint Coordinated regulation of c-Myc and Max in rat liver development
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 290:G145-55. 2006
  8. pmc The physiology and pathophysiology of rapamycin resistance: implications for cancer
    Philip A Gruppuso
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI USA
    Cell Cycle 10:1050-8. 2011
  9. ncbi request reprint Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Biochim Biophys Acta 1743:141-50. 2005
  10. pmc The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells
    Sunny J S Yoo
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    J Cell Biochem 105:290-300. 2008

Collaborators

Detail Information

Publications10

  1. pmc The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat
    Jennifer A Sanders
    Department of Pediatrics, Division of Endocrinology and Metabolism, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903 USA
    Exp Mol Pathol 93:40-9. 2012
    ..mTORC1 signaling plays a key role in the oval cell response and in the development of preneoplastic foci. This pathway may be a target for the chemoprevention of hepatocellular carcinoma...
  2. pmc Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    BMC Physiol 12:1. 2012
    ..In order to investigate the functional role of c-Myc in adult liver, we have developed a hepatocyte-specific c-myc knockout mouse, c-mycfl/fl;Alb-Cre...
  3. pmc The effect of rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats
    Jennifer A Sanders
    Dept of Pediatrics, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Cell Physiol 295:C406-13. 2008
    ..Furthermore, the well-characterized effects of rapamycin in tissue culture systems are not recapitulated in the asynchronous cell proliferation that accompanies normal growth and tissue remodeling...
  4. pmc Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR)
    ROSA H JIMENEZ
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 5:e9084. 2010
    ..The latter are resistant to the growth inhibitory effects of rapamycin, thus providing us with an opportunity to study the gene expression effects of rapamycin without confounding effects on cell proliferation...
  5. pmc Hepatic translation control in the late-gestation fetal rat
    Philip A Gruppuso
    Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Regul Integr Comp Physiol 295:R558-67. 2008
    ..These differences may confer differential sensitivity to the growth inhibitory effects of rapamycin...
  6. pmc Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines
    ROSA H JIMENEZ
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island, USA
    PLoS ONE 4:e7373. 2009
    ..However, resistance to its growth inhibitory effects is common. We hypothesized that hepatic cell lines with varying rapamycin responsiveness would show common characteristics accounting for resistance to the drug...
  7. ncbi request reprint Coordinated regulation of c-Myc and Max in rat liver development
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 290:G145-55. 2006
    ....
  8. pmc The physiology and pathophysiology of rapamycin resistance: implications for cancer
    Philip A Gruppuso
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI USA
    Cell Cycle 10:1050-8. 2011
    ....
  9. ncbi request reprint Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Biochim Biophys Acta 1743:141-50. 2005
    ..We speculate that the nucleolus may act to sequester c-Myc in quiescent hepatocytes while providing a pool of c-Myc that is readily available to reach its targets in the nucleus...
  10. pmc The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells
    Sunny J S Yoo
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    J Cell Biochem 105:290-300. 2008
    ..Our results indicate that the yeast Tap42/TOR paradigm is not conserved in hepatic cells...